LOCUS       NM_009269               2601 bp    mRNA    linear   ROD 12-NOV-2023
DEFINITION  Mus musculus serine palmitoyltransferase, long chain base subunit 1
            (Sptlc1), mRNA.
ACCESSION   NM_009269
VERSION     NM_009269.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Butera A, Agostini M, Cassandri M, De Nicola F, Fanciulli M,
            D'Ambrosio L, Falasca L, Nardacci R, Wang L, Piacentini M, Knight
            RA, Jia W, Sun Q, Shi Y, Wang Y, Candi E and Melino G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   Hines TJ, Tadenev ALD, Lone MA, Hatton CL, Bagasrawala I, Stum MG,
            Miers KE, Hornemann T and Burgess RW.
  TITLE     Precision mouse models of Yars/dominant intermediate
            Charcot-Marie-Tooth disease type C and Sptlc1/hereditary sensory
            and autonomic neuropathy type 1
  JOURNAL   J Anat 241 (5), 1169-1185 (2022)
   PUBMED   34875719
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   Kuo A, Checa A, Niaudet C, Jung B, Fu Z, Wheelock CE, Singh SA,
            Aikawa M, Smith LE, Proia RL and Hla T.
  TITLE     Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is
            required for vascular development and systemic sphingolipid
            homeostasis
  JOURNAL   Elife 11, e78861 (2022)
   PUBMED   36197001
  REMARK    GeneRIF: Murine endothelial serine palmitoyltransferase 1 (SPTLC1)
            is required for vascular development and systemic sphingolipid
            homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Alexaki A, Clarke BA, Gavrilova O, Ma Y, Zhu H, Ma X, Xu L,
            Tuymetova G, Larman BC, Allende ML, Dunn TM and Proia RL.
  TITLE     De Novo Sphingolipid Biosynthesis Is Required for Adipocyte
            Survival and Metabolic Homeostasis
  JOURNAL   J Biol Chem 292 (9), 3929-3939 (2017)
   PUBMED   28100772
  REMARK    GeneRIF: mice with an adipocyte-specific deletion of Sptlc1 show
            that de novo sphingolipid biosynthesis is required for adipocyte
            cell viability and normal metabolic function and that reduced de
            novo sphingolipid biosynthesis within adipocytes is associated with
            adipocyte death, adipose tissue remodeling, and metabolic
            dysfunction
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Cantalupo A, Zhang Y, Kothiya M, Galvani S, Obinata H, Bucci M,
            Giordano FJ, Jiang XC, Hla T and Di Lorenzo A.
  TITLE     Nogo-B regulates endothelial sphingolipid homeostasis to control
            vascular function and blood pressure
  JOURNAL   Nat Med 21 (9), 1028-1037 (2015)
   PUBMED   26301690
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   McCampbell A, Truong D, Broom DC, Allchorne A, Gable K, Cutler RG,
            Mattson MP, Woolf CJ, Frosch MP, Harmon JM, Dunn TM and Brown RH
            Jr.
  TITLE     Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase
            activity in vivo and confers an age-dependent neuropathy
  JOURNAL   Hum Mol Genet 14 (22), 3507-3521 (2005)
   PUBMED   16210380
REFERENCE   7  (bases 1 to 2601)
  AUTHORS   Hanada K.
  TITLE     Serine palmitoyltransferase, a key enzyme of sphingolipid
            metabolism
  JOURNAL   Biochim Biophys Acta 1632 (1-3), 16-30 (2003)
   PUBMED   12782147
  REMARK    Review article
            Erratum:[Biochim Biophys Acta. 2004 Jun 1;1682(1-3):128]
REFERENCE   8  (bases 1 to 2601)
  AUTHORS   Hanada K, Hara T, Nishijima M, Kuge O, Dickson RC and Nagiec MM.
  TITLE     A mammalian homolog of the yeast LCB1 encodes a component of serine
            palmitoyltransferase, the enzyme catalyzing the first step in
            sphingolipid synthesis
  JOURNAL   J Biol Chem 272 (51), 32108-32114 (1997)
   PUBMED   9405408
REFERENCE   9  (bases 1 to 2601)
  AUTHORS   Weiss B and Stoffel W.
