LOCUS       NM_018873               6965 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus SRC kinase signaling inhibitor 1 (Srcin1), mRNA.
ACCESSION   NM_018873 XM_915922
VERSION     NM_018873.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6965)
  AUTHORS   Wang,Y., Su,Q., Tang,H., Lin,X., Yi,Y., Tian,Q., Luo,Z., Fu,M.,
            Peng,J. and Zhang,K.
  TITLE     Circ-USP9X accelerates deep vein thrombosis after fracture by
            acting as a miR-148b-3p sponge and upregulates SRC kinase signaling
            inhibitor 1
  JOURNAL   Clinics (Sao Paulo) 79, 100403 (2024)
   PUBMED   38878321
  REMARK    GeneRIF: Circ-USP9X accelerates deep vein thrombosis after fracture
            by acting as a miR-148b-3p sponge and upregulates SRC kinase
            signaling inhibitor 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6965)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6965)
  AUTHORS   Cui,Q., Liang,S., Li,H., Guo,Y., Lv,J., Wang,X., Qin,P., Xu,H.,
            Huang,T.Y., Lu,Y., Tian,Q. and Zhang,T.
  TITLE     SNX17 Mediates Dendritic Spine Maturation via p140Cap
  JOURNAL   Mol Neurobiol 61 (3), 1346-1362 (2024)
   PUBMED   37704928
  REMARK    GeneRIF: SNX17 Mediates Dendritic Spine Maturation via p140Cap.
REFERENCE   4  (bases 1 to 6965)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6965)
  AUTHORS   Angelini,C., Morellato,A., Alfieri,A., Pavinato,L., Cravero,T.,
            Bianciotto,O.T., Salemme,V., Natalini,D., Centonze,G., Raspanti,A.,
            Garofalo,T., Valdembri,D., Serini,G., Marcantoni,A., Becchetti,A.,
            Giustetto,M., Turco,E. and Defilippi,P.
  TITLE     p140Cap Regulates the Composition and Localization of the NMDAR
            Complex in Synaptic Lipid Rafts
  JOURNAL   J Neurosci 42 (38), 7183-7200 (2022)
   PUBMED   35953295
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6965)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   7  (bases 1 to 6965)
  AUTHORS   Collins,M.O., Yu,L., Coba,M.P., Husi,H., Campuzano,I.,
            Blackstock,W.P., Choudhary,J.S. and Grant,S.G.
  TITLE     Proteomic analysis of in vivo phosphorylated synaptic proteins
  JOURNAL   J Biol Chem 280 (7), 5972-5982 (2005)
   PUBMED   15572359
REFERENCE   8  (bases 1 to 6965)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 6965)
  AUTHORS   Di Stefano,P., Cabodi,S., Boeri Erba,E., Margaria,V., Bergatto,E.,
            Giuffrida,M.G., Silengo,L., Tarone,G., Turco,E. and Defilippi,P.
  TITLE     P130Cas-associated protein (p140Cap) as a new
            tyrosine-phosphorylated protein involved in cell spreading
  JOURNAL   Mol Biol Cell 15 (2), 787-800 (2004)
   PUBMED   14657239
REFERENCE   10 (bases 1 to 6965)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF040944.1, AL596088.14, CJ061326.1 and AK129422.1.
