LOCUS       NM_001358965            1737 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Mus musculus serglycin (Srgn), transcript variant 2, mRNA.
ACCESSION   NM_001358965 XM_006513375
VERSION     NM_001358965.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1737)
  AUTHORS   Qian,Y., Yang,L., Chen,J., Zhou,C., Zong,N., Geng,Y., Xia,S.,
            Yang,H., Bao,X., Chen,Y. and Xu,Y.
  TITLE     SRGN amplifies microglia-mediated neuroinflammation and exacerbates
            ischemic brain injury
  JOURNAL   J Neuroinflammation 21 (1), 35 (2024)
   PUBMED   38287411
  REMARK    GeneRIF: SRGN amplifies microglia-mediated neuroinflammation and
            exacerbates ischemic brain injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1737)
  AUTHORS   Doncheva,A.I., Norheim,F.A., Hjorth,M., Grujic,M., Paivandy,A.,
            Dankel,S.N., Hertel,J.K., Valderhaug,T.G., Bottcher,Y., Ferno,J.,
            Mellgren,G., Dalen,K.T., Pejler,G. and Kolset,S.O.
  TITLE     Serglycin Is Involved in Adipose Tissue Inflammation in Obesity
  JOURNAL   J Immunol 208 (1), 121-132 (2022)
   PUBMED   34872979
  REMARK    GeneRIF: Serglycin Is Involved in Adipose Tissue Inflammation in
            Obesity.
REFERENCE   3  (bases 1 to 1737)
  AUTHORS   Li,Z., Peirasmaki,D., Svard,S. and Abrink,M.
  TITLE     Serglycin-Deficiency Causes Reduced Weight Gain and Changed
            Intestinal Cytokine Responses in Mice Infected With Giardia
            intestinalis
  JOURNAL   Front Immunol 12, 677722 (2021)
   PUBMED   34335577
  REMARK    GeneRIF: Serglycin-Deficiency Causes Reduced Weight Gain and
            Changed Intestinal Cytokine Responses in Mice Infected With Giardia
            intestinalis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1737)
  AUTHORS   Li,H., Kurtzeborn,K., Kupari,J., Gui,Y., Siefker,E., Lu,B.,
            Matlik,K., Olfat,S., Montano-Rodriguez,A.R., Huh,S.H.,
            Costantini,F., Andressoo,J.O. and Kuure,S.
  TITLE     Postnatal prolongation of mammalian nephrogenesis by excess fetal
            GDNF
  JOURNAL   Development 148 (10) (2021)
   PUBMED   34032268
REFERENCE   5  (bases 1 to 1737)
  AUTHORS   Wu,J., Li,H., Han,L., Sun,T., Tian,Y. and Wang,X.
  TITLE     The spatiotemporal expression pattern of Syndecans in murine
            embryonic teeth
  JOURNAL   Gene Expr Patterns 36, 119109 (2020)
   PUBMED   32220631
REFERENCE   6  (bases 1 to 1737)
  AUTHORS   Avraham,S., Avraham,H., Austen,K.F. and Stevens,R.L.
  TITLE     Negative and positive cis-acting elements in the promoter of the
            mouse gene that encodes the serine/glycine-rich peptide core of
            secretory granule proteoglycans
  JOURNAL   J Biol Chem 267 (1), 610-617 (1992)
   PUBMED   1730621
REFERENCE   7  (bases 1 to 1737)
  AUTHORS   Baughman,G., Harrigan,M.T., Campbell,N.F., Nurrish,S.J. and
            Bourgeois,S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
REFERENCE   8  (bases 1 to 1737)
  AUTHORS   Angerth,T., Huang,R.Y., Aveskogh,M., Pettersson,I., Kjellen,L. and
            Hellman,L.
  TITLE     Cloning and structural analysis of a gene encoding a mouse
            mastocytoma proteoglycan core protein; analysis of its evolutionary
            relation to three cross hybridizing regions in the mouse genome
  JOURNAL   Gene 93 (2), 235-240 (1990)
   PUBMED   2121613
REFERENCE   9  (bases 1 to 1737)
  AUTHORS   Kjellen,L., Pettersson,I., Lillhager,P., Steen,M.L., Pettersson,U.,
            Lehtonen,P., Karlsson,T., Ruoslahti,E. and Hellman,L.
  TITLE     Primary structure of a mouse mastocytoma proteoglycan core protein
  JOURNAL   Biochem J 263 (1), 105-113 (1989)
   PUBMED   2532501
REFERENCE   10 (bases 1 to 1737)
  AUTHORS   Avraham,S., Stevens,R.L., Nicodemus,C.F., Gartner,M.C., Austen,K.F.
            and Weis,J.H.
  TITLE     Molecular cloning of a cDNA that encodes the peptide core of a
            mouse mast cell secretory granule proteoglycan and comparison with
            the analogous rat and human cDNA
  JOURNAL   Proc Natl Acad Sci U S A 86 (10), 3763-3767 (1989)
   PUBMED   2726751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ073081.1, AK157945.1, AA209819.1, CJ276881.1 and BU754820.1.
