LOCUS       NM_053188               3613 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus steroid 5 alpha-reductase 2 (Srd5a2), mRNA.
ACCESSION   NM_053188
VERSION     NM_053188.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3613)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 3613)
  AUTHORS   Amato,C.M., Xu,X. and Yao,H.H.
  TITLE     An extragenital cell population contributes to urethra closure
            during mouse penis development
  JOURNAL   Sci Adv 10 (49), eadp0673 (2024)
   PUBMED   39642224
REFERENCE   3  (bases 1 to 3613)
  AUTHORS   Sharkey,C., Long,X., Al-Faouri,R., Strand,D., Olumi,A.F. and
            Wang,Z.
  TITLE     Enhanced prostatic Esr1+ luminal epithelial cells in the absence of
            SRD5A2
  JOURNAL   J Pathol 263 (3), 300-314 (2024)
   PUBMED   38606616
  REMARK    GeneRIF: Enhanced prostatic Esr1[+] luminal epithelial cells in the
            absence of SRD5A2.
REFERENCE   4  (bases 1 to 3613)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3613)
  AUTHORS   Ueda,Y., Suzuki,K., Kajimoto,M., Fujimoto,K., Mahendroo,M., Ema,M.,
            Yamada,G. and Hara,I.
  TITLE     Possible testosterone redundancy for 5alpha-dihydrotestosterone in
            the masculinization of mouse external genitalia
  JOURNAL   Exp Anim 71 (4), 451-459 (2022)
   PUBMED   35613877
REFERENCE   6  (bases 1 to 3613)
  AUTHORS   Seo,Y.K., Zhu,B., Jeon,T.I. and Osborne,T.F.
  TITLE     Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol
            regulatory element binding proteins and statin
  JOURNAL   Exp Cell Res 315 (18), 3133-3139 (2009)
   PUBMED   19500568
  REMARK    GeneRIF: The induction of Srd5a2 through SREBP-2 provides a
            mechanistic explanation for why even though statin therapy is
            effective in reducing cholesterol levels in treating
            hypercholesterolemia it does not compromise androgen production in
            clinical studies.
REFERENCE   7  (bases 1 to 3613)
  AUTHORS   Luu-The,V., Pelletier,G. and Labrie,F.
  TITLE     Quantitative appreciation of steroidogenic gene expression in mouse
            tissues: new roles for type 2 5alpha-reductase,
            20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase
  JOURNAL   J Steroid Biochem Mol Biol 93 (2-5), 269-276 (2005)
   PUBMED   15860270
  REMARK    GeneRIF: observed an abnormally high expression levels of type 2
            5alpha-reductase and 20alpha-HSD in the male and female adrenals,
            respectively, thus indirectly suggesting new roles for these
            sex-specific enzymes
REFERENCE   8  (bases 1 to 3613)
  AUTHORS   Mahendroo,M., Wilson,J.D., Richardson,J.A. and Auchus,R.J.
  TITLE     Steroid 5alpha-reductase 1 promotes
            5alpha-androstane-3alpha,17beta-diol synthesis in immature mouse
            testes by two pathways
  JOURNAL   Mol Cell Endocrinol 222 (1-2), 113-120 (2004)
   PUBMED   15249131
REFERENCE   9  (bases 1 to 3613)
  AUTHORS   Matsui,D., Sakari,M., Sato,T., Murayama,A., Takada,I., Kim,M.,
            Takeyama,K. and Kato,S.
  TITLE     Transcriptional regulation of the mouse steroid 5alpha-reductase
            type II gene by progesterone in brain
  JOURNAL   Nucleic Acids Res 30 (6), 1387-1393 (2002)
   PUBMED   11884637
  REMARK    GeneRIF: molecular cloning & transcriptional activation of the gene
REFERENCE   10 (bases 1 to 3613)
  AUTHORS   Mahendroo,M.S., Cala,K.M., Hess,D.L. and Russell,D.W.
  TITLE     Unexpected virilization in male mice lacking steroid 5
            alpha-reductase enzymes
  JOURNAL   Endocrinology 142 (11), 4652-4662 (2001)
   PUBMED   11606430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025731.18.
