LOCUS       NM_013675              10417 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus spectrin beta, erythrocytic (Sptb), mRNA.
ACCESSION   NM_013675 XM_484156
VERSION     NM_013675.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10417)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10417)
  AUTHORS   Liu,C.H., Seo,R., Ho,T.S., Stankewich,M., Mohler,P.J., Hund,T.J.,
            Noebels,J.L. and Rasband,M.N.
  TITLE     beta spectrin-dependent and domain specific mechanisms for Na+
            channel clustering
  JOURNAL   Elife 9, e56629 (2020)
   PUBMED   32425157
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10417)
  AUTHORS   Liu,C.H., Stevens,S.R., Teliska,L.H., Stankewich,M., Mohler,P.J.,
            Hund,T.J. and Rasband,M.N.
  TITLE     Nodal beta spectrins are required to maintain Na+ channel
            clustering and axon integrity
  JOURNAL   Elife 9, e52378 (2020)
   PUBMED   32052742
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10417)
  AUTHORS   Siddam,A.D., Gautier-Courteille,C., Perez-Campos,L., Anand,D.,
            Kakrana,A., Dang,C.A., Legagneux,V., Mereau,A., Viet,J.,
            Gross,J.M., Paillard,L. and Lachke,S.A.
  TITLE     The RNA-binding protein Celf1 post-transcriptionally regulates
            p27Kip1 and Dnase2b to control fiber cell nuclear degradation in
            lens development
  JOURNAL   PLoS Genet 14 (3), e1007278 (2018)
   PUBMED   29565969
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10417)
  AUTHORS   Huang,Y.S., Delgadillo,L.F., Cyr,K.H., Kingsley,P.D., An,X.,
            McGrath,K.E., Mohandas,N., Conboy,J.G., Waugh,R.E., Wan,J. and
            Palis,J.
  TITLE     Circulating primitive erythroblasts establish a functional, protein
            4.1R-dependent cytoskeletal network prior to enucleating
  JOURNAL   Sci Rep 7 (1), 5164 (2017)
   PUBMED   28701737
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10417)
  AUTHORS   Zimmer,W.E., Ma,Y., Zagon,I.S. and Goodman,S.R.
  TITLE     Developmental expression of brain beta-spectrin isoform messenger
            RNAs
  JOURNAL   Brain Res 594 (1), 75-83 (1992)
   PUBMED   1467942
REFERENCE   7  (bases 1 to 10417)
  AUTHORS   Peters,L.L., White,R.A., Birkenmeier,C.S., Bloom,M.L., Lux,S.E. and
            Barker,J.E.
  TITLE     Changing patterns in cytoskeletal mRNA expression and protein
            synthesis during murine erythropoiesis in vivo
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5749-5753 (1992)
   PUBMED   1385865
REFERENCE   8  (bases 1 to 10417)
  AUTHORS   Avraham,K.B., Prezioso,V.R., Chen,W.S., Lai,E., Sladek,F.M.,
            Zhong,W., Darnell,J.E. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of four hepatocyte-enriched
            transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and
            HNF-4
  JOURNAL   Genomics 13 (2), 264-268 (1992)
   PUBMED   1612587
REFERENCE   9  (bases 1 to 10417)
  AUTHORS   Laurila,P., Cioe,L., Kozak,C.A. and Curtis,P.J.
  TITLE     Assignment of mouse beta-spectrin gene to chromosome 12
  JOURNAL   Somat Cell Mol Genet 13 (1), 93-97 (1987)
   PUBMED   3027903
REFERENCE   10 (bases 1 to 10417)
  AUTHORS   Sassa,S. and Bernstein,S.E.
  TITLE     Studies of erythrocyte protoporphyrin in anemic mutant mice: use of
            a modified hematofluorometer for the detection of heterozygotes for
            hemolytic disease
  JOURNAL   Exp Hematol 6 (5), 479-487 (1978)
   PUBMED   658175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147299.1 and CD804076.1.
