LOCUS       NM_020493               4093 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus serum response factor (Srf), mRNA.
ACCESSION   NM_020493
VERSION     NM_020493.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4093)
  AUTHORS   Xu,Y., Zhang,H., Chen,Y., Pober,J.S., Zhou,M., Zhou,J.H. and Min,W.
  TITLE     SRF SUMOylation modulates smooth muscle phenotypic switch and
            vascular remodeling
  JOURNAL   Nat Commun 15 (1), 6919 (2024)
   PUBMED   39134547
  REMARK    GeneRIF: SRF SUMOylation modulates smooth muscle phenotypic switch
            and vascular remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4093)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4093)
  AUTHORS   Khudayberdiev,S., Weiss,K., Heinze,A., Colombaretti,D., Trausch,N.,
            Linne,U. and Rust,M.B.
  TITLE     The actin-binding protein CAP1 represses MRTF-SRF-dependent gene
            expression in mouse cerebral cortex
  JOURNAL   Sci Signal 17 (835), eadj0032 (2024)
   PUBMED   38713765
  REMARK    GeneRIF: The actin-binding protein CAP1 represses
            MRTF-SRF-dependent gene expression in mouse cerebral cortex.
REFERENCE   4  (bases 1 to 4093)
  AUTHORS   Iram,T., Garcia,M.A., Amand,J., Kaur,A., Atkins,M., Iyer,M.,
            Lam,M., Ambiel,N., Jorgens,D.M., Keller,A., Wyss-Coray,T., Kern,F.
            and Zuchero,J.B.
  TITLE     SRF transcriptionally regulates the oligodendrocyte cytoskeleton
            during CNS myelination
  JOURNAL   Proc Natl Acad Sci U S A 121 (12), e2307250121 (2024)
   PUBMED   38483990
REFERENCE   5  (bases 1 to 4093)
  AUTHORS   Thumu,S.C.R., Jain,M., Soman,S., Das,S., Verma,V., Nandi,A.,
            Gutmann,D.H., Jayaprakash,B., Nair,D., Clement,J.P., Marathe,S. and
            Ramanan,N.
  TITLE     SRF-deficient astrocytes provide neuroprotection in mouse models of
            excitotoxicity and neurodegeneration
  JOURNAL   Elife 13, e95577 (2024)
   PUBMED   38289036
  REMARK    GeneRIF: SRF-deficient astrocytes provide neuroprotection in mouse
            models of excitotoxicity and neurodegeneration.
            Erratum:[Elife. 2024 Jul 01;13:e101107. doi: 10.7554/eLife.101107..
            PMID: 38949864]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4093)
  AUTHORS   Belaguli,N.S., Schildmeyer,L.A. and Schwartz,R.J.
  TITLE     Organization and myogenic restricted expression of the murine serum
            response factor gene. A role for autoregulation
  JOURNAL   J Biol Chem 272 (29), 18222-18231 (1997)
   PUBMED   9218459
REFERENCE   7  (bases 1 to 4093)
  AUTHORS   Spencer,J.A. and Misra,R.P.
  TITLE     Expression of the serum response factor gene is regulated by serum
            response factor binding sites
  JOURNAL   J Biol Chem 271 (28), 16535-16543 (1996)
   PUBMED   8663310
REFERENCE   8  (bases 1 to 4093)
  AUTHORS   Paradis,P., MacLellan,W.R., Belaguli,N.S., Schwartz,R.J. and
            Schneider,M.D.
  TITLE     Serum response factor mediates AP-1-dependent induction of the
            skeletal alpha-actin promoter in ventricular myocytes
  JOURNAL   J Biol Chem 271 (18), 10827-10833 (1996)
   PUBMED   8631897
REFERENCE   9  (bases 1 to 4093)
  AUTHORS   Chen,C.Y., Croissant,J., Majesky,M., Topouzis,S., McQuinn,T.,
            Frankovsky,M.J. and Schwartz,R.J.
  TITLE     Activation of the cardiac alpha-actin promoter depends upon serum
            response factor, Tinman homologue, Nkx-2.5, and intact serum
            response elements
  JOURNAL   Dev Genet 19 (2), 119-130 (1996)
   PUBMED   8900044
REFERENCE   10 (bases 1 to 4093)
  AUTHORS   Latinkic,B.V., O'Brien,T.P. and Lau,L.F.
  TITLE     Promoter function and structure of the growth factor-inducible
            immediate early gene cyr61
  JOURNAL   Nucleic Acids Res 19 (12), 3261-3267 (1991)
   PUBMED   2062642
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165445.1.
