LOCUS       NM_001242411            7718 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus SLIT-ROBO Rho GTPase activating protein 1 (Srgap1),
            transcript variant 2, mRNA.
ACCESSION   NM_001242411
VERSION     NM_001242411.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7718)
  AUTHORS   Rogg,M., Maier,J.I., Dotzauer,R., Artelt,N., Kretz,O.,
            Helmstadter,M., Abed,A., Sammarco,A., Sigle,A., Sellung,D.,
            Dinse,P., Reiche,K., Yasuda-Yamahara,M., Biniossek,M.L., Walz,G.,
            Werner,M., Endlich,N., Schilling,O., Huber,T.B. and Schell,C.
  TITLE     SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process
            Maintenance
  JOURNAL   J Am Soc Nephrol 32 (3), 563-579 (2021)
   PUBMED   33514561
  REMARK    GeneRIF: SRGAP1 Controls Small Rho GTPases To Regulate Podocyte
            Foot Process Maintenance.
REFERENCE   2  (bases 1 to 7718)
  AUTHORS   Fan,X., Yang,H., Kumar,S., Tumelty,K.E., Pisarek-Horowitz,A.,
            Rasouly,H.M., Sharma,R., Chan,S., Tyminski,E., Shamashkin,M.,
            Belghasem,M., Henderson,J.M., Coyle,A.J., Salant,D.J., Berasi,S.P.
            and Lu,W.
  TITLE     SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA
            activity and destabilizes kidney podocyte adhesion
  JOURNAL   JCI Insight 1 (19), e86934 (2016)
   PUBMED   27882344
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7718)
  AUTHORS   Hwang,D.Y., Kohl,S., Fan,X., Vivante,A., Chan,S., Dworschak,G.C.,
            Schulz,J., van Eerde,A.M., Hilger,A.C., Gee,H.Y., Pennimpede,T.,
            Herrmann,B.G., van de Hoek,G., Renkema,K.Y., Schell,C., Huber,T.B.,
            Reutter,H.M., Soliman,N.A., Stajic,N., Bogdanovic,R., Kehinde,E.O.,
            Lifton,R.P., Tasic,V., Lu,W. and Hildebrandt,F.
  TITLE     Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer
            risk for congenital anomalies of the kidney and urinary tract
  JOURNAL   Hum Genet 134 (8), 905-916 (2015)
   PUBMED   26026792
  REMARK    GeneRIF: Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and
            SRGAP1 confer risk for congenital anomalies of the kidney and
            urinary tract
REFERENCE   4  (bases 1 to 7718)
  AUTHORS   Chen,Z.B., Zhang,H.Y., Zhao,J.H., Zhao,W., Zhao,D., Zheng,L.F.,
            Zhang,X.F., Liao,X.P. and Yi,X.N.
  TITLE     Slit-Robo GTPase-activating proteins are differentially expressed
            in murine dorsal root ganglia: modulation by peripheral nerve
            injury
  JOURNAL   Anat Rec (Hoboken) 295 (4), 652-660 (2012)
   PUBMED   22271578
  REMARK    GeneRIF: srGAP1 and srGAP3 are largely expressed in subpopulations
            of dorsal root ganglion neurons following sciatic nerve lesion.
REFERENCE   5  (bases 1 to 7718)
  AUTHORS   Brunskill,E.W., Georgas,K., Rumballe,B., Little,M.H. and
            Potter,S.S.
  TITLE     Defining the molecular character of the developing and adult kidney
            podocyte
  JOURNAL   PLoS One 6 (9), e24640 (2011)
   PUBMED   21931791
REFERENCE   6  (bases 1 to 7718)
  AUTHORS   Bacon,C., Endris,V., Andermatt,I., Niederkofler,V., Waltereit,R.,
            Bartsch,D., Stoeckli,E.T. and Rappold,G.