            
            On Jan 6, 2006 this sequence version replaced NM_013675.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147299.1, AK147704.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10392             AK147299.1         2-10393
            10393-10417         CD804076.1         303-327
FEATURES             Location/Qualifiers
     source          1..10417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.73 cM"
     gene            1..10417
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /note="spectrin beta, erythrocytic"
                     /db_xref="GeneID:20741"
                     /db_xref="MGI:MGI:98387"
     exon            1..613
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..815
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             668..7657
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /note="spectrin beta chain, erythrocyte; beta-I spectrin;
                     beta-spectrin 1; brain erythroid spectrin (235E); spectrin
                     R; spectrin beta 1"
                     /codon_start=1
                     /product="spectrin beta chain, erythrocytic"
                     /protein_id="NP_038703.3"
                     /db_xref="CCDS:CCDS36477.1"
                     /db_xref="GeneID:20741"
                     /db_xref="MGI:MGI:98387"
                     /translation="MTSATEFENVGNQPPFSRINARWDAPDDELDNDNSSARLFERSR
                     IKALADEREVVQKKTFTKWVNSHLARVSCRISDLYKDLRDGRMLIKLLEVLSGEMLPR
                     PTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQ
                     DIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPD
                     LIDFDKLKDSNARHNLEHAFDVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHY
                     FSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTISVLNSRKFANSL
                     SGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDI
                     NRAWESLEEAEYQRELALRSELIRQEKLEQLARRFDRKAAMRETWLNENQRLVTQDNF
                     GYDLAAVEAAKKKHEAIETDTAAYEERVKALEDLAQELEKENYHDQKRIIARKDNILR
                     LWSYLQELLRSRRQRLEATLALQKLFQDMLHSIDWMDEIKAHILSAEFGKHLLEVEDL
                     LQKHKLMEADIAIQGDKVKAITAATLQFAEGKGYQPCDPQVIQDRVSHLEQCFSELSN
                     MAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAF
                     EDELRGLDAHLKQIFQEADDMVAQKQFGHPQIETRVKEVSAQWDHLKELAAFRKKDLQ
                     DAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKEFLEELEESRGV
                     MEHLEHQAQGFPEEFRDSPDVTNRLQALRKLYQQVLTQAELRGHKLQEALDLYTVFGE
                     SDACELWMTEKGKWLDQMDIPNTLEDLEVVQHRFDILDQEMKTLMAQIDGVNLAANNL
                     VESGHPRSGEVKQYQDRLNKRWQAFQAVVSEQREAVDSALRVNNYCVDCEETSKWIMD
                     KTKVVESTKDLGQDLAGVIAIQRKLSGLERDVLAIRDRVSALERESQYLMESHPEQKE
                     DIGQRQADVEKLWKGLQDALQGQELSLGEASKLQAFLQDLDDFKAWLSMAQKAVASED
                     MPESLPEAEQLLQQHAAIKEEIDAHRDDYHRVKASGEKVIEGQTDPDYQLLGQRLEGL
                     DTDWDALRRMWESRGNTLTQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLAAAE
                     AGIRKFEDFLVSMENNRDKILSPVDSGNKLVAEGNLYSNKIMEKVQLIEDRHKKNNEK
                     AQEATVLLKDNLELQNFLQNCKELTLWINDKLLTSPDVSYDEARNLHNKWMKHQAFMA
                     ELASHQGWLENIDAEGRQLMAEKPQFKDVVSERLEALHKLWEELQSTAKAKAEQLSAA
                     RSSDLRLQTHADLNKWIGAMEDQLRSDDLGKDLTTVNRMLAKLKRVEEQVNLRKEELE