            
            On Mar 21, 2007 this sequence version replaced NM_020493.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051950.1, SRR7652917.1092399.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-835               AC165445.1         90974-91808
            836-1102            AC165445.1         93310-93576
            1103-1364           AC165445.1         95344-95605
            1365-1484           AC165445.1         96116-96235
            1485-1676           AC165445.1         97100-97291
            1677-1753           AC165445.1         97624-97700
            1754-4093           AC165445.1         97958-100297
FEATURES             Location/Qualifiers
     source          1..4093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..4093
                     /gene="Srf"
                     /note="serum response factor"
                     /db_xref="GeneID:20807"
                     /db_xref="MGI:MGI:106658"
     exon            1..835
                     /gene="Srf"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1849
                     /gene="Srf"
                     /codon_start=1
                     /product="serum response factor"
                     /protein_id="NP_065239.1"
                     /db_xref="CCDS:CCDS28831.1"
                     /db_xref="GeneID:20807"
                     /db_xref="MGI:MGI:106658"
                     /translation="MLPSQAGAAAALGRGSALGGNLNRTPTGRPGGGGGTRGANGGRV
                     PGNGAGLGQSRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEME
                     LGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKR
                     KTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSP
                     DSPPRSDPTTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQ
                     TAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQ
                     LPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMT
                     SSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGV
                     PQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE"
     exon            836..1102
                     /gene="Srf"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1364
                     /gene="Srf"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1484
                     /gene="Srf"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1676
                     /gene="Srf"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1753
                     /gene="Srf"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..4093
                     /gene="Srf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2585..2590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srf"
                     /note="hexamer: AATATA"
     polyA_site      2608
                     /gene="Srf"
ORIGIN      
        1 agccagcgcg tggtcccggc cccctccacc cgcggtctcg gccgcggcca gcagcccctg
       61 ccccgcgggg gacgctgacg gccgcagggc gcgcctcccc ggcacacgga cagggggcgc
      121 tgcgcgcggc ctggggcaac cccggccata ggggcaggaa agtgagggcc caggtcggcc
      181 cgggcgtgca ggggccccgg gctcgcagcg gcggccgcgg cagcaagagc ggctttagta
      241 acagcgcgag tgccgggtgg aaccgagaag ccgatggcgg cagctgcccc gattcctcgc
      301 tgacttgccc gtcagccctc ctgcactgag cgccatgtta ccgagccaag ctggggccgc
      361 ggcggctctg ggccggggct cggccctggg gggcaacctg aaccggaccc cgacggggcg
      421 gccgggcggc ggcggcggga ctcgcggggc gaacgggggc cgggtccccg ggaacggcgc
      481 ggggctcggc cagagtcgtc tggagcggga ggctgcagcg gcagcggcgc ccaccgccgg
      541 ggccctctac agcggcagcg agggcgactc cgagtccggc gaggaggagg agctgggcgc
      601 cgagcggcgc ggcctcaagc ggagcctgag cgagatggag ctcggcgtgg tggtcggtgg
      661 gcctgaggcg gcggcggcgg ccgccggggg ctacgggccg gtgagcggcg cggtgagcgg
      721 ggccaagccg gggaagaaga cccggggccg cgtgaagatc aagatggagt tcatcgacaa
      781 caagctgcgg cgctacacga ccttcagcaa gaggaagacg ggcatcatga agaaggccta
      841 tgagctgtcc acgctgacag ggacacaggt gctgttgctg gtggccagtg agacaggcca