  TITLE     Evidence for a role of srGAP3 in the positioning of commissural
            axons within the ventrolateral funiculus of the mouse spinal cord
  JOURNAL   PLoS One 6 (5), e19887 (2011)
   PUBMED   21655271
REFERENCE   7  (bases 1 to 7718)
  AUTHORS   Bacon,C., Endris,V. and Rappold,G.
  TITLE     Dynamic expression of the Slit-Robo GTPase activating protein genes
            during development of the murine nervous system
  JOURNAL   J Comp Neurol 513 (2), 224-236 (2009)
   PUBMED   19137586
  REMARK    GeneRIF: Data show that srGAP3 is expressed in ventricular zones of
            neurogenesis in many different tissues of the central nervous
            system.
REFERENCE   8  (bases 1 to 7718)
  AUTHORS   Wong,K., Ren,X.R., Huang,Y.Z., Xie,Y., Liu,G., Saito,H., Tang,H.,
            Wen,L., Brady-Kalnay,S.M., Mei,L., Wu,J.Y., Xiong,W.C. and Rao,Y.
  TITLE     Signal transduction in neuronal migration: roles of GTPase
            activating proteins and the small GTPase Cdc42 in the Slit-Robo
            pathway
  JOURNAL   Cell 107 (2), 209-221 (2001)
   PUBMED   11672528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138257.1, CB521559.1, CD351674.1, CX569081.1, BU706317.1,
            BU704234.1, CV556288.1 and AC153494.25.
            
            Transcript Variant: This variant (2) lacks an alternate coding
            exon, that causes a frameshift; however, it contains an alternate
            downstream exon that restores the reading frame. The resulting
            isoform (2) has a different internal segment compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120893.1, SRR7345562.3877666.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AK138257.1         2-292
            292-959             CB521559.1         1-668
            960-1341            CD351674.1         307-688
            1342-1592           CX569081.1         101-351
            1593-2284           BU706317.1         34-725
            2285-2611           BU704234.1         405-731
            2612-3224           CV556288.1         154-766
            3225-7718           AC153494.25        33596-38089         c
FEATURES             Location/Qualifiers
     source          1..7718
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 69.96 cM"
     gene            1..7718
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /note="SLIT-ROBO Rho GTPase activating protein 1"
                     /db_xref="GeneID:117600"
                     /db_xref="MGI:MGI:2152936"
     exon            1..189
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..3311
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /note="isoform 2 is encoded by transcript variant 2; Rho
                     GTPase activating protein 13; rho GTPase-activating
                     protein 13"
                     /codon_start=1
                     /product="SLIT-ROBO Rho GTPase-activating protein 1
                     isoform 2"
                     /protein_id="NP_001229340.1"
                     /db_xref="CCDS:CCDS56751.1"
                     /db_xref="GeneID:117600"
                     /db_xref="MGI:MGI:2152936"
                     /translation="MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQ
                     LLQDLQDFFRKKAEIETEYSRNLEKLAERFMAKTRSTKDHQQFKKDQNLLSPVNCWYL
                     LLNQVRRESKDHATLSDIYLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNE
                     LYTVMKTYHMYHSESISAESKLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKI
                     EKMKEKRQAKYSENKLKSIKARNEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHAS
                     LNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEF
                     QSHMGDEVCQVSAQQPVQAELMLRNQQLQSRLATLKIESEEVKKTTEATLQTIQDMVT
                     IEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKLREFLEGS
                     NLITKLQAKHDLLQRTLGEGHRAEYMTTSRGRRNSHARHQDSGQVIPLIVESCIRFIN
                     LYGLQHQGIFRVSGSQVEVNDIKNSFERGENPLSDEQSNHDINSVAGVLKLYFRGLEN
                     PLFPKERFTDLISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDE
                     NMMDPYNLAICFGPTLMPVPEIQDQVSCQAHVNEIVKTIIIHHETIFPDAKELDGPVY
                     EKCMAGGDYCDSPYSEHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELS
                     FKKGASLLLYHRASEDWWEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSG
                     PVTEDKSSSKDMNSPTDRHSDSYLARQRKRGEPPPPGRRPGRTSDGHCPLHPPHALSN
                     SSIDLGSPNLASHPRGLLQNRGLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRR
                     STSSGQYTGFNDHKPLDPETIAQDIEETMNTALNELRELERQSTVKHAPDVVLDTLEQ
                     VKNSPTPATSTESLSPLHNVALRGSEPQIRRSTSSSSETMSTFKPMVAPRMGVQLKPP
                     ALRPKPAVLPKTNPTMGPAAPSQGPTDKSCTM"
     exon            190..385
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            386..548
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            549..611
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            612..794
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            795..923
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1145
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1247
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1445
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1530
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1558
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1592
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1653
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1731
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1866
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1972
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2197
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2277
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2458
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2593
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2933
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..7718
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7698..7703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /note="hexamer: AATAAA"
     polyA_site      7718
                     /gene="Srgap1"
                     /gene_synonym="4930572H05Rik; Arhgap13"
                     /note="major polyA site"
ORIGIN      
        1 gggtgctgcc tctggcttct ctgcgagagg gagttacaac tctctgcttc tccacggaga
