LOCUS       NM_001162503            1676 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sulfide quinone oxidoreductase (Sqor), transcript
            variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001162503
VERSION     NM_001162503.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1676)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1676)
  AUTHORS   Griffiths,K.K., Wang,A., Jonas,E.A. and Levy,R.J.
  TITLE     Sulfide quinone oxidoreductase contributes to voltage sensing of
            the mitochondrial permeability transition pore
  JOURNAL   FASEB J 38 (4), e23494 (2024)
   PUBMED   38376922
  REMARK    GeneRIF: Sulfide quinone oxidoreductase contributes to voltage
            sensing of the mitochondrial permeability transition pore.
REFERENCE   3  (bases 1 to 1676)
  AUTHORS   Marutani,E., Morita,M., Hirai,S., Kai,S., Grange,R.M.H.,
            Miyazaki,Y., Nagashima,F., Traeger,L., Magliocca,A., Ida,T.,
            Matsunaga,T., Flicker,D.R., Corman,B., Mori,N., Yamazaki,Y.,
            Batten,A., Li,R., Tanaka,T., Ikeda,T., Nakagawa,A., Atochin,D.N.,
            Ihara,H., Olenchock,B.A., Shen,X., Nishida,M., Hanaoka,K.,
            Kevil,C.G., Xian,M., Bloch,D.B., Akaike,T., Hindle,A.G.,
            Motohashi,H. and Ichinose,F.
  TITLE     Sulfide catabolism ameliorates hypoxic brain injury
  JOURNAL   Nat Commun 12 (1), 3108 (2021)
   PUBMED   34035265
  REMARK    GeneRIF: Sulfide catabolism ameliorates hypoxic brain injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1676)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1676)
  AUTHORS   Jia,J., Wang,Z., Zhang,M., Huang,C., Song,Y., Xu,F., Zhang,J.,
            Li,J., He,M., Li,Y., Ao,G., Hong,C., Cao,Y., Chin,Y.E., Hua,Z.C.
            and Cheng,J.
  TITLE     SQR mediates therapeutic effects of H2S by targeting mitochondrial
            electron transport to induce mitochondrial uncoupling
  JOURNAL   Sci Adv 6 (35), eaaz5752 (2020)
   PUBMED   32923620
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1676)
  AUTHORS   Ackermann,M., Kubitza,M., Hauska,G. and Pina,A.L.
  TITLE     The vertebrate homologue of sulfide-quinone reductase in mammalian
            mitochondria
  JOURNAL   Cell Tissue Res 358 (3), 779-792 (2014)
   PUBMED   25130143
  REMARK    GeneRIF: The present report demonstrates the presence and specific
            localization of SQRDL in various mammalian tissues.
REFERENCE   7  (bases 1 to 1676)
  AUTHORS   Linden,D.R., Furne,J., Stoltz,G.J., Abdel-Rehim,M.S., Levitt,M.D.
            and Szurszewski,J.H.
  TITLE     Sulphide quinone reductase contributes to hydrogen sulphide
            metabolism in murine peripheral tissues but not in the CNS
  JOURNAL   Br J Pharmacol 165 (7), 2178-2190 (2012)
   PUBMED   21950400
  REMARK    GeneRIF: Levels of mRNA encoding SQR were higher in the colonic
            muscularis externa and the liver than in the brain.
