LOCUS       NM_001081011            8040 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus SLIT-ROBO Rho GTPase activating protein 2 (Srgap2),
            mRNA.
ACCESSION   NM_001081011 XM_001000846
VERSION     NM_001081011.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8040)
  AUTHORS   Libe-Philippot,B., Iwata,R., Recupero,A.J., Wierda,K., Bernal
            Garcia,S., Hammond,L., van Benthem,A., Limame,R., Ditkowska,M.,
            Beckers,S., Gaspariunaite,V., Peze-Heidsieck,E., Remans,D.,
            Charrier,C., Theys,T., Polleux,F. and Vanderhaeghen,P.
  TITLE     Synaptic neoteny of human cortical neurons requires
            species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition
  JOURNAL   Neuron 112 (21), 3602-3617 (2024)
   PUBMED   39406239
REFERENCE   2  (bases 1 to 8040)
  AUTHORS   Assendorp,N., Fossati,M., Libe-Philippot,B., Christopoulou,E.,
            Depp,M., Rapone,R., Dingli,F., Loew,D., Vanderhaeghen,P. and
            Charrier,C.
  TITLE     CTNND2 moderates the pace of synaptic maturation and links human
            evolution to synaptic neoteny
  JOURNAL   Cell Rep 43 (10), 114797 (2024)
   PUBMED   39352808
REFERENCE   3  (bases 1 to 8040)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 8040)
  AUTHORS   Schmidt,E.R.E., Zhao,H.T., Park,J.M., Dipoppa,M.,
            Monsalve-Mercado,M.M., Dahan,J.B., Rodgers,C.C., Lejeune,A.,
            Hillman,E.M.C., Miller,K.D., Bruno,R.M. and Polleux,F.
  TITLE     A human-specific modifier of cortical connectivity and circuit
            function
  JOURNAL   Nature 599 (7886), 640-644 (2021)
   PUBMED   34707291
  REMARK    Erratum:[Nature. 2022 Jan;601(7893):E10. doi:
            10.1038/s41586-021-04302-8.. PMID: 34997244]
REFERENCE   5  (bases 1 to 8040)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8040)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 8040)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 8040)
  AUTHORS   Wong,K., Ren,X.R., Huang,Y.Z., Xie,Y., Liu,G., Saito,H., Tang,H.,
            Wen,L., Brady-Kalnay,S.M., Mei,L., Wu,J.Y., Xiong,W.C. and Rao,Y.
  TITLE     Signal transduction in neuronal migration: roles of GTPase
            activating proteins and the small GTPase Cdc42 in the Slit-Robo
            pathway
  JOURNAL   Cell 107 (2), 209-221 (2001)
   PUBMED   11672528
REFERENCE   9  (bases 1 to 8040)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 8040)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY779945.1, AK084412.1, CF164437.1, BC030457.1 and AC165436.5.
            
            On Oct 6, 2007 this sequence version replaced NM_001081011.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC151081.1, SRR1660813.53198.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               BY779945.1         1-121
            122-1204            AK084412.1         1-1083
            1205-1300           CF164437.1         482-577
            1301-3832           BC030457.1         608-3139
            3833-8040           AC165436.5         108618-112825
FEATURES             Location/Qualifiers
     source          1..8040
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.93 cM"
     gene            1..8040
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /note="SLIT-ROBO Rho GTPase activating protein 2"
                     /db_xref="GeneID:14270"
                     /db_xref="MGI:MGI:109605"
     exon            1..129
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            130..785
