LOCUS       NM_145134               2232 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus splA/ryanodine receptor domain and SOCS box containing
            4 (Spsb4), mRNA.
ACCESSION   NM_145134
VERSION     NM_145134.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2232)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2232)
  AUTHORS   Filippakopoulos,P., Low,A., Sharpe,T.D., Uppenberg,J., Yao,S.,
            Kuang,Z., Savitsky,P., Lewis,R.S., Nicholson,S.E., Norton,R.S. and
            Bullock,A.N.
  TITLE     Structural basis for Par-4 recognition by the SPRY domain- and SOCS
            box-containing proteins SPSB1, SPSB2, and SPSB4
  JOURNAL   J Mol Biol 401 (3), 389-402 (2010)
   PUBMED   20561531
  REMARK    GeneRIF: SPSB1 and SPSB4 bind strongly to both Par-4 and VASA
            peptides.
REFERENCE   3  (bases 1 to 2232)
  AUTHORS   Kuang,Z., Lewis,R.S., Curtis,J.M., Zhan,Y., Saunders,B.M.,
            Babon,J.J., Kolesnik,T.B., Low,A., Masters,S.L., Willson,T.A.,
            Kedzierski,L., Yao,S., Handman,E., Norton,R.S. and Nicholson,S.E.
  TITLE     The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for
            proteasomal degradation
  JOURNAL   J Cell Biol 190 (1), 129-141 (2010)
   PUBMED   20603330
REFERENCE   4  (bases 1 to 2232)
  AUTHORS   Xing,Y., Gosden,R., Lasko,P. and Clarke,H.
  TITLE     Murine homologues of the Drosophila gustavus gene are expressed in
            ovarian granulosa cells
  JOURNAL   Reproduction 131 (5), 905-915 (2006)
   PUBMED   16672355
REFERENCE   5  (bases 1 to 2232)
  AUTHORS   Masters,S.L., Yao,S., Willson,T.A., Zhang,J.G., Palmer,K.R.,
            Smith,B.J., Babon,J.J., Nicola,N.A., Norton,R.S. and Nicholson,S.E.
  TITLE     The SPRY domain of SSB-2 adopts a novel fold that presents
            conserved Par-4-binding residues
  JOURNAL   Nat Struct Mol Biol 13 (1), 77-84 (2006)
   PUBMED   16369487
REFERENCE   6  (bases 1 to 2232)
  AUTHORS   Takasato,M., Osafune,K., Matsumoto,Y., Kataoka,Y., Yoshida,N.,
            Meguro,H., Aburatani,H., Asashima,M. and Nishinakamura,R.
  TITLE     Identification of kidney mesenchymal genes by a combination of
            microarray analysis and Sall1-GFP knockin mice
  JOURNAL   Mech Dev 121 (6), 547-557 (2004)
   PUBMED   15172686
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC121121.13
            and AC120869.12.
            
            On Mar 21, 2007 this sequence version replaced NM_145134.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF403039.2, BC094332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC121121.13        95199-95360
            163-1009            AC120869.12        3269-4115
            1010-2232           AC120869.12        54986-56208
FEATURES             Location/Qualifiers
     source          1..2232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.74 cM"
     gene            1..2232
                     /gene="Spsb4"
                     /gene_synonym="D030068E18Rik; SSB-4; Ssb4"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 4"
                     /db_xref="GeneID:211949"
                     /db_xref="MGI:MGI:2183445"
     exon            1..162
                     /gene="Spsb4"
                     /gene_synonym="D030068E18Rik; SSB-4; Ssb4"
                     /inference="alignment:Splign:2.1.0"
     exon            163..1009
                     /gene="Spsb4"
                     /gene_synonym="D030068E18Rik; SSB-4; Ssb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1137
                     /gene="Spsb4"
                     /gene_synonym="D030068E18Rik; SSB-4; Ssb4"
                     /note="SPRY domain-containing SOCS box 4; SPRY
                     domain-containing SOCS box protein SSB-4"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 4"
                     /protein_id="NP_660116.1"
