LOCUS       NM_025291                979 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus steroid receptor RNA activator 1 (Sra1), transcript
            variant 1, mRNA.
ACCESSION   NM_025291
VERSION     NM_025291.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 979)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 979)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 979)
  AUTHORS   Hong,C.H., Ho,J.C. and Lee,C.H.
  TITLE     Steroid Receptor RNA Activator, a Long Noncoding RNA, Activates
            p38, Facilitates Epithelial-Mesenchymal Transformation, and
            Mediates Experimental Melanoma Metastasis
  JOURNAL   J Invest Dermatol 140 (7), 1355-1363 (2020)
   PUBMED   31945347
  REMARK    GeneRIF: Steroid Receptor RNA Activator, a Long Noncoding RNA,
            Activates p38, Facilitates Epithelial-Mesenchymal Transformation,
            and Mediates Experimental Melanoma Metastasis.
REFERENCE   4  (bases 1 to 979)
  AUTHORS   Chen,G., Yu,D., Nian,X., Liu,J., Koenig,R.J., Xu,B. and Sheng,L.
  TITLE     LncRNA SRA promotes hepatic steatosis through repressing the
            expression of adipose triglyceride lipase (ATGL)
  JOURNAL   Sci Rep 6, 35531 (2016)
   PUBMED   27759039
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 979)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 979)
  AUTHORS   Rakeman,A.S. and Anderson,K.V.
  TITLE     Axis specification and morphogenesis in the mouse embryo require
            Nap1, a regulator of WAVE-mediated actin branching
  JOURNAL   Development 133 (16), 3075-3083 (2006)
   PUBMED   16831833
REFERENCE   7  (bases 1 to 979)
  AUTHORS   Zhao,X., Patton,J.R., Davis,S.L., Florence,B., Ames,S.J. and
            Spanjaard,R.A.
  TITLE     Regulation of nuclear receptor activity by a pseudouridine synthase
            through posttranscriptional modification of steroid receptor RNA
            activator
  JOURNAL   Mol Cell 15 (4), 549-558 (2004)
   PUBMED   15327771
  REMARK    GeneRIF: Results identify a pseudouridine synthase, mPus1p, as a
            coactivator for retinoic acid receptor (mRAR)gamma when coexpressed
            with steroid receptor RNA activator.
REFERENCE   8  (bases 1 to 979)
  AUTHORS   Xu,B. and Koenig,R.J.
  TITLE     An RNA-binding domain in the thyroid hormone receptor enhances
            transcriptional activation
  JOURNAL   J Biol Chem 279 (32), 33051-33056 (2004)
   PUBMED   15180993
REFERENCE   9  (bases 1 to 979)
  AUTHORS   Lanz,R.B., Chua,S.S., Barron,N., Soder,B.M., DeMayo,F. and
            O'Malley,B.W.
  TITLE     Steroid receptor RNA activator stimulates proliferation as well as
            apoptosis in vivo
  JOURNAL   Mol Cell Biol 23 (20), 7163-7176 (2003)
   PUBMED   14517287
  REMARK    GeneRIF: Steroid receptor RNA activator stimulates proliferation as
            well as apoptosis in vivo
REFERENCE   10 (bases 1 to 979)
  AUTHORS   Lanz,R.B., McKenna,N.J., Onate,S.A., Albrecht,U., Wong,J.,
            Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     A steroid receptor coactivator, SRA, functions as an RNA and is
            present in an SRC-1 complex
  JOURNAL   Cell 97 (1), 17-27 (1999)
   PUBMED   10199399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097874.1, AK010375.1 and BQ748094.1.
            
            On Sep 2, 2009 this sequence version replaced NM_025291.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is also supported by available conservation
            data. The use of an alternative upstream start codon would result
            in a protein that is 12 aa longer.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007302.1, DV053615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY097874.1         1-18
            19-870              AK010375.1         5-856
            871-979             BQ748094.1         539-647
FEATURES             Location/Qualifiers
     source          1..979
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..979
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="steroid receptor RNA activator 1"
                     /db_xref="GeneID:24068"
                     /db_xref="MGI:MGI:1344414"
     exon            1..64
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..702
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="isoform a is encoded by transcript variant 1;
                     steroid receptor RNA activator protein"
                     /codon_start=1
                     /product="steroid receptor RNA activator 1 isoform a"
                     /protein_id="NP_079567.2"
                     /db_xref="CCDS:CCDS29156.2"
                     /db_xref="GeneID:24068"
                     /db_xref="MGI:MGI:1344414"
                     /translation="MMRCPAGGAEVEMAELYVKPGNKERGWNDPPQFSYGLQTQTGGP
                     KRTPLTKRVAAPQDGSPRAPETSGPPPVDHPPPSSKASRPPPMGSCPATGVEPPSSPV
                     IESETLIEDVLRPLEQALEDCHGHTKKQVCDDISRRLALLREQWAGGKLSIPVKKRMA
                     LLVQELLHHQWDAADDIHRSLMVDHVTEVSQWMVGVKRLIAEKKSLSSEETKEEKFTV
                     EPENQTIPGFQQPS"
     exon            65..190
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..387
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..496
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..969
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      859..864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="hexamer: AATAAA"
     regulatory      871..876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="hexamer: AATAAA"
     polyA_site      878
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="major polyA site"
     polyA_site      910
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="major polyA site"
     polyA_site      969
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
ORIGIN      
        1 gaaatgatgc gctgccccgc tggcggtgcg gaagtggaga tggcggagct gtacgtgaag
       61 cccggcaaca aggaacgcgg ctggaacgac ccgccacaat tctcctacgg gctccagact
      121 cagactggtg gacccaaacg cactcccctt actaagaggg tcgcggcccc acaggatgga
      181 tcccctagag ccccagaaac ttctggacca cctccagtgg atcatccacc tccttcaagt
      241 aaggcttcca ggcctccgcc catggggagc tgtcctgcta ctggtgtgga gcccccaagt
      301 tccccagtca ttgagtctga aactctgata gaagacgtgc tgagacctct ggaacaggca
      361 ttggaggact gccatggtca cacaaagaaa caggtatgtg atgatatcag ccgacgcttg
      421 gcgctgcttc gagaacagtg ggctggaggg aagttgtcaa tacctgtaaa gaagaggatg
      481 gcactgctag tgcaagaact tttacatcac cagtgggatg cagcagatga cattcaccga
      541 tcactcatgg ttgaccatgt gactgaggtc agtcagtgga tggtgggagt aaaaagatta
      601 attgcagaaa agaagagtct atcttcagag gagaccaaag aagagaaatt tacagtggaa
      661 cctgagaacc agacaatacc aggcttccaa cagccatcat aatgcctgtg gctccccaga
      721 ctcacttcac ctgacttcct atgccttagt gtggaaggct tcttcttcct ttttaccacc
      781 agggagacta ttggtcttgt gggtcttgac caaagatcct atctagacca ctgcaagatc
      841 acttgttatg tacatttcaa taaacatctc aataaacatc tcaatggtgg gaagtgggta
      901 ggaaagatga gccattctga tgtcagactg gttctttgtg gtgtcagctt ccctgctcca
      961 tggacactaa aaaaaaaaa
//