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             719..3934
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /note="formin binding protein 2; FBP-27; formin-binding
                     protein 27"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 2"
                     /protein_id="NP_001074480.2"
                     /db_xref="CCDS:CCDS48355.1"
                     /db_xref="GeneID:14270"
                     /db_xref="MGI:MGI:109605"
                     /translation="MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQ
                     LLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLL
                     LNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNEL
                     YSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEK
                     HVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDII
                     DQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYN
                     NVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTME
                     ATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFY
                     FTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVV
                     ESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLK
                     LYFRGLEHPLFPKDIFHDLIACVTMDNLQERAVHIRKVLLVLPKPTLIIMRYLFAFLN
                     HLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPNP
                     RELEGPIYSRGGSMEDYCDSTHGETTSAEDSTQDVTAEHHTSDDECEPIEAIAKFDYV
                     GRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPK
                     SEIEVMSEPPEEKVTARTGASCPSGGHVADIYLANINKQRKRPESGSIRKAFRSDSHG
                     LGSSLTDSSSLGVGASCRPSSQPIMSQNLPKEGPDKCSISGHGSLNSISRHSSLKNRM
                     DSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELQELERQSSAKHTPDV
                     VLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKM
                     AAPVKPPATRPKPTVFPKTNATSPGVNSSASPQATDKSCTV"
     exon            786..978
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1141
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1204
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1420
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1549
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1774
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1876
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2074
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2159
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2187
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2212
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2273
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2351
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2486
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2592
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2817
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2897
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3078
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3225
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3550
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..8040
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6777..6782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /note="hexamer: AATAAA"
     polyA_site      6798
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /note="major polyA site"
