LOCUS       NM_001177667            8039 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus spectrin alpha, non-erythrocytic 1 (Sptan1),
            transcript variant 2, mRNA.
ACCESSION   NM_001177667
VERSION     NM_001177667.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8039)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8039)
  AUTHORS   Wang,J., Jia,C., Gao,Q., Zhang,J. and Gu,X.
  TITLE     iASPP regulates neurite development by interacting with Spectrin
            proteins
  JOURNAL   Front Mol Neurosci 16, 1154770 (2023)
   PUBMED   37284462
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8039)
  AUTHORS   Yan,L., Yin,H., Mi,Y., Wu,Y. and Zheng,Y.
  TITLE     Deficiency of Wdr60 and Wdr34 cause distinct neural tube
            malformation phenotypes in early embryos
  JOURNAL   Front Cell Dev Biol 11, 1084245 (2023)
   PUBMED   37228654
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8039)
  AUTHORS   Rudolf,M.A., Andreeva,A., Kim,C.E., DeNovio,A.C., Koshar,A.N.,
            Baker,W., Cartagena-Rivera,A.X. and Corwin,J.T.
  TITLE     Stiffening of Circumferential F-Actin Bands Correlates With
            Regenerative Failure and May Act as a Biomechanical Brake in the
            Mammalian Inner Ear
  JOURNAL   Front Cell Neurosci 16, 859882 (2022)
   PUBMED   35602553
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8039)
  AUTHORS   Yao,Q., Wang,H., Chen,H., Li,Z., Jiang,Y., Li,Z., Wang,J., Xing,Y.,
            Liu,F., Yu,D. and Yin,S.
  TITLE     Essential Role of Sptan1 in Cochlear Hair Cell Morphology and
            Function Via Focal Adhesion Signaling
  JOURNAL   Mol Neurobiol 59 (1), 386-404 (2022)
   PUBMED   34708331
REFERENCE   6  (bases 1 to 8039)
  AUTHORS   Hoopes,C.W., Taketo,M., Ozato,K., Liu,Q., Howard,T.A., Linney,E.
            and Seldin,M.F.
  TITLE     Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors
            RXR alpha, RXR beta, and RXR gamma
  JOURNAL   Genomics 14 (3), 611-617 (1992)
   PUBMED   1358808
REFERENCE   7  (bases 1 to 8039)
  AUTHORS   Zimmer,W.E., Ma,Y., Zagon,I.S. and Goodman,S.R.
  TITLE     Developmental expression of brain beta-spectrin isoform messenger
            RNAs
  JOURNAL   Brain Res 594 (1), 75-83 (1992)
   PUBMED   1467942
REFERENCE   8  (bases 1 to 8039)
  AUTHORS   Pilz,A., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Comparative mapping of mouse chromosome 2 and human chromosome 9q:
            the genes for gelsolin and dopamine beta-hydroxylase map to mouse
            chromosome 2
  JOURNAL   Genomics 12 (4), 715-719 (1992)
   PUBMED   1315305
REFERENCE   9  (bases 1 to 8039)
  AUTHORS   Bloom,M.L., Lee,B.K., Birkenmeier,C.S., Ma,Y., Zimmer,W.E.,
            Goodman,S.R., Eicher,E.M. and Barker,J.E.