REFERENCE   8  (bases 1 to 1676)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   9  (bases 1 to 1676)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1676)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075598.1 and BP772838.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011153.1, AK075598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1658              AK075598.1         2-1659
            1659-1676           BP772838.1         32-49               c
FEATURES             Location/Qualifiers
     source          1..1676
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.67 cM"
     gene            1..1676
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /note="sulfide quinone oxidoreductase"
                     /db_xref="GeneID:59010"
                     /db_xref="MGI:MGI:1929899"
     exon            1..81
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            82..332
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1451
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /EC_number="1.8.5.8"
                     /note="flavo-binding protein; sulfide quinone
                     reductase-like"
                     /codon_start=1
                     /product="sulfide:quinone oxidoreductase, mitochondrial"
                     /protein_id="NP_001155975.1"
                     /db_xref="CCDS:CCDS16669.1"
                     /db_xref="GeneID:59010"
                     /db_xref="MGI:MGI:1929899"
                     /translation="MAPLVTVVSSPRARLFACFLRLGTQQAGPLQLHTGACCTAKNHY
                     EVLVLGGGAGGITMATRMKRRVGAENVAIVEPSERHFYQPIWTLVGAGAKELSLSVRS
                     TLSVIPSGVQWIQDRVAELNPDENCIRTDSGKEISYRYLIIALGIQLDYEKIKGLPEG
                     FAYPKIGSNYSVKTVEKTWKALQGFKEGNALFTFPNTPVKCAGAPQKIMYLSEAYFRK
                     TGKRPKANIIFNTALGTIFGVKKYADALQEIIRERDVSVNYKHNLIEVRPDKQEAVFE
                     ILDKPGETHVIPYEMLHVTPPMSAPDVLKRSPVADSAGWVDVDKETLQHKKYPNVFGI
                     GDCTNLPTSKTAAAVAAQSGILDRTMCLIMKNQRPIKKYDGYTSCPLVTGYNRVILAE
                     FDYTAQPLETFPFDQSKERITMYLMKADMMPFLYWNMMLRGYWGGPAFLRKLFHLGMN
                     "
     exon            333..503
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            504..557
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            558..752
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            753..962
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1146
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1214
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1393
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1666
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /note="hexamer: AATAAA"
     polyA_site      1666
                     /gene="Sqor"
                     /gene_synonym="0610039J17Rik; 4930557M22Rik; Sqrdl"
                     /note="major polyA site"
ORIGIN      
        1 ggggctatgc gaggccagcg ctccagcgcc acagtagttt ctgctgcgcc agcgctgggg
       61 cccacggtgt cgctcagccc gcctgatcta tcctggtgat ggccccactg gtcactgttg
      121 tctccagtcc acgtgcccgg ctctttgcct gttttcttag gctgggcact cagcaggccg
      181 gacccctcca attgcataca ggagcctgct gcacagccaa gaaccactat gaggtgctgg
      241 tacttggtgg gggagctgga gggatcacca tggccactcg aatgaagagg agagttggag
      301 cagagaatgt ggccattgtt gaacccagtg agaggcactt ctaccagcca atctggacac
      361 tagtgggcgc gggtgccaaa gagttgtcct tgtcagtccg ttccacactg agtgtgattc
      421 catccggagt gcagtggatt caagatagag tggcggaact taacccagac gagaactgta
      481 tccgcacaga cagtggcaag gagatctcct acagatacct tatcatcgct cttggaatcc
      541 agctggacta tgagaagatt aaaggactac ctgaaggctt tgcttatccc aaaatagggt
      601 ccaattactc agtgaagaca gtggagaaga catggaaggc cctgcagggt ttcaaggaag
      661 gcaatgccct tttcaccttc ccaaacactc cggtgaagtg tgctggtgcc ccccagaaga
      721 tcatgtacct atcagaagcc tacttcagga agactggaaa gcgacccaag gcaaacatca
      781 tcttcaacac agctttagga acaatttttg gagttaagaa gtatgcagat gccttgcagg
      841 agatcattcg ggagagggac gtctctgtca actataagca caaccttatt gaggtccgac
      901 ctgacaagca ggaggccgtt tttgagatcc tggacaagcc tggggagacg catgtgattc
      961 cttatgaaat gcttcatgtc acaccaccta tgagtgcacc agatgtcctc aagaggagtc
     1021 ctgtggctga ttctgctggc tgggtggacg tggacaaaga gactctgcag cataagaaat
     1081 acccgaatgt gtttggcatt ggggactgca ccaatcttcc aacttcaaag actgctgctg
     1141 cagtagctgc ccagtctgga atccttgata gaacaatgtg tctgattatg aagaaccaaa
     1201 gacccataaa aaagtatgat ggttatacct cgtgcccact ggtaactggc tacaaccgag
     1261 tgattcttgc tgagtttgac tacacagctc agcccctgga aaccttccct tttgatcaga
     1321 gtaaagagcg aattactatg tacctaatga aggctgacat gatgccattc ctgtactgga
     1381 atatgatgct cagaggctac tggggaggtc cagccttctt gcgaaagctg tttcatctgg
     1441 gcatgaatta aagatggctc acagcttgct tttcttggat ggcttctgga tcaaaatcgc
     1501 agttactgat tgacatgaca gatacaaagg actcagaacc tcacccttta aggaggttgg
     1561 acatggtgac ctttctaggc ctctgaatag ctatcatgtg gacaacccag aacgagtctt
     1621 tggaaacatc caagtgaaat aataaaactc tattttctaa ataaaaaaaa aaaaaa
//
