LOCUS       NM_011018               2030 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus sequestosome 1 (Sqstm1), transcript variant 1, mRNA.
ACCESSION   NM_011018
VERSION     NM_011018.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2030)
  AUTHORS   Wang,J., Yi,H., Li,J., Yang,Y., Sun,G., Xue,Y. and He,L.
  TITLE     P62-autophagic pathway degrades SLC7A11 to regulate ferroptosis in
            doxorubicin-induced cardiotoxicity
  JOURNAL   Life Sci 356, 122981 (2024)
   PUBMED   39147314
  REMARK    GeneRIF: P62-autophagic pathway degrades SLC7A11 to regulate
            ferroptosis in doxorubicin-induced cardiotoxicity.
REFERENCE   2  (bases 1 to 2030)
  AUTHORS   Yang,S., Li,Y., Tian,M., Deng,W., Liu,D., Chen,C., Zhu,Z.,
            Zheng,H., Yang,G., Li,L. and Yang,M.
  TITLE     Hypothalamic P62 (SQSTM1) regulates energy balance by modulating
            leptin signaling
  JOURNAL   Theranostics 14 (17), 6605-6624 (2024)
   PUBMED   39479445
  REMARK    GeneRIF: Hypothalamic P62 (SQSTM1) regulates energy balance by
            modulating leptin signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2030)
  AUTHORS   Dong,M.Z., Ouyang,Y.C., Gao,S.C., Gu,L.J., Guo,J.N., Sun,S.M.,
            Wang,Z.B. and Sun,Q.Y.
  TITLE     Protein phosphatase 4 maintains the survival of primordial
            follicles by regulating autophagy in oocytes
  JOURNAL   Cell Death Dis 15 (9), 658 (2024)
   PUBMED   39245708
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2030)
  AUTHORS   Zhao,T., He,M., Zhu,Z., Zhang,T., Zheng,W., Qin,S., Gao,M.,
            Wang,W., Chen,Z., Han,J., Liu,L., Zhou,B., Wang,H., Zhang,H.,
            Xia,G., Wang,J., Wang,F. and Wang,C.
  TITLE     P62 promotes FSH-induced antral follicle formation by directing
            degradation of ubiquitinated WT1
  JOURNAL   Cell Mol Life Sci 81 (1), 221 (2024)
   PUBMED   38763964
  REMARK    GeneRIF: P62 promotes FSH-induced antral follicle formation by
            directing degradation of ubiquitinated WT1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2030)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2030)
  AUTHORS   Lee,C.K., Klopp,R.G., Weindruch,R. and Prolla,T.A.
  TITLE     Gene expression profile of aging and its retardation by caloric
            restriction
  JOURNAL   Science 285 (5432), 1390-1393 (1999)
   PUBMED   10464095
REFERENCE   7  (bases 1 to 2030)
  AUTHORS   Okazaki,M., Ito,S., Kawakita,K., Takeshita,S., Kawai,S.,
            Makishima,F., Oda,H. and Kakinuma,A.
  TITLE     Cloning, expression profile, and genomic organization of the mouse
            STAP/A170 gene
  JOURNAL   Genomics 60 (1), 87-95 (1999)
   PUBMED   10458914
REFERENCE   8  (bases 1 to 2030)
  AUTHORS   Yanagawa,T., Yuki,K., Yoshida,H., Bannai,S. and Ishii,T.
  TITLE     Phosphorylation of A170 stress protein by casein kinase II-like
            activity in macrophages
  JOURNAL   Biochem Biophys Res Commun 241 (1), 157-163 (1997)
   PUBMED   9405250
REFERENCE   9  (bases 1 to 2030)
  AUTHORS   Ishii,T., Yanagawa,T., Yuki,K., Kawane,T., Yoshida,H. and Bannai,S.
  TITLE     Low micromolar levels of hydrogen peroxide and proteasome
            inhibitors induce the 60-kDa A170 stress protein in murine
            peritoneal macrophages
  JOURNAL   Biochem Biophys Res Commun 232 (1), 33-37 (1997)
   PUBMED   9125146
REFERENCE   10 (bases 1 to 2030)
  AUTHORS   Ishii,T., Yanagawa,T., Kawane,T., Yuki,K., Seita,J., Yoshida,H. and
            Bannai,S.
  TITLE     Murine peritoneal macrophages induce a novel 60-kDa protein with
            structural similarity to a tyrosine kinase p56lck-associated
            protein in response to oxidative stress
  JOURNAL   Biochem Biophys Res Commun 226 (2), 456-460 (1996)
   PUBMED   8806656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY267273.1, AK028898.1 and CX240486.1.
