LOCUS       NM_033218               5004 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus sterol regulatory element binding factor 2 (Srebf2),
            transcript variant 1, mRNA.
ACCESSION   NM_033218 XM_127995
VERSION     NM_033218.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5004)
  AUTHORS   Kim,H., Choi,I.A., Umemoto,A., Bae,S., Kaneko,K., Mizuno,M.,
            Giannopoulou,E., Pannellini,T., Deng,L. and Park-Min,K.H.
  TITLE     SREBP2 restricts osteoclast differentiation and activity by
            regulating IRF7 and limits inflammatory bone erosion
  JOURNAL   Bone Res 12 (1), 48 (2024)
   PUBMED   39191742
  REMARK    GeneRIF: SREBP2 restricts osteoclast differentiation and activity
            by regulating IRF7 and limits inflammatory bone erosion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5004)
  AUTHORS   Diercks,A.H., Podolskaia,I.S., Murray,T.A., Jahn,A.N., Mai,D.,
            Liu,D., Amon,L.M., Nakagawa,Y., Shimano,H., Aderem,A. and Gold,E.S.
  TITLE     Oxysterol binding protein regulates the resolution of TLR-induced
            cytokine production in macrophages
  JOURNAL   Proc Natl Acad Sci U S A 121 (33), e2406492121 (2024)
   PUBMED   39361877
REFERENCE   3  (bases 1 to 5004)
  AUTHORS   Chen,Y., Liu,Z., Chen,H., Wen,Y., Fan,L. and Luo,M.
  TITLE     Rhythm gene PER1 mediates ferroptosis and lipid metabolism through
            SREBF2/ALOX15 axis in polycystic ovary syndrome
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167182 (2024)
   PUBMED   38653359
  REMARK    GeneRIF: Rhythm gene PER1 mediates ferroptosis and lipid metabolism
            through SREBF2/ALOX15 axis in polycystic ovary syndrome.
REFERENCE   4  (bases 1 to 5004)
  AUTHORS   Plebanek,M.P., Xue,Y., Nguyen,Y.V., DeVito,N.C., Wang,X.,
            Holtzhausen,A., Beasley,G.M., Theivanthiran,B. and Hanks,B.A.
  TITLE     A lactate-SREBP2 signaling axis drives tolerogenic dendritic cell
            maturation and promotes cancer progression
  JOURNAL   Sci Immunol 9 (95), eadi4191 (2024)
   PUBMED   38728412
  REMARK    GeneRIF: A lactate-SREBP2 signaling axis drives tolerogenic
            dendritic cell maturation and promotes cancer progression.
REFERENCE   5  (bases 1 to 5004)
  AUTHORS   Toshima,T., Yagi,M., Do,Y., Hirai,H., Kunisaki,Y., Kang,D. and
            Uchiumi,T.
  TITLE     Mitochondrial translation failure represses cholesterol gene
            expression via Pyk2-Gsk3beta-Srebp2 axis
  JOURNAL   Life Sci Alliance 7 (7), e202302423 (2024)
   PUBMED   38719751
  REMARK    GeneRIF: Mitochondrial translation failure represses cholesterol
            gene expression via Pyk2-Gsk3beta-Srebp2 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5004)
  AUTHORS   Klingenspor,M., Bodnar,J., Xia,Y.R., Welch,C., Lusis,A.J. and
            Reue,K.
  TITLE     Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs)
            to mouse chromosomes 11 and 15 respectively
  JOURNAL   Mamm Genome 8 (7), 539-540 (1997)
   PUBMED   9196007
REFERENCE   7  (bases 1 to 5004)
  AUTHORS   Shimano,H., Horton,J.D., Hammer,R.E., Shimomura,I., Brown,M.S. and
            Goldstein,J.L.
  TITLE     Overproduction of cholesterol and fatty acids causes massive liver
            enlargement in transgenic mice expressing truncated SREBP-1a
  JOURNAL   J Clin Invest 98 (7), 1575-1584 (1996)
   PUBMED   8833906
REFERENCE   8  (bases 1 to 5004)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 5004)
  AUTHORS   Myohanen,S., Wahlfors,J., Alhonen,L. and Janne,J.
  TITLE     Nucleotide sequence of mouse spermidine synthase cDNA
  JOURNAL   DNA Seq 4 (5), 343-346 (1994)
   PUBMED   7803821
REFERENCE   10 (bases 1 to 5004)
  AUTHORS   Kauppinen,L., Myohanen,S., Halmekyto,M., Alhonen,L. and Janne,J.
