LOCUS       NP_001229274             118 aa            linear   ROD 17-SEP-2024
DEFINITION  spexin isoform 1 precursor [Mus musculus].
ACCESSION   NP_001229274 XP_620381 XP_913145
VERSION     NP_001229274.1
DBSOURCE    REFSEQ: accession NM_001242345.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 118)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (residues 1 to 118)
  AUTHORS   Li,D., Liu,Y., Li,C., Zhou,Z., Gao,K., Bao,H., Yang,J., Xue,G.,
            Yin,D., Zhao,X., Shen,K., Zhang,L., Li,J., Li,C., Song,J., Zhao,L.,
            Pei,Y., Xuan,L., Zhang,Y., Lu,Y., Zhang,Z.R., Yang,B., Li,Y. and
            Pan,Z.
  TITLE     Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on
            Galanin Receptor 2
  JOURNAL   Circulation 150 (2), 111-127 (2024)
   PUBMED   38726666
  REMARK    GeneRIF: Spexin Diminishes Atrial Fibrillation Vulnerability by
            Acting on Galanin Receptor 2.
REFERENCE   3  (residues 1 to 118)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 118)
  AUTHORS   Chen,Y., He,M., Lei,M.M.L., Ko,W.K.W., Lin,C., Bian,Z. and
            Wong,A.O.L.
  TITLE     Mouse Spexin: (III) Differential Regulation by Glucose and Insulin
            in Glandular Stomach and Functional Implication in Feeding Control
  JOURNAL   Front Endocrinol (Lausanne) 12, 681648 (2021)
   PUBMED   34025589
  REMARK    GeneRIF: Mouse Spexin: (III) Differential Regulation by Glucose and
            Insulin in Glandular Stomach and Functional Implication in Feeding
            Control.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 118)
  AUTHORS   Zhuang,M., Lai,Q., Yang,C., Ma,Y., Fan,B., Bian,Z., Lin,C., Bai,J.
            and Zeng,G.
  TITLE     Spexin as an anxiety regulator in mouse hippocampus: Mechanisms for
            transcriptional regulation of spexin gene expression by
            corticotropin releasing factor
  JOURNAL   Biochem Biophys Res Commun 525 (2), 326-333 (2020)
   PUBMED   32093887
  REMARK    GeneRIF: Spexin as an anxiety regulator in mouse hippocampus:
            Mechanisms for transcriptional regulation of spexin gene expression
            by corticotropin releasing factor.
REFERENCE   6  (residues 1 to 118)
  AUTHORS   Walewski,J.L., Ge,F., Lobdell,H. 4th, Levin,N., Schwartz,G.J.,
            Vasselli,J.R., Pomp,A., Dakin,G. and Berk,P.D.
  TITLE     Spexin is a novel human peptide that reduces adipocyte uptake of
            long chain fatty acids and causes weight loss in rodents with
            diet-induced obesity
  JOURNAL   Obesity (Silver Spring) 22 (7), 1643-1652 (2014)
   PUBMED   24550067
  REMARK    GeneRIF: Spexin is a novel hormone involved in weight regulation,
            with potential for obesity therapy.
REFERENCE   7  (residues 1 to 118)
  AUTHORS   Toll,L., Khroyan,T.V., Sonmez,K., Ozawa,A., Lindberg,I.,
            McLaughlin,J.P., Eans,S.O., Shahien,A.A. and Kapusta,D.R.
  TITLE     Peptides derived from the prohormone proNPQ/spexin are potent
            central modulators of cardiovascular and renal function and
            nociception
  JOURNAL   FASEB J 26 (2), 947-954 (2012)
   PUBMED   22038051
  REMARK    GeneRIF: newly identified peptides derived from the NPQ/spexin
            precursor contribute to CNS-mediated control of arterial blood
            pressure and salt and water balance and modulate nociceptive
            responses
REFERENCE   8  (residues 1 to 118)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   9  (residues 1 to 118)
  AUTHORS   Sonmez,K., Zaveri,N.T., Kerman,I.A., Burke,S., Neal,C.R., Xie,X.,
            Watson,S.J. and Toll,L.
  TITLE     Evolutionary sequence modeling for discovery of peptide hormones
  JOURNAL   PLoS Comput Biol 5 (1), e1000258 (2009)
   PUBMED   19132080
REFERENCE   10 (residues 1 to 118)
  AUTHORS   Mirabeau,O., Perlas,E., Severini,C., Audero,E., Gascuel,O.,
            Possenti,R., Birney,E., Rosenthal,N. and Gross,C.
  TITLE     Identification of novel peptide hormones in the human proteome by
            hidden Markov model screening
  JOURNAL   Genome Res 17 (3), 320-327 (2007)
   PUBMED   17284679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142413.4, AK043509.1, AK045625.1 and BG092156.1.
            
            On or before Jul 5, 2012 this sequence version replaced
            XP_913145.3, XP_620381.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..118
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 74.03 cM"
     Protein         1..118
                     /product="spexin isoform 1 precursor"
                     /note="neuropeptide Q"
                     /calculated_mol_wt=10581
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2569
     Region          27..118
                     /region_name="Spexin"
                     /note="Neuropeptide secretory protein family, NPQ, spexin;
                     pfam15171"
                     /db_xref="CDD:464543"
     Site            35..36
                     /site_type="cleavage"
                     /note="Cleavage, by prohormone convertase 2.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (D3Z752.1)"
     mat_peptide     36..49
                     /product="Spexin-1. /id=PRO_0000430218"
                     /note="propagated from UniProtKB/Swiss-Prot (D3Z752.1)"
                     /calculated_mol_wt=1621
     Site            49
                     /site_type="amidation"
                     /note="Glutamine amide. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (D3Z752.1)"
     Region          52..77
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (D3Z752.1)"
     Site            52..53
                     /site_type="cleavage"
                     /note="Cleavage, by prohormone convertase 2.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (D3Z752.1)"
     mat_peptide     53..70
                     /product="Spexin-2. /id=PRO_0000430220"
                     /note="propagated from UniProtKB/Swiss-Prot (D3Z752.1)"
                     /calculated_mol_wt=2141
     Site            72..73
                     /site_type="cleavage"
                     /note="Cleavage, by prohormone convertase 2.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (D3Z752.1)"
     CDS             1..118
                     /gene="Spx"
                     /gene_synonym="B230216G23Rik; Npq"
                     /coded_by="NM_001242345.1:11..367"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS85181.1"
                     /db_xref="GeneID:319552"
                     /db_xref="MGI:MGI:2442262"
ORIGIN      
        1 mkgpsvlavt avvlllvlsa lenssgapqr lsekrnwtpq amlylkgaqg rrflsdqsrr
       61 keladrpppe rrnpdlellt lpeaaalfla sleksqkgad eggnfdksel ledrlfnw
//
