LOCUS       NM_011480               4347 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus sterol regulatory element binding transcription factor
            1 (Srebf1), transcript variant 1, mRNA.
ACCESSION   NM_011480 NM_172559
VERSION     NM_011480.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4347)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 4347)
  AUTHORS   Jin,Q., Qi,D., Zhang,M., Qu,H., Dong,Y., Sun,M. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer growth and metastasis through
            SREBP1-mediated RAS palmitoylation
  JOURNAL   Cell Mol Biol Lett 29 (1), 112 (2024)
   PUBMED   39169280
  REMARK    GeneRIF: CLDN6 inhibits breast cancer growth and metastasis through
            SREBP1-mediated RAS palmitoylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4347)
  AUTHORS   Diercks,A.H., Podolskaia,I.S., Murray,T.A., Jahn,A.N., Mai,D.,
            Liu,D., Amon,L.M., Nakagawa,Y., Shimano,H., Aderem,A. and Gold,E.S.
  TITLE     Oxysterol binding protein regulates the resolution of TLR-induced
            cytokine production in macrophages
  JOURNAL   Proc Natl Acad Sci U S A 121 (33), e2406492121 (2024)
   PUBMED   39361877
REFERENCE   4  (bases 1 to 4347)
  AUTHORS   Lee,E.H., Lee,J.H., Kim,D.Y., Lee,Y.S., Jo,Y., Dao,T., Kim,K.E.,
            Song,D.K., Seo,J.H., Seo,Y.K., Seong,J.K., Moon,C., Han,E.,
            Kim,M.K., Ryu,S., Shin,M., Roh,G.S., Jung,H.R., Osborne,T.F.,
            Ryu,D., Jeon,T.I. and Im,S.S.
  TITLE     Loss of SREBP-1c ameliorates iron-induced liver fibrosis by
            decreasing lipocalin-2
  JOURNAL   Exp Mol Med 56 (4), 1001-1012 (2024)
   PUBMED   38622198
  REMARK    GeneRIF: Loss of SREBP-1c ameliorates iron-induced liver fibrosis
            by decreasing lipocalin-2.
REFERENCE   5  (bases 1 to 4347)
  AUTHORS   Rong,S., Xia,M., Vale,G., Wang,S., Kim,C.W., Li,S., McDonald,J.G.,
            Radhakrishnan,A. and Horton,J.D.
  TITLE     DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic
            steatosis by increasing phosphatidylethanolamine in the ER
  JOURNAL   Cell Metab 36 (3), 617-629 (2024)
   PUBMED   38340721
  REMARK    GeneRIF: DGAT2 inhibition blocks SREBP-1 cleavage and improves
            hepatic steatosis by increasing phosphatidylethanolamine in the ER.
REFERENCE   6  (bases 1 to 4347)
  AUTHORS   Shimano,H., Shimomura,I., Hammer,R.E., Herz,J., Goldstein,J.L.,
            Brown,M.S. and Horton,J.D.
  TITLE     Elevated levels of SREBP-2 and cholesterol synthesis in livers of
            mice homozygous for a targeted disruption of the SREBP-1 gene
  JOURNAL   J Clin Invest 100 (8), 2115-2124 (1997)
   PUBMED   9329978
REFERENCE   7  (bases 1 to 4347)
  AUTHORS   Shimano,H., Horton,J.D., Shimomura,I., Hammer,R.E., Brown,M.S. and
            Goldstein,J.L.
  TITLE     Isoform 1c of sterol regulatory element binding protein is less
            active than isoform 1a in livers of transgenic mice and in cultured
            cells
  JOURNAL   J Clin Invest 99 (5), 846-854 (1997)
   PUBMED   9062341
REFERENCE   8  (bases 1 to 4347)
  AUTHORS   Shimomura,I., Shimano,H., Horton,J.D., Goldstein,J.L. and
            Brown,M.S.
  TITLE     Differential expression of exons 1a and 1c in mRNAs for sterol
            regulatory element binding protein-1 in human and mouse organs and
            cultured cells
  JOURNAL   J Clin Invest 99 (5), 838-845 (1997)
   PUBMED   9062340
REFERENCE   9  (bases 1 to 4347)
  AUTHORS   Rooke,K., Briquet-Laugier,V., Xia,Y.R., Lusis,A.J. and
            Doolittle,M.H.
