LOCUS       NM_001164406             876 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus steroid receptor RNA activator 1 (Sra1), transcript
            variant 2, mRNA.
ACCESSION   NM_001164406
VERSION     NM_001164406.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Hong,C.H., Ho,J.C. and Lee,C.H.
  TITLE     Steroid Receptor RNA Activator, a Long Noncoding RNA, Activates
            p38, Facilitates Epithelial-Mesenchymal Transformation, and
            Mediates Experimental Melanoma Metastasis
  JOURNAL   J Invest Dermatol 140 (7), 1355-1363 (2020)
   PUBMED   31945347
  REMARK    GeneRIF: Steroid Receptor RNA Activator, a Long Noncoding RNA,
            Activates p38, Facilitates Epithelial-Mesenchymal Transformation,
            and Mediates Experimental Melanoma Metastasis.
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Chen,G., Yu,D., Nian,X., Liu,J., Koenig,R.J., Xu,B. and Sheng,L.
  TITLE     LncRNA SRA promotes hepatic steatosis through repressing the
            expression of adipose triglyceride lipase (ATGL)
  JOURNAL   Sci Rep 6, 35531 (2016)
   PUBMED   27759039
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Rakeman,A.S. and Anderson,K.V.
  TITLE     Axis specification and morphogenesis in the mouse embryo require
            Nap1, a regulator of WAVE-mediated actin branching
  JOURNAL   Development 133 (16), 3075-3083 (2006)
   PUBMED   16831833
REFERENCE   7  (bases 1 to 876)
  AUTHORS   Zhao,X., Patton,J.R., Davis,S.L., Florence,B., Ames,S.J. and
            Spanjaard,R.A.
  TITLE     Regulation of nuclear receptor activity by a pseudouridine synthase
            through posttranscriptional modification of steroid receptor RNA
            activator
  JOURNAL   Mol Cell 15 (4), 549-558 (2004)
   PUBMED   15327771
  REMARK    GeneRIF: Results identify a pseudouridine synthase, mPus1p, as a
            coactivator for retinoic acid receptor (mRAR)gamma when coexpressed
            with steroid receptor RNA activator.
REFERENCE   8  (bases 1 to 876)
  AUTHORS   Xu,B. and Koenig,R.J.
  TITLE     An RNA-binding domain in the thyroid hormone receptor enhances
            transcriptional activation
  JOURNAL   J Biol Chem 279 (32), 33051-33056 (2004)
   PUBMED   15180993
REFERENCE   9  (bases 1 to 876)
  AUTHORS   Lanz,R.B., Chua,S.S., Barron,N., Soder,B.M., DeMayo,F. and
            O'Malley,B.W.
  TITLE     Steroid receptor RNA activator stimulates proliferation as well as
            apoptosis in vivo
  JOURNAL   Mol Cell Biol 23 (20), 7163-7176 (2003)
   PUBMED   14517287
  REMARK    GeneRIF: Steroid receptor RNA activator stimulates proliferation as
            well as apoptosis in vivo
REFERENCE   10 (bases 1 to 876)
  AUTHORS   Lanz,R.B., McKenna,N.J., Onate,S.A., Albrecht,U., Wong,J.,
            Tsai,S.Y., Tsai,M.J. and O'Malley,B.W.
  TITLE     A steroid receptor coactivator, SRA, functions as an RNA and is
            present in an SRC-1 complex
  JOURNAL   Cell 97 (1), 17-27 (1999)
   PUBMED   10199399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY097874.1, AK010375.1 and BQ748094.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. It encodes isoform b, which has a shorter and distinct
            C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF584304.1, BG087662.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BY097874.1         1-18
            19-393              AK010375.1         5-379
            394-767             AK010375.1         483-856
            768-876             BQ748094.1         539-647
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..876
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="steroid receptor RNA activator 1"
                     /db_xref="GeneID:24068"
                     /db_xref="MGI:MGI:1344414"
     exon            1..64
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..459
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="isoform b is encoded by transcript variant 2;
                     steroid receptor RNA activator protein"
                     /codon_start=1
                     /product="steroid receptor RNA activator 1 isoform b"
                     /protein_id="NP_001157878.1"
                     /db_xref="GeneID:24068"
                     /db_xref="MGI:MGI:1344414"
                     /translation="MMRCPAGGAEVEMAELYVKPGNKERGWNDPPQFSYGLQTQTGGP
                     KRTPLTKRVAAPQDGSPRAPETSGPPPVDHPPPSSKASRPPPMGSCPATGVEPPSSPV
                     IESETLIEDVLRPLEQALEDCHGHTKKQNFYITSGMQQMTFTDHSWLTM"
     exon            65..190
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..387
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..393
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..866
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      756..761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="hexamer: AATAAA"
     regulatory      768..773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="hexamer: AATAAA"
     polyA_site      775
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="major polyA site"
     polyA_site      807
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
                     /note="major polyA site"
     polyA_site      866
                     /gene="Sra1"
                     /gene_synonym="Sra; Srap; Straa1; Strra1"
ORIGIN      
        1 gaaatgatgc gctgccccgc tggcggtgcg gaagtggaga tggcggagct gtacgtgaag
       61 cccggcaaca aggaacgcgg ctggaacgac ccgccacaat tctcctacgg gctccagact
      121 cagactggtg gacccaaacg cactcccctt actaagaggg tcgcggcccc acaggatgga
      181 tcccctagag ccccagaaac ttctggacca cctccagtgg atcatccacc tccttcaagt
      241 aaggcttcca ggcctccgcc catggggagc tgtcctgcta ctggtgtgga gcccccaagt
      301 tccccagtca ttgagtctga aactctgata gaagacgtgc tgagacctct ggaacaggca
      361 ttggaggact gccatggtca cacaaagaaa cagaactttt acatcaccag tgggatgcag
      421 cagatgacat tcaccgatca ctcatggttg accatgtgac tgaggtcagt cagtggatgg
      481 tgggagtaaa aagattaatt gcagaaaaga agagtctatc ttcagaggag accaaagaag
      541 agaaatttac agtggaacct gagaaccaga caataccagg cttccaacag ccatcataat
      601 gcctgtggct ccccagactc acttcacctg acttcctatg ccttagtgtg gaaggcttct
      661 tcttcctttt taccaccagg gagactattg gtcttgtggg tcttgaccaa agatcctatc
      721 tagaccactg caagatcact tgttatgtac atttcaataa acatctcaat aaacatctca
      781 atggtgggaa gtgggtagga aagatgagcc attctgatgt cagactggtt ctttgtggtg
      841 tcagcttccc tgctccatgg acactaaaaa aaaaaa
//