                     ELFADAPSLGAEAGDTDMSIEKRFLDLLEPLGRRKKQLELSKAKLQISRDLEDETLWV
                     EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHAPRVEDVLRRGQELVKAAEIDC
                     QDIEERLGHLQSSWDTLREAAAGRLQRLRDAHEAQQYYLDAGEAEAWISEQELYVFSD
                     EPPKDEEGAIVMLKRHLRQQRTVEEYGRNIKQLAGRAQSLLSAGHPEGEQIIRLQGQV
                     DKQYAGLKDMAEERRRRLENMYHLFQLKREADDLEQWITEKEMVASSQEMGQDFDHVT
                     MLRDKFRDFARETGAIGQERVDNVNTIIERLIDAGHSEAATIAEWKDGLNDMWADLLE
                     LIDTRMQLLAASYDLHRYFYTGTEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFE
                     RELHLLGVQVQQFQDVATRLQTAYAGEKADAIQSKEQEVSAAWQALLDACAGRRAQLV
                     DTADKFRFFSMVRDLLSWMESIIRQIETQERPRDVSSVELLLKYHQGIKAEINTRAKN
                     FSTCLELGESLLQRQHQASDEIREKLQQVISRRQEMNDKWEARSDRLHMLLEVCQFSR
                     DASVAEAWLIAQEPYLASRDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTL
                     ELKERQTPERPTEEPGPQEEEGETAGEAPQVHHAATERTSPGEERGPWPQDLQPPPLP
                     GHHKDEQEKSVGDERPATEPLFKVLDTPLSEGDEPTTLPAQRDLGHTVQMEGYLGRKH
                     DLEGPNKKASNRSWNNLYCVLRNSQLTFYKDAKNLALGVPYHGEEPLALRHAICEIAV
                     NYKKKKHVFKLRLSNGSEWLFHGKDEEEMLMWLQSMSTAINESQSIRVKAQSLPLPSL
                     AGPDASVGKKEKEKRFSFFPKKK"
     exon            816..967
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1141
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1233
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1314
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1430
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1543
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1731
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1849
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2008
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2311
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2462
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..3333
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3471
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..4228
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4431
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4432..4522
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4523..4669
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4670..4933
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4934..5140
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5141..5230
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5231..5509
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5510..5640
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5641..5845
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            5846..6220
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6221..6465
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6466..6604
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6605..6689
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6690..6886
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6887..6936
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            6937..7012
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7013..7272
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7273..7446
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7447..7489
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            7490..10394