            
            On Mar 19, 2014 this sequence version replaced NM_011018.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U40930.1, SRR1660821.101709.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY267273.1         185-213
            30-1120             AK028898.1         2-1092
            1121-1234           CX240486.1         194-307
            1235-2030           AK028898.1         1093-1888
FEATURES             Location/Qualifiers
     source          1..2030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 30.36 cM"
     gene            1..2030
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /note="sequestosome 1"
                     /db_xref="GeneID:18412"
                     /db_xref="MGI:MGI:107931"
     exon            1..268
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /inference="alignment:Splign:2.1.0"
     exon            269..364
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /inference="alignment:Splign:2.1.0"
     exon            365..594
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /inference="alignment:Splign:2.1.0"
     exon            595..736
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /inference="alignment:Splign:2.1.0"
     exon            737..817
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1038
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1234
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..2030
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /note="hexamer: ATTAAA"
     polyA_site      1757
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
     regulatory      2004..2009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /note="hexamer: AATAAA"
     polyA_site      2027
                     /gene="Sqstm1"
                     /gene_synonym="A170; OSF-6; Osi; p62; STAP; STONE14"
                     /note="major polyA site"
ORIGIN      
        1 ataaaagctg ggctctcggc gccgccgctg cccagctgtt tcgtccgtac ctagaccgcg
       61 gttatggcgt cgttcacggt gaaggcctat cttctgggca aggaggaggc gacccgcgag
      121 atccgccgct tcagcttctg cttcagcccg gagccggagg cggaagccca agccgcggcc
      181 ggcccggggc cctgcgagag gctgctgagc cgagtggctg tgctgttccc cacgctgagg
      241 cctggcggct tccaggcgca ctaccgcgat gaggatgggg acttggttgc cttttccagt
      301 gatgaggagc tgacaatggc tatgtcctat gtgaaagatg acatcttccg catctacatt
      361 aaagagaaga aggagtgccg gcgggaacat cgcccaccat gtgctcagga ggcaccccga
      421 aacatggtgc accccaatgt gatctgtgat ggttgcaacg ggcctgtggt gggaactcgc
      481 tataagtgca gtgtgtgccc agactacgac ctgtgcagcg tgtgcgaggg gaagggcctg
      541 cacagggaac acagcaagct catctttccc aacccctttg gccacctctc tgatagcttc
      601 tctcatagcc gctggcttcg gaagctgaaa catggacact ttggctggcc tggctgggag
      661 atgggcccac cggggaactg gagcccacgt cctcctcgtg caggggatgg ccgcccttgc
      721 cctacagctg agtcagcttc tgctccacca gaagatccca atgtcaattt cctgaagaat
      781 gtgggggaga gtgtggcagc tgccctcagc cctctaggca ttgaggttga cattgatgtg
      841 gaacatggag ggaagagaag ccgcctgaca cccactaccc cagaaagttc cagcacaggc
      901 acagaagaca agagtaacac tcagccaagc agctgctctt cggaagtcag caaacctgac
      961 ggggctgggg agggccctgc tcagtctctg acagagcaaa tgaaaaagat agccttggag
     1021 tcggtgggac agccagagga acagatggag tcgggaaact gctcaggagg agacgatgac
     1081 tggacacatt tgtcttcaaa agaagtggac ccatctacag gtgaactcca gtctctacag
     1141 atgccagaat cggaagggcc aagctctcta gacccctcac aggaaggacc cacagggctg
     1201 aaggaagctg ccctataccc acatctccca ccagaggctg atccccggct gattgagtcc
     1261 ctctcccaga tgctgtccat gggtttctcg gatgaaggcg gctggctcac caggctccta
     1321 cagaccaaga attacgacat cggggctgct ctggacacga tccagtattc gaagcaccct
     1381 ccaccattgt gatagtgctg tggccaagcc ccaccccctt tgtcttgtag ttgcatcacg
     1441 tagagcagca gggcttctat agataggccc agtgtcttgg cattcttgta gaatcttcag
     1501 gtgggaatgt gtgatgcctt ttcaggcaat aggaaagtgc atgaggagag ttttgaatgt
     1561 gcatatgctg acgcctgaga acagacccag gtacccgtgg ctgagctgag cttcctctgc
     1621 tttccctagg cctggcctct gcagggaact gcagcacaca ctgcactccc acctgctctt
     1681 gccgccagca ttgcaccagc agtccagaat tcctgcctga caacccgtgt ttcctttatt
     1741 aaaagtgatt agtacaactg ctagttattt tcaacaaata aagccattat gttaagaggg
     1801 gactgtccat agtgagtgaa aggtggcagg caggggccta cagctcctag ggaatggaga
     1861 attcatgtga agccgaatga aggatcttat cttatactgt ccccctttct aatggccact
     1921 ctttagtgtt tgtgtctaat gttaatgctt aaagcacagg acccccatgt agcttcctct
     1981 gacttggttt gtaagtaacc tgtaataaaa tggcatatgc actttaacca
//
