LOCUS       NM_021287               9894 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus spectrin beta, non-erythrocytic 2 (Sptbn2), mRNA.
ACCESSION   NM_021287 XM_129130
VERSION     NM_021287.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9894)
  AUTHORS   Stansak,K.L., Baum,L.D., Ghosh,S., Thapa,P., Vanga,V. and
            Walters,B.J.
  TITLE     PCP auto count: a novel Fiji/ImageJ plug-in for automated
            quantification of planar cell polarity and cell counting
  JOURNAL   Front Cell Dev Biol 12, 1394031 (2024)
   PUBMED   38827526
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9894)
  AUTHORS   Goodrich,E.J. and Deans,M.R.
  TITLE     Emx2 lineage tracing reveals antecedent patterns of planar polarity
            in the mouse inner ear
  JOURNAL   Development 151 (10) (2024)
   PUBMED   38682291
REFERENCE   3  (bases 1 to 9894)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 9894)
  AUTHORS   Knapp,L., Sun,H., Wang,Y.M., Chen,B.J., Lin,X., Gao,N., Chen,P. and
            Ren,D.
  TITLE     Rab11a Is Essential for the Development and Integrity of the
            Stereocilia and Kinocilia in the Mammalian Organ of Corti
  JOURNAL   eNeuro 10 (6) (2023)
   PUBMED   37225424
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9894)
  AUTHORS   Hong,Y., Walling,B.L., Kim,H.R., Serratelli,W.S., Lozada,J.R.,
            Sailer,C.J., Amitrano,A.M., Lim,K., Mongre,R.K., Kim,K.D.,
            Capece,T., Lomakina,E.B., Reilly,N.S., Vo,K., Gerber,S.A.,
            Fan,T.C., Yu,A.L., Oakes,P.W., Waugh,R.E., Jun,C.D., Reagan,P.M.
            and Kim,M.
  TITLE     ST3GAL1 and betaII-spectrin pathways control CAR T cell migration
            to target tumors
  JOURNAL   Nat Immunol 24 (6), 1007-1019 (2023)
   PUBMED   37069398
REFERENCE   6  (bases 1 to 9894)
  AUTHORS   Stankewich,M.C., Gwynn,B., Ardito,T., Ji,L., Kim,J., Robledo,R.F.,
            Lux,S.E., Peters,L.L. and Morrow,J.S.
  TITLE     Targeted deletion of betaIII spectrin impairs synaptogenesis and
            generates ataxic and seizure phenotypes
  JOURNAL   Proc Natl Acad Sci U S A 107 (13), 6022-6027 (2010)
   PUBMED   20231455
  REMARK    GeneRIF: betaIII spectrin disruption impairs synaptogenesis by
            disturbing the intracellular pathways selectively regulating
            protein trafficking to the synapse
REFERENCE   7  (bases 1 to 9894)
  AUTHORS   Legendre,K., Safieddine,S., Kussel-Andermann,P., Petit,C. and
            El-Amraoui,A.
  TITLE     alphaII-betaV spectrin bridges the plasma membrane and cortical
            lattice in the lateral wall of the auditory outer hair cells
  JOURNAL   J Cell Sci 121 (Pt 20), 3347-3356 (2008)
   PUBMED   18796539
REFERENCE   8  (bases 1 to 9894)
  AUTHORS   Ogawa,Y., Schafer,D.P., Horresh,I., Bar,V., Hales,K., Yang,Y.,
            Susuki,K., Peles,E., Stankewich,M.C. and Rasband,M.N.
  TITLE     Spectrins and ankyrinB constitute a specialized paranodal
            cytoskeleton
  JOURNAL   J Neurosci 26 (19), 5230-5239 (2006)
   PUBMED   16687515
REFERENCE   9  (bases 1 to 9894)
  AUTHORS   Stankewich,M.C., Tse,W.T., Peters,L.L., Ch'ng,Y., John,K.M.,
            Stabach,P.R., Devarajan,P., Morrow,J.S. and Lux,S.E.
  TITLE     A widely expressed betaIII spectrin associated with Golgi and
            cytoplasmic vesicles
  JOURNAL   Proc Natl Acad Sci U S A 95 (24), 14158-14163 (1998)
   PUBMED   9826670
REFERENCE   10 (bases 1 to 9894)
  AUTHORS   Zagon,I.S., Higbee,R., Riederer,B.M. and Goodman,S.R.