  TITLE     Mapping of the gene for calreticulin (Calr) to mouse chromosome 8
  JOURNAL   Mamm Genome 8 (11), 870-871 (1997)
   PUBMED   9337407
REFERENCE   10 (bases 1 to 4347)
  AUTHORS   Shimano,H., Horton,J.D., Hammer,R.E., Shimomura,I., Brown,M.S. and
            Goldstein,J.L.
  TITLE     Overproduction of cholesterol and fatty acids causes massive liver
            enlargement in transgenic mice expressing truncated SREBP-1a
  JOURNAL   J Clin Invest 98 (7), 1575-1584 (1996)
   PUBMED   8833906
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY288773.1, BC056922.1 and
            AL669954.6.
            
            On or before Nov 23, 2017 this sequence version replaced
            NM_172559.1, NM_011480.3.
            
            Summary: This gene encodes a transcription factor that binds to the
            sterol regulatory element-1 (SRE1), which is a decamer flanking the
            low density lipoprotein receptor gene and some genes involved in
            sterol biosynthesis. The protein is synthesized as a precursor that
            is attached to the nuclear membrane and endoplasmic reticulum.
            Following cleavage, the mature protein translocates to the nucleus
            and activates transcription by binding to the SRE1. Sterols inhibit
            the cleavage of the precursor, and the mature nuclear form is
            rapidly catabolized, thereby reducing transcription. The protein is
            a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip)
            transcription factor family. Alternatively spliced transcript
            variants have been characterized for this gene. [provided by
            RefSeq, Nov 2017].
            
            Transcript Variant: This variant (1, also known as SREBP-1a)
            represents the longest transcript and encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056922.1, AK052628.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY288773.1         2-42
            42-780              BC056922.1         1-739
            781-781             AL669954.6         45092-45092         c
            782-4347            BC056922.1         741-4306
FEATURES             Location/Qualifiers
     source          1..4347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..4347
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /note="sterol regulatory element binding transcription
                     factor 1"
                     /db_xref="GeneID:20787"
                     /db_xref="MGI:MGI:107606"
     exon            1..175
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..3489
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; sterol regulatory element-binding protein 1;
                     adipocyte determination- and differentiation-dependent
                     factor 1"
                     /codon_start=1
                     /product="sterol regulatory element-binding protein 1
                     isoform a precursor"
                     /protein_id="NP_035610.1"
                     /db_xref="CCDS:CCDS24785.1"
                     /db_xref="GeneID:20787"
                     /db_xref="MGI:MGI:107606"
                     /translation="MDELAFGEAALEQTLAEMCELDTAVLNDIEDMLQLINNQDSDFP
                     GLFDAPYAGGETGDTGPSSPGANSPESFSSASLASSLEAFLGGPKVTPAPLSPPPSAP
                     AALKMYPSVSPFSPGPGIKEEPVPLTILQPAAPQPSPGTLLPPSFPAPPVQLSPAPVL
                     GYSSLPSGFSGTLPGNTQQPPSSLPLAPAPGVLPTPALHTQVQSLASQQPLPASAAPR
                     TNTVTSQVQQVPVVLQPHFIKADSLLLTAVKTDAGATVKTAGISTLAPGTAVQAGPLQ
                     TLVSGGTILATVPLVVDTDKLPIHRLAAGSKALGSAQSRGEKRTAHNAIEKRYRSSIN
                     DKIVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLRSAHKSKSLKD
                     LVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSFGSRASSSGGSDSEP
                     DSPAFEDSQVKAQRLPSHSRGMLDRSRLALCVLAFLCLTCNPLASLFGWGILTPSDAT
