LOCUS       NM_134054               1363 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus serine palmitoyltransferase, small subunit A (Sptssa),
            mRNA.
ACCESSION   NM_134054
VERSION     NM_134054.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Parthibane,V., Lin,J., Acharya,D., Abimannan,T., Srideshikan,S.M.,
            Klarmann,K., Yang,A., Soheilian,F., Nagashima,K., Fox,S.D.,
            Andresson,T., Tessarollo,L., Keller,J.R., Acharya,U. and
            Acharya,J.K.
  TITLE     SSSPTA is essential for serine palmitoyltransferase function during
            development and hematopoiesis
  JOURNAL   J Biol Chem 296, 100491 (2021)
   PUBMED   33662400
  REMARK    GeneRIF: SSSPTA is essential for serine palmitoyltransferase
            function during development and hematopoiesis.
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1363)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1363)
  AUTHORS   Siow,D., Sunkara,M., Dunn,T.M., Morris,A.J. and Wattenberg,B.
  TITLE     ORMDL/serine palmitoyltransferase stoichiometry determines effects
            of ORMDL3 expression on sphingolipid biosynthesis
  JOURNAL   J Lipid Res 56 (4), 898-908 (2015)
   PUBMED   25691431
REFERENCE   7  (bases 1 to 1363)
  AUTHORS   Lau,C.G. and Marikawa,Y.
  TITLE     Morphology-based mammalian stem cell tests reveal potential
            developmental toxicity of donepezil
  JOURNAL   Mol Reprod Dev 81 (11), 994-1008 (2014)
   PUBMED   25269881
REFERENCE   8  (bases 1 to 1363)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 1363)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   10 (bases 1 to 1363)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY072251.1, AK003171.1 and BG091867.1.
            
            On Sep 7, 2006 this sequence version replaced NM_134054.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY093376.1, AK137543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BY072251.1         2-65
            65-1332             AK003171.1         2-1269
            1333-1363           BG091867.1         6-36                c
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 23.46 cM"
     gene            1..1363
                     /gene="Sptssa"
                     /gene_synonym="1110002B05Rik; Ssspta"
                     /note="serine palmitoyltransferase, small subunit A"
                     /db_xref="GeneID:104725"
                     /db_xref="MGI:MGI:1913399"
     exon            1..201
                     /gene="Sptssa"
                     /gene_synonym="1110002B05Rik; Ssspta"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..305
                     /gene="Sptssa"
                     /gene_synonym="1110002B05Rik; Ssspta"
                     /note="small subunit of serine palmitoyltransferase A"
                     /codon_start=1
                     /product="serine palmitoyltransferase small subunit A"
                     /protein_id="NP_598815.2"
                     /db_xref="CCDS:CCDS36445.1"
                     /db_xref="GeneID:104725"
                     /db_xref="MGI:MGI:1913399"
                     /translation="MAGMALARAWKQMSWFYYQYLLVTALYMLEPWERTVFNSMLVSV
                     VGMALYTGYVFMPQHIMAILHYFEIVQ"
     exon            202..1363
                     /gene="Sptssa"
                     /gene_synonym="1110002B05Rik; Ssspta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sptssa"
                     /gene_synonym="1110002B05Rik; Ssspta"
                     /note="hexamer: ATTAAA"
     polyA_site      1345
                     /gene="Sptssa"
                     /gene_synonym="1110002B05Rik; Ssspta"
                     /note="major polyA site"
ORIGIN      
        1 gggtggtggc gggcgggccc caaggcctgg ggctttagga ggtgagcggg ccgcgggccc
       61 gcctgacgct gctacaccgc gggaggcgca tggcgggcat ggcgctggcg cgagcatgga
      121 agcagatgtc ctggttctac taccagtacc tgctggtcac tgcgctctac atgctggagc
      181 cctgggagcg aaccgtgttc aattcgatgc tggtttccgt ggtggggatg gccctgtaca
      241 ctggctacgt cttcatgccc cagcacatca tggctattct gcattacttt gaaattgtac
      301 agtgacgaag atgtgaccag gatccagagg ttcctgggga agatctgcct tgtgaagttg
      361 gaatgagacc tcatcagatg taagatgtgc tacggatgtc cacgtgacca accttataaa
      421 tacaaagact ttaaaaaaaa cttcatgagt agaacaggaa aaatcatcct ggctcatgtg
      481 ttgtgttctt tctttttgat tttaacagag gctcttatat agtagctttt atctatttta
      541 acattgtagt catttgtact ttgatatcag tattttctta acctttgtga ctgtttcaat
      601 attatccagt gaaagctttt cttaatgtaa ctttgagtac atctcaattg ccttctattt
      661 ttaaaaccta aggtcattag ttgggcttta ctgttcttgc tatcatatgg catatacatc
      721 tgcctggata tatttctact cttgaccaaa gttttgtaag aaacaataca gaatttgggg
      781 acgggaggga ggatactttg agaactactt acaaaagatt tatctgcttg cttgaactca
      841 ggagtacggt tttagctccc tagactctta acagcttttg ctctaaaact attaaagtgt
      901 ttcttagtaa tgaaaaagta aagatcttgc taacattaat acaaggaaca tttcaccttt
      961 tagatattaa attcttatgt ggacttattt ccaaccaact ttgatgattc ctgtgattgg
     1021 tgattggtgg ccggcttgta tgacatatgc tgagatacac tgtggagctt ttcatagaag
     1081 gcttatcaga tcctctgagg cagtattgac cctgtatacg ctcaagagtt aatttgatgt
     1141 tgtaacaggc gttgtgaaat gcatttgcac gttgtgataa agacacaatg agatgaattg
     1201 tgcagaacca taaccaaaag aaatgtaaac ttgcttaaaa atcctttcac tctttgtatt
     1261 ttttttaaaa cggtttttat tccttagatg taaaatgact actttttttt ttgatgtaaa
     1321 ctcattaaat tcaaagaaaa atgtagcagt ctcttttatg gtt
//