  TITLE     Transgenic mice over-expressing the human spermidine synthase gene
  JOURNAL   Biochem J 293 (Pt 2) (Pt 2), 513-516 (1993)
   PUBMED   8343131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102176.8 and AC105358.8.
            
            On Sep 2, 2022 this sequence version replaced NM_033218.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172219.1, AF374267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AC102176.8         177737-177973
            238-654             AC105358.8         47970-48386         c
            655-836             AC105358.8         46841-47022         c
            837-983             AC105358.8         45225-45371         c
            984-1205            AC105358.8         42806-43027         c
            1206-1320           AC105358.8         40854-40968         c
            1321-1502           AC105358.8         40537-40718         c
            1503-1695           AC105358.8         39215-39407         c
            1696-1877           AC105358.8         38577-38758         c
            1878-2154           AC105358.8         35867-36143         c
            2155-2324           AC105358.8         32691-32860         c
            2325-2493           AC105358.8         25750-25918         c
            2494-2611           AC105358.8         23962-24079         c
            2612-2721           AC105358.8         23100-23209         c
            2722-2854           AC105358.8         21832-21964         c
            2855-3023           AC105358.8         20338-20506         c
            3024-3209           AC105358.8         18304-18489         c
            3210-3321           AC105358.8         14828-14939         c
            3322-5004           AC105358.8         12745-14427         c
FEATURES             Location/Qualifiers
     source          1..5004
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.49 cM"
     gene            1..5004
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /note="sterol regulatory element binding factor 2"
                     /db_xref="GeneID:20788"
                     /db_xref="MGI:MGI:107585"
     exon            1..237
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..3542
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sterol regulatory element-binding protein 2; sterol
                     regulatory element-binding transcription factor 2"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein 2
                     isoform 1"
                     /protein_id="NP_150087.1"
                     /db_xref="CCDS:CCDS27683.1"
                     /db_xref="GeneID:20788"
                     /db_xref="MGI:MGI:107585"
                     /translation="MDESSELGVLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPD
                     LFSEQLCSSFPGGGSNGGSGNNSSGRGNNGGATDPAVQRSFSQVPLSTFSPSAASPQA
                     PALQVKVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIY
                     QNAATSFQVLQPQVQSLVTSPQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQ
                     TVAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQ
                     VPTLVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLDPPKEGERRTTHNIIEKRYRSS
                     INDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKL
                     LKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDA
                     KVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNTDQHPYSGSGR
                     SVLSLESGAGGWFDWMVPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPHSRPSVTFWRH
                     RKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVR
                     WLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHM
                     ALCAVNLAECAEEKILPSTLIEIHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEH
                     STVPDSLRWLCHPLGQKFFMERSWSIKSAAKESLYCAQRSPADPIAQVHQAFCKNLLE
                     RAVESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGFVTSPFSSSSVLRSA
                     LGPDVICRWWTSAVTMAISWLQGDDAAVRSRFTEVERVPKALEVTESPLVKAVFYTCR
