LOCUS       NM_001412684            4005 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus Rous sarcoma oncogene (Src), transcript variant 5,
            mRNA.
ACCESSION   NM_001412684 XM_036160079
VERSION     NM_001412684.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4005)
  AUTHORS   Frampton,E., Som,P., Hill,B., Yu,A., Naval-Sanchez,M.,
            Nefzger,C.M., Noordstra,I., Gordon,E. and Schimmel,L.
  TITLE     Endothelial c-Src Mediates Neovascular Tuft Formation in
            Oxygen-Induced Retinopathy
  JOURNAL   Am J Pathol 194 (12), 2239-2251 (2024)
   PUBMED   39332676
REFERENCE   2  (bases 1 to 4005)
  AUTHORS   Moye,A.L., Dost,A.F., Ietswaart,R., Sengupta,S., Ya,V., Aluya,C.,
            Fahey,C.G., Louie,S.M., Paschini,M. and Kim,C.F.
  TITLE     Early-stage lung cancer is driven by a transitional cell state
            dependent on a KRAS-ITGA3-SRC axis
  JOURNAL   EMBO J 43 (14), 2843-2861 (2024)
   PUBMED   38755258
  REMARK    GeneRIF: Early-stage lung cancer is driven by a transitional cell
            state dependent on a KRAS-ITGA3-SRC axis.
REFERENCE   3  (bases 1 to 4005)
  AUTHORS   Zhang,L., Zhang,Z.F., Hui,Y.N., He,F., Guan,X.R. and Zhou,J.
  TITLE     Oxidative Stress Participates in Age-Related Cataract Formation by
            Disrupting Connection between Lens Epithelial Cells through
            c-Src/VEGF Pathway
  JOURNAL   Curr Eye Res 49 (4), 380-390 (2024)
   PUBMED   38108278
  REMARK    GeneRIF: Oxidative Stress Participates in Age-Related Cataract
            Formation by Disrupting Connection between Lens Epithelial Cells
            through c-Src/VEGF Pathway.
REFERENCE   4  (bases 1 to 4005)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4005)
  AUTHORS   Barbayianni,I., Kanellopoulou,P., Fanidis,D., Nastos,D.,
            Ntouskou,E.D., Galaris,A., Harokopos,V., Hatzis,P., Tsitoura,E.,
            Homer,R., Kaminski,N., Antoniou,K.M., Crestani,B., Tzouvelekis,A.
            and Aidinis,V.
  TITLE     SRC and TKS5 mediated podosome formation in fibroblasts promotes
            extracellular matrix invasion and pulmonary fibrosis
  JOURNAL   Nat Commun 14 (1), 5882 (2023)
   PUBMED   37735172
  REMARK    GeneRIF: SRC and TKS5 mediated podosome formation in fibroblasts
            promotes extracellular matrix invasion and pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4005)
  AUTHORS   Boyce,B.F., Yoneda,T., Lowe,C., Soriano,P. and Mundy,G.R.
  TITLE     Requirement of pp60c-src expression for osteoclasts to form ruffled
            borders and resorb bone in mice
  JOURNAL   J Clin Invest 90 (4), 1622-1627 (1992)
   PUBMED   1383278
REFERENCE   7  (bases 1 to 4005)
  AUTHORS   Wilkie,T.M., Gilbert,D.J., Olsen,A.S., Chen,X.N., Amatruda,T.T.,
            Korenberg,J.R., Trask,B.J., de Jong,P., Reed,R.R., Simon,M.I. et
            al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat Genet 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 4005)
  AUTHORS   Birkenmeier,E.H., Schneider,U. and Thurston,S.J.
  TITLE     Fingerprinting genomes by use of PCR with primers that encode
            protein motifs or contain sequences that regulate gene expression
  JOURNAL   Mamm Genome 3 (10), 537-545 (1992)
   PUBMED   1421760
  REMARK    Erratum:[Mamm Genome 1993;4(2):133]
REFERENCE   9  (bases 1 to 4005)
  AUTHORS   Nelson,K.K., Knopf,J.L. and Siracusa,L.D.
  TITLE     Localization of phospholipase C-gamma 1 to mouse chromosome 2
  JOURNAL   Mamm Genome 3 (10), 597-600 (1992)
   PUBMED   1358284
REFERENCE   10 (bases 1 to 4005)
  AUTHORS   Collett,M.S. and Erikson,R.L.
  TITLE     Protein kinase activity associated with the avian sarcoma virus src
            gene product
  JOURNAL   Proc Natl Acad Sci U S A 75 (4), 2021-2024 (1978)
   PUBMED   205879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672259.9.