            
            On Jun 24, 2019 this sequence version replaced NM_053188.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125510.1, AK138946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               CT025731.18        165273-165586       c
            315-478             CT025731.18        144704-144867       c
            479-580             CT025731.18        142180-142281       c
            581-731             CT025731.18        139110-139260       c
            732-3613            CT025731.18        132617-135498       c
FEATURES             Location/Qualifiers
     source          1..3613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 45.39 cM"
     gene            1..3613
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /note="steroid 5 alpha-reductase 2"
                     /db_xref="GeneID:94224"
                     /db_xref="MGI:MGI:2150380"
     exon            1..314
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..798
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /EC_number="1.3.1.22"
                     /note="steroid 5 alpha reductase type2; SR type 2; 5
                     alpha-SR2"
                     /codon_start=1
                     /product="3-oxo-5-alpha-steroid 4-dehydrogenase 2"
                     /protein_id="NP_444418.1"
                     /db_xref="CCDS:CCDS28968.1"
                     /db_xref="GeneID:94224"
                     /db_xref="MGI:MGI:2150380"
                     /translation="MPIVCHQVPVLAGSATLATMGTLILCFGKPASYGKHSESVSSGV
                     PLLPARIAWFLQELPSFVVSVGMLAWQPRSLFGPPGNVLLGLFSAHYFHRTFIYSLLT
                     RGRPLSAVIFLKATAFCIGNGLLQAYYLVYCAEYPEEWYTDMRFSVGVFFFILGMGIN
                     IHSDCMLRQLRKPGEVIYRIPQGGLFTYVSGANFLGEIIEWMGYALATWSVPAFAFAF
                     FTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF"
     exon            315..478
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..580
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..731
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..3613
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1516..1521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /note="hexamer: AATAAA"
     polyA_site      1551
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /note="major polyA site"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /note="hexamer: AATAAA"
     polyA_site      3613
                     /gene="Srd5a2"
                     /gene_synonym="5ART2; S5AR 2"
                     /note="major polyA site"
ORIGIN      
        1 gggcagcagc taccagctgt gaacacaggc gagatgccga ttgtgtgcca tcaggtcccg
       61 gtgctggcag gtagcgccac attggccacc atggggaccc tgatcctgtg ctttgggaaa
      121 cccgccagtt acgggaaaca cagcgagagt gtgtcgtcgg gagttcccct cctgcccgca
      181 cgcatagcct ggttcctgca ggagctgcct tcctttgtgg tgtcggtagg gatgctcgct
      241 tggcagccgc gctccctctt tggacctccg gggaatgtgc tgctgggtct cttctccgca
      301 cattacttcc acaggacatt tatttactca ttgctcacca gaggcaggcc tttatcagcg
      361 gtgatctttc tgaaagccac tgccttctgc atagggaacg gactcctgca agcctattac
      421 ctggtttatt gcgcggaata ccctgaggag tggtacacag acatgcggtt tagcgtcggt
      481 gtcttcttct ttattctggg gatggggatc aacatccaca gtgactgcat gctgcgccag
      541 ctcaggaagc ccggagaggt catctacagg atcccacaag gtggcttgtt tacgtatgtg
      601 tctggagcca atttcctggg cgagattatt gaatggatgg gctacgcttt ggccacttgg
      661 tctgttccag cctttgcttt tgcatttttc acactttgtt tcctggggat gcaagctttt
      721 taccaccaca ggttctacct caagatgttt aaggattacc ccaaatctag gaaagccctc