                     AMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVIQLFTCDLLLSLR
                     TALWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRL
                     MAGASPTRTHQLLEHSLRRRPTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSP
                     GQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS"
     exon            238..654
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            655..836
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            837..983
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1205
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1320
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1502
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1695
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1877
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2154
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2324
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2493
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2611
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2721
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2854
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3023
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3209
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3321
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..5004
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4283..4288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /note="hexamer: AATAAA"
     polyA_site      4303
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
     regulatory      4979..4984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /note="hexamer: AATAAA"
     polyA_site      5004
                     /gene="Srebf2"
                     /gene_synonym="bHLHd2; lop13; nuc; SREBP-2; SREBP2;
                     SREBP2gc"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcagc tcaaacatgg cggcggttgg cacggggcgg tgaggcggta ccaggtgggg
       61 gctgtcgggt gtcatgggcg gtggcggcgg taccgcctcc gcgtctccct gagctggacc
      121 tcacggggga ctctgcgcca agctgggcga tggatgagag cagcgagctg ggcgttctgg
      181 agaccatgga gaccctcacg gagctgggcg atgagctgac tctcggggac atcgacgaga
      241 tgctacagtt tgtcagcaat caagtgggag agttccctga tttgttttca gagcaacttt
      301 gtagctcctt ccctggaggt ggcagcaatg gtggcagtgg caacaacagc agtggcagag
      361 gcaacaatgg tggagccaca gaccctgcag tacagcggtc attcagccag gtcccattat
      421 ctaccttctc tccctcagct gcctcccctc aggctccggc cctgcaggtc aaagtctctc
      481 ctaccccacc aagggcaacc cctgttctcc agccgcgacc ccagccccag ccccaacctc
      541 cagctcagct gcagcagcag acggtgatga tcaccccgac gttcagcacc gctccgcaga
      601 cgaggatcat ccagcagcct ttgatatacc agaacgcagc gaccagcttt caagtcctgc
      661 agcctcaagt gcaaagcctc gtgacgtccc cgcaggtgca gcccgtcacc atccagcagc
      721 aggtgcagac ggtacaggcc cagcgggtgt tgacgcagac agccaatggc acactgcaga
      781 cccttgcccc cgccacggta cagacggtcg ctgcgccaca ggtgcagcag gtcccggtcc
      841 tggtgcaacc tcagatcatt aagacagatt cccttgtgtt gaccacgctg aagacagatg
      901 gcagccctgt catggctgca gtccagaacc cggccctcac ggccctcact gcccccatcc
      961 agacagccgc ccttcaagtg ccaaccctgg tgggcagcaa cgggaccatt ctgaccacaa
     1021 tgcctgtgat gatggggcaa gagaaagttc ctatcaagca agtgcctggc ggcgtgaagc
     1081 agctggatcc tcccaaagaa ggagagaggc ggacaacaca caatatcatt gaaaagcgct
     1141 accggtcctc catcaacgac aaaatcatag agttgaagga cttagtcatg gggacagatg
     1201 ccaagatgca caagtctggc gttctgagga aggccattga ttacatcaaa tatctgcagc
     1261 aggtcaatca caagctgcgc caggagaaca tggtgctgaa gctggccaat cagaaaaaca
     1321 agctcctgaa gggcatcgac ctgggcagtc tggtggacag tgatgtggac ttgaaaattg
     1381 atgactttaa ccagaatgtc cttctgatgt ctccgccggc ctccgactcc gggtcccagg
     1441 ccggcttctc tccctattcc attgactctg agccgggcag ccctctgctg gatgacgcaa
     1501 aggtcaagga tgaaccggac tctcctcctg tggcactggg catggtggac cgctctcgaa
     1561 tcctcttatg tgtcctcacc ttcctgggcc tctcctttaa ccccttgact tccttgctgc
     1621 agtggggagg ggcccacaac actgaccagc acccatactc aggctcgggc cgcagtgtac
     1681 tgtcactgga gtcaggtgct gggggctggt ttgactggat ggttccaact ctcctcctgt