  TITLE     Human and murine serine-palmitoyl-CoA transferase--cloning,
            expression and characterization of the key enzyme in sphingolipid
            synthesis
  JOURNAL   Eur J Biochem 249 (1), 239-247 (1997)
   PUBMED   9363775
REFERENCE   10 (bases 1 to 2601)
  AUTHORS   Mandon EC, Ehses I, Rother J, van Echten G and Sandhoff K.
  TITLE     Subcellular localization and membrane topology of serine
            palmitoyltransferase, 3-dehydrosphinganine reductase, and
            sphinganine N-acyltransferase in mouse liver
  JOURNAL   J Biol Chem 267 (16), 11144-11148 (1992)
   PUBMED   1317856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC046323.1.
            
            [WARNING] On Dec 14, 2023 this sequence was replaced by
            NM_009269.3.
            
            On Mar 26, 2003 this sequence version replaced NM_009269.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046323.1, AK079578.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.68 cM"
     gene            1..2601
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /note="serine palmitoyltransferase, long chain base
                     subunit 1"
                     /db_xref="GeneID:268656"
                     /db_xref="MGI:MGI:1099431"
     exon            1..69
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1434
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /EC_number="2.3.1.50"
                     /note="serine-palmitoyl-CoA transferase 1; long chain base
                     biosynthesis protein 1"
                     /codon_start=1
                     /product="serine palmitoyltransferase 1"
                     /protein_id="NP_033295.2"
                     /db_xref="CCDS:CCDS26521.1"
                     /db_xref="GeneID:268656"
                     /db_xref="MGI:MGI:1099431"
                     /translation="MATVAEQWVLVEMVQALYEAPAYHLILEGILILWIIRLVFSKTY
                     KLQERSDLTAKEKEELIEEWQPEPLVPPVSKNHPALNYNIVSGPPTHNIVVNGKECVN
                     FASFNFLGLLANPRVKATAFSSLKKYGVGTCGPRGFYGTFDVHLDLEERLAKFMKTEE
                     AIIYSYGFSTIASAIPAYSKRGDIIFVDSAACFAIQKGLQASRSDIKLFKHNDVADLE
                     RLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEES
                     LSFGVLGEHGRGVTEHYGISIDDIDLISANMENALASVGGFCCGRSFVVDHQRLSGQG
                     YCFSASLPPLLAAAAIEALNIMEENPDIFAVLKKKCQNIHKSLQGVSGLKVVGESLSP
                     ALHLQLEESTGSREKDVKLLQAIVDQCMDKGIALTQARYLDKEEKCLPPPSIRVVVTV
                     EQTEEELQRAASTIREAAQAVLL"
     exon            70..177
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            178..272
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..366
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..439
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..572
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..702
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..792
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..900
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            901..996
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1093
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1148
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1266
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1340
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..2570
                     /gene="Sptlc1"
