LOCUS       NM_001419256            3342 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus splA/ryanodine receptor domain and SOCS box containing
            1 (Spsb1), transcript variant 2, mRNA.
ACCESSION   NM_001419256
VERSION     NM_001419256.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3342)
  AUTHORS   Li,Y., Dormann,N., Brinschwitz,B., Kny,M., Martin,E., Bartels,K.,
            Li,N., Giri,P.V., Schwanz,S., Boschmann,M., Hille,S., Fielitz,B.,
            Wollersheim,T., Grunow,J., Felix,S.B., Weber-Carstens,S.,
            Luft,F.C., Muller,O.J. and Fielitz,J.
  TITLE     SPSB1-mediated inhibition of TGF-beta receptor-II impairs
            myogenesis in inflammation
  JOURNAL   J Cachexia Sarcopenia Muscle 14 (4), 1721-1736 (2023)
   PUBMED   37209006
  REMARK    GeneRIF: SPSB1-mediated inhibition of TGF-beta receptor-II impairs
            myogenesis in inflammation.
REFERENCE   2  (bases 1 to 3342)
  AUTHORS   Pfeifer,M., Brem,R., Lippert,T.P., Boulianne,B., Ho,H.N.,
            Robinson,M.E., Stebbing,J. and Feldhahn,N.
  TITLE     SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the
            Genomes of B Cell Precursors
  JOURNAL   J Immunol 202 (12), 3423-3433 (2019)
   PUBMED   31085591
  REMARK    GeneRIF: these results establish SSB1/2 as safeguards of B cell
            development and unveil their differential requirement in immature
            and mature B lymphocytes
REFERENCE   3  (bases 1 to 3342)
  AUTHORS   Shi,W., Vu,T., Boucher,D., Biernacka,A., Nde,J., Pandita,R.K.,
            Straube,J., Boyle,G.M., Al-Ejeh,F., Nag,P., Jeffery,J.,
            Harris,J.L., Bain,A.L., Grzelak,M., Skrzypczak,M., Mitra,A.,
            Dojer,N., Crosetto,N., Cloonan,N., Becherel,O.J., Finnie,J.,
            Skaar,J.R., Walkley,C.R., Pandita,T.K., Rowicka,M., Ginalski,K.,
            Lane,S.W. and Khanna,K.K.
  TITLE     Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and
            progenitor cells by resolving replicative stress
  JOURNAL   Blood 129 (18), 2479-2492 (2017)
   PUBMED   28270450
  REMARK    GeneRIF: Collectively, Ssb1 and Ssb2 control crucial aspects of
            Hematopoietic stem and progenitor cells function, including
            proliferation and survival in vivo by resolving replicative stress
            to maintain genomic stability.
REFERENCE   4  (bases 1 to 3342)
  AUTHORS   Liu,S., Nheu,T., Luwor,R., Nicholson,S.E. and Zhu,H.J.
  TITLE     SPSB1, a Novel Negative Regulator of the Transforming Growth
            Factor-beta Signaling Pathway Targeting the Type II Receptor
  JOURNAL   J Biol Chem 290 (29), 17894-17908 (2015)
   PUBMED   26032413
  REMARK    GeneRIF: SPSB1 negatively regulates the TGF-beta signaling pathway
            through its interaction with both endogenous and overexpressed
            TbetaRII (and not TbetaRI) via its Spry domain.
REFERENCE   5  (bases 1 to 3342)
  AUTHORS   Feng,Y., Pan,T.C., Pant,D.K., Chakrabarti,K.R., Alvarez,J.V.,
            Ruth,J.R. and Chodosh,L.A.
  TITLE     SPSB1 promotes breast cancer recurrence by potentiating c-MET
            signaling
  JOURNAL   Cancer Discov 4 (7), 790-803 (2014)
   PUBMED   24786206
  REMARK    GeneRIF: Findings define a novel pathway that contributes to breast
            cancer recurrence and provide evidence implicating SPSB proteins in
            cancer.
REFERENCE   6  (bases 1 to 3342)
  AUTHORS   Filippakopoulos,P., Low,A., Sharpe,T.D., Uppenberg,J., Yao,S.,
            Kuang,Z., Savitsky,P., Lewis,R.S., Nicholson,S.E., Norton,R.S. and
            Bullock,A.N.
  TITLE     Structural basis for Par-4 recognition by the SPRY domain- and SOCS
            box-containing proteins SPSB1, SPSB2, and SPSB4
  JOURNAL   J Mol Biol 401 (3), 389-402 (2010)
   PUBMED   20561531
  REMARK    GeneRIF: SPSB1 and SPSB4 bind strongly to both Par-4 and VASA
            peptides.
REFERENCE   7  (bases 1 to 3342)
  AUTHORS   Kleiber,M.L. and Singh,S.M.
