LOCUS       NM_080448               8887 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus SLIT-ROBO Rho GTPase activating protein 3 (Srgap3),
            mRNA.
ACCESSION   NM_080448
VERSION     NM_080448.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8887)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8887)
  AUTHORS   Rogg,M., Maier,J.I., Dotzauer,R., Artelt,N., Kretz,O.,
            Helmstadter,M., Abed,A., Sammarco,A., Sigle,A., Sellung,D.,
            Dinse,P., Reiche,K., Yasuda-Yamahara,M., Biniossek,M.L., Walz,G.,
            Werner,M., Endlich,N., Schilling,O., Huber,T.B. and Schell,C.
  TITLE     SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process
            Maintenance
  JOURNAL   J Am Soc Nephrol 32 (3), 563-579 (2021)
   PUBMED   33514561
REFERENCE   3  (bases 1 to 8887)
  AUTHORS   Spence,E.F., Dube,S., Uezu,A., Locke,M., Soderblom,E.J. and
            Soderling,S.H.
  TITLE     In vivo proximity proteomics of nascent synapses reveals a novel
            regulator of cytoskeleton-mediated synaptic maturation
  JOURNAL   Nat Commun 10 (1), 386 (2019)
   PUBMED   30674877
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8887)
  AUTHORS   Bertram,J., Koschutzke,L., Pfannmoller,J.P., Esche,J., van
            Diepen,L., Kuss,A.W., Hartmann,B., Bartsch,D., Lotze,M. and von
            Bohlen Und Halbach,O.
  TITLE     Morphological and behavioral characterization of adult mice
            deficient for SrGAP3
  JOURNAL   Cell Tissue Res 366 (1), 1-11 (2016)
   PUBMED   27184948
  REMARK    GeneRIF: SrGAP3 plays a role in neurodevelopmental disorders.
REFERENCE   5  (bases 1 to 8887)
  AUTHORS   Koschutzke,L., Bertram,J., Hartmann,B., Bartsch,D., Lotze,M. and
            von Bohlen und Halbach,O.
  TITLE     SrGAP3 knockout mice display enlarged lateral ventricles and
            specific cilia disturbances of ependymal cells in the third
            ventricle
  JOURNAL   Cell Tissue Res 361 (2), 645-650 (2015)
   PUBMED   26104135
  REMARK    GeneRIF: This study found a more than 15-fold enlargement of the
            lateral ventricles of homozygous SrGAP3-deficient mice.
REFERENCE   6  (bases 1 to 8887)
  AUTHORS   Mattar,P., Britz,O., Johannes,C., Nieto,M., Ma,L., Rebeyka,A.,
            Klenin,N., Polleux,F., Guillemot,F. and Schuurmans,C.
  TITLE     A screen for downstream effectors of Neurogenin2 in the embryonic
            neocortex
  JOURNAL   Dev Biol 273 (2), 373-389 (2004)
   PUBMED   15328020
REFERENCE   7  (bases 1 to 8887)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 8887)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 8887)
  AUTHORS   Soderling,S.H., Binns,K.L., Wayman,G.A., Davee,S.M., Ong,S.H.,
            Pawson,T. and Scott,J.D.
  TITLE     The WRP component of the WAVE-1 complex attenuates Rac-mediated
            signalling
  JOURNAL   Nat Cell Biol 4 (12), 970-975 (2002)
   PUBMED   12447388
REFERENCE   10 (bases 1 to 8887)
  AUTHORS   Wong,K., Ren,X.R., Huang,Y.Z., Xie,Y., Liu,G., Saito,H., Tang,H.,
            Wen,L., Brady-Kalnay,S.M., Mei,L., Wu,J.Y., Xiong,W.C. and Rao,Y.
  TITLE     Signal transduction in neuronal migration: roles of GTPase
            activating proteins and the small GTPase Cdc42 in the Slit-Robo
            pathway
  JOURNAL   Cell 107 (2), 209-221 (2001)
   PUBMED   11672528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051262.1, CK032058.1, AC153591.4, AY057899.1 and CF744803.1.