  TITLE     Spectrin subtypes in mammalian brain: an immunoelectron microscopic
            study
  JOURNAL   J Neurosci 6 (10), 2977-2986 (1986)
   PUBMED   3531427
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ119420.1, BC079860.1, AC147618.3 and BE993578.1.
            
            On Jul 24, 2018 this sequence version replaced NM_021287.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147671.1, BC079860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CJ119420.1         2-16
            16-8250             BC079860.1         1-8235
            8251-9524           AC147618.3         41643-42916         c
            9525-9894           BE993578.1         1-370               c
FEATURES             Location/Qualifiers
     source          1..9894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.1 cM"
     gene            1..9894
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /note="spectrin beta, non-erythrocytic 2"
                     /db_xref="GeneID:20743"
                     /db_xref="MGI:MGI:1313261"
     exon            1..437
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..616
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..768
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            769..942
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1034
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1115
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1231
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1344
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1532
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1650
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1809
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2112
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2266
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..3137
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3138..3275
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3276..4032
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4235
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4326
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            4327..4473
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4737
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            4738..4962
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            4963..5052
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            5053..5313
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            5314..5444
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            5445..5649
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            5650..6024
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            6025..6269
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            6270..6408
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            6409..6493
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            6494..6690
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            6691..6833
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            6834..6909
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            6910..6960
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            6961..7181
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            7182..7355