  TITLE     Divergence of the vertebrate sp1A/ryanodine receptor domain and
            SOCS box-containing (Spsb) gene family and its expression and
            regulation within the mouse brain
  JOURNAL   Genomics 93 (4), 358-366 (2009)
   PUBMED   19101625
  REMARK    GeneRIF: Spsb1 is responsive to stress caused by ethanol exposure
            in the mouse brain, which suggests that Spsb genes have acquired
            different regulatory mechanisms.
REFERENCE   8  (bases 1 to 3342)
  AUTHORS   Xing,Y., Gosden,R., Lasko,P. and Clarke,H.
  TITLE     Murine homologues of the Drosophila gustavus gene are expressed in
            ovarian granulosa cells
  JOURNAL   Reproduction 131 (5), 905-915 (2006)
   PUBMED   16672355
REFERENCE   9  (bases 1 to 3342)
  AUTHORS   Masters,S.L., Yao,S., Willson,T.A., Zhang,J.G., Palmer,K.R.,
            Smith,B.J., Babon,J.J., Nicola,N.A., Norton,R.S. and Nicholson,S.E.
  TITLE     The SPRY domain of SSB-2 adopts a novel fold that presents
            conserved Par-4-binding residues
  JOURNAL   Nat Struct Mol Biol 13 (1), 77-84 (2006)
   PUBMED   16369487
REFERENCE   10 (bases 1 to 3342)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606914.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3270986.1,
                                           SRR12282455.32558565.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AL606914.9         135166-135350
            186-441             AL606914.9         180451-180706
            442-1283            AL606914.9         182946-183787
            1284-3342           AL606914.9         191862-193920
FEATURES             Location/Qualifiers
     source          1..3342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 80.46 cM"
     gene            1..3342
                     /gene="Spsb1"
                     /gene_synonym="1110014L01Rik; 4930422J18Rik; SSB-1; SSB1"
                     /note="splA/ryanodine receptor domain and SOCS box
                     containing 1"
                     /db_xref="GeneID:74646"
                     /db_xref="MGI:MGI:1921896"
     exon            1..185
                     /gene="Spsb1"
                     /gene_synonym="1110014L01Rik; 4930422J18Rik; SSB-1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..441
                     /gene="Spsb1"
                     /gene_synonym="1110014L01Rik; 4930422J18Rik; SSB-1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..1283
                     /gene="Spsb1"
                     /gene_synonym="1110014L01Rik; 4930422J18Rik; SSB-1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             590..1411
                     /gene="Spsb1"
                     /gene_synonym="1110014L01Rik; 4930422J18Rik; SSB-1; SSB1"
                     /note="SPRY domain-containing SOCS box protein SSB-1"
                     /codon_start=1
                     /product="SPRY domain-containing SOCS box protein 1"
                     /protein_id="NP_001406185.1"
                     /db_xref="GeneID:74646"
                     /db_xref="MGI:MGI:1921896"
                     /translation="MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMP
                     PVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQI
                     TWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKT
                     YPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWG
                     HCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGKERLGAIPALPLPASLKAYLLYQ"
     exon            1284..3342
                     /gene="Spsb1"
                     /gene_synonym="1110014L01Rik; 4930422J18Rik; SSB-1; SSB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3314..3319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spsb1"
                     /gene_synonym="1110014L01Rik; 4930422J18Rik; SSB-1; SSB1"
                     /note="hexamer: AATAAA"
     polyA_site      3342
                     /gene="Spsb1"