            
            [WARNING] On Mar 22, 2024 this sequence was replaced by
            NM_001358965.2.
            
            On Dec 15, 2017 this sequence version replaced XM_006513375.2.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK129760.1, SRR7345562.878963.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               CJ073081.1         2-384
            384-1119            AK157945.1         197-932
            1120-1296           AA209819.1         151-327
            1297-1297           CJ276881.1         173-173
            1298-1434           AA209819.1         328-464
            1435-1737           BU754820.1         1-303               c
FEATURES             Location/Qualifiers
     source          1..1737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.42 cM"
     gene            1..1737
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /note="serglycin"
                     /db_xref="GeneID:19073"
                     /db_xref="MGI:MGI:97756"
     exon            1..107
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /inference="alignment:Splign:2.1.0"
     exon            108..302
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..688
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /note="proteoglycan, secretory granule; proteoglycan 1,
                     secretory granule; gp600; mastocytoma proteoglycan core
                     protein; secretory granule proteoglycan core protein"
                     /codon_start=1
                     /product="serglycin precursor"
                     /protein_id="NP_001345894.1"
                     /db_xref="CCDS:CCDS23889.1"
                     /db_xref="GeneID:19073"
                     /db_xref="MGI:MGI:97756"
                     /translation="MQVPVGSRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPNGFF
                     ANCIEEKGPQFDLIDESNNIGPPMNNPVLMEGPSKDFISNYDDYGSGSGSGSGSGSGS
                     GSGSGSGFLGDMEWEYQPTDESNIVYFNYKPFDRILTEQNQDQPEDDFII"
     exon            303..447
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /inference="alignment:Splign:2.1.0"
     exon            448..1721
                     /gene="Srgn"
                     /gene_synonym="Prg; Prg1; Sgc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgagcca agagccggac agcttaagat ctcaccggaa ggagaacgcc acagaaagcc
       61 agcagacccc gctcctcggc cggccgtgtg gcccaggcag gtcagaggaa actgtgacgt
      121 gtgttcttgg gcagggtctg aggttttgga acctctttct aaaagggaca gaaagagcac
      181 cctgctacat ttgctaatcc agaggctgag tggagccgag ctggtcagga tgcaggttcc
      241 cgtcggcagc aggcttgtcc tggctctcgc cttcgtcctg gtttggggat cttcagtgca
      301 aggttatcct gctcggagag ccaggtacca gtgggtccgc tgcaaaccga atggcttttt
      361 tgcgaactgc atcgaggaga agggaccaca gtttgaccta atagatgaat ccaataacat
      421 cggccctccc atgaataatc ctgttttgat ggaaggaccc tcaaaagatt tcatctccaa
      481 ttatgatgac tatgggtcag gttcgggctc cggctctggc tccggctctg gctcgggttc
      541 cggctccgga agtggcttcc taggtgacat ggaatgggaa taccagccaa cagatgaaag
      601 caatattgtc tatttcaact ataagccttt tgacaggatt ctcactgagc aaaaccaaga
      661 ccaaccagaa gacgatttta ttatatgaat gtgacggtct ctgtctcccc acctccatgt
      721 ggaacaatgt attcagtata cttagtgtac cacgtttaaa tgaccagtct caggataaag
      781 agttttacag aaaatttaaa atgcctggaa aagactcttg aatcctgtta cccctttcct
      841 cattaactcg taaggaatta tgctttaatg ctgttaccta tcttgttgtt ctggaaaatg
      901 cctgcattta tgtgtattga atcaacattt aagaaattaa cacacacccc cattattata
      961 caataacttt caaagccata ctggttttga aaattttaat ttgatagcaa gttgatgaac
     1021 aatctttcat acctaaagtg ttcaggaacc caactcgcat tgtgaattac aaatatattc
     1081 ctttatgtga ttaaaaagaa aataaagtga aacacagtgg cctcctaccg tggctatgtg
     1141 acatggttta catggtgagg ggtagatatt gagctgtggc cattggatgt gacagggaag
     1201 accaaatgtt atcgaaaaat gttgtgggtt ttttgtttgt ttgtttgttt gttttttgtt
     1261 gttgtttttg agacagggtt tccaggacag gttgtcctgt aactcactct gtagaccagg
     1321 atggctagat tcagaaatcc tcatgcttct gcctcccaag tgctgggatt aaaggcatgc
     1381 gccacccccc accccacccc cggggttgtt gtgggtttta aagttagaaa cttaacgcct
     1441 caaataacat ggagttgtgg tctcaacggc tcataatgct ttacctttgt ctagatgcct
     1501 gttcagggtc aaatgttact ccattaaagt gaacatataa ccaaaggggg gagatgtcat
     1561 ctggaacttc ctgttctaat ccagggaata gttactttga aaaaataatc aatcatatta
     1621 tacatattaa tatataataa ttttataata cagtatataa tattggtgta ggtgatattt
     1681 aatataaata atataataaa aagtgtatgt aattgataac aaaaaaaaaa aaaaaaa
//