  TITLE     Brain beta spectrin isoform 235 (Spnb-2) maps to mouse chromosome
            11
  JOURNAL   Mamm Genome 3 (5), 293-295 (1992)
   PUBMED   1638088
REFERENCE   10 (bases 1 to 8039)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ054332.1, BC158015.1, BC150941.1 and CX206486.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the coding region, compared to variant 4. It encodes
            isoform 2, which is shorter than isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               CJ054332.1         2-165
            165-5984            BC158015.1         1-5820
            5985-7893           BC150941.1         5821-7729
            7894-8039           CX206486.1         141-286
FEATURES             Location/Qualifiers
     source          1..8039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.93 cM"
     gene            1..8039
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /note="spectrin alpha, non-erythrocytic 1"
                     /db_xref="GeneID:20740"
                     /db_xref="MGI:MGI:98386"
     exon            1..226
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            227..466
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..7663
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     spectrin alpha chain, brain; alpha-II spectrin; fodrin
                     alpha chain; spectrin, non-erythroid alpha chain;
                     alpha-spectrin 2, brain; spectrin alpha chain,
                     non-erythrocytic 1; alphaII-spectrin"
                     /codon_start=1
                     /product="spectrin alpha chain, non-erythrocytic 1 isoform
                     2"
                     /protein_id="NP_001171138.1"
                     /db_xref="CCDS:CCDS50558.1"
                     /db_xref="GeneID:20740"
                     /db_xref="MGI:MGI:98386"
                     /translation="MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY
                     RFQFFQRDAEELEKWIQEKLQVASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL
                     DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED
                     VMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVSQFAAKLIQE
                     QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWIKEKEQ
                     LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSASQIQV
                     KREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELAND
                     VAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAASHYASDEVREKLSILSEERT
                     ALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKK
                     HEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMHRR
                     AQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSAN
                     QSRIDALEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGIKLREANQQQQ
                     FNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ
                     ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEET
                     WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF
                     AAEDVKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVG
                     STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPMDDETGKELV
                     LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA
                     SRENLLEEQGSIALRQGQIDNQTRITKEAGSVSLRMKQVEELYQSLLELGEKRKGMLE
                     KSCKKFMLFREANELQQWITEKEAALTNEEVGADLEQVEVLQKKFDDFQKDLKANESR
                     LKDINKVAEDLESEGLMAEEVQAVQQQEVYGAMPRDEADSKTASPWKSARLMVHTVAT
                     FNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYG
                     HDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQA
                     WTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL
                     ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQ
                     RRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI
                     NVQEEKIAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQT
                     LQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADR
                     IRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF
                     NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA
                     DSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESW
                     IKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIG
                     QEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVAS
                     EDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG
                     LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV
                     QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKAIEARHASLMKRWTQLL
                     ANSATRKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIK
                     ALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKI
                     IKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLES
                     QLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLG
                     MRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDL
                     PMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALS
                     SEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN"
     exon            467..592
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            593..733
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            734..880
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1014
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1159
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1314
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1450
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1552
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1690
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1801
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1879
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2035
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2240
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2422
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2666
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2789
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..3007
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3100
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3101..3235
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3384
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3444
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3643
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3748
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..3772
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3808
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3809..3856
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..3948
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4093
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4275
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4276..4375
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4376..4573
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4574..4720
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4721..4824
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4825..4987
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            4988..5002
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5003..5134
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5135..5272
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5273..5377
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5378..5586
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5587..5707
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5708..5829
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5830..5962
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            5963..6061
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6062..6221
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6222..6298
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6299..6508
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6509..6805
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6806..6918
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6919..6936
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6937..6991
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            6992..7188
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            7189..7242
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            7243..7389
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            7390..7537
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     exon            7538..8018
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7993..7998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /note="hexamer: AATAAA"
     polyA_site      8018
                     /gene="Sptan1"
                     /gene_synonym="2610027H02Rik; Spna-2; Spna2"
                     /note="major polyA site"
ORIGIN      
        1 ggagcagcga gtcccgcctc tcgcgtcgcc aaccggggca cttccctcac gctcgcgctc
       61 ggccgccgcg ggggcgcgcg cggccgctta taaaagccac agtgcgcgcg cgccgccgtc
      121 actatccgct gcggagcgaa cggcgtgagg caggggccgc ggcggcgcat ctttttcctc
      181 agcagccctc agcgcggcga cccacgcccc tcacccccag gagccgaaaa tggatccaag
      241 tggggtcaaa gtgctggaaa cagccgagga catccaggag agacgacagc aagtcctgga
      301 tcggtaccac cgcttcaagg agctctctac cttacggcgt cagaagctgg aggattccta
      361 tcggttccag ttttttcaaa gagatgctga ggagttggag aagtggattc aggagaagct