     regulatory      7972..7977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
                     /note="hexamer: ATTAAA"
     polyA_site      7991
                     /gene="Srgap2"
                     /gene_synonym="9930124L22Rik; FBP2; Fnbp2; srGAP3"
ORIGIN      
        1 ggtcttgcgg agttggcgga gtctccttag ggaactgggg ggccgaactg cgtagaagag
       61 ggtggcgggg aggagaacgc taagtgggaa gcggaacctt gggcctggga ccggtcgcgg
      121 cagagccagg ctagtgaacc ggagcaaaga cttccgaccc actctgcgct gcagcggcac
      181 ccttttggga tttgatttgc agaatctttg agctggtaac acacacacac acacacacac
      241 acacacacac acacacaatc ccgcgaagaa cgcctagccc tcctctggca ccccaagaca
      301 aacccactcc ctcctaggga cacagctggg cgcgtccaca cccccgcatc ccctacacca
      361 tgttgtgcgg aaggacttcc actcccagcc tgtgtcgttg atgtcagacc ccaggccagc
      421 ctccgggcgc tgcagttctc ctggttaatg ctgcggttgt ggttagggct ttagtactta
      481 agccagccgc cgccgccccc cacttcccca cccccggcct cagcgcccac agtctgcatg
      541 tgtgtgcagt agccggctgc ccatcccgcc gctcgtgttc tcctggagct ctggatacca
      601 ccgcggggca tttctctgcc tgtgggagaa gtggccttgg aggcattgat atcagtggtt
      661 ggatttttcc cgtggatcta tcaattcaca attcggattt ggaagaaaga aggaaaacat
      721 gacgtctcca gccaaattca aaaaggataa ggagatcatc gcagagtacg atactcaggt
      781 caaagagatt agggctcagc tcacagagca gatgaaatgc ctagatcagc aatgtgagct
      841 ccgggtgcag ctgttgcagg acctgcagga cttcttccgc aagaaggctg agattgaaat
      901 ggactactct cgaaacctgg agaagctagc cgagcgcttt ctagccaaga cacgaagcac
      961 caaggaccag caatttaaga aggaccagaa tgttctttct ccagtcaact gctggaacct
     1021 cctcttaaac caagtgaagc gggagagcag ggatcatacc accctgagtg acatctacct
     1081 gaataatata attcctcgat ttgttcaagt cagcgaggac tcaggaagac tctttaaaaa
     1141 gagtaaagaa gttggccagc aactccaaga tgatttgatg aaagtcctga acgagcttta
     1201 ctcggtcatg aagacatatc acatgtacaa tgccgacagc atcagtgctc agagcaaact
     1261 gaaggaagca gagaaacaag aagagaagca aattggcaaa tcagtaaagc aagaggaccg
     1321 gcagacccct cgctcccctg actccacagc caatgtccgc attgaggaga agcatgtccg
     1381 gaggagctca gtgaagaaga ttgagaagat gaaggagaag cgacaagcca agtacacaga
     1441 aaataagctg aaggccatta aagcccggaa tgagtattta ttggctttgg aggcaaccaa
     1501 tgcatctgtc ttcaagtact atatccatga cctgtctgat attattgatc aatgttgtga
     1561 cctaggctac catgctagcc tgaaccgggc tctacgcact ttcctatctg ctgaattaaa
     1621 tctggaacag tcaaaacatg aaggtctgga tgctattgaa aatgcagtag aaaacctaga
     1681 tgccaccagt gacaagcaac ggctcatgga gatgtacaac aatgtttttt gcccccctat
     1741 gaaatttgaa ttccagcccc acatgggaga tatggcctct caactctgtg cccagcagcc
     1801 tgtccagagt gagctggtgc agagatgcca acagctgcag tctcgcttat ccactttgaa
     1861 gattgagaat gaagaggtga aaaagacaat ggaggccacc ctgcagacca ttcaagacat
     1921 tgtgactgtt gaggattttg atgtatctga ctgcttccag tatagcaatt ccatggagtc
     1981 tgtcaaatca actgtctctg aaacattcat gagcaagccc agcattgcta agaggagagc
     2041 gaaccagcaa gagacggaac agttttattt cacgaaaatg aaggagtact tggagggtag
     2101 gaacctcatc acaaagctac aagccaagca tgacctcctg cagaaaaccc tgggagaaag
     2161 tcagcggaca gactgtagtc ttgccaggcg aagctcaact gtgaggaaac aggattccag
     2221 ccaagcaatt cctctggtgg tagaaagctg catccggttt attagcagac atggcctaca
     2281 acatgaggga attttccggg tttctggatc acaagtagaa gtgaacgaca taaaaaacgc
     2341 ctttgagaga ggagaggatc ccctggctgg ggaccagaat gaccatgaca tggactctat
     2401 agctggtgtc ctcaagcttt acttccgggg cctggaacac ccgctcttcc ctaaagacat
     2461 cttccatgac ttgattgcct gtgtcacaat ggacaacctg caagagagag ctgtgcatat
     2521 ccggaaagtc cttctggtcc tgcccaagcc cactctgatt atcatgagat atctctttgc
