LOCUS       NM_030237               1602 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus spermatogenic leucine zipper 1 (Spz1), mRNA.
ACCESSION   NM_030237
VERSION     NM_030237.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1602)
  AUTHORS   Nguyen,T.T.T., Tokuhiro,K., Shimada,K., Wang,H., Mashiko,D.,
            Tonai,S., Kiyozumi,D. and Ikawa,M.
  TITLE     Gene-deficient mouse model established by CRISPR/Cas9 system
            reveals 15 reproductive organ-enriched genes dispensable for male
            fertility
  JOURNAL   Front Cell Dev Biol 12, 1411162 (2024)
   PUBMED   38835510
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1602)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1602)
  AUTHORS   Lu,Y., Liao,S., Tu,W., Yang,B., Liu,S., Pei,X., Tao,D., Lu,Y.,
            Ma,Y., Yang,Y. and Liu,Y.
  TITLE     DNA demethylation facilitates the specific transcription of the
            mouse X-linked Tsga8 gene in round spermatidsdagger
  JOURNAL   Biol Reprod 100 (4), 994-1007 (2019)
   PUBMED   30541061
REFERENCE   4  (bases 1 to 1602)
  AUTHORS   Wang,L.T., Wang,S.N., Chiou,S.S., Liu,K.Y., Chai,C.Y., Chiang,C.M.,
            Huang,S.K., Yokoyama,K.K. and Hsu,S.H.
  TITLE     TIP60-dependent acetylation of the SPZ1-TWIST complex promotes
            epithelial-mesenchymal transition and metastasis in liver cancer
  JOURNAL   Oncogene 38 (4), 518-532 (2019)
   PUBMED   30154425
REFERENCE   5  (bases 1 to 1602)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 1602)
  AUTHORS   Hsu,S.H., Hsieh-Li,H.M., Huang,H.Y., Huang,P.H. and Li,H.
  TITLE     bHLH-zip transcription factor Spz1 mediates mitogen-activated
            protein kinase cell proliferation, transformation, and
            tumorigenesis
  JOURNAL   Cancer Res 65 (10), 4041-4050 (2005)
   PUBMED   15899793
REFERENCE   7  (bases 1 to 1602)
  AUTHORS   Hrabchak,C. and Varmuza,S.
  TITLE     Identification of the spermatogenic zip protein Spz1 as a putative
            protein phosphatase-1 (PP1) regulatory protein that specifically
            binds the PP1cgamma2 splice variant in mouse testis
  JOURNAL   J Biol Chem 279 (35), 37079-37086 (2004)
   PUBMED   15226296
  REMARK    GeneRIF: the interaction between Spz1 and PP1cgamma2 may be
            required for proper regulation of spermatogenesis and fertility in
            males
REFERENCE   8  (bases 1 to 1602)
  AUTHORS   Hsu,S.H., Hsieh-Li,H.M. and Li,H.
  TITLE     Dysfunctional spermatogenesis in transgenic mice overexpressing
            bHLH-Zip transcription factor, Spz1
  JOURNAL   Exp Cell Res 294 (1), 185-198 (2004)
   PUBMED   14980513
  REMARK    GeneRIF: Spz1 has a regulatory role during spermatogenesis.
REFERENCE   9  (bases 1 to 1602)
  AUTHORS   Hsu,S.H., Shyu,H.W., Hsieh-Li,H.M. and Li,H.
  TITLE     Spz1, a novel bHLH-Zip protein, is specifically expressed in testis
  JOURNAL   Mech Dev 100 (2), 177-187 (2001)
   PUBMED   11165476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154363.2, AK006437.2 and AF271697.1.