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            7356..7398
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            7399..9876
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8231..8236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /note="hexamer: ATTAAA"
     polyA_site      8250
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /note="major polyA site"
     regulatory      8808..8813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /note="hexamer: AATAAA"
     polyA_site      8831
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
     regulatory      8881..8886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /note="hexamer: ATTAAA"
     polyA_site      8921
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
     regulatory      9855..9860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
                     /note="hexamer: ATTAAA"
     polyA_site      9876
                     /gene="Sptbn2"
                     /gene_synonym="Spnb3"
ORIGIN      
        1 gtgcatttgc tctgatttgg gcatatttcc ttcctctcct aggcagatag cagctcacct
       61 tggttaatgc cattaaaccg tagaccactc agctgctaat aaaccaggaa gaaacccggc
      121 cgtgctagga ctagaaatgt ccatccctgc ccccaacccc cttaagacag tgactaggcc
      181 ggaattctcc tggttgataa atgagaggag ctgaggagcc gctgtgatga cggttccgag
      241 aatctgattt gtgagaaggc gaatctccag gagcaccatg gagatgcttt tggaaagcgg
      301 gccagcctac ctgccagaag gaggacgaga gaaagggggc aaggcagaga gaaacgctta
      361 agcgagatgg cctggaggtg ccccaaaagg gacctttgaa aaggaaacgg aggccgcatc
      421 tcggggaaac ctcggaggaa caggaagcca cccaccacca tgagcagcac tctgtcaccc
      481 actgactttg acagcttgga gatccagggc cagtacagtg acatcaacaa ccgctgggac
      541 ctgcctgact cagactggga caatgacagc agttcggccc gcctctttga gaggtccagg
      601 atcaaggccc tggcagatga gcgagaagcc gtgcagaaga aaaccttcac caagtgggtg
      661 aactcccacc tggcccgggt gacatgccgg gtgggagacc tgtacagcga cctgcgggac
      721 gggcgcaacc tcctgaggct cctggaggtg ctctcgggag agaccctgcc aaaacctacc
      781 aagggccgaa tgcggattca ctgcctggag aatgtagata aagcgctgca gttcctgaag
      841 gagcagaagg tgcacttgga aaacatgggc tcccatgaca ttgtggacgg aaaccaccgt
      901 ctgacccttg ggctagtgtg gaccatcatc ctccgatttc agatccaaga catcagtgtg
      961 gagacagaag acaacaagga gaagaagtca gccaaggatg ccctgctgct gtggtgccag
     1021 atgaagactg caggataccc caatgtcaat gtgcacaact ttaccaccag ttggagagat
     1081 gggctggcct ttaatgccat tgtgcacaaa caccggccag acctgttgga ttttgagtcc
     1141 ctgaagaagt gtaatgcaca ctacaatctg cagaatgctt tcaatctggc tgaaaaggaa
     1201 cttggcctga cgaagctcct ggatcctgaa gatgtgaatg tagaccagcc cgacgagaag
     1261 tctatcatca cctacgtggc cacttactac cactacttct ccaagatgaa ggccctggct
     1321 gtggaaggca aaagaattgg caaggtccta gaccatgcca tggaggcaga acacctggta
     1381 gagaaatacg agtccctggc ctctgaactg ctgcagtgga ttgagcaaac gatcgtgacc
     1441 ctcaatgacc gacagctggc caactccctg agtggagtcc agaaccagct gcagtctttc
     1501 aactcctatc gcactgtgga gaagccaccc aagttcacgg agaaagggaa cttggaggtg
     1561 ttgctcttca ccatccagag caagctacgg gccaacaacc agaaggtcta cacaccccgg
     1621 gaaggccggc tcatctcgga catcaacaag gcctgggagc ggctggagaa agccgaacat
     1681 gagcgagagc tagcgctgcg cacagagctg atccgccagg agaagctgga gcaactggct
     1741 gctcgcttcg accgcaaggc tgccatgcgg gagacctggc tcagtgagaa ccagcgactt
     1801 gtgtcccagg acaactttgg gctggaactg gcagcagtgg aggctgcagt gagaaagcat