                     GTHRSSGRSMLEAESRDGSNWTQWLLPPLVWLANGLLVLACLALLFVYGEPVTRPHSG
                     PAVHFWRHRKQADLDLARGDFPQAAQQLWLALQALGRPLPTSNLDLACSLLWNLIRHL
                     LQRLWVGRWLAGQAGGLLRDRGLRKDARASARDAAVVYHKLHQLHAMGKYTGGHLAAS
                     NLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALHFLTRFFLSSARQACLA
                     QSGSVPLAMQWLCHPVGHRFFVDGDWAVHGAPPESLYSVAGNPVDPLAQVTRLFREHL
                     LERALNCIAQPSPGAADGDREFSDALGYLQLLNSCSDAAGAPACSFSVSSSMAATTGP
                     DPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQDTERPLPRAALYSFKAAR
                     ALLDHRKVESSPASLAICEKASGYLRDSLASTPTGSSIDKAMQLLLCDLLLVARTSLW
                     QRQQSPASVQVAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAMRRVFLHEATAR
                     LMAGASPARTHQLLDRSLRRRAGSSGKGGTTAELEPRPTWREHTEALLLASCYLPPAF
                     LSAPGQRMSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS"
     exon            176..595
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..774
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..912
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1134
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1246
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1461
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1657
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1836
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2098
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2265
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2434
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2537
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2647
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2780
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2946
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3147
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3259
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3260..4327
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3798..3803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /note="hexamer: AATGAA"
     polyA_site      3814
                     /gene="Srebf1"
                     /gene_synonym="ADD1; bHLHd1; SREBP1"
                     /note="major polyA site"
ORIGIN      
        1 aggtggctcc gcccgcggaa cccagtttcc ggggaacttt tccttaacgt gggcctagtc
       61 cgaagccggg tgggcgccgg cgccatggac gagctggcct tcggtgaggc ggctctggaa
      121 cagacactgg ccgagatgtg cgaactggac acagcggttt tgaacgacat cgaagacatg
      181 ctccagctca tcaacaacca agacagtgac ttcccgggcc tgtttgacgc cccctatgct
      241 gggggtgaga caggggacac aggccccagc agcccaggtg ccaactctcc tgagagcttc
      301 tcttctgctt ctctggcctc ctctctggaa gccttcctgg gaggacccaa ggtgacacct
      361 gcacccttgt cccctccacc atcggcaccc gctgctttaa agatgtaccc gtccgtgtcc
      421 cccttttccc ctgggcctgg gatcaaagag gagccagtgc cactcaccat cctacagcct
      481 gcagcgccac agccgtcacc ggggaccctc ctgcctccga gcttccccgc accacccgta
      541 cagctcagcc ctgcgcccgt gctgggttac tcgagcctgc cttcaggctt ctcagggacc
      601 cttccaggaa acactcagca gccaccatct agcctgccgc tggcccctgc accaggagtc
      661 ttgcccaccc ctgccctgca cacccaggtc caaagcttgg cctcccagca gccgctgcca
      721 gcctcagcag cccctagaac aaacactgtg acctcacagg tccagcaggt cccagttgta
      781 ctgcagccac acttcatcaa ggcagactca ctgctgctga cagctgtgaa gacagatgca
      841 ggagccaccg tgaagactgc aggcatcagc accctggctc ctggcacagc cgtgcaggca
      901 ggtcccctgc agaccctggt gagtggaggg accatcttgg ccacagtacc tttggttgtg
      961 gacacagaca aactgcccat ccaccgactc gcagctggca gcaaggccct aggctcagct
     1021 cagagccgtg gtgagaagcg cacagcccac aatgccattg agaagcgcta ccggtcttct
     1081 atcaatgaca agattgtgga gctcaaagac ctggtggtgg gcactgaagc aaagctgaat
     1141 aaatctgctg tcttgcgcaa ggccatcgac tacatccgct tcttgcagca cagcaaccag
     1201 aagctcaagc aggagaacct gaccctacga agtgcacaca aaagcaaatc actgaaggac