     2581 cttcctcaat cacttatcac agttcagtga agagaacatg atggacccct acaaccttgc
     2641 catctgcttc gggccctcac tgatgtcagt gccagagggc cacgaccagg tgtcctgtca
     2701 agcccacgtg aatgagctga tcaaaaccat catcatccaa catgagaaca ttttcccaaa
     2761 ccccagggag ctggagggtc ccatctacag cagaggagga agcatggagg attactgtga
     2821 cagcactcat ggagagacta cctctgctga agactccacc caggacgtta cagcggagca
     2881 ccacacaagc gatgatgaat gtgagcccat agaagccatt gccaagtttg actacgtagg
     2941 ccggacagcc cgagaactgt ctttcaagaa gggagcatcc ctgctgctct accagcgagc
     3001 ttctgatgac tggtgggagg gccggcacaa cggtatagat ggactcatcc cccatcagta
     3061 catcgtagtc caagacaccg aggacggtgt cgtggagagg tccagcccca agtctgagat
     3121 tgaggtcatg tctgagccac ctgaagaaaa ggtgacagcc agaacggggg ccagctgtcc
     3181 cagtgggggt catgtagctg atatttatct tgcaaacatc aacaagcaaa ggaagcgtcc
     3241 agaatctggg agcatcagaa aagcatttcg gagtgacagc catgggctgg gcagttctct
     3301 gactgactcc tcctccctgg gggtgggggc tagctgccgt ccatcctccc agcccatcat
     3361 gagccagaat ctccccaagg aagggccaga taagtgttcc atcagcggcc atggcagcct
     3421 caactctatc agccgccact catccttgaa gaaccggatg gacagtccgc agatccggaa
     3481 gaccgctacg gcaggaaggt caaaaagttt caataaccat cggcccatgg accctgaagt
     3541 cattgcacag gatattgaag caacaatgaa ctctgccctg aatgagcttc aagagctaga
     3601 gcggcagagc agtgctaagc acacacctga tgtggttctg gacaccttgg aaccactcaa
     3661 gacctccccg gtggtagccc ccacatctga gccctccagc cctctgcaca cccagctcct
     3721 caaggaccct gagcctgcct tccagcgcag cgctagtact gctggggaca ttgcctgcgc
     3781 cttccggcct gtaaagtctg tcaagatggc tgctccagtc aaaccaccag ccacacggcc
     3841 caagccaact gtcttcccca aaacaaacgc cactagccct ggtgtcaatt catctgcttc
     3901 cccacaggcc actgacaagt cttgtactgt ctaaggggta taacataatt attctagaca
     3961 aggagactgg ccgtttctaa aatcttccta tttaagtagc ttggggactc agttgaaaat
     4021 taggttctaa gttgttctta caggaattag ccttcccatt acccagacct cgagaatgaa
     4081 gcccttgtta ctgctttccc cgttctggtc cttcctccac tctttgcttc cctctgttgt
     4141 tggaatccag ccagctccag tacatactgt tcttaggtta gccagtgaca ggttgtccat
     4201 gatcgggttg ctgcgatatc tgccaaggca agacataggg acataagcct acgtctgtcc
     4261 cttcagacca tagaggacac cttgaccaga tgtttggctg cagctctcag tgacatcttg
     4321 tttttcagta ctgatttaaa aaatcatata tagcccagtt ttcattttat ataaatatat
     4381 atatatatat ttgtgtgtat gtgcatgcac atgcacaccc atatacaaca caggtttttc
     4441 tagcctctcc tggtcataga ccactctttg ttgtggtggc agttcacaca gaagccacct
     4501 ggagtctctg ttctcatcac aaactttgtt ctgtttggaa cagagaaacc tggcctttga
     4561 gatctctgtc ataaacattt agcagaatgg gacagtcctg tgacctgccg tgcgggtggg
     4621 attctgtctt cttcctcttg ctgtgaggga gccaccggtt gtttgcattt gctctgctcc
     4681 atgctgtaga agtgcatcct agtcttatct cggagctttg gaagtttttc tgaacataga
     4741 gacttttctt ccgttcctgt ctttgtctct gacacaccat tttccatgta agatgttttc
     4801 caatataaga cagttctata gctagctcct tttagagtaa aaagtcttaa agttttattg
     4861 tgtttatggc agatttaaaa agggtaggaa atgagtcctt ctttctccca ctatttttgg
     4921 catctgatac ttttaaaatt tgccattcca ttaaaaaaaa ttaagttgct ctctgctaat
     4981 ccaaaaattg ggcccagatt aaaactattt caagttcacc tcttggctta gttttgttat
     5041 aaagctctcg ggatgaacag gggcttgaaa atccctcgat aaattctaga agtgctgcct
     5101 cttgaaactg ttttttgttt atccaaacaa gggtgactaa gggaactttg acctccacca
     5161 actcaaaact gttttcccaa aaccagaatc ttaaaaaagg gaaaaactga atgtgtcaca
     5221 ttgggtcctg cctttgacct ttttctaccg ttagatgctc tcccaaccta caagcctggt