     1861 gaagccattg agacagacat tgtcgcctac agtggccggg tgcaggcggt ggatgctgta
     1921 gctgcagaac tggctgctga gcactaccat gacattaagc gcattgcggc acgtcagaac
     1981 aacgtggccc ggctctggga cttcttacgg caaatggtgg ctgcccgccg tgagagactt
     2041 cttctcaacc tggagctgca gaaagtgttt caggacctgc tctacctcat ggactggatg
     2101 gcagagatga agggccgact gcagtctcag gacttgggca agcacctggc tggagtggag
     2161 gacctcctgc agctacacga actggtggag gcggacatcg cggttcaggc tgagagggtt
     2221 cgagcggtca gcgcctctgc cctgcgtttc tgcgacccag ggaaagagta taggccatgt
     2281 gacccacagc tggtgtcaga gagggtggcc actctggagc agagctatga ggccctgtgt
     2341 gaattggcag cgactagaag ggcccgactg gaagagtcac gtcgtctctg gaggttcctc
     2401 tgggaagtgg gtgaggctga ggcctgggtc cgggagcagc agcacctcct ggcctcagct
     2461 gatacaggcc gggacctgac tggtgtcctt cgcctgctca acaagcacgc agccctacgg
     2521 ggtgagatga gtggccgtct ggggcccctg aagctcaccc tggagcaagg tcagcagtta
     2581 gtcgctgagg gccaccctgg agccaaccaa gcctcaaccc gtgcagccga gctccaggcc
     2641 cagtgggagc gactagaagc cctggccgag gagcgagccc agcagctggc acaggctgcc
     2701 agcctctacc agttccaggc agatgcaaat gacatggagg cctggttggt ggatgcactg
     2761 cgcctggtat ctagccccga ggtagggcac gacgagttct ccacacaggc cctggccagg
     2821 cagcacaggg cccttgaaga ggagatccga gcccaccggc ctacactgga tgccctgagg
     2881 gagcaggctg cagccctgcc acctgcactg agccacacac cggaggtaca gggcagggtg
     2941 cccactctgg agcagcacta tgaggagctg caggcccgag ccggtgagcg tgcacgagcc
     3001 ctggaggcag ccctggcgtt ctataccatg ctcagcgagg ctggggcctg tggcctctgg
     3061 gtagaggaga aggagcaatg gctcaacggg ctggccctac ctgagcgcct ggaggacctg
     3121 gaggtggtcc agcagaggtt tgagaccctg gagcctgaaa tgaacgccct ggctgcacgg
     3181 gttactgctg tcaatgacat cgctgagcag ctgctgaagg ccagtccacc aggcaaggac
     3241 cgcatcattg gcacccagga gcagctcaac caaaggtggc agcagtttcg gtccctggca
     3301 gatggcaaaa aggcggctct gacatcagcc ctgagcatcc agaattacca cctagagtgc
     3361 acagagaccc aggcctggat gagagagaag actaaggtca ttgagtccac ccagggcctg
     3421 ggcaatgatc tagctggtgt gctggccctg cagcggaagt tggcgggtac tgagagagat
     3481 ctggaagcta tctctgcccg ggtgggtgag ctgacccaag aggcaaatgc cttggctgct
     3541 gggcacccag ctcaagctcc tgccatcaac acccggcttg gagaggtaca agcaggatgg
     3601 gaagatcttc gggcgaccat gaggcggaga gaagagtccc tgggtgaggc tcggcggctg
     3661 caggatttcc tgcgcagctt ggatgacttc caggcctggc taggccgcac acagaccgct
     3721 gtagcctccg aagaagggcc agccaccctt cccgaggcag aagccctctt agcccagcac
     3781 gcagctctgc ggggagaagt ggagagagcc cagagcgagt acagccgcct caggaccttg
     3841 ggcgaggagg tgaccagaga ccaggctgat ccccagtgcc tcttcctcag acagaggctg
     3901 gaagcccttg gaaccggctg ggaggagctg ggtcgcatgt gggagagccg gcaaggccgc
     3961 ctggcccagg cccatggctt ccaggggttt ttaagagatg ctcgccaggc tgagggtgtt
     4021 ctcagcagcc aggaatatgt cttgtctcac acggagatgc cagggacact gcaggcggca
     4081 gatgcagcca ttaaaaagct ggaagacttc atgagcacta tggacgccaa tggagagcgc
     4141 atccgcggac tcctggaggc tggacgtcag ctggtgtcca agggcaatat ccatgctgag
     4201 aagatccaag agaaggcgga ctccatcgag aagaggcaca gaaagaatca ggaggcggtg
     4261 cagcagcttt taggacgcct tcgggacaac cgagagcagc agcacttctt gcaagactgt
     4321 caggagctga gactctggat cgatgagaag atgctgacag ctcaggatgt gtcctatgac
     4381 gaagctcgca acctgcacac caagtggcag aaacaccagg cattcatggc cgagcttgca
     4441 gccaacaagg actggctgga caaagtggac aaggaagggc gggagctgac tcttgaaaag
     4501 ccagaactca aagtcgtagt gtcagagaag ctggaggacc tgcaccggcg ctgggatgaa