     1261 ctggtgtcag cttgtggcag tggaggaggc acagatgtgt ctatggaggg catgaaaccc
     1321 gaagtggtgg agacgcttac ccctccaccc tcagacgccg gctcaccctc ccagagtagc
     1381 cccttgtctt ttggcagcag agctagcagc agtggtggta gtgactctga gcccgacagt
     1441 ccagcctttg aggatagcca ggtcaaagcc cagcggctgc cttcacacag ccgaggcatg
     1501 ctggaccgct cccgcctggc cctgtgtgta ctggcctttc tgtgtctgac ctgcaatcct
     1561 ttggcctcgc ttttcggctg gggcattctc actccctctg atgctacggg tacacaccgt
     1621 agttctgggc gcagcatgct ggaggcagag agcagagatg gctctaattg gacccagtgg
     1681 ttgctgccac ccctagtctg gctggccaat ggactactag tgttggcctg cttggctctt
     1741 ctctttgtct atggggaacc tgtgactagg ccacactctg gcccggctgt acacttctgg
     1801 agacatcgca aacaagctga cctggatttg gcccggggag atttccccca ggctgctcaa
     1861 cagctgtggc tggccctgca agcgctgggc cggcccctgc ccacctcaaa cctggatctg
     1921 gcctgcagtc tgctttggaa cctcatccgc cacctgctcc agcgtctctg ggtgggccgc
     1981 tggctggcag gccaggccgg gggcctgctg agggaccgtg ggctgaggaa ggatgcccgt
     2041 gccagtgccc gggatgcggc tgttgtctac cataagctgc accagctgca tgccatgggc
     2101 aagtacacag gaggacatct tgctgcttct aacctggcac taagtgccct caacctggct
     2161 gagtgcgcag gagatgctat ctccatggca acactggcag agatctatgt ggcagcggcc
     2221 ctgagggtca aaaccagcct cccaagagcc ctgcacttct tgacacgttt cttcctgagc
     2281 agcgcccgcc aggcctgcct agcacagagc ggctcggtgc ctcttgccat gcagtggctc
     2341 tgccaccctg taggtcaccg tttctttgtg gacggggact gggccgtgca cggtgccccc
     2401 ccggagagcc tgtacagcgt ggctgggaac ccagtggatc cgctggccca ggtgacccgg
     2461 ctattccgtg aacatctcct agagcgagcg ttgaactgta ttgctcagcc cagcccaggg
     2521 gcagctgacg gagacaggga gttctcagat gcccttggat atctgcagtt gctaaatagc
     2581 tgttctgatg ctgccggggc tcctgcttgc agtttctctg tcagctccag catggctgcc
     2641 accactggcc cagacccagt ggccaagtgg tgggcctcac tgacagctgt ggtgatccac
     2701 tggctgaggc gggatgaaga ggcagctgag cgcttgtacc cactggtaga gcatatcccc
     2761 caggtgctgc aggacactga gagacccctg cccagggcag ctctgtactc cttcaaggct
     2821 gcccgggctc tgctggacca cagaaaggtg gaatctagcc cagccagcct ggccatctgt
     2881 gagaaggcca gtgggtacct gcgggacagc ttagcctcta caccaactgg cagttccatt
     2941 gacaaggcca tgcagctgct cctgtgtgat ctacttcttg tggcccgtac cagtctgtgg
     3001 cagcggcagc agtcaccagc ttcagtccag gtagctcacg gtaccagcaa tggaccccag
     3061 gcctctgctc tggagctgcg tggtttccaa catgacctga gcagcctgcg gcggttggca
     3121 cagagcttcc ggcctgctat gaggagggta ttcctacatg aggccacagc tcggctgatg
     3181 gcaggagcaa gtcctgcccg gacacaccag ctcctggatc gcagtctgag gaggagggca
     3241 ggttccagtg gcaaaggagg cactacagct gagctggagc cacggcccac atggcgggag
     3301 cacaccgagg ccctgctgtt ggcatcctgc tatctgcccc ctgccttcct gtcggctcct
     3361 gggcagcgaa tgagcatgct ggccgaggcg gcacgcaccg tagagaagct tggcgatcac
     3421 cggctactgc tggactgcca gcagatgctc ctgcgcctgg gcggcggaac caccgtcact
     3481 tccagctaga ccccaaagct ttcccttgag gacctttgtc attggctgtg gtcttccaga
     3541 gggtgagcct gacaagcaat caggaccatg ccgacctcta gtggcagatc tggaaattgc
     3601 agaggctgca ctggcccgat ggcaccctct tgctctgtag gcaccttagt ggcttttccc
     3661 tagctgaggc tcaccctggg agacctgtac atagtgtaga tccggctggg cctggctcca
     3721 gggcaggccc atgtactact ttgacttttg caaactttat tttcataggt tgagaaattt
     3781 tgtacagaat attaaaaaat gaaattattt ataacttcag ttttgtttat ctgggtaggc
     3841 agatgtctgc ctcagctgat tgctatcttt cctggcttgt cctttgggaa gccggacttc
     3901 ccatctgttg taaggtgtat ttgctggctt ggtgatgcta tgttgagcca ccttggccct
     3961 ctgatctcat ggctcataac ccttgagggg ccttgatggt ctcagttgtt cctttgcctt
     4021 ccagccctcc accaggtaat aaccccgtat atccagaaac acacacagtt ccctagtcat
     4081 ctctgtgcac cagcataggc gaaggatcag ggcccattag tgagtagact gggaaccctg
     4141 tttgtgtccc ccggcccctt ccctctactc ccaacccctt agggaatctg gtcggcatcc
     4201 acaggccgca cacttccaaa acaatcgtgg tatctttatt gacttttttt tttctgaatg
     4261 caatgactgt tttttttttt tttaactctt aaggaaaata aacatctttt agaaacagct
     4321 cgatacaaaa aaaaaaaaaa aaaaaaa
//