            
            On Oct 14, 2022 this sequence version replaced XM_036160079.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.23818.1,
                                           SRR7345562.1304812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL672259.9         16878-17009
            133-240             AL672259.9         17423-17530
            241-317             AL672259.9         31796-31872
            318-494             AL672259.9         48186-48362
            495-749             AL672259.9         49672-49926
            750-849             AL672259.9         51129-51228
            850-867             AL672259.9         51438-51455
            868-966             AL672259.9         55305-55403
            967-1070            AL672259.9         55574-55677
            1071-1220           AL672259.9         57224-57373
            1221-1376           AL672259.9         58468-58623
            1377-1556           AL672259.9         60026-60205
            1557-1633           AL672259.9         61078-61154
            1634-1787           AL672259.9         61720-61873
            1788-1919           AL672259.9         61985-62116
            1920-4005           AL672259.9         62348-64433
FEATURES             Location/Qualifiers
     source          1..4005
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.35 cM"
     gene            1..4005
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /note="Rous sarcoma oncogene"
                     /db_xref="GeneID:20779"
                     /db_xref="MGI:MGI:98397"
     exon            1..132
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            133..240
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            241..317
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            318..494
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            495..749
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     CDS             503..2128
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 5;
                     neuronal proto-oncogene tyrosine-protein kinase Src;
                     p60-Src; proto-oncogene c-Src"
                     /codon_start=1
                     /product="proto-oncogene tyrosine-protein kinase Src
                     isoform 1"
                     /protein_id="NP_001399613.1"
                     /db_xref="GeneID:20779"
                     /db_xref="MGI:MGI:98397"
                     /translation="MGSNKSKPKDASQRRRSLEPSENVHGAGGAFPASQTPSKPASAD
                     GHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDL
                     SFKKGERLQIVNNTRKVDVREGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGK
                     ITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSG
                     GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLR
                     LEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY
                     AVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVH
                     RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK
                     SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR
                     KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL"
     exon            750..849
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            850..867
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            868..966
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1070
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1220
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1376
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1556
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1633
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1787
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1919
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..4005
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3985..3990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /note="hexamer: ATTAAA"
     polyA_site      4005
                     /gene="Src"
                     /gene_synonym="pp60c-src"
                     /note="major polyA site"
ORIGIN      
        1 ctctcggtct gtctctccgg gcccggaatc caaccggccg ccccgccgga gcggccaggc
       61 cgctgcccgc cagcgccgcg cgccccgctg gggtccgccc gggcgcgtcc ggagctcacg
      121 gtcgccgtgc agcctcgccc ctgcgcaggc ccagcgaccg atggactcag aagttggcaa
      181 aagttttggg gtttcactac cgccaccagg tccgcttgcc cacccaggca ggtactggag
      241 gacagaatac ggagaccaag agtgctgagc gacctgtgta gccatgacag gctgagccag
      301 gatctgaacc aaggcagcat ctctgcaggt gcggatgttg cgacccaggg agagggagca