            
            On Oct 13, 2006 this sequence version replaced NM_018873.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF040944.1, U59873.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AF040944.1         6-198
            194-461             AL596088.14        224593-224860       c
            462-883             AF040944.1         467-888
            884-1073            CJ061326.1         288-477
            1074-3656           AK129422.1         231-2813
            3657-6965           AL596088.14        182256-185564       c
FEATURES             Location/Qualifiers
     source          1..6965
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.0 cM"
     gene            1..6965
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /note="SRC kinase signaling inhibitor 1"
                     /db_xref="GeneID:56013"
                     /db_xref="MGI:MGI:1933179"
     exon            1..159
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3791
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /note="p130Cas-associated protein; Snap-25-interacting
                     protein"
                     /codon_start=1
                     /product="SRC kinase signaling inhibitor 1"
                     /protein_id="NP_061361.2"
                     /db_xref="CCDS:CCDS36294.1"
                     /db_xref="GeneID:56013"
                     /db_xref="MGI:MGI:1933179"
                     /translation="MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRF
                     SNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQ
                     DRMREQVGGWTVDPVCLLSSLCSHLHGDSTPSGAGQPAQQPNYWSFKTRSSRHTQGAQ
                     PGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLF
                     LQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYE
                     LEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPA
                     SHLASSSPPPGLPSGLPSGLPSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPTG
                     QGVSPSPSAILERRDVKPDEDLAGKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGD
                     PFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAGAGGPLYGDGYGFRLPPSSP
                     QKLADVSAPSGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKARSTGSA
                     STAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRG
                     SEPETPSEKVEGSNGAATPSAPVCGSGSKSSGATPVSGPPPPSASSTPAGQPTAVSRL
                     QMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQED
                     PLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVAHNHRLVPGPELEEKAL
                     VLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTL
                     AQIRRQVDEGMWPPPNNLLNQSPKKVAAETDFSKGLDFEIPPPSPPLNLHELSGPAEG
                     TPLTPKSTNPTKGLDASSKRNTDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQ
                     AELLKAIPDLDCASKTHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYR
                     TEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSVFIKKAESEELEVQKPQVK
                     LRRAVSEVVRPASTPPIMASAIKDEDDEERIIAELESGGSSVPPMKVVTPGASRLKAA
                     QGPAGSPDKGKHGKQRTEYMRIQAQQQATKPSKEVSGPNETSSPGSEKPSGSRTSIPV
                     LTSFGARNSSISF"
     exon            160..461
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            462..560
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            561..584