      421 tcaagttgca tctgatgaga actacaaaga cccaaccaac ttgcagggaa agctgcagaa
      481 gcaccaagcc tttgaagctg aagtacaggc taactcagga gccattgtga agctggacga
      541 gacaggaaac ttgatgattt ctgaagggca ctttgcatct gaaaccatcc ggacacgttt
      601 aatggagctg caccggcagt gggaactgct tttggagaag atgcgggaga aaggaatcaa
      661 actgctgcag gcacagaagc tggtgcagta tttgcgggag tgtgaggatg taatggactg
      721 gatcaatgac aaggaagcaa ttgtgacttc tgaggagctg ggccaggacc tggagcatgt
      781 agaggtgcta cagaagaagt ttgaagagtt tcagactgat ctggctgctc atgaagaaag
      841 agttaatgaa gtgagccagt ttgctgccaa actcatccag gagcagcacc cggaagagga
      901 gctgatcaag accaagcagg atgaggtgaa tgcagcatgg cagcgactga aaggcctggc
      961 tcttcaaagg cagggcaagc tgttcggtgc tgctgaggtc cagcgcttta acagggatgt
     1021 agatgagacc attggttgga ttaaggagaa agagcagtta atggcctctg atgacttcgg
     1081 cagagactta gcaagtgttc aagctctgct tcgaaagcat gagggtctgg agagagatct
     1141 tgctgctcta gaggacaagg tgaaagccct gtgtgctgag gctgaccgcc tgcaacagtc
     1201 acaccctctg agtgccagcc agatccaggt gaagcgagag gagctgatta ccaactggga
     1261 acagatccga actctggcag cagagagaca tgcacggctt gatgactcgt acaggcttca
     1321 gcgctttctt gctgacttcc gtgacctcac aagctgggta actgaaatga aagccctcat
     1381 caatgcagat gaactggcca atgatgtggc tggtgctgaa gccctgctgg acaggcatca
     1441 agagcacaag ggtgagatcg acgctcatga agatagcttt aagtctgcag atgagtctgg
     1501 gcaagctctg cttgcggcta gtcactatgc ctcagatgaa gtgagggaga agctgagcat
     1561 cctctccgag gagagaactg ccctgctgga gctgtgggag cttcggaggc agcagtatga
     1621 gcagtgcatg gacttgcagc tcttctaccg tgacactgag caggtggaca actggatgag
     1681 caagcaggag gcattcctgc taaatgaaga cttgggtgac tccttagaca gtgtggaagc
     1741 tcttttgaag aagcatgagg actttgaaaa atctctcagt gcccaggaag aaaaaatcac
     1801 agcccttgat gaatttgcaa ccaaactcat ccaaaataac cactacgcaa tggaagatgt
     1861 agcgactcga cgagatgctc tcctgagccg ccgcaatgcc cttcatgagc gagccatgca
     1921 tcgccgggca cagctggctg attccttcca tctgcagcag ttcttccgtg attctgatga
     1981 gctcaaaagt tgggtcaacg agaagatgaa aacggccacc gatgaagctt ataaagatcc
     2041 atccaacctg caagggaaag tccaaaagca tcaggctttt gaggctgagc tttcagcaaa
     2101 ccagagccgg attgatgccc ttgagaaagc tgggcagaag ctaatagatg tcaaccacta
     2161 tgccaaggaa gaagtagcag ctcgtatgaa tgaggtcatc agtttgtgga agaaacttct
     2221 agaggccaca gaactgaaag gaataaagct ccgagaagcc aaccagcagc aacaatttaa
     2281 tcgaaatgtt gaagacattg aattgtggct gtatgaagta gaaggtcatt tggcttcaga
     2341 tgattatggt aaagacctca ctaatgtcca gaacctccag aagaagcatg ctctgctaga
     2401 ggcggatgtt gctgctcacc aggatcgaat tgatggcatc acaattcagg cccgccagtt
     2461 ccaagatgct ggccattttg atgccgaaaa tattaagaag aagcaagagg cccttgtggc
     2521 tcgctatgag gctcttaagg aacccatggt ggcccggaaa cagaagctgg cagattctct
     2581 tcgtctgcag cagctcttcc gggatgtgga ggacgaagaa acctggattc gagaaaagga
     2641 gcctattgct gcatccacta acagaggcaa agatcttatt ggagtccaga atctgctaaa
     2701 gaaacaccaa gctttgcaag cagagattgc tgggcatgaa cctcgaatca aagcagtgac
     2761 acaaaaggga aatgccatgg tggaggaagg ccattttgct gcagaggatg tgaaggccaa
     2821 actgagtgag ctcaaccaga agtgggaggc tctgaaagcc aaagcctccc agcggaggca
     2881 ggatctagag gactcgctgc aggcccagca gtactttgcc gatgccaatg aggctgagtc
     2941 ctggatgcgg gagaaggagc ccattgtggg cagtacggac tatgggaagg atgaagactc
     3001 tgctgaggct ctactcaaga agcatgaagc tttgatgtcc gatctcagcg cctatggcag
     3061 cagcatccag gctctgcgag aacaggccca gtcatgccgg caacaagtgg cccccatgga
     3121 tgatgagact gggaaggagc tagtcttggc tctctatgac tatcaagaga agagtcctcg
     3181 tgaggtcacc atgaagaaag gggatatcct caccttgctc aacagcacaa acaaggattg
     3241 gtggaaagtg gaagtgaatg accggcaggg tttcgtgcca gctgcatatg tgaagaagct
     3301 ggaccccgcc cagtcagcct cgagggagaa cctcctagaa gagcagggca gcattgctct
     3361 gcggcagggg caaattgaca accagacacg cataactaag gaggccggca gtgtatctct
     3421 gcgtatgaaa caggtggaag aactatatca gtctctgctg gaactgggtg agaagagaaa
     3481 aggcatgttg gagaagagtt gcaagaagtt catgttgttc cgggaagcaa acgagttaca
     3541 gcagtggatc actgagaagg aggctgctct aaccaatgag gaggttggcg ctgacttgga
     3601 gcaggttgag gtgctgcaga agaagtttga tgacttccag aaggatctga aagccaatga
     3661 gtctcggctg aaggacatta acaaagtagc agaagacctg gagtctgaag gtctgatggc
     3721 agaggaagtg caagctgtgc agcagcagga ggtgtatggt gcgatgccca gggatgaagc
     3781 agattccaag acggcctccc catggaagtc tgctcgactg atggtccata cagtggctac
     3841 cttcaactcc atcaaggagc tgaatgagcg ttggcggtcc ctgcaacagc tggctgagga
     3901 acgtagccag ctcttgggca gtgcacacga agtacagagg tttcacagag atgctgatga
     3961 aactaaagaa tggattgaag agaagaatca ggctctgaac acagacaact atggccatga
     4021 tttagctagt gtccaggccc tgcagcgcaa acatgaaggc tttgagaggg accttgcagc
     4081 tcttggtgac aaggtgaatt cccttgggga aacagcccaa aggctgatcc agtcccaccc
     4141 tgaatctgca gaggacttaa aggaaaagtg cacagagtta aaccaggcct ggaccagcct