            
            On Jun 30, 2009 this sequence version replaced NM_030237.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC050748.1, AK006437.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC154363.2         2977-3014
            39-266              AK006437.2         1-228
            267-1403            AF271697.1         1-1137
            1404-1599           AK006437.2         1366-1561
            1600-1602           AC154363.2         4576-4578
FEATURES             Location/Qualifiers
     source          1..1602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 47.75 cM"
     gene            1..1602
                     /gene="Spz1"
                     /gene_synonym="1700027M20Rik"
                     /note="spermatogenic leucine zipper 1"
                     /db_xref="GeneID:79401"
                     /db_xref="MGI:MGI:1930801"
     exon            1..1602
                     /gene="Spz1"
                     /gene_synonym="1700027M20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1403
                     /gene="Spz1"
                     /gene_synonym="1700027M20Rik"
                     /note="bhlh-zip transcription factor SPZ1; spermatogenic
                     Zip 1"
                     /codon_start=1
                     /product="spermatogenic leucine zipper protein 1"
                     /protein_id="NP_084513.3"
                     /db_xref="CCDS:CCDS26683.1"
                     /db_xref="GeneID:79401"
                     /db_xref="MGI:MGI:1930801"
                     /translation="MSDTDNSAEMPARCPSPNPAPGAKQEPPNSGITISLLEIGSLPT
                     VCYHSFPPPKNSICPVEKRGRVQKFSNLLKDVKDVLKNIAGVEEKSTVGEPFDDAYIP
                     EDLSELNVRGVEKKNKIRFKDDLFIHFDPEREQNTMKQMLLKNQSAKNMVPKFARDLC
                     NAEETRGFDGMLLSVKRPRNGSLHLRGEYRKLRNNMEQLLQEADHWSKQHNELSELMR
                     SYQECQNETQETTDKDRACLQNQPNNGLSTKQKLEEQVKKLSHDTHALHLIAALLENE
                     CQVLQQRVDILKDFHLHEAGLGHEKPLQMSCEQDKKCPKLAEADKTDAFKHTTRATEG
                     TIRKPKILRSPDVCFTKKARNNRFNARVAKKSLVGKRRTVSSFR"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spz1"
                     /gene_synonym="1700027M20Rik"
                     /note="hexamer: AACAAG"
     polyA_site      1602
                     /gene="Spz1"
                     /gene_synonym="1700027M20Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcaatgaca gaataaagac ctagtagctg gggcctcaga gaaaatacca gaagcctagc
       61 agaagggaga tggagctcca gctccaggtc ccccttccca cctcctcccc ctgggctgtc
      121 tgagatgtaa ccttctacct gaataccacc tccctggggt cagtcattaa ctctggccca
      181 taactcctgc ctggttccat ctcctccacc gactcccagg agactgccat ctgctctccc
      241 tggactctct gggtcctcag gtcccaatgt cggacacaga caactcagcg gagatgcccg
      301 cccggtgtcc atctcctaac cctgctcctg gtgctaagca agaaccaccg aactctggga
      361 tcaccatttc cctccttgaa atcggatcac tccccactgt ctgctaccac tccttcccac
      421 caccaaagaa tagcatctgt ccagtagaga aaagagggag ggtacagaaa tttagcaatc
      481 tcttaaaaga cgttaaggat gttctcaaaa acatagcagg cgttgaagag aagtctacag
      541 ttggggagcc ttttgatgat gcctatattc ctgaagacct gtcagaactt aacgtcagag
      601 gtgttgagaa gaaaaataaa atacgattta aagatgatct attcattcat ttcgacccag
      661 agagagaaca gaacacaatg aagcagatgt tattgaaaaa ccagagtgct aagaacatgg
      721 taccaaagtt tgcaagggac ctgtgcaatg cagaagaaac gagaggcttc gacggcatgc
      781 tgctgagcgt gaaaagaccg cggaatggat cccttcacct tcgcggagag tacagaaaac
      841 tcaggaacaa catggagcag ttactgcagg aagcagatca ctggagtaaa cagcataacg
      901 aactcagcga actaatgagg tcatatcagg aatgccagaa cgaaacccaa gaaactactg
      961 acaaggatcg agcctgtttg caaaaccaac ccaacaatgg gctatccacc aagcagaagc
     1021 tggaggagca ggtgaagaag ctaagccatg acacccacgc gctgcatttg atcgcagccc
     1081 tgctagagaa tgaatgtcag gtcctacaac agagggtaga catcctcaag gatttccatc
     1141 tccacgaagc gggactgggg cacgagaagc ctttgcagat gtcctgtgag caggacaaga
     1201 aatgtccgaa gttagcggaa gcagacaaga cggacgcttt caagcatacc acgagggcaa
     1261 cggaaggcac gattaggaaa ccgaagatcc tcaggagccc ggatgtttgc tttactaaga
     1321 aggctcggaa taaccgcttc aacgcccgtg ttgcaaagaa atctctggtg gggaaaagga
     1381 gaaccgttag cagctttcgg tagaagtcgc cagaagcaga tacaacttga gacaaaactg
     1441 tcatcaaccc agggtagaga gcttctgatt ccaccaagga ggaggcctag gataagagga
     1501 acctatatta tctcagtagt tagagaagtt tgggccttaa caaccattgt atgaccgtta
     1561 accaagtgaa aatttgaata aaaacaagaa tataaaagga aa
//