     5281 gcttgaaaca ctggctcttt tacatcgtgc ttccccagga gcaccagagc taggaaatca
     5341 caccatggga tcatgtgttt caacagctcc ctgccgctca ggctcattct ctgtttcctg
     5401 gcttgaatgc tatgctttta ttttaactgt attgttttct atagttcaag agagatgggt
     5461 ttgtcatttg ggttggaatc tctgagtgtt cttagctttg ggctagaaat gatccttttg
     5521 gaccaacttg tgaagctggc agttgaatct gtagaaagtg gtggatgcct ctctctgagt
     5581 gaagggaatg gggagcttga aggagtcact aacgagaaga gtaacttgca gcaccaggaa
     5641 gactgccccc tgagctagag cagagagagc ttgagtggtg tgagtctgac tgcatggggc
     5701 accccttggt cctttggatg tctgatcctt gctgtgcttt ttactgacct gggcttgtac
     5761 tgctcctgag ccaatagggg cttccagacc caaggatccg tttccttgat gactaagaag
     5821 ccccaccctt ccctttttac attcctccta acctaagtga gcagagtttc caccctgccc
     5881 tacatcctct ctccaggcac taccctctaa gaaggtaaaa gcaaaggttc ttgaagacca
     5941 tgctttgggc ctgtactttc cttcttgcct tctctcttaa tcctgtacat tatttgtgtt
     6001 ttttcatccc tttggtccga tgtccatctg ctgatttgca taatgaactg gacagtgtac
     6061 aagtggttcc ctactaaccc cagctctggg agcctagctg tcttccttat ctctggtgct
     6121 tctgacgcct gtgagacggt cctgttagaa ggagtaggaa ccagaaggag gagagtcctc
     6181 cgcagcagag ctcacttcaa ctggaattga ggttgcacac tgtgatttca caaccaaaag
     6241 ccaaaaggag ccggccaccc caggccttag gcaaccagcc ttcctcaaat aggcttgcct
     6301 gaaaccagca tgatgtttcc aagagccctg ctctgcccct cgtggcatgg atcctttccc
     6361 tggtgtggac ttaagtctct ggggaagaaa agtgggtggg gctaccagca tcccagtttg
     6421 gaaagtagag gagtttgcca ccagcagctt agaaactgga aatgctggtc tctgccagcc
     6481 tcctcaggcc accctcattt atccccaagg agatgagaaa tccttccagt accaggatga
     6541 acagaccact ggaagggctg gtgtgcatgg acttcagttc agaagagaac ttagatcttc
     6601 cagggaactg cagtgttgtg gcgtctgatt tgtatgtcac atttgtgtaa aatggtatgt
     6661 tctttaaaat ggtgttgata actggaatat tgtatgtatg cttgaagatg ctttgtgcga
     6721 acctaagact cactcagcca atgctggatt gggaaaaatc caaagcacaa cttcaaaata
     6781 aaatacattt ttaggttttg ccgctgtacg tcacctccct tcccctctcc ctgaaagcag
     6841 tgaagtaaca aagtctgagc cttgcaacag taggaactag gtgactttga gtgccacctc
     6901 ctttcccctc tacagcatta ctcccattta gcccatgtgt ggagcctcag agagtttgaa
     6961 ggaagtctcc agcatactat tcaccagtcc gtggttgtaa gaacttccct caacagaacc
     7021 caccttttgt tttcaatgcg gacggctttc atttccagct ttatgatcag cgttccccac
     7081 ttgaaagcct agccaggcca tggtgatgca tgcctgtaat cccagtatgg agacatgtgg
     7141 atctatgcga gatggaggcc agcctgatct acagagtgag tgccaggaca tctggggcta
     7201 cacagagaag ccagccctgt cttgggggag ggggggaaga aagaaaagaa aagaaaaaga
     7261 aagaaagaaa ggaaggaaga aaggaagaaa gaaagacaga cagacctatg aaactggttg
     7321 gaaacttacc aactataact aagggttgcc agacagctct gtagtttaag tttgcctgca
     7381 tgcatgtctg catagtaaat gtatgcagtg acatggaggt cagaagtagg catcaggtcc
     7441 tctggaactg aacagacaca gcagacagtt ttgagccacc atgtagggct ggaaactgaa
     7501 ctctggtcat ctgcaagaac aatcagtgct ctgaactgct gagccatctc tccagtctgc
     7561 caatggaatg gctattgtct ttcacagcta gatccccaag tctgcctttg gctatccctg
     7621 tatatggaaa aaggtctgac tgacaggtct gtcttgctgc cggtggaggt ggagagtaca
     7681 gggagacttc cactcgctta gagatagatg ccttgtgttt taatagaaaa tgaacatgat
     7741 ggtggagttc ataaaaagta acagctggtt tctctaccac atatcctgcc aagagatgtt
     7801 ccagaagccc aaagcaatgg agccagccag tcatggactg aaacctccaa acttgtcccc
     7861 tggaggcttc cagataagga aaaactgagt ctgcagtgtg tgtgtgtgta aatgtacata
     7921 tacattgtca gattcataga gattacttgc ctctgcctcc tgagtgctga aattaaaagc
     7981 atgcaccacc atgcccttca caattatttt tttctaagat gttgctgaat tcttaaaaca
//