      781 attccattca tcttttaaag aaccctaact ttaaggaaca aagcttctat ggagaaactg
      841 cccagctgct gaaactataa actgtaaact ataactgaac agtgtcttgc tcgcatatat
      901 atatttgatg atgtatgtgt taataggtct cctgtgattc cagttgcttg aggcatgcac
      961 agtcatgcct gttcagccta tactcctgtc tgcccagaga gctctaacct aatttccttt
     1021 cggagactca taggggccat tttattctta gctatcccat ctagaagctt ccctgttctc
     1081 tatttttttt tccaatgtca gatctgaaga taggactttt ttcttattct ttgtcacttt
     1141 gggggaagtt ctgcagtcaa aacctttggg ctgacaaaat gaaaaatgaa atgataacat
     1201 ttgcaggaaa gtgggaagaa ctggaaatta ttatattaag caacctaacc ctgactcaga
     1261 aagacaaata ctgcatgatt tttttcatat gcaggttcta gattttaata tatacatata
     1321 tatacctgca tctgttcata tgtgtatgtt gagggtcata tagttcattg atttagaaag
     1381 gagatcatta gaaggggaaa agaggtcttg aggagaagga agaagaggga aataaactgt
     1441 gtcgcatgaa agcagagagg gaggaaggga agcagcagga gaaatgtagg tgagcagggg
     1501 aggaggattg gcaaaaataa agtatgcatg aaaatgccat aataaaacca attactttgt
     1561 atgtttgttt taaacaacca accagcctgc cagccaacca acttatcaac taactaacta
     1621 atcaatcaac aagccaacca accaactaat caaccagcca gccaaccaac tcatcaacta
     1681 actaatcaat caacaagcca accaaccaac caatcaatca accaactaat caaccagcca
     1741 accaaccaac caaccaacca accaaaaatg aatgtctggg ctgagggcag tgcttaaaga
     1801 agtaattaaa agcatacctt ttgtatgccc gcagagtggc aaagatttac aagtttaagc
     1861 accatagacc ccagagcatg cttaaatgaa agactggtcc cagcttcctc tgcattagtt
     1921 aattaggaat atatatatat acatatatat atacatacat atatatatat atatatatat
     1981 atatatatat atatatatat ataagcttta ataatggagt tccccttttg gacctaagtc
     2041 caaatgtaca gcgtctcagc cagtgatcat cgggtattct aggaggtttc atagtgatca
     2101 ccgggtattc taggagctac cataacttca ttcacaacac tgctatggat tttcttgatt
     2161 gtcaggtttt atggaacaca aagaaaaaga tacagccatg agtggcccct gagagaataa
     2221 agaattgtgt tgcaacagac agtgtgaaca cctatcagaa acacttctaa gtatgagaag
     2281 ttcatgtgta aggcactaga ccgttcaagt tgaagagctg tttgcgatga tgtgaagggt
     2341 aacagaagct ctgagcaagt ttcttctgga atttcttcct tatgatcctt gagacatatt
     2401 ttagaagatg tgtcccagtg gtaggttgaa catcagctct cagtcccaat ggcagatgca
     2461 agatctgcat gatctgtcca gatagatgct cgtctgggta gaaaacccct ttcatccagt
     2521 tcagacaggt ttcacattta gttttatttt actttatctt acacttcaag tttcaaattg
     2581 taaaaattag gaggtttcta cataaaccga agccctggtg ttcttttaaa atggttactc
     2641 tccatctttc taacagggag ctcctcaggt tgtggtgatt ccaaccataa aattaccttt
     2701 gctgctactt cagaactgta atgttgctac tattatgaat cataaagtaa atatctgtgt
     2761 tttccaatgg ccttaggtag ccccttggga aaatgtcata tgccacccaa aggggtcatg
     2821 acccacaggt tgagaaccca ggcttttaaa agttggaagg agaggcataa gagacagaag
     2881 ataatgggag ggtgaatata atcaaagtat tatacccaaa tcagaaggtt tagtgagatg
     2941 atgaatgtat gtcactggtt ctccaccttc ctaatgctgt gaccctttaa tccagttcct
     3001 catattctgg tgaccccccc ccccccaaac cataaaagca ttttgttgtt acttcatggc
     3061 tgtaatttgg ctattgttaa aaattgtaat gtaaatacct tatctgcagg aaatatgata
     3121 tctgaccacc aaaagggtcg agagccccag gctgagaact gctggtatat gctgacctca
     3181 gcattctaag cctggttcct gtgtgagcga gcctgaggac tgggtagtac atgaacactt
     3241 aggtgtacag cctccgggga agggatggct tccgcaaaga ggctgcaatg cgggttctgt
     3301 gagggaggga ctgagcactc ggaatcagag tggttgaata cttatctcct ctgccccagg
     3361 tgggtgggtg ggttcaacac catttgcaaa catgcttgag aaaccgatct ccagttttat
     3421 tatttggtcc ataaaccgac tgttagttga cacaggggtc ataagaggtc taaagtagga
     3481 tacataatga agacccagac tattgtgtta caagcaagtg ctcctccttg tttgccaaat
     3541 gcctctcgag tcatgaccac caccattgct tgaataaaaa acgacccaga tcttctgtgg
     3601 catttacaat gta
//