                     /gene_synonym="E030036H05; Lcb1; SPT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgcctga ccatggcgac agtggcggag cagtgggtgc tggtggagat ggtgcaggcg
       61 ctgtacgagg ctccagcata ccatcttatt ttggaaggaa tcctaatact ttggataatc
      121 agactcgttt tctctaaaac ttacaagttg caggagcgtt ctgatcttac agccaaggaa
      181 aaggaagaac tgattgaaga gtggcagcca gagcccctcg tccctccagt ctccaagaac
      241 caccctgctc tcaactacaa catcgtgtcc ggccctccaa cccacaacat cgtggtgaat
      301 ggaaaagagt gtgtcaactt tgcctccttt aacttccttg ggctgctggc caaccctcga
      361 gttaaggcca cagctttttc atctttaaag aagtacggag tgggtacctg tggtcctcga
      421 gggttctatg gcacatttga tgtccatctg gatttagaag agcgcctggc aaagtttatg
      481 aagaccgaag aagccatcat ttactcgtat ggcttctcca ccatagccag tgccattcct
      541 gcgtactcta agagagggga catcatcttt gtggacagtg cggcctgctt tgctatccag
      601 aaaggattac aggcatcaag aagtgacatt aagttattta agcataatga tgtggctgac
      661 ctggagcgac tgctaaaaga acaagagatt gaagatcaaa agaatcctcg caaggcccgt
      721 gtgactcggc ggttcatcgt ggtggagggc ttgtacatga acactggaac catctgtccc
      781 cttccagaac tggttaaatt aaaatataaa tataaagcaa gaatattcct ggaggagagc
      841 ctgtcctttg gagtccttgg ggagcacggg cgaggagtca ccgagcacta tgggatcagt
      901 attgatgata ttgaccttat cagtgctaac atggagaatg cactcgcttc tgtcgggggc
      961 ttctgctgtg gccgctcctt cgtggttgac catcagcggc tctccggtca aggatactgc
     1021 ttttctgctt cgttacctcc cctgctagct gctgctgcca ttgaggccct caacatcatg
     1081 gaagagaatc cagatatttt tgcagtttta aagaaaaaat gccagaacat ccataagtct
     1141 ctacaaggtg tttcgggttt aaaagtggtg ggagagtccc tttctccggc gcttcatctc
     1201 cagctggaag agagcacggg ctctcgggag aaagatgtga agctgcttca agcaatcgta
     1261 gatcagtgca tggataaggg catcgcattg actcaggcac ggtacttgga caaggaagag
     1321 aagtgccttc ctcctccaag catcagggtt gtggtcactg tggagcagac ggaggaagag
     1381 ctacagaggg ctgcatccac catcagggag gcggcccagg ctgtgctgtt gtaggctcct
     1441 gcccagtgct tcagccatgt cacctgcgga cggaactact cagagacctc cagctgccca
     1501 gggtgtggct gtgcttgaat acacagccag agtggatggt tgtatccagc aggagctgac
     1561 ttgtagagga tgacagatga cagcatatcc ctggtgtttc tgcagtgccg tgtgctctgt
     1621 caggatgctt cactgtcatt tgtattcgct tttgtttaaa actggagctt ccattttccc
     1681 tctgtcgtct gtgggaatga ttcaataagc acttctccgt atccatagaa aaggactttg
     1741 cagctaagag ggactctcca tgtatccagt tactgtggga gactgagaga ctgtgtcctc
     1801 ccctgtcctc aggcagagct cagtggtggc tgctatgcag atactctgtg tgtgttataa
     1861 acgtcataca acatggtgat cctaggactc tatgtgctcc agttactgat actgtcctgt
     1921 ctaatctgag cttcactaac agatcttcat accgcttcct aagcaataat ctgaatcaaa
     1981 cgttatttta tttttgtgta attgacttta tattttttat atattctcta gtcagttttg
     2041 ggaagagggt tattattctg atccccaaat acaaatcatg cccttggtat tttctaatat
     2101 gtccaatgtc ctttttcatg gtggttttgt ccaggagcat agacctgtgg gctttttcta
     2161 agctgagaaa aatgagacct ttcctctttc actctataaa ttccagatgc ctccgaaaaa
     2221 tagggatgct ctaaacgtga tttccgagct ctacactggc tgccgttgtc cttagcgagc
     2281 gtgttgagtg atataaaggc ttgtgacatg tgccacggat cgtgtgcatg gaaggccttc
     2341 tcttgttgca cgggcagagg agtcaggtca tttaaatgtc attttctgat gtgcgttcat
     2401 gtgaaccatg ggtcggcatc ttcttaagtg atctgtgaca tttttaatgt ttctatttca
     2461 tacgtgcctt gtgattgctg ctgctgtgag ggtacactcc tgtcggggaa aagtctgttt
     2521 tggtttggtt tttaatgaaa taaacctcca agagcttaca ttcctgaaaa aaaaaaaaaa
     2581 aaaaaaaaaa aaaaaaaaaa a
//