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10375..10380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /note="hexamer: AATAAA"
     polyA_site      10394
                     /gene="Sptb"
                     /gene_synonym="D330027P03Rik; Gm1301; ja; jaundiced;
                     mKIAA4219; Spnb-1; Spnb1"
                     /note="major polyA site"
ORIGIN      
        1 gtcccttcca gcctatctcc ggaggggcat tacagccggg gcgccctcct cacccaccct
       61 atggcctaaa cgggtcttta gatgtttttt caaaaccaga tcgtagtctg cagggacgct
      121 aggcgggaaa ggctgggagg actccttttc gccgccagct tgcggctccg ggcacacaaa
      181 ttaggccgga gcagcagagt cgagtcctct tcccgtggca aggggctctg tgtgtgcggg
      241 atcaggggag gtgagagagg accctggcgt cccaggtccc agcggcggcg gcgctagcgg
      301 ctaggcaggt gcccccgggc gcgcagtctg attggcaggt gcaggagtgg gtggggaagg
      361 cgggcctggc gctgcgggag gctgcagccc cgcctccccg cccccgccgc gggactatct
      421 ggtcccggca gcagcgatgt cccccggcag gaatgtccct cctcagataa tgttatttat
      481 atctctgggc gggtccgcgg ctccgctgca ccaggcgccc ggcggccact gtgccaggag
      541 ccccgtgctg ccctcctccc cctgcgccgc cgcccccggg ctcggggtag ccgccgcttc
      601 agccccagcg cagggaccct tccatgaaga ctgagccagg cacagctgct aagaagagcc
      661 tgctgacatg acatcggcca cggagtttga aaacgtgggc aaccagccac cattcagccg
      721 gattaacgcc cgctgggatg cccccgatga cgaactggat aatgacaaca gctcagccag
      781 gctctttgag aggtcacgga tcaaggcctt ggcagatgag cgggaagtgg tccagaagaa
      841 aacctttacg aaatgggtga actcccacct ggctcgagtg tcctgccgca tcagcgacct
      901 ctacaaggac ctgcgggacg gacggatgct catcaagctg ctggaggtgc tctctggaga
      961 gatgctgcca aggccgacca agggcaagat gcgcatccac tgcctggaga acgtggacaa
     1021 agccctgcag ttcctcaagg aacagcgcgt gcacctggaa aacatgggct cccacgacat
     1081 tgtggatggt aaccaccgcc tggtcctggg cctcatctgg accatcatcc ttcgattcca
     1141 gattcaggac attgttgtcc aaactcaaga aggtcgggag acacgctcag ccaaggatgc
     1201 tctgctcctg tggtgccaga tgaagacagc aggctacccc catgtcaatg taaccaactt
     1261 cacctccagc tggaaggatg gcctggcctt caatgcccta atacacaaac accggcctga
     1321 cctcatcgac tttgacaagc tgaaggactc caatgcccgg cataacctgg agcatgcttt
     1381 tgatgtagcc gagcgccagc tcggcattat cccactcctt gaccccgaag atgtcttcac
     1441 agaaaacccc gatgagaaat ccatcatcac ctacgtggtg gcgttttatc actacttctc
     1501 caagatgaag gtgctggcgg tggagggcaa gcgagttggc aaggtcatcg accacgccat
     1561 cgagaccgag aagatgattg aaaagtacag tgggctagcc tcagacctgc tcacttggat
     1621 tgaacaaacc attagcgtcc taaacagccg caagtttgcc aactcgttga gtggcgtcca
     1681 gcagcagcta caggccttca gcacctaccg tactgtggag aagccaccca agtttcagga
     1741 gaaggggaat ctggaagtcc tcctattcac tatccaatcc cggatgagag ccaacaatca
     1801 gaaggtgtac acgccccacg atgggaagct ggtgtctgac atcaacaggg cctgggagag
     1861 cctggaggaa gcagagtacc aaagggagct ggctctgagg agcgagctca ttcggcagga
     1921 gaagctggag cagctggcgc ggcgcttcga ccggaaggct gccatgagag agacgtggct
     1981 caatgaaaac cagcgcctgg tgacccagga taactttggg tatgacctgg cagctgtgga
     2041 ggccgccaag aagaagcacg aagccattga gaccgacaca gctgcctatg aggagcgggt
     2101 aaaggcgctg gaggacctgg cccaggagct ggagaaggag aattaccatg accagaagcg
     2161 tatcattgcc cggaaggaca acatcctccg tctgtggagc tacctgcagg agctgctgcg
     2221 atcccggcga cagaggctgg aggccaccct ggcactgcag aaactctttc aggacatgct
     2281 gcacagcatc gattggatgg atgagatcaa ggctcacatc ttgtctgctg aatttgggaa
     2341 gcacttgtta gaggttgaag acctgctgca gaagcacaag ctaatggagg ccgacattgc