      901 tgtgtatacc tttgccaccc gcaaactgca gcccatgatc accagtgaga ccggcaaggc
      961 gctgattcag acctgcctca actcgccaga ctctccgccc cgctcagacc ccaccacaga
     1021 ccagagaatg agtgccactg gctttgaaga gccagatctc acctaccagg tgtcggaatc
     1081 tgacagcagt ggggaaacca aggacacact gaagccagca ttcacagtca ccaacctgcc
     1141 gggtaccacc tccacaatcc agacagcacc cagcacctct accaccatgc aagtcagcag
     1201 cggcccctcc ttccccatca ccaactacct ggcaccagtg tctgctagtg tcagccccag
     1261 cgctgtcagc agtgccaacg ggactgtgct caagagtaca ggcagcggcc ctgtctcctc
     1321 tgggggcctt atgcagctgc ctaccagctt caccctcatg cctggtgggg cagtggccca
     1381 gcaggtccct gtgcaggcca ttcatgtgca ccaggcccca cagcaagcgt ctccctctcg
     1441 tgacagcagc acagacctca cgcagacctc ctccagcggg acagtgacgt tgcccgccac
     1501 catcatgacg tcgtctgtac ccacaactgt gggtggccac atgatgtacc ctagtcccca
     1561 tgcagtgatg tatgccccca cctcaggcct ggctgatggc agcctcaccg tgctcaatgc
     1621 cttctctcag gcaccatcca ccatgcaggt gtcccacagc caggtccagg agccaggtgg
     1681 tgtccctcag gtgttcctga cagcaccgtc tgggaccgtg cagatccctg tctctgcagt
     1741 tcagcttcac cagatggctg tgatagggca gcaagctggg agcagcagca acctcaccga
     1801 gctacaggtg gtgaacctgg atgccaccca cagcaccaag agtgaatgat ccgcccgtca
     1861 ccctggacag acggcccaag ggacggcacc acttatttat tgttgccttt tcacggtttc
     1921 tttacacaca cactgactgg ccgaaggagg gaggcgggga gaaggagcgg gcagccacag
     1981 gactatgccc tctcactcca gccaaagaaa cgggcctgcc tgccctcccc agctgccctc
     2041 cttcctgctc tgcctgtcat gctgttgatg gtgcagctct cctccctcct cagaccccct
     2101 gccagcctgg ctcaatttgc tatgagtatt agctgacccg atgggactgt gccaccttcc
     2161 cactcacagg ccttctgtgg gactgggcac agtgttcccg tccgaggaaa catttggggc
     2221 cctctctcca gcctctttgg cgacctctgg ttagctttgt gtctgccatg gtctgggtca
     2281 aaagagcccg gcccctgccc ctcagggagc cagctgggag agatatgggg gcttgtgccc
     2341 tcagccgatg ccctctgccc ctttcagctc ctgaagcagc tgggcctgtg caccgggcag
     2401 gttactgggg ccgcctgccc tgccttgcct ctgttcccgc ggacctgcag gggctcctgg
     2461 gttggaggga accactgtta gcggtctctt cctccccttg gtcttccccc ttctcccagc
     2521 tgctttactt aagagttgat tttgaacttt ttatttgagg agatgacgtg aaaacaaatc
     2581 tataaatata tatttttaaa atatttaact tttttttaat ggcgtttttc tcatccccct
     2641 ccctgcccaa actcctcttg gggaagctct tgggctccct agaactgtct gggcccctgg
     2701 ggacagccac cccatgagct tggggtccac cagtgtgtgt gtgtgggaga ttctgggatt
     2761 gctccacatc ctgggttctt tccaggagaa aggtggggga ggggccctca ggccaagcca
     2821 cagaaggggg atgggaggtc ccgcagttct aggcctcttt tgccctctag ggttgttgct
     2881 aggaaaaggg aagatggaga ccaaatgtgg gggtggggtg ggaggggtca gggagaggag
     2941 attgatgtcc tttgtgccac agtatggtcg ttgcagcctg tgctccccca ggcttgcaga
     3001 tacctggggc ccaaggtgca gtgggcagga tggagttcgg gaggtaggga gatacaggaa
     3061 tgggggtcag aggtaaaagc tcttgggctg agtgcagcaa tggggggcca gaggtgggca
     3121 gctctcccag ggagtgagca gctactgtaa cttttttaaa ttaagacaaa aagccttgaa
     3181 gaaaatgact ttatttttct aagtgtaacc tcagtattta tgtaatttgt acagggccat
     3241 gccccatccc ttaaaatccc tttggggacc ttgagggtgg gctagcatag gggagggtgt
     3301 tttaccctgt gtcagagcca gcctaaacca cctgtatcca ttaaaggagc tttttccggg
     3361 agggcagttg gggtagggtg tcactaaacc cttgttgctg ccttcagtag gaacaagcct
     3421 acttctgcgg ttaggtggag gggttgggaa ggttttatgc acagcctacg tttcatgggg
     3481 atgatctgct gacgtttaag agccccctga acctctaatc cccattactg tcttccccag
     3541 ctgggatgcc acctttctgg cctttctcct ggaaatagct ggggcgtttg ggtggctttc
     3601 aagactgggg catggtaaac caggggtcag agttggggag cttgggactc aggtctgtaa
     3661 ctgcccagcc cccttctctg ctcctgtttc actcctctgc cgcccactca tggcccctcc
     3721 cccaacaccg gaggtgttga ttcctcctca caaaagatag agcctgggca agtgattcag
     3781 gccaagtgct taccaacgtg tgctgtgtga ttgtggcctt gggagaacct gtttgtcagg
     3841 caggactgag gtggcatttc tatgtgcagc aacccttggt gtatccctaa ttaagtggct
     3901 ctaggggtgt gtgcgcgcgc ctgtgtccga gtgaatacgt gtgtgaatgt ggagtgcgtg
     3961 tggtatatcc gtggtttcta cttctcctgg gatgttgacc caggaatagt ggacatggtc
     4021 acatcttctg tacagagctt tcttttgtat taaaaaaata ctctttcaat aaatgtatca
     4081 tttttgtgca cag
//