     4561 ctggagacca ctacccaagc caaggcccgc agtctttttg atgccaaccg ggcagagcta
     4621 tttgctcaaa gctgttctgc cctggagagc tggctggaga gcctgcaggc ccagctgcac
     4681 tcagatgact atggcaaaga cctcaccagt gtcaacattc tgctgaagaa gcaacagatg
     4741 ctggaacgag agatggctgt gagagagaag gaggtagagg cgatacaggc ccaggcccag
     4801 gccctggccc aggaagacca gagtgcaggg gaggtagaaa ggacctcaag ggctgtggag
     4861 gagaagttca gggccttgtg tcaacccatg aaagaacgct gccggcgcct gcacgcctcc
     4921 cgggagcagc accagttcca ccgggatgtg gaggatgaga tattgtgggt gactgagcgg
     4981 cttcccatgg ccagctctct ggaacatggc aaggacttgc ccagtgtcca gcttctcatg
     5041 aagaaaaacc agaccctgca gaaggagatc cagggccatg agccccggat tgcagacctc
     5101 aaagagaggc agcgcactct gggaacagca gcagcaggtc cagagctggc tgagctccaa
     5161 gaaatgtgga aacgcctgag ccatgagctg gagcttcggg gcaagcggct ggaggaagct
     5221 cttcgagccc agcaattcta tcgtgatgct gcagaggccg aggcttggat gggtgagcag
     5281 gagttacaca tgatgggcca ggaaaaggcc aaggatgagc tgagcgccca ggcagaagtg
     5341 aagaagcatc aggtattgga acaagccctt gctgactatg cccagaccat caaacaacta
     5401 gcagccagca gtcaagatat gattgaccat gaacatccag agagcacaag actaacaata
     5461 cgccaagccc aggtggacaa gctgtacgcc agcctgaagg agctggcagg agagcggcgc
     5521 gagcgcctgc aggagcacct ccggctgtgc cagctccgca gagagctgga tgacctggaa
     5581 cagtggatac aggagcgtga agttgtggca gcctcccatg aactgggcca agactatgag
     5641 cacgtgacta tgcttcggga caaattccga gagttctcca aggacaccag caccattggc
     5701 caggagcgcg tagacagtgc caatgcactg gccaatgggc tcattgctgg gggccatgct
     5761 gcacgggcca ctgtggccga gtggaaggac agtctcaatg aggcctgggc tgacctgctg
     5821 gagctgctgg acacaagagg tcaggtgctg gctgctgcgt atgagctgca gcgcttcctg
     5881 catggagccc gccaagccct ggcacgggta cagcacaagc agcagcagct tccagacggg
     5941 actggccgtg acctcaatgc tgctgaggcc ctgcagcgcc ggcactgtgc ctatgagcac
     6001 gacatccaag ccctcagcac tcaggtccag caagttcaag atgatggcca aaggctacag
     6061 aaggcctatg ctggagacaa ggctgaggaa attggccgtc acatgcaggc agtggctgag
     6121 gcctgggccc agctccaggg aagttctgct gcccgccgac agctgttact ggataccacg
     6181 gacaaattcc gattctttaa ggctgtccga gagttgatgc tgtggatgga tgggattaac
     6241 ctgcagatgg atgcccagga gcggccccgg gatgtgtcct ctgcagattt agtcatcaaa
     6301 aaccaacaag gaatcaaagc agagatagag gccagagcag acaggttctc ctcctgcatt
     6361 gacatggggc aggagctgct ggcccggagc cactatgctg ctgaggagat ctcagagaag
     6421 ctgtctcagc tacagtcccg gcgccaggag acagctgaca agtggcagga gaagatggac
     6481 tggctacagc ttgttttgga ggtgcttgtg tttgggagag atgcagggat ggcggaggcc
     6541 tggctgtgca gtcaggagcc attggtgcga agtgcagaac tgggttgcac tgtggacgaa
     6601 gtagagagcc tcatcaagcg acacgaagcc tttcagaagt cggccgtggc ctgggaagag
     6661 cgtttcagtg cgctggagaa gctcactgcg ctggaagagc gggaaaatga gcggaaaagg
     6721 aagagggagg aggaggaacg gaggaaacag cctcctactt cagagcccat ggctagtcag
     6781 ccagaaggga gtctggtaga tggccagaga gttcctgaca ctgcctggga tgggactcag
     6841 tcaaaattgc caccatccac acaagcaccc agtgttaatg gggtctgcac ggacaccgac
     6901 tcctcacagc ccctgttgga acagcagaga cttgaacaga gcaatgtccc cgaaggacct
     6961 ggatctggca caggagacga gtccagtggg ccccggggag agaggcagac cctgccccgg
     7021 ggccctgctc cttctccaat gccccagagc agatcatctg aagcagctca tggtgccacc
     7081 ctgcccacac gaggacctga gctctctgct caggaacaga tggaagggat gctgtgccgc
     7141 aaacaagaga tggaagcctt caacaagaaa gctgccaaca ggtcatggca gaatgtgtac