       61 ctggccggtg accacccgac aagaacttgc ccattggaaa gcaagcccgg aacagccgga
      121 gaatgtccac cccgagcaga ttcaagaagg acaaagagat catagccgag tatgaaagtc
      181 aagtcaaaga aatccgagcc cagctggtag aacaacaaaa atgcctggag cagcagacag
      241 agatgcgagt tcagctgctc caggacctac aagatttctt ccggaaaaaa gccgaaattg
      301 agacggaata ttctcggaac ctggagaagc tggcagaaag gttcatggcc aaaacaagaa
      361 gcactaagga ccatcaacag ttcaagaaag accaaaacct gttgtctcca gtgaactgct
      421 ggtatttgct cctgaaccaa gtgagaagag agagcaaaga ccacgccact ttgagtgaca
      481 tctatctgaa caatgtcatc atgcggttca tgcagataag cgaggactcc acccggatgt
      541 ttaaaaagag caaagagatt gcgttccagc ttcacgagga cctcatgaag gttctgaatg
      601 agctctacac ggtgatgaaa acctaccaca tgtaccactc agagagcatc agtgcagaga
      661 gtaagctgaa agaagccgag aaacaagagg agaagcagat tgggaggtcc ggcgacccag
      721 tcttccacat taggctggaa gagaggcatc agaggcggag ctctgtgaag aaaattgaaa
      781 aaatgaagga aaagagacaa gcaaaatatt cagaaaataa gctgaaatcg atcaaagccc
      841 gcaacgagta tctcctaaca cttgaagcaa ccaacgcctc cgtgttcaag tattacatcc
      901 atgatctttc agacttaata gactgctgtg atctcggcta ccatgcaagt ctgaacagag
      961 ccctcagaac gtacctctcg gcggagtaca accttgaaac ctccagacac gaaggcttag
     1021 acatcattga aaacgctgtg gacaatttag agcccaggag tgacaagcag aggttcatgg
     1081 agatgtaccc tgcggcattc tgcccgccaa tgaaattcga gtttcagtct cacatgggtg
     1141 atgaggtgtg tcaggtcagc gcccagcagc ccgtccaggc ggagctcatg ctcaggaacc
     1201 aacagctgca gtcccgactg gccacactca agatcgagag cgaggaggtc aagaaaacga
     1261 cagaagccac cctccagacg atccaagata tggtcaccat tgaggactat gatgtgtctg
     1321 agtgtttcca gcacagccga tccacagagt ctgtgaagtc cactgtgtca gaaacctacc
     1381 tgagtaaacc cagcatcgcc aagagacgag ccaaccagca agaaacggag cagttctact
     1441 tcatgaaact tcgagagttc ctggaaggca gtaacctcat cacaaagctg caggctaagc
     1501 atgacttgct gcagaggact cttggagaag gccatagagc tgaatatatg actacaagcc
     1561 ggggacgaag gaactctcac gcaagacatc aggactcagg ccaggttatc cctctcattg
     1621 tggaaagctg catccgattc attaatctct atggccttca gcaccagggg attttcagag
     1681 tgtctggctc ccaggtggaa gtgaacgata tcaagaattc tttcgagaga ggtgagaacc
     1741 ctctgtccga tgagcagagc aaccacgata tcaactcggt ggccggcgtg ctgaagctgt
     1801 acttccgagg gctggaaaac cccctctttc ctaaggaaag gtttactgac ctgatttcct
     1861 gtatcagaat agataacctc tatgagaggg cgctccacat ccgcaaactc ctcctgacct
     1921 tgcccaggtc ggtccttata gtgatgaggt acctgtttgc cttcctcaat cacctctccc
     1981 agtacagtga cgagaacatg atggaccctt acaatctggc catttgcttc ggcccaacac
     2041 tgatgccggt tccagagata caggaccaag tgtcttgcca ggcacacgtg aacgagattg
     2101 tgaagaccat catcatccat cacgagacta ttttcccaga tgctaaagaa ctggacggcc
     2161 ccgtgtatga gaaatgcatg gccggaggcg actactgcga cagcccctac agtgagcatg
     2221 gtacattgga ggaggtggac caagacgccg gcacagagcc ccacaccagt gaagacgagt
     2281 gtgagcccat cgaagccata gccaagtttg actacgtcgg gcggtcagct agagagctgt
     2341 ccttcaagaa gggtgcatcc ctgctgctgt atcaccgagc ctccgaggat tggtgggaag
     2401 gcagacacaa cgggatcgat ggccttgtgc ctcatcagta catagttgtg caagatatgg
     2461 acgatacatt ttcagacacg ctgagccaaa aggccgacag cgaagccagc agcgggccag
     2521 tcactgaaga caagtcctca tccaaggaca tgaactcccc gactgaccgc cattctgata
     2581 gctatttagc cagacaaaga aagagaggag agccaccccc tccgggaaga cgtcccggca