     2401 catccaaggg gacaaagtga aggccatcac agcggccacc ctgcagttcg ctgaggggaa
     2461 agggtatcaa ccttgtgacc cccaggtcat ccaggaccgt gtcagccacc tagagcagtg
     2521 cttcagtgaa ctgagcaaca tggcagctgg acggaaggct cagctggagc agtctaagcg
     2581 actctggaag ttcttctggg agatggatga ggccgaaagc tggatcaagg agaaggagca
     2641 gatctactcc tccctggact acggcaagga cctgaccagc gtgctcatct tacagcgcaa
     2701 gcacaaggcc tttgaggatg agctccgtgg gctggacgcc catctgaaac agatcttcca
     2761 ggaggctgac gacatggttg cacaaaagca gtttggacac ccacagatcg agacccgtgt
     2821 caaagaagtg tcagctcagt gggaccacct gaaggagctg gctgcctttc gtaagaaaga
     2881 cctgcaggat gcggaaaact tcttccagtt ccagggtgat gcagacgacc tgaaggcttg
     2941 gctgcaagac gctcaccggc tgctctctgg tgaagatgta gggcaagatg aaggagccac
     3001 gagggccctg ggaaagaagc acaaggagtt cctggaggag ctggaggaga gccgaggggt
     3061 gatggagcac ttggagcacc aagcccaggg cttccccgag gagtttcgag attccccaga
     3121 tgtaacaaac cgactccagg cactcaggaa gctctaccag caggtactga cccaggcaga
     3181 attgcgtgga cacaagctgc aggaagccct ggacttgtac accgtgtttg gggagtcaga
     3241 tgcctgtgag ctgtggatga cggagaaggg gaagtggctg gaccagatgg atatcccaaa
     3301 cacgctggag gatctggagg tggtgcagca caggtttgac atcctggacc aggagatgaa
     3361 gaccttgatg gcgcagattg atggagtgaa ccttgccgcc aacaacctgg tagagagtgg
     3421 ccacccacga agtggggagg tgaagcaata tcaggaccgc ctgaacaaga ggtggcaggc
     3481 cttccaggca gtggtgtcag agcagagaga ggctgtggac tcagctctcc gagtaaacaa
     3541 ttactgtgta gactgtgagg agaccagcaa gtggatcatg gacaagacga aggttgtgga
     3601 gtcaaccaag gacttgggac aggacctggc aggtgtaatt gccatccagc ggaagttgtc
     3661 agggttggag cgggatgtat tggccatccg ggatcgtgtg agtgccctgg aacgggagtc
     3721 ccagtacttg atggagtcac accctgagca gaaagaggac attggccagc ggcaagcaga
     3781 tgttgagaag ctgtggaagg gcctgcaaga tgccttgcaa ggtcaggagc tctccttagg
     3841 cgaggccagc aagctgcagg ctttcctgca agatctggat gacttcaagg cctggctgtc
     3901 catggcccaa aaggcagtgg cctccgagga catgcctgag tcactcccag aggcggagca
     3961 gctcctacag cagcatgcag ccattaagga agagattgat gcgcacagag acgattacca
     4021 tagggtcaag gcctctgggg agaaagtgat cgaaggccag accgacccag attaccagct
     4081 tctgggccag cggttagagg gcctagatac tgactgggat gctctacgcc ggatgtggga
     4141 gagccgaggg aacacgctca cccagtgcct gggctttcag gagttccaga aagatgccaa
     4201 gcaggctgaa gccatcctca gcaaccagga atacactctg gctcacttgg agcctccgga
     4261 ctccctagcg gcagcagagg cgggcatccg aaagtttgag gatttcctag tatctatgga
     4321 aaacaaccga gacaagatcc tgagtcctgt ggactctggc aacaagctgg tggccgaggg
     4381 caacctgtat tcgaacaaga tcatggagaa ggtgcagctg attgaagaca ggcacaagaa
     4441 gaacaatgag aaggcccagg aggctacagt tctcctaaaa gacaacctgg agttgcagaa
     4501 cttcctccag aactgcaagg agctcactct ctggatcaat gacaagctgc tgacgtctcc
     4561 agacgtctcc tatgatgaag ctcgcaacct tcacaacaaa tggatgaaac accaggcgtt
     4621 tatggcagaa ctggcttcac accaagggtg gcttgagaac attgacgcag aggggaggca
     4681 gctgatggca gagaagcccc agttcaagga tgtggtatca gagaggctgg aagccctgca
     4741 caagctctgg gaggagctgc agtccaccgc caaggcgaag gcagaacaac tctcagccgc
     4801 gcggagctct gacctgcgcc tgcagaccca cgccgacctt aacaaatgga tcggtgccat
     4861 ggaggaccag ctgcgatcag acgacctggg caaggatctc accactgtca accggatgtt
     4921 ggctaagttg aagcgagtgg aggaacaagt gaatttgcgg aaggaggagc tggaggaact
     4981 ctttgccgac gcgccctcgc taggagcgga ggcaggagac acggacatga gcatcgaaaa