            
            On Jul 27, 2007 this sequence version replaced NM_080448.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.182448.1, AF496547.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2178              AK051262.1         2-2179
            2179-2796           CK032058.1         70-687
            2797-2885           AC153591.4         70538-70626
            2886-3335           AY057899.1         1-450
            3336-3771           CF744803.1         128-563
            3772-8887           AC153591.4         86455-91570
FEATURES             Location/Qualifiers
     source          1..8887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.54 cM"
     gene            1..8887
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /note="SLIT-ROBO Rho GTPase activating protein 3"
                     /db_xref="GeneID:259302"
                     /db_xref="MGI:MGI:2152938"
     exon            1..837
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             771..4070
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /note="SLIT-ROBO Rho GTPase activating protein 2; brain
                     stress early protein Gbi; srGAP2; rho GTPase-activating
                     protein 14; WAVE-associated Rac GTPase-activating protein"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 3"
                     /protein_id="NP_536696.4"
                     /db_xref="CCDS:CCDS39590.1"
                     /db_xref="GeneID:259302"
                     /db_xref="MGI:MGI:2152938"
                     /translation="MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQ
                     LLQDLQEFFRRKAEIELEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLV
                     LHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNEL
                     YTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGELSMNLLRHEDRPQRRSSVKKI
                     EKMKEKRQAKYSENKLKCTKARNDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHAS
                     LARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCSQVFCPPLKFEF
                     QPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLT
                     VEDFDVSDAFQHSRSTESIKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGS
                     NLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSM
                     EAFIKDSGQAIPLVVESCIRFINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVD
                     DQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPADRVHPIQQILITLP
                     RVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHVNEV
                     IKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGTIDEVDHDNGTEPHTS
                     DEEVEQIEAIAKFDYVGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYI
                     VVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRL
                     RSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLSRGRIESPEKRRM
                     ATFGSAGSINYPDKKALTEGLSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTAL
                     HELRELERQNTVKQAPDVVLDTLEPLKNPPGPISSEPASPLHTIVIRDPDAAMRRSSS
                     SSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMF
                     PNSSSDKSGTM"
     exon            838..1030
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1193
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1256
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1442
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1571
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1793
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1895
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2093
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2178
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2206
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2309
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2370
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2448
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2583
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2689
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2917
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..2997
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3178
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3328
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3656
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..8887
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8861..8866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /note="hexamer: AATAAA"
     polyA_site      8887
                     /gene="Srgap3"
                     /gene_synonym="Arhgap14; D130026O08Rik; Gbi; MEGAP;
                     mKIAA0411; WRP"
                     /note="major polyA site"
ORIGIN      
        1 agtccagccc tgggtccagc ggagctaaaa cgctacagcc gggaaaactt ccacctccct
       61 ctcctggttt tgatcctcac cgtccagcag acccgaggcg ccgatcgacc ggagggagga
      121 tgagagatga ccggtccttt ggcaacctga ccatttcctt agcagagcct tccaaagcga
      181 accggagact ggccacacga cccaggaggc gccgcgcctc ttgtggatgt gtgtgtatga
      241 gtgagcaagc gggtgtgtgt gtgtgagtga gggtgtgtgt gtgtatgcgt gtgtgtgtgt
      301 gtgtgcgcgc gtgtgtgtat gcgcgcgctt gtggtgtgga tgggtgtgtg cacagcacaa
      361 ttgcgtggaa gcgtgtctgg gtgagcgtgt gtgtgcactc gtgaatgtgt ttgtgtgtgt
      421 gtgtgtacgt gtgtgtgtgt gtttgtgtgt gctcttggct gctattatta ttattttgga
      481 agaaaaatcc tggaaatctg gggcaggtta tggtactccc agggtgactt cttttgcaag
      541 aggagctgac cagagcaagc cactagagcc atttccctgc cagcagagag cattttcctc
      601 ccagaagaag gatttcaacc ccggggctct gtagccaagt aaaagagatt agcccttgaa
      661 acctgtgaaa tcgaccattg ctgtgtgatt acccaggctt gggagaggac ttggagagag
      721 aaggagaaat agatcaaaca gcctgtcagt tctctttgcc acgtcggaag atgtcatctc
      781 aaactaagtt caagaaagac aaagagatca ttgctgaata tgaagcccaa ataaaagaga
      841 tccgcacgca gctggtggag cagttcaaat gcctggagca gcagtccgag tcgcggctgc
      901 agctgctgca agacttgcag gagttcttcc gcaggaaagc tgagattgag ctggagtatt
      961 cccgaagcct ggagaagctg gctgagcgct tctcctccaa gattcgcagc tcccgggagc
     1021 accagttcaa gaaggatcaa tacctcctct cgcccgtgaa ctgttggtat ctggtactgc
     1081 atcagactcg gcgggagagc cgagaccatg ccaccctcaa cgacatcttc atgaacaatg
     1141 tcatcgtccg cctctcccag atcagtgaag atgtcatcag actcttcaaa aagagcaaag
     1201 agattggcct gcagatgcat gaggagctgc tgaaggtcac caacgagctc tacacagtca