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            585..780
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            781..979
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1073
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1936
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2029
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2073
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2264
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2440
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2571
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2572..2719
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2966
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3201
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3356
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3509
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3656
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..6965
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4368
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
     regulatory      4788..4793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /note="hexamer: AGTAAA"
     polyA_site      4822
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
     regulatory      6935..6940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /note="hexamer: AATAAA"
     polyA_site      6965
                     /gene="Srcin1"
                     /gene_synonym="mKIAA1684; P140; p140Cap; SNIP"
                     /note="major polyA site"
ORIGIN      
        1 ggcggggccc gcgcccccgg cccgcccgcc tggcaccgcg ccccggggct ggggccgagc
       61 gagaagcccg cgaggcggcg agagggcgag cgccaggcag gccggcccgg ggcccccgcc
      121 ccccgcgccc ccgcccgatg gggaacgctc cgtcccaaga tccggagcgg agcagccccc
      181 ccatgctgtc tgcagacgat gccgagtacc ctcgggagta ccggaccctg gggggtgggg
      241 gcggaggtgg cagcgggggc cggcgcttct ccaacgtggg gctggtgcac acctcggagc
      301 gccggcacac ggtgatcgct gcccagagcc tggaggccct cagcgggctc cagaaagcgg
      361 atgctgaccg caagcgagat gcgttcatgg accacctgaa gagcaagtac cctcagcacg
      421 ccctggccct gcgaggtcag caggacagga tgcgagaaca ggtcggcggc tggaccgtgg
      481 accctgtgtg cctcctcagc tccctctgtt cccacctcca cggcgactcc accccctcag
      541 gggctggcca gcctgcccag caaccaaact actggagttt caagacccgc agctcgcgcc
      601 atactcaggg agcccagcca gggctagcag accaggcagc caagctgtcc tacgcctcgg
      661 ctgagtcgct ggagacaatg tccgaggccg agctgcccct gggcttcagc aggatgaacc
      721 gcttccgaca gagcttgcct ctctcccgct ctgccagcca gaccaagctg cgctcaccag
      781 gggtcctgtt cctgcagttt ggagaggaga cacgacgtgt acacatcacg catgaggtca
      841 gcagcttgga cacgctgcac gcactcatcg cgcacatgtt ccctcagaag ctcaccatgg
      901 gcatgcttaa gtcgcccaac accgccatcc tcatcaagga cgaggctcgc aatgtcttct
      961 acgagctgga agacgtccgg gatatccaag accgaagtat cattaagatc tataggaagg
     1021 agccgttgta tgctgctttt cctggctcac acctcaccaa cggtgacctc cggagagaaa
     1081 tggtttacgc gtcgcgggag tcgtcgccca cgcggcgcct caacaacctg tcgcccgcat
     1141 cgcacctagc atctagctcc ccgcctccag ggctgccatc ggggctgcct tcgggactgc
     1201 catcgggctc gccttcgcgt tcacgcctct cctatgctgg gggccggccg ccctcttacg
     1261 ccggcagccc ggtgcaccac gcggctgagc gactgggagg cgccccgacc ggccagggcg
     1321 tgagccccag ccccagcgcc atcctggagc ggcgcgacgt gaagccagat gaggacctgg
     1381 cgggcaaggc tggcggcatg gtgctggtga agggcgaggg cctctatgcc gatccctacg
     1441 ggctgctgca cgagggccgt ctgagcctgg ccgccgcggc gggagaccca ttcgcatacc