     5041 gcggttccta gaccttctag aacctctggg gaggaggaag aagcagctgg aattgtccaa
     5101 agccaagcta caaatcagcc gggacttaga ggatgagacg ctctgggtgg aagagaggct
     5161 gccactggct cagtcagctg actatggcac taatctgcaa actgtgcagc tgttcatgaa
     5221 gaagaaccag accctgcaga atgagattct cggccatgcg ccacgggtgg aggatgtgct
     5281 acgtcgaggg caggagctgg tgaaggcagc cgagatcgac tgccaagaca tcgaggagcg
     5341 cctggggcat ctgcagagct cgtgggacac gctgcgggag gcagcagctg gccggctgca
     5401 gcgcctgcgg gatgctcacg aggcacagca gtactacctg gatgcaggcg aggccgaagc
     5461 ctggatcagc gagcaggagc tatatgtgtt ctctgatgaa ccccctaagg atgaagaggg
     5521 agccattgtg atgctcaaac ggcacctgcg gcagcagcgc actgtggagg agtatggacg
     5581 gaatatcaaa cagctggctg gccgtgccca gagcctgcta tctgcaggcc accctgaggg
     5641 ggaacagatc atcagactcc aggggcaggt ggataagcag tacgcggggc tgaaggacat
     5701 ggctgaagag cggaggcgga ggctggagaa catgtaccac ctgttccagc tgaagagaga
     5761 ggctgacgac ttagagcagt ggattacgga aaaagagatg gtggcctcgt cccaagaaat
     5821 ggggcaggat tttgaccacg tgactatgct acgtgacaag ttccgagact ttgcccggga
     5881 gaccggggcc atcgggcagg agcgagtgga caacgtgaat acgatcattg agcggctcat
     5941 cgatgcgggc cacagcgagg cggccaccat cgctgagtgg aaggatggac tcaatgacat
     6001 gtgggcggac ctgctggagc tcattgacac ccgcatgcag ctgctggctg cctcctacga
     6061 cctgcaccgc tatttctaca caggcaccga gatcctgggc ctcatagatg agaagcacag
     6121 agagctgccg gaggacgtgg ggctggacgc cagcactgct gagtccttcc accgggtcca
     6181 cactgccttc gagcgggaac tccacctcct aggagtgcag gtacagcagt tccaggacgt
     6241 ggccacccga ctgcagacag cgtatgccgg ggagaaggca gatgctatcc agagcaaaga
     6301 gcaggaggtg tcagcggcct ggcaggcact gctcgatgcg tgtgccgggc gccgagctca
     6361 gctggtggac acagcagaca agttccgctt cttcagcatg gtgcgagacc tcctctcctg
     6421 gatggagagc atcatcaggc agatcgagac ccaggagaga cccagggatg tttcctctgt
     6481 ggaattgctc ttgaagtatc atcagggcat caaggcagag atcaatacca gggccaagaa
     6541 cttcagcacc tgcctagagc ttggggagtc cctgctacag aggcaacacc aggcctcgga
     6601 cgagatccgg gagaaattgc agcaagtgat atccaggagg caggagatga atgacaagtg
     6661 ggaggcccgc tctgacaggc tccacatgct tctggaagtg tgccagttct cgagggatgc
     6721 ctctgtggcc gaggcatggt tgattgccca ggagccctac ctggccagcc gggactttgg
     6781 acatacagtg gacagcgtag aaaagcttat caagaggcac gaggcgtttg agaagtccac
     6841 agccagctgg gcagagcgct ttgccgccct ggagaagccc accacgcttg agcttaagga
     6901 acgccagact ccagaaagac ccacagagga acctgggcct caagaggagg aaggcgagac
     6961 agctggcgag gccccccagg tccaccatgc ggccacagag agaacatctc cgggggaaga
     7021 aagaggacca tggcctcagg acctgcaacc accacccctg ccaggacacc acaaagacga
     7081 gcaggagaaa tccgttgggg atgagaggcc tgccacagag cccctcttta aagtcctgga
     7141 cacgcccctg agtgagggtg acgagcccac gaccctgcca gcccagcgag acctcgggca
     7201 cactgtgcag atggagggct acctgggccg aaagcacgac ctagaggggc ccaacaagaa
     7261 ggcctctaac aggtcctgga acaacctgta ctgtgtgctc aggaatagtc agctgacctt
     7321 ctacaaggat gctaagaacc tggcccttgg ggtgccctac catggagagg agcccctggc
     7381 cctgaggcac gccatctgtg agattgctgt caactataag aagaagaagc atgtgtttaa
     7441 gctgaggtta agcaatggca gcgagtggct cttccatggc aaggatgagg aggagatgct
     7501 gatgtggcta cagagcatga gcacggccat caacgagtcc cagagcatcc gtgtcaaggc
     7561 tcagagtctg cctctgcctt ccctggctgg tcctgatgcc agcgttggca agaaggaaaa
     7621 ggagaaaagg tttagcttct tccccaaaaa gaagtagcag ctgggggccc ctgtgggcgg
     7681 ggccagccag gcagcactgc agtgtgcatc gggacaagca aggacaagga gcccatggcc
