LOCUS       NM_133675               1753 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus serine palmitoyltransferase, small subunit B (Sptssb),
            transcript variant 2, mRNA.
ACCESSION   NM_133675
VERSION     NM_133675.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1753)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1753)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1753)
  AUTHORS   Zhao,L., Spassieva,S., Gable,K., Gupta,S.D., Shi,L.Y., Wang,J.,
            Bielawski,J., Hicks,W.L., Krebs,M.P., Naggert,J., Hannun,Y.A.,
            Dunn,T.M. and Nishina,P.M.
  TITLE     Elevation of 20-carbon long chain bases due to a mutation in serine
            palmitoyltransferase small subunit b results in neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 112 (42), 12962-12967 (2015)
   PUBMED   26438849
REFERENCE   4  (bases 1 to 1753)
  AUTHORS   Lau,C.G. and Marikawa,Y.
  TITLE     Morphology-based mammalian stem cell tests reveal potential
            developmental toxicity of donepezil
  JOURNAL   Mol Reprod Dev 81 (11), 994-1008 (2014)
   PUBMED   25269881
REFERENCE   5  (bases 1 to 1753)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1753)
  AUTHORS   Han,G., Gupta,S.D., Gable,K., Niranjanakumari,S., Moitra,P.,
            Eichler,F., Brown,R.H. Jr., Harmon,J.M. and Dunn,T.M.
  TITLE     Identification of small subunits of mammalian serine
            palmitoyltransferase that confer distinct acyl-CoA substrate
            specificities
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8186-8191 (2009)
   PUBMED   19416851
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9931]
REFERENCE   7  (bases 1 to 1753)
  AUTHORS   Singh,J., Young,L., Handelsman,D.J. and Dong,Q.
  TITLE     Molecular cloning and characterization of a novel androgen
            repressible gene expressed in the prostate epithelium
  JOURNAL   Gene 348, 55-63 (2005)
   PUBMED   15777716
  REMARK    GeneRIF: ADMP (androgen down regulated gene expressed in mouse
            prostate) expression appears to be androgen-dependent in the kidney
            and brain of normal intact mouse suggesting tissue specific
            regulation by androgens.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004017.1, AC122009.2 and BC022628.1.
            
            On Nov 23, 2013 this sequence version replaced NM_133675.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022628.1, AK004017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AK004017.1         2-28
            28-29               AC122009.2         35207-35208
            30-584              AK004017.1         32-586
            585-978             AC122009.2         74368-74761
            979-1744            AK004017.1         975-1740
            1745-1753           BC022628.1         1725-1733
FEATURES             Location/Qualifiers
     source          1..1753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 32.3 cM"
     gene            1..1753
                     /gene="Sptssb"
                     /gene_synonym="1110032A04Rik; ADMP; Sssptb"
                     /note="serine palmitoyltransferase, small subunit B"
                     /db_xref="GeneID:66183"
                     /db_xref="MGI:MGI:1913433"
     exon            1..64
                     /gene="Sptssb"
                     /gene_synonym="1110032A04Rik; ADMP; Sssptb"
                     /inference="alignment:Splign:2.1.0"
     exon            65..159
                     /gene="Sptssb"
                     /gene_synonym="1110032A04Rik; ADMP; Sssptb"