     7201 tgtgtacttc ggcgtgggag cctcggcttt tacaaggatg ccagggcagc tagtgcagga
     7261 gtgccctacc atggagaagt gcctgtcagc ctggccaggg cccagggaag tgtggccttt
     7321 gattatcgga aacgcaaaca tgttttcaag ctgggcttac aggatggcaa agaataccta
     7381 ttccaggcca aggacgaggc agagatgagc tcatggctga gagtggtgaa tgcagccatt
     7441 gccactgcat cctctgcccc tggagagtca gaagagccag tggtgcccag tgccagccgg
     7501 ggtctgaccc gggccatgac catgccccca gtgtcacagc ctgagggttc catcgtgctt
     7561 cgaagcaagg atggcagaga aagagagcga gaaaaacgat tcagcttctt taagaagaac
     7621 aagtagtcgg ggcaagactc ccaggccagc tccctccctc tgttcagaaa actgccaggg
     7681 actgtcgaca gagaccaccc tcttggcagg acaactgcct gctgctaggg tctgctgcta
     7741 aggtcaaccc atcaccagga actgtcactg gggacaaaag agtgttccca caaccttctc
     7801 ttctgctatt taattcaact ggtggtggga cccaggctac ccctaatacc acccattcct
     7861 accttgtcac ctcttcccaa gccttatacc tccacccatc cccccaccat ggtgcagata
     7921 gtgccaccct caacgtgggc tatgtgggaa ccattgtccc tgcctcaggg tcattgtgcc
     7981 accacagcta gggtgtgcca tccaccattc agttctttgc ctctgggatc agccaggacc
     8041 ctcagagctg aagcaggcag gacctgaggg caggagcgcc agatgatgaa gtcggaggcg
     8101 ctgaagcctt ccctgcctat cctgcctcac cctctgactc aaggggctgc ttgtttccag
     8161 ccactctagg tggctcccaa gtgtgagttg ttcaggagta gccacatcct tgagcctatc
     8221 caaggaggtg attaaacagc tcgacttctc tcactgcctc tgggtgttgt tgctttcctg
     8281 accgtagcct ctcctggtct cctgcatgtc agatagccac tgtacgccca gcttctgagc
     8341 ccccacaaac tgtgtgatcc tgagagcctc cctgcccagt ctccccatga tagtgatctg
     8401 tttcactggg ctgacctatg ctaagcctct gtttaaacca aagacatcca ctgtgggttg
     8461 ggctgatgat aattaacagt attcatgatc aaaggaagca agtcactctc cctggtgcac
     8521 acttttttgt taaatttctt gccgtgcatg caaggcaagc actctaaact acaactcctc
     8581 gctaattttc ctcactccca agtgtctcaa ctgttttcaa taaggagtag tgagggttat
     8641 taccacaacc tagtcttaac tgctgctcag ccatcagtgg aaaggtgagc acctttctgt
     8701 ctttcccata aaatcaaggg agctcccaca gaatcagaag agtggcaggt cctacctcct
     8761 gaattctagg tcaccctaga aagccataag gatatcctga gtatgtaaat aaacacacaa
     8821 tgtattctag agatggagag agtatttgtt cttaaacttt gcaatgtata aacagaaggt
     8881 attaaaaatt gcaagtcttg agtctgtttg actcaggaaa actactgtct tcagcataac
     8941 tggccaggga ccccaagcag ccctgactac catcagtcaa aacaaagaca agcagagcca
     9001 ggtgtatgta gactaggaac tattatgaca cagccccaag ctgggctcca cacatcagat
     9061 ctggcacagc acattattca cagggtaagt attctctctc tcagggacgg cctttctctt
     9121 aggtggtttc agtcgcccca caacagtgta acagcaacac cccattctca ggcaaaacaa
     9181 acgtcagcac acattttcct cataactctc cttcagctgt tacacatgga gcgttattgt
     9241 ggagagctca gatcatgggg cttgggggaa aaagcagtaa ttggaaaagt ttgaaagcag
     9301 atgtactatg tgtgagagga attaatggag aaatggcctt gcaattgagt gctaggcaga
     9361 gcagtaactg aatgaaaagg aaggacagga attaggtgaa agtctacacg tgtggcagct
     9421 aaagccactt gagaataggg ttccacatag gacagataag agggtaaaca gagggctagg
     9481 gagcaagtct tcaggaaaga catcttggag tatcggtggg agagaggaga aggatgatag
     9541 atagaacggg gccctgaaag ctatggggac aaaaataaca ccagtgttgg ccctgcagac
     9601 cggtgggaag cagggatcag cagcaatgaa tgggctcata ctttgcactt ttaccgacca
     9661 ccactgacga gggtgggttt tgcttgtgtt gacccacatg gaagctaatg gccacagtgg
     9721 actactgagt atgcaacgtg tggcaagtgt aaactgcgat gtgctgaagg tatgaaataa
     9781 cagatattca ggacttcaag gggaattcaa ttatctcaat ttttatattg gtctcatgtt
     9841 agaatgtcaa aaatattaaa atagatttca aggtttaaaa aaaaaaaaaa aaaa
//