     4201 agggaagcgt gcagaccagc gcaaggccaa attgggtgac tcccatgatc tgcagcgctt
     4261 ccttagcgat ttccgggacc tcatgtcttg gatcaatgga atacgagggt tggtatcttc
     4321 agatgaacta gccaaggacg tcactggagc tgaggctttg ctggagcgac accaggaaca
     4381 ccggacagaa attgatgcca gggctggcac tttccaggca tttgagcagt ttgggcagca
     4441 gctgttagct cacgggcact atgccagccc ggagatcaaa gagaaacttg atattcttga
     4501 ccaggagcgc acagacctgg agaaggcctg ggtccagcgc aggatgatgc tggaccactg
     4561 cctggagttg cagctgttcc atcgggactg tgaacaagca gaaaactgga tggctgcccg
     4621 ggaggccttc ctaaacacag aagacaaagg agactcgctg gacagtgtgg aggcactgat
     4681 caaaaaacat gaagactttg acaaagctat caatgtccag gaagaaaaga tagctgccct
     4741 gcaggccttt gccgaccagc tcattgccgt tgaccactat gccaagggag acattgcaaa
     4801 ccgacgcaat gaggtccttg accggtggcg ccgcctaaaa gcccagatga ttgaaaaaag
     4861 gtcaaaactt ggagaatctc aaacacttca gcagttcagc cgggatgtgg atgagattga
     4921 agcctggatc agtgagaagt tacagacagc cagtgatgag tcatacaagg accccaccaa
     4981 catccagctt tccaagctgt tgagcaagca ccagaagcac caagcctttg aggcagaact
     5041 gcacgccaat gctgaccgaa tccgtggagt tatcgacatg ggcaactccc tcattgagcg
     5101 tggggcctgt gctggcagtg aggatgctgt caaggcccgc ctggctgccc ttgcagacca
     5161 gtggcagttc ctggtgcaga aatcagctga gaagagccag aagctaaaag aggcaaataa
     5221 gcagcagaac ttcaacactg gaatcaaaga ctttgacttc tggctctctg aggtggaggc
     5281 tctcctggca tcggaagatt atggcaaaga cctggcttct gtgaacaact tgctgaaaaa
     5341 gcatcagctg ctagaggcag acatctcggc ccacgaggat cgtctgaagg acctgaacag
     5401 ccaggctgac agcctgatga ctagcagtgc cttcgacacc tcccaagtga aagagaagcg
     5461 ggacaccatc aatggacgct tccagaagat caagagcatg gccacctccc gaagagcgaa
     5521 actgagcgag tcccaccgcc tgcaccagtt cttccgggac atggacgacg aggagtcctg
     5581 gatcaaggag aagaagttgt tagtgagctc tgaggactat ggcagagacc tcactggtgt
     5641 tcagaatctg aggaagaaac acaagcggct agaagctgaa ctggctgcac atgaacccgc
     5701 cattcagggt gtcctggaca ctgggaagaa gctgtctgat gacaacacca tcgggcagga
     5761 ggagatccag caacggcttg cacagtttgt ggagcactgg aaggaactaa agcagctggc
     5821 ggctgcgcgg ggccagcggc tagaggagtc cttggagtat cagcagtttg tagccaacgt
     5881 ggaagaggag gaggcttgga tcaatgagaa gatgactctg gtggccagcg aagactatgg
     5941 agacactctt gctgctatcc agggcttact gaagaaacac gaagcttttg agacagactt
     6001 cactgtccac aaggatcggg tgaatgatgt ctgtactaat ggacaagacc tcattaagaa
     6061 gaacaatcac catgaggaga acatctcttc aaagatgaag ggtctgaatg gaaaggtgtc
     6121 tgatctggag aaagcagcag ctcagaggaa agcaaagctg gatgagaact cagccttcct
     6181 tcagttcaac tggaaggctg acgtggtaga gtcctggatt ggtgaaaagg agaacagctt
     6241 gaaaacagat gactatggcc gagatctgtc ttctgtccaa actctgctca caaaacagga
     6301 gacatttgat gctggcctgc aggccttcca gcaggagggt attgccaata tcactgccct
     6361 caaagaccag ctgctagctg ccaagcacat tcagtctaag gccatcgagg cccgacatgc
     6421 ctccctcatg aagaggtgga cccagctgtt ggccaattca gctacccgga agaagaagtt
     6481 gctggaggcc cagagtcatt tccgtaaggt agaagacctc ttcctgacct ttgccaaaaa
     6541 ggcatcggct ttcaatagct ggtttgagaa tgcagaggaa gacctcacag acccagtgcg
     6601 ctgcaactct ctggaagaaa tcaaagccct tcgagaggct cacgatgcct tccgctcatc
     6661 cctcagctct gcacaggctg acttcaacca gctagccgag ctggaccgcc agatcaagag
     6721 tttccgggtg gcctccaacc cctatacctg gttcacgatg gaggccctgg aagagacctg
     6781 gagaaacctc cagaagatca ttaaggaacg agaactggag ctgcagaagg aacagcggcg
     6841 gcaggaggag aatgacaagc tgcgccaaga atttgcccag catgccaacg ccttccacca
     6901 gtggatccag gaaacaagaa cgtatctcct cgacgggtcc tgcatggtgg aagagtcggg
     6961 aactctggaa tctcagcttg aagctaccaa acgcaagcac caggagattc gagccatgag
     7021 aagtcagctg aagaagatcg aggacctggg ggctgccatg gaggaagccc tcatcctgga
     7081 caacaagtac acggagcaca gcactgtggg cctggcccag cagtgggacc agttagacca
     7141 gctgggcatg cgcatgcagc acaacctgga gcagcagatc caggccagga acacaacagg
     7201 agtgactgag gaggccctca aggaattcag catgatgttc aaacacttcg acaaggacaa
     7261 gtctggccgg ctgaaccatc aggagttcaa atcctgtctt cgctccctgg gctatgatct
     7321 gccaatggtt gaggaaggag agcctgatcc tgagtttgag gcaattctgg acactgttga
     7381 tcccaacagg gatggccacg tctccctgca agaatacatg gctttcatga tcagccgcga
     7441 aacggagaat gtcaagtcca gtgaagagat cgagagtgct ttccgggccc tcagctctga
     7501 gggcaagcct tatgtgacca aggaggagct ctaccagaac ctgacccggg aacaagctga
     7561 ctattgtgtc tcccacatga agccctatgt ggatggcaag ggccgagaac ttccaactgc
     7621 cttcgactac gtcgagttca cccgctcact ctttgtgaat tgatcaatcc tcttggcttg
     7681 taggcaagcc tgacctacac tgcttgccct gttatctcta tctatctatc acctttgctg
     7741 catgtcactt cctctgcttt caaggagaat attccagaca gtgttacttt ccagtgtaac
     7801 cataagcctg cttagcttgg ggtaagactt agtagaaaat ggtgcttcaa taaaccgctt
     7861 ccagtcacaa tcaccaatgt tgtgggaccc agacccatgt ttgagccagc tgccctcatt
     7921 cccacttaaa tcaaagcagc tggctcagct cccttgtttc tcttcccaaa tcctgttttc
     7981 atgtaaaaga aaaataaagg actcatttcc cctctaaaaa aaaaaaaaaa aaaaaaaaa
//