     1261 tgaaaaccta ccacatgtac catgcagaga gcatcagtgc agaaagcaag ctgaaggagg
     1321 ctgagaagca ggaggagaaa cagtttaaca agtcaggaga gctaagcatg aacctgctcc
     1381 ggcacgagga cagaccccag cgccgcagct ccgtgaagaa gattgagaag atgaaggaga
     1441 agaggcaggc caagtattct gagaacaagc tcaagtgcac gaaggcccgg aatgattacc
     1501 tgctgaatct ggcagccacc aacgcagcta tcagcaaata ctacatccac gatgtctctg
     1561 atctcatcga ttgctgtgat ttgggctttc acgccagcct ggcccgcact tttcggacct
     1621 acctctcagc agaatataac ctggagacct ctcgccatga gggtctggac gtcatagaga
     1681 atgcagtgga caacctggac tcccggagtg acaagcacac agtcatggat atgtgcagcc
     1741 aggtcttttg ccctccactc aagtttgagt tccagcccca catgggggat gaggtctgcc
     1801 aggtcagtgc acagcagcct gtccagacag agctgctcat gcggtaccac cagctgcagt
     1861 ccaggctggc cactctcaag attgagaatg aagaggttcg gaaaaccctg gatgccacca
     1921 tgcagacctt acaggacatg ctgaccgtgg aagacttcga tgtctctgac gccttccaac
     1981 acagccgatc tacagagtcc ataaagtcag ctgcttctga gacctacatg agcaaaatca
     2041 acatcgccaa aaggagagcc aaccagcagg aaacagaaat gttttatttt acaaaattta
     2101 aagaatatgt gaatggcagt aacctcatca ccaagctgca agccaagcat gacttactca
     2161 agcagaccct gggtgaaggg gagagagcag agtgcggcac gaccaggccc ccctgtcttc
     2221 cccctaaacc acagaaaatg aggagaccta ggcctctttc agtgtatagc cataaactct
     2281 ttaacggcag tatggaagcg ttcattaagg attcaggaca agctatacca cttgtagttg
     2341 agagctgtat tcgattcatc aatttatatg gactccagca gcaggggatc ttcagagttc
     2401 cagggtctca ggttgaagtc aatgacatca agaattcctt tgagagaggt gaagaccccc
     2461 tcgtggatga ccaaaatgag cgagatatca attcagttgc tggtgtttta aaactgtatt
     2521 tccgaggact ggaaaaccca ctctttccta aggaaaggtt tcaagatttg atatctacta
     2581 ttaaactgga gaacccagct gacagggtgc acccaatcca gcagatcctc atcaccctgc
     2641 cccgcgtggt cattgtggtc atgagatacc tctttgcttt cctcaatcac ctttcccagt
     2701 acagtgatga gaacatgatg gatccctaca acttggccat ctgcttcggg cccaccctca
     2761 tgcacatccc cgatgggcag gaccctgtat cctgccaggc gcatgtcaat gaagtcatca
     2821 aaactatcat catccaccat gaagccattt tccccagccc tcgggagcta gagggacccg
     2881 tgtacgaaaa atgcatggct ggaggggaag agtactgtga cagcccacac agtgagccgg
     2941 ggaccattga tgaagttgac catgacaatg gcacggagcc tcacaccagt gacgaagaag
     3001 tggagcagat tgaggccatc gccaagtttg actatgtggg gcggtcccct cgtgaactat
     3061 ccttcaaaaa aggggcctca ctactcctgt atcaccgtgc ctcagaggac tggtgggagg
     3121 gccgccacaa cggtgtagat ggactcatcc ctcatcagta catagttgta caggacatgg
     3181 acgatgcctt ctccgatagc ctgagccaaa aggctgacag cgaggccagc agtgggccac
     3241 tgctggatga caaggcctct tccaagaatg acctccagtc ccccacagag cacatctctg
     3301 attacggctt tgggggggtg atgggccgag tgcgactacg gtccgacgga gcagccatcc
     3361 ccaggcgccg aagtgggggc gacacacaca gcccaccccg gggcttgggt cccagcatag
     3421 acacgccacc ccgagctgct gcctgcccca gcagccccca caaaatcccc ctcagccggg
     3481 gacggatcga gagccctgag aagagaagga tggcgacttt cgggagcgct ggcagtatca
     3541 actaccctga caagaaggcg ctgacagaag ggctctccat gaggtcgact tgcggttcca
     3601 cgcgacacag cagcctaggg gaccacaagt ccctggaggc tgaggccctg gcagaagaca
     3661 tcgagaagac catgagcacc gctctgcatg agttgcggga acttgagaga cagaacactg
     3721 tcaagcaggc accagatgtg gtgctggaca ccctggagcc cctgaagaat ccaccaggcc
     3781 ccatcagctc agagcccgcc agccccctgc acaccattgt catccgagac cctgatgctg