     7741 tcgacctttg cagtggccag tcctcctccc gcctgccact cactgcctgc agcctgcctg
     7801 ctcaagttgc tgggccagcc ccagggcccc acactgcact gcaatagctg ccttgcctgc
     7861 ctggcctccc taatgcctgc caacagccct ccacttcccc taccccaagc agctggctgg
     7921 gctccaggga ctggaggtcc agctcctttg gggctggaaa cggttctgta cggcatatac
     7981 tctcctcttc ctgcctacaa gctgggatgt ctgatggcct tcctccagca ctgcccacta
     8041 ccaccacagc aaatcccctt tgggatcact gaccatagtc agctagggaa aggaaaagta
     8101 atattgacaa tggttgccct gttccttagg ggcaggagga agggccttca gaatcaggta
     8161 aggggctagt ggagtaccaa ggggactata tggatgtcaa gctttgagta ctgccattct
     8221 cctccccgtg ggctccttca gagataggat tctctcctca gggctagtat gtcccttctt
     8281 ttctcttctc atacccttaa gagtttgggt gagtccccag tgagtgagcc tctttctccc
     8341 tttgatcctc ctggcatcaa cagaattcct cacactgctc tcttggaaac cctagtatag
     8401 cttagggttc agacctctgc cacaggaggg acagacaggt cccaacactg cttaaggctc
     8461 tgcctatatt gcggctcttt ctcccattcc cagctgcagc caaaccagca gtacgtggtc
     8521 agggctggtg ccagatacaa gctgaatacc catgccctgc agtcaagtat ctcaaagcta
     8581 catgtccccc tccccctccg ccagccctgc agctggcacc aaccaggcca gtggctggac
     8641 acagagctgt ttattaccta agggtgacaa atgcaggctt gtgacacaat aacccctgga
     8701 acacagggat gaatgttgag gctattagaa aggtgtggct cctcttggtt ggtttctgca
     8761 gacctagtct tagattttgg ggtcacatgg tatagagatc accaaacaac cactacccct
     8821 cttcaagcat taaaaggggc tctgcagcct gtccctgggg agtgcttttc catgcctatg
     8881 ggagactagg accacgggtc ctacaggcat gctctgcttc acaactaaaa gcaacacagc
     8941 tccagcccaa catgacagct ggagttaggt ccaaaagatg gtcgaggtga gggcaagggg
     9001 ccttttcgcc tagatcatct gtgtccctag ggcccacagc cagattctac tgccttcccc
     9061 atgggtaagg ctcaatggta ggcatacggt tactaggcct tcccagaatt cctcattgtt
     9121 gaccaggcag gtatagctca gagatcagtt gcaccctgta gcccccaaca tgatctgagt
     9181 atgaactcaa ctccagtaga ctacgaccac cttagccagt ggggcctgat ttcttcatct
     9241 ccacagccag tctgtaactt ggtttcagcg tataggaccc tataactctc tcctacaggg
     9301 aacatagagg gcaccattca ccagcctctt tgtacagctg gagaaaccaa agcagtaggc
     9361 agggaggcat ctgcaccctg acaataaaaa tggccttggt acactgaaag gcacgtctat
     9421 cttctgggag aggaagtggg ctcctcgatg aagcattagg tggcaagcag cgccctcagg
     9481 cagctcccct ggcttagtct ggggggccaa gggatgaggg tctacatttc ccttccacgt
     9541 gtactcaagt agcgcctgaa gtgagaattt cccggtaact ccacagagcc aggaaagaaa
     9601 aggctccaat ggaagagcta ggatttcacc gcaaaggata tacaagggca gtaagctgca
     9661 ttggacctcc catcacagcc agctccccac acttgcactc atgtcaccca ggccccaagg
     9721 cactcgacac actggactga ctttgtggga accctgtgaa ctccagggat gggctctcat
     9781 ggtgccctgg caaggctgac ttttctcctg gtattttcta ctttgcagtc ttccccgaca
     9841 gtattctcaa actgggttaa cactgctcca gtccacacca gcatcacagg cttcctcccc
     9901 agggcggttg gaggaagctc tctgggcaca gccaggcagc tctccttccc tcccgttgcc
     9961 tttgtcctgg gcctgggcag acaggctgag gaggagcaga gggtcctggg accctcccac
    10021 cccacctctc ctggtactaa cagaagtctg tgtaggctcg gctccctccc ctcctccaca
    10081 ttctccttcc tgactactgg agggcaacag gtcccctagg cgggtcctgg atctccttcc
    10141 tctgtcacca agaggaggca gattcagagg aggaagagaa cagcaggcca cgtggcttgg
    10201 tctcttggac aagctcaggg aggacacaga aagtgaagtg aaggtagaga gatggaaccc
    10261 tgttgggcac agatcatgcc atctggggct ggtcctgggg ctggctgggc cttgtcctcc
    10321 acctgctcaa atgtgcttcc accaaccaga agaaccccat ttactagttt ttctaataaa
    10381 tcaataatac tctgaaaaaa aaaaaaaaaa aaaaaaa
//