      361 gcttgcctag ggacacggag caggagaggt gcaacagggt ctttaggcca agaccccgga
      421 tactacagct ggtgtctgca ccaaggcccc agtctgctcc ccagatccac tggggtagct
      481 ctgctaccta tcagccagga ccatgggcag caacaagagc aagcccaagg acgccagcca
      541 gcggcgccgc agcctggagc cctcggaaaa cgtgcacggg gcagggggcg ccttcccggc
      601 ctcacagaca ccgagcaagc ccgcctccgc cgacggccac cgcgggccca gcgccgcctt
      661 cgtgccgccc gcggccgagc ccaagctctt cggaggcttc aactcctcgg acaccgtcac
      721 ctccccgcag agggcggggc ctctggcagg tggggtgacc acctttgtgg ccctctatga
      781 ctatgagtca cggacagaga ctgacctgtc cttcaagaaa ggggagcggc tgcagattgt
      841 caataacacg aggaaggtgg atgtcagaga gggagactgg tggctggcac actcgctgag
      901 cacgggacag accggttaca tccccagcaa ctatgtggcg ccctccgact ccatccaggc
      961 tgaggagtgg tactttggca agatcactag acgggaatca gagcggctgc tgctcaacgc
     1021 cgagaacccg agagggacct tcctcgtgag ggagagtgag accacaaaag gtgcctactg
     1081 cctctctgta tccgacttcg acaatgccaa gggcctaaat gtgaaacact acaagatccg
     1141 caagctggac agcggcggtt tctacatcac ctcccgcacc cagttcaaca gcctgcagca
     1201 gctcgtggct tactactcca aacatgctga tggcctgtgt caccgcctca ctaccgtatg
     1261 tcccacatcc aagcctcaga cccagggatt ggccaaggat gcgtgggaga tcccccggga
     1321 gtccctgcgg ctggaggtca agctgggcca gggttgcttc ggagaggtgt ggatggggac
     1381 ctggaacggc accacgaggg ttgccatcaa aactctgaag ccaggcacca tgtccccaga
     1441 ggccttcctg caggaggccc aagtcatgaa gaaactgagg cacgagaaac tggtgcagct
     1501 gtatgctgtg gtgtcggaag aacccattta cattgtgaca gagtacatga acaaggggag
     1561 tctgctggac tttctcaagg gggaaacggg caaatatttg cggctacccc agctggtgga
     1621 catgtctgct cagatcgctt caggcatggc ctatgtggag cggatgaact atgtgcaccg
     1681 ggaccttcga gccgccaata tcctagtagg ggagaacctg gtgtgcaaag tggccgactt
     1741 tgggttggcc cggctcatag aagacaacga atacacagcc cggcaaggtg ccaaattccc
     1801 catcaagtgg accgcccctg aagctgctct gtacggcagg ttcaccatca agtcggatgt
     1861 gtggtccttt gggattctgc tgaccgagct caccactaag ggaagagtgc cctatcctgg
     1921 gatggtgaac cgtgaggttc tggaccaggt ggagcggggc taccggatgc cttgtccccc
     1981 cgagtgcccc gagtccctgc atgaccttat gtgccagtgc tggcggaagg agcccgagga
     2041 gcggcccacc ttcgagtacc tgcaggcctt cctggaagac tactttacgt ccactgagcc
     2101 acagtaccag cccggggaga acctataggg actgtgtgcg cagaactgtc acctctaggc
     2161 ttccgggtgt tgcctccgat gcacctgcct cccttcatcc tctctctggg gctgcgttgc
     2221 ctcggcaatg ccccttttgg agcatggaag ggcttcaggg atggggcagc ctggaaggac
     2281 aggtggaggc tggtacagtg actgtcccat gcctgccatg gccacaggct ctctctgtgc
     2341 attctctctg gagttagcct gcttctcaca ggacacttgt gacagcagag ctgggggtgg
     2401 ttttccagcc tcgacccact gcgctcacct ggcactgccc cactttcttc accctgggtc
     2461 tgtttcaagc cggccagaga gcctttccaa agaggaatga ggcccaggcc ttggctatac
     2521 gtacttcctg cccctggcca tccttgttgg aggcttctgg gtggaacact gggtctagaa
     2581 ccttcttccg tggctctcag gcagcccaag gcccaacacc agttgggata agtgtcagag
     2641 tgagcacccc ctcagcccgt cctccacaag ggacccttga gatcactgac acatcacccc
     2701 catttctctg ctggaaaaaa ccagaatcca ggaggggttg tgacctgccc aagaccaagg
     2761 gcagtttagg gttgaggtgg gcttggcacc tggtgctcct tctgttcctc aggaactaac
     2821 gagaactgtc ctccaaggca gggggcaggg tggggcctga gagtggcttc aagtcggcag
     2881 ggttctgctg cccctgatgc tcatgggtct gtcccgggga aagaggcaag caggaggctg
     2941 agccaggagc gaggggtaga aagtggtggt gtggaacagg cttctgtttg tcacagtgtg
     3001 ggtgggctgg ggtggaggga gctctcaggc tgcagagaca gtcaagtaga agaggaagag
     3061 ctaaggggtg tggagtcctg ctcctccatt tgtcctgatc atttcaacac ctggcccttg
     3121 ctctcctgcc cgtgccagga ctccctaact cagggaggga ggggaggtcc ttagctgggg
     3181 gaaaggaggc gagggtcctt actgctgtgt accaacactg accccgccct ctctgagctg
     3241 tactctctgc ccgtgactat ggcctctgtc attgctccgt tccaaccacc cccccccccc
     3301 ccccccgtat tgatagatcc acagctgggc gtccaagggg gtcctggaac agcagacatc
     3361 tgactgtctg gtccctggct cctctgacca gcccttaggc tatgtggtgg cttctctctg
     3421 cctcagtgtc cgggtctgta aggtgggcag ttgatgattt gtggcatctc aaccaagggc
     3481 ccctgtgtgt gtgtgtttgt gtgtgtgtac acatatctgt gcctgtgtgt cttcccttgt
     3541 gtccatattt aatgtgtaag aacatcccta ctctatccca gacacgacca tttcacccat
     3601 tgccccatca cagcaataat gtccccgcta ctggggaccc gagccagcca ggccatgttt
     3661 gcagggaagg atgccaagca gggcctgccc tgacagttcc actttactcc catattctcc
     3721 ccgtgctcct ggcgagcctg agcttgccac ccggttctcc ctgcccgact ccagctgccc
     3781 aaggaccttt gtgtaaggtg gcctcaactg tctggttttc tttttttctt tctttttaac
     3841 agtgttttgt agatttcaga tgactatgca gaggccttgg ggacccctcc ccagctctgg
     3901 gcagggcctg gggatcccac attccatgcc caggcttggg ggagggggac ccagacttgt
     3961 tgtacatatt ttgcatactg tctgattaaa cacaaacaga cctca
//
