LOCUS       NM_026040               2658 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus serum response factor binding protein 1 (Srfbp1),
            mRNA.
ACCESSION   NM_026040 XM_003689318
VERSION     NM_026040.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2658)
  AUTHORS   Zhang,X., Williams,E.D., Azhar,G., Rogers,S.C. and Wei,J.Y.
  TITLE     Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac
            mitochondrial function in aging?
  JOURNAL   Exp Gerontol 82, 150-159 (2016)
   PUBMED   27337995
  REMARK    GeneRIF: P49/STRAP expression was increased in the old versus young
            adult mouse hearts and also increased with advancing population
            doubling levels in cultured human umbilical vein endothelial cells.
            The increased expression of p49/STRAP in late life may alter the
            status of histone acetylation and impact mitochondrial dynamics and
            thereby reduce mitochondrial function and cardiac performance
            during mammalian senescence.
REFERENCE   2  (bases 1 to 2658)
  AUTHORS   Zhang,X., Azhar,G., Rogers,S.C., Foster,S.R., Luo,S. and Wei,J.Y.
  TITLE     Overexpression of p49/STRAP alters cellular cytoskeletal structure
            and gross anatomy in mice
  JOURNAL   BMC Cell Biol 15, 32 (2014)
   PUBMED   25183317
  REMARK    GeneRIF: Overexpression of p49/STRAP reduced actin content in
            cultured cells and resulted in smaller cell size versus control
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2658)
  AUTHORS   Sajedi,E., Gaston-Massuet,C., Andoniadou,C.L., Signore,M.,
            Hurd,P.J., Dattani,M. and Martinez-Barbera,J.P.
  TITLE     DNMT1 interacts with the developmental transcriptional repressor
            HESX1
  JOURNAL   Biochim Biophys Acta 1783 (1), 131-143 (2008)
   PUBMED   17931718
REFERENCE   4  (bases 1 to 2658)
  AUTHORS   Lisinski,I., Matsumoto,H., Yver,D.R., Schurmann,A., Cushman,S.W.
            and Al-Hasani,H.
  TITLE     Identification and characterization of p49/STRAP as a novel
            GLUT4-binding protein
  JOURNAL   Biochem Biophys Res Commun 344 (4), 1179-1185 (2006)
   PUBMED   16647043
  REMARK    GeneRIF: 49-kDa protein (p49/STRAP) specifically interacts with an
            acidic amino acid motif (Q7IGSEDG) in the N-terminus of GLUT4.
REFERENCE   5  (bases 1 to 2658)
  AUTHORS   Zhang,X., Azhar,G., Zhong,Y. and Wei,J.Y.
  TITLE     Identification of a novel serum response factor cofactor in cardiac
            gene regulation
  JOURNAL   J Biol Chem 279 (53), 55626-55632 (2004)
   PUBMED   15492011
  REMARK    GeneRIF: p49/STRAP may be an important SRF cofactor in the
            transcriptional regulation of mammalian cardiac muscle genes
            throughout the life span
REFERENCE   6  (bases 1 to 2658)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109203.9.
            
            On Feb 8, 2019 this sequence version replaced NM_026040.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012865.1, AK147692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC109203.9         61968-62060         c
            94-182              AC109203.9         52069-52157         c
            183-255             AC109203.9         51381-51453         c
            256-327             AC109203.9         44049-44120         c
            328-409             AC109203.9         40160-40241         c
            410-1130            AC109203.9         38782-39502         c
            1131-1168           AC109203.9         37698-37735         c
            1169-2658           AC109203.9         35820-37309         c
FEATURES             Location/Qualifiers
     source          1..2658
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 28.21 cM"
     gene            1..2658
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /note="serum response factor binding protein 1"
                     /db_xref="GeneID:67222"
                     /db_xref="MGI:MGI:1914472"
     exon            1..93
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            94..182
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            183..255
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            256..327
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            328..409