                     /inference="alignment:Splign:2.1.0"
     exon            160..1753
                     /gene="Sptssb"
                     /gene_synonym="1110032A04Rik; ADMP; Sssptb"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..419
                     /gene="Sptssb"
                     /gene_synonym="1110032A04Rik; ADMP; Sssptb"
                     /note="isoform a is encoded by transcript variant 2;
                     androgen down regulated in mouse prostate; small subunit
                     of serine palmitoyltransferase B"
                     /codon_start=1
                     /product="serine palmitoyltransferase small subunit B
                     isoform a"
                     /protein_id="NP_598436.1"
                     /db_xref="CCDS:CCDS38453.1"
                     /db_xref="GeneID:66183"
                     /db_xref="MGI:MGI:1913433"
                     /translation="MDFKRVKEYFAWLYYQYQIITCCAVMEPWEQSMLNTIILTIVAM
                     VVYTAYVFIPIHIRLAWEFFSKICGYDSSISN"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sptssb"
                     /gene_synonym="1110032A04Rik; ADMP; Sssptb"
                     /note="hexamer: AATGAA"
     polyA_site      1753
                     /gene="Sptssb"
                     /gene_synonym="1110032A04Rik; ADMP; Sssptb"
                     /note="major polyA site"
ORIGIN      
        1 acagtgacaa gctaacagaa gctggggaga agccagagca tctaagctca ttctaaggca
       61 ggagacgaag aaataaagcc cagagaggag aaataatcta caccagattg ttcagaggaa
      121 aagcatcacc gagtaccaag cctggatact cctgcacagg cagacttttc ccagcttaag
      181 gaagagccat ggatttcaag cgcgtgaagg agtattttgc ctggctctat tatcaatacc
      241 agatcatcac ctgctgtgct gtcatggagc cttgggaaca atcgatgctc aacaccatca
      301 tactgaccat tgtggctatg gtggtataca ctgcctatgt cttcatcccc atccacatcc
      361 gcctggcttg ggaatttttc tccaaaatat gtggctatga cagttccatt tctaactgat
      421 ctcatctgaa ttcggtgaaa gggcataacg tgttcacatt gcttacaact tactgacttg
      481 ggtgaccgta tcatctttca cctctgacct gaccagcact ctctctatgc actgtcccgc
      541 acatcctgcc tggagtatga gataggtttt cccccacttg cttttgtaca tgcaatattg
      601 tgcatcaggt gatagaaaag gcgatgactt taaccccata gcccacattt gctcaactct
      661 atggctttag gtttcttttg aaatcaggat gctttgaaat aaaacttttc tggaaaatag
      721 gcttataaga gacatgacaa agtcatattt acactactct cttcatatta ttctatacta
      781 aaggatatgt tacaaaagta ttcttcatag gctactgtca aaagtaccct gaacttgttt
      841 acaatttatt aaaagatggg aataaataga tgaaccttta aagtcttatt ttctgggaaa
      901 tagctaatac ctaaaattcg tttcttcttc ttttttaaat tttcattttc tttgctttag
      961 ctaaaattct tttagtttaa agtaacaggc cagagacagt tatcttttct tcagattttg
     1021 tttcagcatc gtttcaaatg ctcctgaaat ctagctttat tacagcttta aaggaatgac
     1081 ttttttttcc cctaggtaaa caaataacta ttatacgaga gaataattta agtttaagaa
     1141 acaaaggata atcaaagcaa attcagatac tgtgactttg gatcacgccc cactttacat
     1201 gatgctggag acagaagaag agagattgtt gttttgctgt gccttcagtg aaaggaaggg
     1261 aagctgtgtg tcctaggcta caggaagaaa agctaataaa taggctggaa gtaatagcca
     1321 ggcagcaggg agtcgggagc tccagttaaa ggctttgata tagcagctcc tttgcacagc
     1381 agaaacaaaa tttattaaat ttctctcaaa atgtttatct tcaaagcaga tgtaagattt
     1441 taattatagt gctgagtcaa acataaaagc caaagaccaa gccttgcagc ttttctttcc
     1501 tctcaataaa tattaacatt agtgattctg gtaaaataaa taaataaatg aaccggcttt
     1561 ggacaatatt ggcacctttg ttttaggaga gaaatcttcc aagtagacat ccaaagaaag
     1621 atatttggca cgcaaaaatc aacctgcatg tctgtttaaa aaaacataat gtacatttta
     1681 aagagaaacc agatatgaaa tatatactta ctgatttttg caaaataaaa tgaagtttac
     1741 ttttataagc aaa
//