                     /db_xref="CCDS:CCDS23419.1"
                     /db_xref="GeneID:211949"
                     /db_xref="MGI:MGI:2183445"
                     /translation="MGQKLSGSLKSVEVREPALRPAKRELRGLEPGRPARLDQLLDMP
                     AAGLAVQLRHAWNPEDRSLNVFVKDDDRLTFHRHPVAQSTDGIRGKVGHARGLHAWQI
                     HWPARQRGTHAVVGVATARAPLHSVGYTALVGSDSESWGWDLGRSRLYHDGKNRPGVA
                     YPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDGQYLGVAFRGLKGKKLYPVVSAVWG
                     HCEVTMRYINGLDPEPLPLMDLCRRSIRSALGRQRLRDIGSLPLPQSLKNYLQYQ"
     exon            1010..2232
                     /gene="Spsb4"
                     /gene_synonym="D030068E18Rik; SSB-4; Ssb4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spsb4"
                     /gene_synonym="D030068E18Rik; SSB-4; Ssb4"
                     /note="hexamer: AATAAA"
     polyA_site      2232
                     /gene="Spsb4"
                     /gene_synonym="D030068E18Rik; SSB-4; Ssb4"
                     /note="major polyA site"
ORIGIN      
        1 tcgagaggac gcgccgctgg ttgagaagca gcagccagca tccgcggggt cgctcgggcg
       61 cccctgcgtg ggcggcagtg gcagcagacc tctctcccgg gagtcccgga cctgccagcg
      121 ctggggattc ctcccaggca ggcgctcgcc ctctctttta tggagcttgg gtccctgcca
      181 cagcccagca gaggctgtgg aggtcatcca tcaagaagcc tggttcccag cctcagggtc
      241 catccttgga taccaggatt ggaggcatct gcgaggtagc agtggccagc agtggtccct
      301 tccccatagt gaaccatggg tcagaagctc tctgggagcc tcaagtctgt ggaggtgcga
      361 gagccagcgc ttcggccagc taagcgggag ctccgcggct tagaacctgg gcgaccggca
      421 cgtctagacc agctgctgga catgcctgcg gcagggttgg cagtacagct gagacacgcg
      481 tggaaccccg aggaccgctc cctcaatgtc tttgtcaagg atgacgaccg cctcaccttc
      541 caccggcacc cagtagccca gagcacagat ggcatccgtg gcaaggtggg ccatgcccgg
      601 ggtctgcacg catggcagat ccattggccc gctaggcagc ggggcaccca cgctgtggtg
      661 ggcgtggcca cggcccgagc ccctttgcac tctgtgggtt acaccgcact ggtgggcagt
      721 gactccgagt cgtggggctg ggacctgggt cgcagccgcc tctaccacga cggcaagaac
      781 cggcctgggg tggcataccc agccttcctg gggccagatg aagcctttgc tctgccagat
      841 tccttattgg tcgtactgga catggacgag ggcacgctca gcttcatcgt ggatggccag
      901 tacctgggcg tggccttccg tggcctcaag ggcaagaaac tatacccggt ggtgagtgct
      961 gtgtggggtc actgcgaagt caccatgcgc tacatcaacg gccttgaccc tgagcctctg
     1021 ccgctgatgg acctgtgccg gcgatccatc cgctcagccc tgggccgaca gcgcctgcgt
     1081 gacatcggct ccctgcccct gcctcagtct ctgaaaaact acctgcagta ccagtgagcg
     1141 gcgctgagga tcggctgtca tctgtggtca cacagctcca gagcgtcagg acacatcagt
     1201 gacttggaaa aggaatgcct gttgccattg ctgccaccga ccaggaccag gaggccacct
     1261 cgtgaaccag agtgtagaga ccattatctt cctcaagaga atgaataaaa cattgggcag
     1321 gagacggcat ccagttagtt ccccactgca gacagaccca ggaaaattgg ccagtggaga
     1381 gaaaatgggt tctgaataat gaatgacaga agccagccct tgatggtctc ctccacgcct
     1441 gcccctggcc agggcagaga gactgtcctc cattttaaga cttggtacca ctttgagaga
     1501 tgagtccagg gtcccacagc agggcaaaag cacctggcct tacctctctg agccggtttc
     1561 ctcatcccct cctgccctct tccgtcatgg ataaagttct ttggccattc ccctccccac
     1621 tttattcagg gacatgaatc tgatgacttg ccctggggac agagtttctt cttgggtatg
     1681 atcattgtaa gtagtgtttg catttttttt ttttgaaaga ggagtgtggt gaaggtggct
     1741 ttctcccaaa ggtgctaagg aagatggggc cctcgtgaca ccaagtctga gacaccctga
     1801 gtatccaggg ctctggcagc catcattcag ggtgaagcct ggctgtcaca aagctttctt
     1861 tgagcaaatt attttttcac tgtaggagac ttccagtttg tttctcgttt ccaatatgtg
     1921 tgtgatgcac cgtttattta tcagctgggg ccccgcggtg tggccttggg actgcaaagg
     1981 tgggtataac agtctctgca ggacctgaga cctatcctct cacagaatgt tgctgctgct
     2041 gctgctgctg ccgccagcgc caccatttgg catcttttgt gtgttccaag ataccctcca
     2101 cccagactca gttttaactg gaaatcatca cagagtagga tacagagcca gacagtgcag
     2161 cctacactgt aatgtgaatg tgacctacaa gcaaggaaca tttctaataa aagtttgtca
     2221 ttctgtcctt ca
//