     1501 cgggcgcggg cggcttgtac aagcggggtt ccgtgcgctc tctcagcacc tactccgctg
     1561 ccgcgctgca gtccgacctg gaggactcgc tgtacaaggc gggcgctggc ggcccgctct
     1621 acggagacgg ctatggcttc cgtctgccgc cctcgtcccc gcagaagctg gccgacgtct
     1681 cggcgccctc cgggggacct ccacccccgc acagccccta ctccgggcca cccagccgcg
     1741 gctcgccggt gcgccagtcc ttccgcaaag attcgggctc ctcgtcggtc tttgctgaga
     1801 gtcctggagg caaggcccgc agcaccggga gtgcctccac ggccggagca ccaccttctg
     1861 aactcttccc tggacctggg gagcgctccc ttgtagggtt cgggccgccg gtgccagcca
     1921 aagacacaga gaccagggaa cgcatggagg ctatggagaa gcagattgcc agcctcactg
     1981 gcctagtaca gagtgcccta ctgcgaggct cagagccgga gaccccaagt gagaaggttg
     2041 aaggctccaa tggagcagcc actccctcag caccagtgtg tgggtcaggc agtaagagta
     2101 gcggggccac tccggtgtcg ggccctcccc cgccctcggc cagcagcacc cctgcagggc
     2161 agcccactgc tgtcagccgt ctgcagatgc agctgcatct gcgtggccta cagaacagcg
     2221 ctagcgacct gcgtggccag cttcagcagc tgcgcaagct ccagctccag aaccaggagt
     2281 cggtgcgcgc gctgctgaag cgcaccgagg cggagctgag catgcgcgtg tcggaggcgg
     2341 cgcggcggca ggaggacccg ctgcagcggc agcgcaccct ggtggaggag gagcgtttgc
     2401 gttacctcaa cgacgaggag ctcattactc agcagctcaa tgacctcgag aagtcagtgg
     2461 agaagatcca gagagacgtg gcccataacc accggctagt gccgggtcct gagttggaag
     2521 agaaggcgct ggtgctgaag cagcttgggg agacgctgac ggagctcaag gctcatttcc
     2581 caggcctgca gagtaagatg cgggtggtgc tgcgcgtgga ggtggaggca gtgaagttcc
     2641 tgaaggagga acctcaacgc cttgacgggc tcctcaagcg ctgccggggg gtcactgaca
     2701 cgctggccca gatccgaagg caagtggatg agggtatgtg gccccccccc aacaacctcc
     2761 tgaaccagtc ccccaagaag gtggcagctg aaaccgactt cagcaaaggc ttggattttg
     2821 aaataccacc cccgagtcct ccactgaatc ttcacgagct gagtggacct gccgaaggca
     2881 cccctctcac cccaaagagc actaacccca ccaaaggcct ggatgcttcc agcaagagaa
     2941 acacggacaa agctgtgtct gttgaggctg cggagagaga ctgggaagag aagcgggcag
     3001 ccctgaccca gtacagcgcc aaggacatca accggctgct ggaagagacc caggctgagc
     3061 tgctcaaggc tatccctgac ctggactgtg ccagcaagac ccacccaggc cctgctccca
     3121 ctccagacca caagccccct aaggcacccc atggtcagaa ggcagctccc cggacagagc
     3181 ccagtgggag aagaggatca gatgagctca cagtgccccg ataccgcaca gagaagccct
     3241 ccaagtcacc cccgccaccc cctccccgcc ggagcttccc ttcctcccat ggcctgacca
     3301 caacacgcac tggagaagtg gtggtcacca gtaagaaaga ctcagtcttc atcaagaagg
     3361 ctgagtccga ggagctagag gtccagaagc cccaggtgaa gctgcgccgt gctgtgtctg
     3421 aggtggtccg ccccgcatcc acgccgccca ttatggcctc tgccatcaag gacgaggacg
     3481 acgaggagag gatcattgct gagctggaga gtggtggtag cagcgtgcca cccatgaagg
     3541 tggtgactcc cggagcctcg aggctgaagg cggcccaggg cccagcaggc agccctgata
     3601 aaggcaaaca tggcaagcaa cgaacggaat acatgaggat ccaggcccag cagcaggcca
     3661 ctaaaccatc taaagaggtg agcggtccga atgagacctc aagccccggc tcagaaaagc
     3721 cctctggttc cagaacctcc atccctgtat tgacttcctt tggggcaagg aattcttcca
     3781 tctccttcta gaagcccctc atgccaccac cccagcccgc ccctcccata ctcccgccat
     3841 ccgtccctcc ttcctttcat gcccgctcta ccctgcccac tctcacgcct gaaaggttgc
     3901 agggggcatg gccctttgcc ctctcatctc ctcttggtgt ttttggtttt ttaagcgatt
     3961 tcctttaatt atctttcttt tccttttttt cttttttaaa gagcaaatga gaaagctaaa
     4021 aaccaaacac accaacttcc cctgacttcc ggttccctag cggcctctgc tccgcccact
     4081 tcctgtcatc ttcttcccct ctgctctttc accctcctcc cctcccctcc ccccaagtcc
     4141 atccaaagtt cccacctcct ctaacttccc aagaacactt ggaacaaact ctgagccacg
     4201 gagacttgga gcggagcgag gcccccctcc cgttactggg ttccttcctg gaggaacaga