     1741 ggctggtaaa tggtgtgatt gtcttgagcg tctttgtgaa gctgttggtc cacggggagc
     1801 cggtgattcg cccacactca cgcccctcag tcaccttctg gagacaccgg aagcaggcag
     1861 acctagacct cgccaaaggt gatttcgcag ctgctgctgc caacctacaa acctgcttat
     1921 ccgtgctggg ccgggcgctg cccacctccc gcctggactt ggcctgcagc ctctcctgga
     1981 atgtgatccg ctacagcctg cagaagctgc gcctggtacg ctggttactc aagaaggtct
     2041 tccagcgctg gcgggctact cccgccactg cagctggctt tgaggatgag gctaagagca
     2101 gcgcaaggga tgcggcactg gcctaccaca ggctgcacca gctgcacatc acagggaagc
     2161 ttccggcggg atctgcctgt tcagatgtgc acatggctct gtgtgctgtg aacctggccg
     2221 agtgtgcgga ggagaaaatc ctaccaagca cactgattga gatccacctg acagcggcca
     2281 tggggctcaa gacccgctgt ggaggcaagc tgggcttctt ggctagctac ttcttaaatc
     2341 gtgcccagag tctgtgtggc ccagagcata gcactgtccc cgactccctg cgctggctat
     2401 gccatccctt gggccagaag tttttcatgg agcgaagctg gtcgatcaag tcagcagcca
     2461 aggagagcct gtactgcgcc cagaggagcc cagctgaccc cattgcccag gtacaccagg
     2521 cgttctgcaa aaacctgcta gaaagagcgg tggagtcctt ggtgaaacct caggccaaga
     2581 agaaggcagg cgaccaggaa gaagagagct gtgaattttc cagtgctcta gagtatttga
     2641 aattacttca ttcttttgtg gactctgtgg gatttgtgac ctcaccattc tccagcagtt
     2701 ccgtgctcag gtcggccctt ggccccgatg tcatctgccg gtggtggacg tccgcagtca
     2761 ccatggccat cagctggctc cagggagacg atgcagctgt gcgctctcgt tttactgaag
     2821 tagagcgggt ccccaaggcc ctggaagtga ccgagagtcc cttggtgaag gccgtcttct
     2881 atacctgtag agccatgcat gcctccctct ctgggaaagc tgacgggcag cagaactcct
     2941 tctgtcactg tgagagggcc agtggtcacc tgtggagcag tctcaacgtc agcggcacta
     3001 cttctgatcc ttcacttaac catgtgatcc agctgttcac ctgtgacctg ctactgtcgc
     3061 tgaggacagc actctggcaa aagcaggcca gtgccagcca gctcctgggt gagacctacc
     3121 atgcatccgg cactgagctg gccggcttcc agcgggacct gggcagcctt cgaaggctgg
     3181 cccatagctt ccgcccagcc taccgcaagg tgttcctgca tgaagccact gtgcgcctga
     3241 tggcaggagc cagccctacc cgtacacacc agctgctgga gcatagccta cggcggcgcc
     3301 ccactcagaa caccaagcat ggagaggtag acacctggcc tggccaacga gagcgagcta
     3361 ctgccatcct gctggcctgc cgccatcttc ccctctcttt cctgtcttcc ccgggccagc
     3421 gggcagtgct gctggctgaa gctgcccgca ccctggagaa ggtgggtgac cgccgttcct
     3481 gcagtgactg ccagcagatg attgtcaagc tgggcggtgg cactgccatc gctgcctcct
     3541 gaccaccgtc tggggcctgg tccacttctt tccacctttt tgtctctttc tcccaggatc
     3601 ttccctctgt ctcccagact gtctcccatc tgtttctctc cctcctccca gagctgtgag
     3661 gatgaaggca agactgattg ttctgagctg ttacctgcca aggcttttgg atcatttcgg
     3721 gccagtagga ccatgggcag agctccttaa cactgctgtg gtaaatccac ggtccaagcc
     3781 caggcgggct gagaagagag atggcctgag caggaacgga gctctcctca gttggaagca
     3841 atgtggggcg ctgcgagccc ctcccagtcc tctagagact gtctcctttc tgcctctggt
     3901 tctctttgtt gttgttacgt ttcattccag tttttgtttt taatcaggct ttctctggga
     3961 actaggtctt tgcaccagag agcattttgc attctggact tgatagacgc accccttttt
     4021 atacagatgt ttttatatgt gtgtgctcag gcctgccgag atgcagggca aagttgctgt
     4081 ggcatctttg ttcctctccc tgggtctgca ctccctcccc tgtgcctgac taagccttgt
     4141 tcattgttct ttcatcctta caagggacag ccagccaagg aggaaaggag cccagccctg
     4201 gggaggtggg tgggagggag gcaggggcag gtctagggat gggtgaaaaa taatgtcggc
     4261 attgtttttt aattttttaa aaaataaatg gtatcttatt taattgtcct gttccttccc
     4321 actccttccc cccctccccc agacggccgc ctgagctcag ggtgggccca tggggctgga
     4381 caggatgagg tcaccattgg gcctgagggc caggggtctc cagcatgact tgtttgctct
     4441 ccctccccca ccctcactcc tacctcccat agaagtgtat tcttatccct agttcctgtc
     4501 tgagtaagcc agggtggcag acgctggtcc caaacctcac ccagcaacca gcctctcatt
     4561 ttcagggcag gcagcagaga cccgggtctc ttgccttgag atggggggag tcctaggaag
     4621 aagagtggtc tggtcctgtt tctgcagact gcttggctca gggcttcctg agagacttga
     4681 gaggaactgt ccctcctccc tcatgcttct cctcatccct tcaagctggt tgaagagagt
     4741 aggcaggggc ggggccccga ggtgcttcaa ccccacctac tctgccttcc acctctcccc
     4801 aaccatcact gtaatttatg gcccccgccg tggggcagcc tagcccttgt gtctgtgtat
     4861 atactgtgcc ttttctcctt gtcgaggggt gggaggggtt ggtttttcac tgaacagggg
     4921 atatgcctat gtcttcatca gtgttgaaac attcaccatg tgctggacgt aggttttcaa
     4981 taaacacaga ttggtaccac ctaa
//
