LOCUS       NM_027141               2229 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus splA/ryanodine receptor domain and SOCS box containing
            3 (Spsb3), transcript variant 3, mRNA.
ACCESSION   NM_027141
VERSION     NM_027141.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2229)
  AUTHORS   Ohmura,S., Mizuno,S., Oishi,H., Ku,C.J., Hermann,M., Hosoya,T.,
            Takahashi,S. and Engel,J.D.
  TITLE     Lineage-affiliated transcription factors bind the Gata3 Tce1
            enhancer to mediate lineage-specific programs
  JOURNAL   J Clin Invest 126 (3), 865-878 (2016)
   PUBMED   26808502
REFERENCE   2  (bases 1 to 2229)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   3  (bases 1 to 2229)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   4  (bases 1 to 2229)
  AUTHORS   Kargul,G.J., Nagaraja,R., Shimada,T., Grahovac,M.J., Lim,M.K.,
            Nakashima,H., Waeltz,P., Ma,P., Chen,E., Schlessinger,D. and
            Ko,M.S.
  TITLE     Eleven densely clustered genes, six of them novel, in 176 kb of
            mouse t-complex DNA
  JOURNAL   Genome Res 10 (7), 916-923 (2000)
   PUBMED   10899141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166102.2.
            
            On Jan 20, 2022 this sequence version replaced NM_027141.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 5, and 6 all encode the same
            isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF403038.1, AK009325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-705               AC166102.2         54750-55454         c
            706-843             AC166102.2         54421-54558         c
            844-1021            AC166102.2         51878-52055         c
            1022-1209           AC166102.2         51583-51770         c
            1210-1312           AC166102.2         51403-51505         c
            1313-1438           AC166102.2         51202-51327         c
            1439-2229           AC166102.2         50188-50978         c
FEATURES             Location/Qualifiers
     source          1..2229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..2229
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 3"
                     /db_xref="GeneID:79043"
                     /db_xref="MGI:MGI:1891471"
     exon            1..705
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..843
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /inference="alignment:Splign:2.1.0"
     CDS             718..1782
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /note="isoform a is encoded by transcript variant 3; SPRY
                     domain-containing SOCS box protein 3"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 3
                     isoform a"
                     /protein_id="NP_081417.3"
                     /db_xref="CCDS:CCDS28501.1"
                     /db_xref="GeneID:79043"
                     /db_xref="MGI:MGI:1891471"
                     /translation="MARRTRSSRAWHFVLSAARRDTDARAVALAGSSNWGYDSDGQHS
                     DSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDED
                     FDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVY
                     GTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGS
                     IIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTS
                     LQYLCCYRLRQLRPNSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCNHWKSPVPPPGTA
                     TPGAESLETRPCQRKRCRRS"
     exon            844..1021
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1209
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1312
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1438
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..2229
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2202..2207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /note="hexamer: ATTAAA"
     polyA_site      2229
                     /gene="Spsb3"
                     /gene_synonym="2310012N15Rik; 3300001M01Rik; mKIAA4204;
                     SSB3; Tce1"
                     /note="major polyA site"
ORIGIN      
        1 gtcaggcgtc agggacggca tcgctgtggc gagatccgcg agcctttggc gagggaagca
       61 accttcagcc ccgcggaggc cgagcgtggc tacgtccagg gacatctctg gttcattcat
      121 tgggttccta ctgtgtgttc ttatacggcg ctcagccaac ccaactgctg tggagtgctg
      181 tgcgcggccc cgcccggctt ctttgtggat ggccggggcg aggtagggta gtacagtggg
      241 tctacagggg gacaggaggc agctaggaca gagtcgacta ttagacaaag acagtccact
      301 cgggagagga gatccggacc tctcaaagcc tttcattttg tcccaagaac gatgtcaagc
      361 cagtgagttt aaggttgtat caaagactga gtttgtagtg tgcagagccg gatgggtgag
      421 agggagttgt gtggtgcagg aagcggtggg ggtctccaat ggcaaggagg ggtgtcagga
      481 gtggatgaca gcggtgtttc tggcatgagg aactggatgc tgtggatgcc atttgccaaa
      541 gtggaccgcg gaggaggagc aagttaagtg tcaaatgcct gaggggcaac agctcctgaa
      601 cagaatgcag agatgggctg ggacacatcc aaagtcatgg gtgtctgggt tgtgtttcac
      661 accatcgccc tgggcttgat tgaggtgctc agatactcga gccaggttct ctccactatg
      721 gcccggcgta cacggagtag cagggcatgg catttcgtcc tgagcgcagc ccgccgagat
      781 acagatgccc gggctgtggc tctggcaggc agctctaact ggggctatga ctctgatggg
      841 cagcacagcg actccgactc tgaccctgag tactcctccc tgccaccatc catccccagt
      901 gctgtgcctg tgacaggaga gtccttctgt gactgcgagg gccagaatga ggctaccttc
      961 tgcaacagtc tgcacacagc acaccgtggc aaggactgcc ggtgtggtga ggaggatgag
     1021 gattttgatt gggtctggga tgacctgaac aagtcctcag ccaccttgct gagctgtgat
     1081 aatcgcaagg tcagctttca catggagtat agctgtggca ctgcagccat tcggggcacc
     1141 aaggagctag gggatggcca acacttctgg gaaatcaaga tgacctctcc agtgtatggc
     1201 acagacatga tggtgggcat tgggacgtcg gatgtagacc tggacaagta ccaccacacg
     1261 ttctgcagcc tgctgggcag ggatgaggac agctgggggc tctcctacac tgggctcctc
     1321 caccacaaag gtgacaagac gagcttctct tcacgctttg gccagggctc cattattggt
     1381 gtgcacttgg acacctggca tgggacactg acattcttca agaacaggaa gtgcatagga
     1441 gtggctgcta ctcggcttca aaacagaagg ttctacccga tggtttgctc cacggctgcc
     1501 aagagcagca tgaaagtcat ccgctcctgc gccagctcca catccctgca gtacctgtgc
     1561 tgctaccgct tgcgccaact gcggccaaat tcaggggaca ccctcgaggg cctgcccttg
     1621 ccacctggcc tcaagcaagt gctgcataac aagctgggct gggttctgag catgaactgc
     1681 aaccactgga aatcccctgt gccccctcct ggcacagcta cacctggtgc cgagagtctg
     1741 gagaccaggc cctgtcagag gaagcgctgc cgaagaagct gacttctccc ctgggaacgc
     1801 agataccttc ctctttctcg cccttccagg gcagcaggag agggaagaac tgaggtccag
     1861 gcttttccct atctccctga ggccaggaca gtcttctccg gtgaccatgg agtgaaggtc
     1921 attctactgc ctgtgctggt agggaagccg tactcctatt tgtcctttga gttgccacgt
     1981 gtcttgggaa ctgcagctag gcacctgtga acctagattc caagcccggg aggctggccg
     2041 acgaagggga gtgcattcat atcccgggga gaagatgggc tgtccccacc cacggggccg
     2101 tggggctttc ctgacttgca ctgcatgttg tcagctcctg ctgcagagat ggcagtgggt
     2161 gccctgtgaa ggggttttgt cttgtccctc tatgttatat cattaaaaga gccttcacaa
     2221 atgcccaag
//