     4261 tggacaagga ctgacccagc atcaggctgg acaatggaca agggagaccc tggccttgga
     4321 gacgcccact gtctgtccag ccttcgaaga gacagaactc tgctgctggc ctgtggtttt
     4381 tctttcaaac cagggtgggc ctggaagcag gcctagctgg aggggatccc cagagaagag
     4441 gccaaggctg ggtgtgagga gggaaagggg ggacactagg tgccagggga gaagccggct
     4501 cgctgctgct cagtgtccgg ctggtgctag caacagatgg aaggaggtct ccaggacacc
     4561 tgttatggaa ggtgcttctg gggacagcct gcccctgggg atctgccttg ggagagggca
     4621 gttctgagag gggcatctgg tacttttagt tccctaattt agcactttaa atgccattaa
     4681 cttattttat gggggtgggg tggggaagat ggaagggcct agaaacatgt ttggagggtg
     4741 ggaagggtct ggtttgaggg atacagggag acgggacggg tgggtgcagt aaagtctctg
     4801 acccctagag ggcgcaactt gaccttcagc cagcctctat gatttgaggg ttttcaggga
     4861 aggcatgaga tgcgacgact tgccggtggg gatctggtga ccacttgtca ggtgtttgag
     4921 ggtccccaag gcagaagagc cagttagtac tccagtctgg ataccttgca ggggtcctgc
     4981 acaggacaga ctggctttga atgggtccag gagtctaagg gagaggctga cttggttctg
     5041 gcctggcccc cagccgctac agtggggcca gagcaagaag gaagaagatc gggaaggtgg
     5101 aggggcttcc ctttggagca caaagcatgt aagcacagag gtgtggtctt gggaccagtc
     5161 ccacagtagc acagagagga gccattgaag ggacagaacc ccaggaccct ggcgcccagc
     5221 aggggaaagc caagcggcag ctgttgaggg tttgggttgg gagggaaaac tgggttgtgt
     5281 ttcctttctt tgattttgtt tatttttatt tctatttttg ttttgttagt ttgctcttgt
     5341 tttctagctt tgggtcattt ttgtactaag gcaagcaagc ctttttgaaa aataacaaaa
     5401 gaagaagaaa aaaatccctc ccagaaaaaa aaacaaaaac aaaaaacaaa acaaaaaaca
     5461 aaaaaaccta aaaaaaatag aaaaaaaaaa aggacctcac aatgatgcaa ttacttttaa
     5521 ttgcaagcaa ctctttacat ttaagtgaag tgtcttaaca ttttatattg ttttaaaaat
     5581 atatttacat attatatata tataatatac gtaatataaa tatatataaa tatttaaaaa
     5641 agaaaaaaaa aaaaagaaaa ccacagcaca ctctccctgg ccactgtctg gcaggggagg
     5701 ggctggggac aggcgtgtgg cctggtttct gtagtccctg tggagcagtt tggtttgatt
     5761 tggctgtaca gagacccctg gcttgggagg ggagggggag gggcccctcc actccatttc
     5821 tctttgcttg ctactctttg cttgccccca cacccgctca gccctgagac ctgagtgtgc
     5881 gcccctccgt cattgtcctg agttgagtgt cctttgtgga gagacaggga ggtggaagaa
     5941 gtgactattc atgcaggggc tgccccacga gctcaggcaa ggcccccgtg ggctttgcgt
     6001 agttctagtt cttcaatttg gttactgcgc gagtgtgtcc tggaaggaat ttgtatggga
     6061 ttgtgtgcag cctctgtgtg tgtgtgcaca cgctggcaca agcctacata acttgtgtgt
     6121 gcacatgcat gggttgtgtg tgcataggca aaacgtgata ttgtatgtgt gaagccttgt
     6181 acatgtatgt gaatgtgacc tgcctggtat caacatgatt gtgtgaggag agccttggga
     6241 gtaaggacgt gtgtgatgtg tgtggacacg cctggctgtt cacgtgagga ccacataggg
     6301 atgggtttag ataacgtcag ctgtgggtat ggttgtatgc aggtgcaggc aggcgtgtga
     6361 gagggtctct gtgtgtgaga gtactcgtgt gcatgtgtgt gttccatcat ccctgcacca
     6421 ctcgcccggc acccctccca agctccccac cccacctgtc ttctcaaagc ccacagcacg
     6481 tcaatccccg cccccacccc cagctgcatg cgcctcgccg ctatccatca gtgtgtgctt
     6541 gacaagagaa actgccacat cgggggaccc tgtacctggt cccctcaccc ctgcccgctg
     6601 tgctgtgata ctcgcatggg gggttctctc tggccccttc cacaatatac tcttttcccc
     6661 aggggcctcg ggcaaaggct ctgagtgagg tcccaagtgg ggccccccaa ggccagcccg
     6721 gctccacacc cacccgtcca ccctgtaggg cctgtgttgg tgtagaagtg atggcgtctg
     6781 tggatattgt gacctctgtc agtgtaaatt gacgatttct aaatggaaag ggttgctgtg
     6841 ttttctgtct cctttttaat gtcctttctc tcttccccac ctccccgctc tcttcccgtc
     6901 ccttttggtt tttctagccg agtgttgggg ctttaataaa acttgtttct tttttctctc
     6961 ctgga
//