     2641 ggaccagcga tggccattgt cccctgcatc ccccgcatgc tctgtctaac tcctcaattg
     2701 atctgggatc cccaaaccta gccagtcacc ccaggggcct gttgcagaac cgtggcctca
     2761 ataatgacag tcctgagagg cggcgccggc cgggccacgg cagcctgacc aatatcagcc
     2821 ggcatgactc cctcaagaag atcgacagcc ctcctatccg gaggtccaca tcatcagggc
     2881 agtacacagg cttcaatgac cacaagccac tggaccccga gacgattgct caggatattg
     2941 aggagaccat gaacactgct ttgaacgaac tccgtgaact cgagaggcag agcacagtga
     3001 agcacgcccc cgatgtcgtg ctagacactt tggagcaagt gaagaactcg cccacccctg
     3061 cgacttccac agaatcactc agcccactgc acaatgtcgc cctcaggggc tcagagccac
     3121 agattcgccg gagcaccagc tcctccagcg agacaatgag tactttcaag cctatggtgg
     3181 cgccccggat gggcgtccag ctgaagcccc cagcccttag gccaaagcct gctgttcttc
     3241 caaaaacaaa ccctacgatg ggacctgccg caccttccca gggtcccaca gacaagtctt
     3301 gcacgatgta aaaacaaagg tcacgagggg aggggggatg tctgaagatg aaaatgaatt
     3361 agtggcaaga gtgggtgatc cacaaccttc cttggtcttg cgcttataac tggagagttt
     3421 ggcttttcta tgttgtgtcg aatgtaatga tgtctgggac tagctaaatt aacatgggca
     3481 tttgtatttt gtaatttttt ttaataactg gacattatcg tcgttttaaa gacaatagaa
     3541 acacttagac ttacttgaaa aatccaatgc tgcacccttg taatgaaggc aacacctcac
     3601 ccaacactgc gtatggcttc agatttagtg tagcccaggt gagtgtccca gaagcaagag
     3661 aacccaaatc ccaggtctta ctggagtgtc atcacctgcc acgcatgatc tgtgacactt
     3721 gtgggatgag cactcgttgc ctagcaaccg acaacaagca cctctaaccc tgtccagagt
     3781 agcagcccgc acctgatgaa ggtcacagaa ggaggctcct gtgggacctt cagttcatgg
     3841 cttgaaggag ttcagtggtg gacccttcca taaaactcat ctccctggat ccaggttaaa
     3901 gactcagtgg aagtgtgtag aagatactcg gacattgctt gaactgaagc tagaagaggc
     3961 tgtaagggaa actgtctcca tgcctgttga catggttccc tcaaagaact cgatcggccc
     4021 cggagaagtc caagtccacc ccccacacac acacttacaa tggactagag cagccgagtc
     4081 ataaggactt tctggttaca ccacaaactc ctgcagatgt tttcaataac tgcctgagaa
     4141 atatgtctgc cttcccctac tcccccctgc aaccagacag gaaatgaatc cttggttcct
     4201 ttatgccaca aaggcccagt ggtccccaat cggaagcccc agctctgcta gccacagctc
     4261 tctctgagcc aagccagatc tggctactgt actgagcgag agccatgtga ggccaccatg
     4321 ggaagacgac cttgtggcgc cgggatggtg ccttcccagt tttgtacctc agaatcatga
     4381 cttctgttct cctcctgttt gtgtttgcct tttgaatttt gcattataat ctctacagac
     4441 ctcctgtagt ccagtgggct ccactgggga cctctttccc tggtatttta gcatatagcc
     4501 atttttcttt atcatatata ctatattttt cctctatctt aaaaaaaata tgatagattt
     4561 gtgtttgttt ggttctgggg actgacaggg actgcttgca tgctaagtat acactaccac
     4621 tgagctgtac atcccagctc ttgcccctcc cccccaagat cattctggac acaactgttt
     4681 tcattaagat acaaatcaca attttcctag ccgtagcacc cgaacttcct gatgaggcaa
     4741 acagagggct caaagcaaac cccttgggac ccacccacca ttaattacct tctaggttta
     4801 atttcaaact ggtggtgctg attgcatttg catgcccacc taagagtagc acagcactga
     4861 caataactcc tgcagaaacc aaccaagacc tgcgctaaag tcaaggtcat gacccatggc
     4921 tacctcagtt tgccagtata gtcattccac tgcaggaaaa aatattgatg aactattccc
     4981 tttccaagcc actctcctca tttcacaaat gtaccgaaga catactccct acccccaggt
     5041 acttcaagta tggtaaagtt ttaaacctca aatttttcag aaccattctt tctgaccatt
     5101 ttgcaaaaga agccatggag acccagccag gactgccctt tgactgacaa tgactgctgg