     3841 ctatgcgccg aagcagcagc tcatcgacgg agatgatgac caccttcaag ccagccctgt
     3901 cagctcgcct ggctggtgcc cagctgcgtc cgccccccat gcgtccggtc agacctgtgg
     3961 ttcagcaccg atccagcagc agcagcagct caggtgtggg cagcccggca gtgacaccca
     4021 cggagaagat gttccctaat agctcctcgg acaagtctgg caccatgtga cctgcaggac
     4081 tggtgacact gccatggccc actgcagcac accaaggcct agggtggcct tagtggcttc
     4141 cactagcttc ccagggatct cctggccttg gagggcagat cctggaaggt cagcctggga
     4201 gggtgtatgt ctgtggagag cagaggccca ggcgttagct gcaactcccg ctcagccatg
     4261 tgaatgccac agacctcttg taggcaaaca gacatgccaa ggaatgctgg agcaagatca
     4321 gtcccaagga cagtgtttcc taagattgag gcagatgctt accagcttct catattgtca
     4381 ctggaaaatt attctctcga tattctctac atacgtatat atgtgtatgt atataaatac
     4441 atgcatatat acgcatatgt gtacgtatgt gtctgtaggt gtgtgtatat atatatattt
     4501 atgcatctat atacatatac tagagagctg gacatacaca catgctaact gtatatagac
     4561 gctccttttt tttttctttt tatgaaactt agatttacct cagacccatg ccaccaaaca
     4621 tctcccactc ttacttggtg ggatttgcag ggacttctct gggagaactt agaggcccca
     4681 cagtaactgc gaacgaagca atataccact aacctgcaga gacacaaaac cagaaacagt
     4741 ctccagctgt ctccagaagt cgtggccttc cagaacagtc tgtctgcccc tcaaggaagg
     4801 gtggggcagg cagtaccccc aagcaggctg cccctaaagg tggggaaccc ttcatagaaa
     4861 acccttcacc caccccccta gagaccctgc cctgtcaccc ggaggccaaa ggtcaactgt
     4921 acccccagaa ggcacagggg aagttggtgt gaagaccctt gagtttgtat actgactcag
     4981 gatggtgaga tgctgtggtt gggggtgtgg gggagaacag gaggaaacaa acaaaaccca
     5041 aaacagtagt atggagtagt tcaaacctta cacgtgctgt agggacaaat ctgtgctgac
     5101 tgtacaagtt ttacttctct catcttcaaa atatttaatg gttttttttt tcctcctcgt
     5161 tctactgatt atgctttgtc agatttggaa ctaaatgggc aaggaggcat tcagtcacat
     5221 catgtctgtt tgagagcagt ccacactctg ttccccgctg gagcctccag tgcccagcca
     5281 tcccttggcc tccatcctag gaggactgtg ctaggaagca ccgtaggctg ggatgctatg
     5341 aaaacggcag tgctcctcac cctcccttcc cctcctcttc ttccattcct tctaaagcag
     5401 ttaatgtaga caaacatggt ggtagaaaca aggtacgtga ttctgtagtg tcacagcagc
     5461 ctcctgcatg gctcttgttt gattccgttt tacctgcttt ttttgttgtc tccattttcc
     5521 agatatttcc agaattgttg gataatgcac cacaggcgaa tcaaatccta gtgggaccat
     5581 ttctactctc cctctgcatg ccaaaccaac caaggatatc tccttctcct cttcctcctc
     5641 ctcctcctcc tcctcctcct cctcctcctc ctcttctctc tctctctctc tctctctctc
     5701 tctctctctc acacacacac acacacacac acacacacac acacacacac acacactggc
     5761 tggttctctg cctacctcca agttttacaa tccacaatct ggaatctgtg tcacagcccc
     5821 cacaggagcc ctgtgaccca tagctacacc actcctgtca cctacagatg ctttgaagtg
     5881 ccatccttgg catttcttcc ctttgggttt acttccacca tttcttgggt cctccattga
     5941 aaggaatctt gaccgcttcc ccagggaggg acctagtgag tcattggtcc ttgagtgtgg
     6001 ggagaatcac ccattctgcc ttgcctgtac gatcagcact gagtacactg tggaatcaag
     6061 aatgggctcc aaatgagaat gccaggaaga tgcccgaacc atcaagcctc cccttccctc
     6121 tcaactcctg ctgtgatggg ccctctgttt tttgagcaca taaagatatc tccattttat
     6181 agttgaagac agtaaggcct gggggtggga ggactgggac ctgcacaaga tatgccagat
     6241 ggcctagtgg gctgcattgg gctcaggaag ccctcatttc caggaatctg ctatctctgc
     6301 tatgcatccg ggagataaga cttctttttt gtatcccagg gctatttcca gatttttaag