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            410..1130
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1168
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..2658
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1440..1445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /note="hexamer: AATAAG"
     polyA_site      1469
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /note="major polyA site"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /note="hexamer: AATAAA"
     polyA_site      1998
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
     regulatory      2639..2644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /note="hexamer: ATTAAA"
     polyA_site      2658
                     /gene="Srfbp1"
                     /gene_synonym="2810036K01Rik; p49/STRAP"
                     /note="major polyA site"
ORIGIN      
        1 gcaatcgccg gtgctcacgt gctggagatg gcggctgacc ctcttcctcc gtccgcaatg
       61 gttcagccgg ggactctgaa cctcaataac gaggttgtaa agatgagaaa agaagtgaag
      121 cgaatccgag ttctggtcat ccgaaaactt gtcaggagtg tcggcagact gaagtccaaa
      181 aagggcacag aagatgcact gttgaaaaac caaaggcgag cccaaaggtt gcttgaggag
      241 atccatgcca tgaaggaatt gaaacctgat gttgtaacta aatctgctct tagtgatgat
      301 atcaactttg aaaaaacttg caaaaagccg gattctaccg cgaccgacag agcggttgcc
      361 agattagcag gtcacccgct tctgaagaag aaaattgatg tgctaaaaga tgctgtccag
      421 gccttcaaag atgcaaggca gagtgctcca gcggccgaat catctgagag tacttcagga
      481 gaaggccggt gtaaggacat tgcaaggtca aaggatgatg cacgtgagtc acagcatcct
      541 gagagaactg ttgtcaggga gcagaaggca aaggacacca acacggcagc aaagaatgca
      601 gcaagtggtt caaaagaaaa actggccaag acagagcagg cacccagagc agggaccact
      661 ccagggtctc aggggaggcc ttcaggaaag ggtgctgggg ttaactctga acaccagggg
      721 gccccagccc caggggacag caaccagggg aaagcctcaa ccaaaacccc ggaggacagc
      781 gtgtgtgaac ctgctaataa cggtgtcagt gaggaagagg agagcgaggg ggaaaaggag
      841 tattttgatg acagcactga agaacggttc tacaaacagt cttctgcatc tgaggacagc
      901 gacagtggtg acgacttctt cattggaaaa gtcagacgga ctcgaaagaa ggaatctggt
      961 gtccattcct cggccaagga actgaagccc ctcccaaagg taccatctaa aacaagtaca
     1021 cttgaaaccc cctgggatgt aagaaacgat aaacacaggc caattccaga agccaggaag
     1081 ttcgaatccg tgtttttcca ctcgttggct ggacctaaaa gctccagaag ggatcccaga
     1141 gaacaggccc caaagaataa agccccagat tttccagaaa atgaaccccc agtcaagaag
     1201 cagtttacaa agagtgcata cagaggcttt gagagtgtga agcagacgat gcaggcacct
     1261 ctgcatccgt cctgggaagc gagcaggagg cggaaggagc agcagtccaa aatcgctgtg
     1321 tttcagggga aaaaaattac atttgatgat tgatttgata cttgctgcct ctttgcaagc
     1381 gttctgtcaa aatttttggt tttgttttta actaacatgt tatttaaact tgcattttaa
     1441 ataagtctct ttcaaagagt tataaaatat attgcttgtt tttctttttt tatgtgaatt
     1501 tagggaatat ttacataatc ttttcacaga tctctaaatt tatttcataa gaatgcttgc
     1561 cccaaattat ttcttacata aagtaattta gatattacgg aattttaggt tttctcattc
     1621 atgattacaa aatatatttc gctagttaag ctttcccttt tgccttcaaa ataaggcaaa
     1681 cagggcttag gagatggctc acttcctggg gcccgatggc ctgagtttga cccctgtgat
     1741 tcccttggta tgagggcaga actaattcac aaagtcgttc tctgattgca catacactgt
     1801 ggcacatgcc tatgtacata caaatatgtt cacatataat aaatgtcata taaaaaatgt
     1861 taggacatat ttaaaataat agtgagaaaa gaaagaaatt aggactaaaa aatattttta
     1921 taagcaaaac agaaatggca attttcattg tggatataga aatagtatat aaataaatat
     1981 taatttgtga tagttgcagt tacttgtgac ttatctttgc agtgtttgag caacttgctt
     2041 atgtgtagca acacctaaaa gttaagttct aagtacccct gcaatgagta tttccattca
     2101 ttgaagaatg gatcaataga gccctagttt ttctgtccat ggaccaagtc caggatatag
     2161 tgttcatggt acagaaaagt tatgcatggt gtctagtcac ttaggcaaat attggagtac
     2221 aacactggga attgaaccta gggcctcatg cattctaggt cttatacatg ctctaccact
     2281 gaggaccttg ctgtgtggct caaacagggc tgggttttta ctctcacagt accaagatgc
     2341 aggcatttta acttgtgttg aaatgtagaa gaggagggat tgaagtggct aaataggagt
     2401 tcttggactc ctaaagaacc atgtactcca tacagtaaag gaaaagaggt ttgtaaaaga
     2461 tgcttgcctg tttcatacag tgcagtgact tgtgttcaaa ggaaaagaaa gaggtttgta
     2521 aaagatcctc gcctgtttca tacagtacag tgaccttaaa ggaaaagaga gaggtttgta
     2581 aaagatcctt gcctgtttgc cttttattgc tgtggaagac aagaaagatg gttagttaat
     2641 taaacagtgc taactgaa
//