     5161 tctctttgga agtttactat ctcctaaagg aacccaccac ttatttagaa aacaataacg
     5221 attcttagaa ccatttttcc ttgacggatg ataccaacag gaggcaggag aaactggccg
     5281 ccttttgagt tcatttataa aggcttttct taagcttaat tttagctttt cagatcttcc
     5341 ttagacagct cccaggcaat cccctccacc cacctccccc cacccccccc agtccaaggc
     5401 cttcagtgct ccacctataa ctttctaccc ctaggtcagg actctgctgc cttgaataac
     5461 aaaggccatg cttttgtact gccagggcct cttcctctag gaaatggctc ctggttgact
     5521 ccatcgctcc tgtatcttcc tcatcttctc tcctgtacct actgtcattt ccaggctcac
     5581 tttggtctca aatgaaagca aagagtgtag acggtctcca ggtaagcacc ttaacactta
     5641 acagttaagt ctcctttctc agagatggct caacaggcct gttttccccc accactctga
     5701 ctttggtacc ctttgagcca tgcacacaat agcttaaggt aaggcatccc ccctgcacag
     5761 aggatcctag aaactgtccg tcaagctccc taaaagctgc agccatggaa aagggtcggc
     5821 ttgcagggcc tggtttgaaa cacagatgta gcacagcagg aaggtacaag gaaacgaacc
     5881 ccaaggtgct ctcacttctc cctcatttcc aggtctcacg gtccatacat acgtagttta
     5941 gagataggag caaatgactg tcagccgaga tacccgtctc cacatgcact aaagattcgt
     6001 agctgataga accacgcggt ttgcacccct gatggaggtt ttgcaaagcc ctgtggtgtg
     6061 tgtttcgagt ttgaggtgtg gattgctagg acatggtgct cattctctag agagtgtcac
     6121 ataaacttct gagggcactg tgtaaacctt gagttcttgt cacaagccac accattgttc
     6181 aacagttttc cttgtgttca ctcaacataa tctgacgccc agtgccccac gagccagcca
     6241 caggacaatt catagttgag gtctcactca ttcaactacc atagtcatga gtaaatacca
     6301 gtggataaag agttcccaag ggtcagatgg tctctcttga gttttctgtc tctgcatttg
     6361 ccagtctcca agtggctcta tagtttaact aagaagctgg gttggtagta gtggccttag
     6421 cattttggaa tgctcagtct ctgacgtcta catgctgaag gaatcgtgat ctaacatctg
     6481 aaacccaaca gtaaggaggc catgagtcca ttgagagtct atttgggttg attttttttt
     6541 tcctggccac agtagaaaag accatgaatg caggaactgc atgtgggacg ccatctctgg
     6601 tatctgccac tgagactctg gaacacagag agcctcaaag tgcaaataga acctccttct
     6661 taagactgac ccctgagctg agagcccccc actcccccaa gctccagcag gctggagcct
     6721 caggcttgca gcggatgact ttggcacaga ctgtaaagcc agagactgag tttcacccat
     6781 cctaatatac tttatttaaa aaaaaaaaaa aaaagtctca gtggtatagt cacaatgggt
     6841 aactaactgt atctttaaat tacataggga attttgttgt atgtttaaat acccgtaccc
     6901 agttccatat tgcttatctt agaaactagt aaaagaaaac tatataaacc gtgtgtttgt
     6961 ggatgcccct ctgtagagcg ttcacttagg ttccgtgtgt agtgtgacgg tgatcgtaga
     7021 tatcgacagc gtagtaggtg gccgagtcac aggagagatt gctctgtccc tgcattctga
     7081 acgttaactc ccgcccacgt aaataaacca gtattgtcct ttcctgtcgg tttggtcagt
     7141 tgcagtaccg gtagctttct gcttgtgacg gttacctaag tgtgtcaatg tacatctgta
     7201 gtatgtacat gtgaaagtgc cttcctacct tagcgtttag cctagctctt ggactgtggc
     7261 ccactaggtc ccgcccactt ccttcatttc cagccacgcc ccacagtgtt ctgaaacccc
     7321 ctccgctcct tcccagcctc tccccacccc catcatcctc ccgtgcctct gtcacgtgca
     7381 tctcgcatcc acgtggatta ccgcactgtc ttgttgccct cctagacgtg actgtgcctt
     7441 tctcaccccg ctgtgactcc ctgccgtctg atccaacctt cccacccaca gtgccactgc
     7501 catcctgtcc cttgctctgt accggttctc tctgaggtga ggagaaaagt gatgctttta
     7561 cagtcctgga agaaatgatg atgttttgtt aatttgtcgt gacgatgcac ttttctgtat
     7621 agtacagtac atttttggca tgtaccatta caggcttcag tatacggtcg ggtttgttct
     7681 tcaaggtgta gctttataat aaatatgata gttctgga
//