     6361 tccactcacc tcccaggcaa aaatgcaata ttctctgcct ggataccaga tagaagcaaa
     6421 attgagttta caaatctatt accggacaca cctattgcca gttacgctgt gcagatttgt
     6481 ctctgggttg acttatttca ttttccttac tgcctctccc ccaaatgtcc caagagcaga
     6541 gcctcagctg ttttccttaa gcatctatct ttcccccatt ggcaagtggc tgatgaattc
     6601 acatttaggg aagcacacac acagatggca gatgagtccc cagctcttcc aacccccaat
     6661 ctgagctttg atgcagaaca aatggaaaag cactgtccac ccccatcccc aacacacttc
     6721 ttcatctggt ccccttgcat gtctcagcca cccccaggtc ccaactcagc cccaactcag
     6781 tcccatcggt gtctatctag tgtgagcatc tcccttctga ctcctgcctg tttttagtcc
     6841 actatatatt gctgtatttg ttaaatgctg gaaagtaact gttaaaatgt gaaactgtaa
     6901 ttttttaaaa tgaaggctac aattacatta tagccattgc cactcaccaa atctttgcac
     6961 ctagtagata gatcgatgta aaaacaaata ccagaaacct aattgtacag tgattggggt
     7021 ggggggtgta gtaacatagt tagtagtcct caatatagcc aagcgtacaa ggggaagtgg
     7081 tgtctaccaa tgttcatcac cattattgag agctgtactg atcagttagt ttataacggg
     7141 catttaaaaa attttatttt ggcttcatgg aatgatttct taacctccaa cttaccccga
     7201 ggtcaagcct tttgtcttta tgtataacta gtgttcagtc tgttttagga atgaaccagc
     7261 aagatgttca tttaattaaa actgaccaaa gacaattaat tcctggtcta gtttcctggg
     7321 caccgtgtgg cccagttgcc actaaagacc tttctccgat caatttgaga acaagccgag
     7381 cttccaaccc gactcaccct ccctgccctc cttctctttg tcctcgtcga gctgctctga
     7441 gctgtgggat cctgtgaaca actgtcgtct ttccttctct tcagtgctaa cttctcacct
     7501 tgaagcgcct tttgagcccc cccggacaga gcacacaact ggagggaatt gtgggcgtgg
     7561 gaattaagac gagggagtct tttctctgaa gtcactaaac cagggatcag gagggaaacg
     7621 gattcctaag gaacggaaag gtttatatcc aatgaagaaa tcaaatcgga gcggaaagag
     7681 acacagggaa atggagccat ccgttggcta ctggctggaa ccagcagttc agagatctgc
     7741 cttataaaca ctttagactg gtgtgtggta cgcaagggga gctggtggga gagaagcctg
     7801 tccagatgtt cccttccttg gcatctccta gagtgccttg ttgggtgcat ccctttctta
     7861 ttcaggaggc atggatgcag aggacatatc gtgacttggt acttggtcat cattgagtgg
     7921 ccagcgcaca tacatttgga acgagtgctg gaaaactctc caaggactaa cacaacagcc
     7981 ctccctctca gcctttctgt ttctaacttc tcctcttcca gatggttcca cactagagca
     8041 aatgcctcat tcttccgaaa aacccagaaa ggggtggagt ggggtgtcat ttctagctgc
     8101 ggtagtgggt cctgtcgtac tgggaggaaa aggtgtgaca ggggaggaaa aggcagaaag
     8161 gggtgaacca aggcattgct tagctgattt tctgctgtgc agagctaagg ctgacagttc
     8221 gtgttcactt ccctgtggtt ctctggggtc tcttctccac tgagatgaat tccaagtgga
     8281 gaattccaca tactccaagc tacccatggg aactgccaga agggacttca ctgtcagtcc
     8341 gagacctcct gacctcttaa agttgatctg ccagcatact gttgtcccat cctttgggac
     8401 tggccaaatg gctattgcag tcctttgctg acaactcctt tctgtgcaaa ctgtcccagg
     8461 caaatcacaa agctgttcct tgaagtggaa ccaccagatt gcactttcct tccctgatgg
     8521 atgtgggtcg aggctagctc tgctgcccag gccctcgttc caggcagtgt gactgtttac
     8581 atggtttggc aataggtttg cttctgattg cttcagagtg gctggtctgt tttgtttgct
     8641 ttgctttctt tcttccccca aattatgaca ggaaaaacaa actgaaacca ccctaggaaa
     8701 ttgctggttg cctgtcccca tgtgatgcta actgttgccc tcttctgggt atcatttctc
     8761 taccttatga ccaaaatgcc cgtcctatag agtgtctgat tggatcctct gttgcgtatt
     8821 ctgatggtgc ctgctggttt gatgtggagc tatcctgtga aataaaacag cttaactttt
     8881 tctcaaa
//