                     /gene_synonym="1110014L01Rik; 4930422J18Rik; SSB-1; SSB1"
                     /note="major polyA site"
ORIGIN      
        1 gtcggtggct ttttcttctc agcgcaggag tcgcgctcga gcggcccgcg cgcttgctgc
       61 aggaaccagc tccaggcgct ggcgccgggg ccacggggag gaagcgactt cgctctctgc
      121 agcgggcgcg gccctgggca ccgcgagcct ccggagctcc aagagctgcg gcctctctgt
      181 gcgcgggaac gagcgagcac attctagaac atcagaatca agtgccagct gtgccgagcc
      241 ctctctagga cactgtctcc attgggtttc ggatgagcat gtgacacacg ggcgacaccc
      301 atgttatacg tgaacagagg gaaacttgga caaaccaaaa gtgagccgta gtcggtgcac
      361 aaggcgcaga gtcctgagcg agttcgggag cctcggagac aggcctgggg acatgccctg
      421 tggactccag ccgagggaga ggcaatacag agtgcttcac gacctttgga gatcgcctag
      481 caacctccct taggggttct gtccggcccc gaccagagat ctggagtcaa cgacccaaga
      541 ttgatgagtt tgccttggga gtcagtggaa aggtgaaata aaggccaaca tgggtcagaa
      601 ggtcacagga gggatcaaga ctgtggacat gcgggacccc acataccgac ctctgaagca
      661 ggaactccag gggctggatt actgcaagcc cacccggctg gacctgctgc tcgacatgcc
      721 ccctgtgtcc tacgatgtgc agctgctcca ctcctggaac aataacgacc gttcgctcaa
      781 cgtcttcgtg aaggaagatg acaagttgat ctttcaccgg catccggtgg cccagagcac
      841 ggacgccatc aggggcaaag ttgggtacac acgtggactg catgtatggc agatcacatg
      901 ggccatgagg caacgaggca cgcatgccgt ggtgggggtg gccacagcag atgccccttt
      961 gcactccgtt gggtacacaa cccttgtagg aaataaccat gaatcctggg gctgggacct
     1021 ggggcgtaac cgtctctacc acgacggcaa gaaccagcca agtaaaacat acccagcctt
     1081 tctggagccg gacgagacat tcattgtccc tgactccttt ctcgtggccc tggacatgga
     1141 tgatgggacc ttaagtttca tcgtggatgg acagtacatg ggagtggctt tccggggact
     1201 caagggtaaa aagctgtatc ctgtagtgag tgccgtctgg ggccactgtg agatccgcat
     1261 gcgctacttg aacggacttg atcctgagcc cctgccactc atggacctgt gccggcgttc
     1321 ggtgcgccta gcgctgggaa aggagcgcct gggtgccatc cccgctctgc cgctacctgc
     1381 ctccctcaaa gcctacctcc tctaccagtg atccaaatcc caggaccgcc atacgacagc
     1441 cacctggtgc caagtcactg agcccgttgg ggtccgccga cccctgcgcc tgggatggat
     1501 gcccaccctc agccatgggc agacgtgccc cctcatccta ccggctgcct ctgctggggg
     1561 aacctatgcc aacggacttc tcccttccca acactggctg aagcagcagc acccaggccc
     1621 ttccctgaac cagatgcaga gaataaacta tgagaacctc tctcaggcgc cttctgctct
     1681 caggtggagt gggctgcccc ccactctctg cagagagagg ctacacccac ctggggggtc
     1741 ctgggaggta agactagtag gaggtgccag ggctgagtcc aaaagcagga atggccagga
     1801 ccaggccata cagatgaagc tcaggatgtc acataccatg gacactgaga cagaacccca
     1861 ggttggactt cccttgggcc aacgagtgcc agctttaatg tcagctgccg gtgctctgtg
     1921 gcctgtattt attctttaaa cagtagcaaa ggccatttat ttattccact tagaaaggaa
     1981 accttggtgg gtggcttccc tcgatgtgct ttcccccacc tccctggaat gtgtgtgcca
     2041 cacctgtcct tgtcccaggc caggactgtg gcacatgagc tggtgtgcac agatacacgt
     2101 atgtcgtcgt gcatgacccc tgactagttc ctaagtagcc ctgcaccaag caccagagca
     2161 gaccccaaga gaggcccgtg caagtcccca tgtccccagg tccctgcttc tgttgccttg
     2221 ggcactcata caccggcaca cgtgtttcag cctcttgact tccatgagct tcgaattttg
     2281 cccccgattc ttctgatatt tcccattggc atcctccaaa gctctgggcc tggagggcca
     2341 ttaggacaca tggaatgagt ggggtctcca gcccctggga aagccactgg caaggcagga
     2401 ttagaaagac caagagcagg gtggggcgcc atgaagcctg tatgcctctc aggctcaaga
     2461 ccccgccaca cacccactca agcctcagaa gtggtgtgta gggcagcccc aggagaggaa
     2521 tgcctgtcct agcagcacgt acatggagca ccccacatgt gctccagccc tctggctgtt
     2581 tctcttgctc tagaatcaac tccctacatt gggaatgtag ccatttggta gaggacttgc
     2641 ctagcctgca ggaagctcac gttccatccc ctgcaccaag gagaatcaaa gctcaggagg
     2701 ctgaggcagg aggattgctg tcagtggtgt acagaggtca tggccatcct gggctatatt
     2761 aaaccttgtc ctttaagaaa aagaaaagaa atcaacttcc attgaatctg agttctgctc
     2821 atttctgcac aggtacaata gatgacttta tttgttgaaa aatgtttaat atatttacat
     2881 atatatatat ttgtaagaag cattttaagc agctgctgta gggtacctta aaaaaaaaac
     2941 ttccagtaga gtataaattt taaagcacag aattggtgcc aagactagat aaagaatgta
     3001 aattattctc tttatatttt gaggttcttt tcctttttgg ggcctttgtc agactgcaca
     3061 accttacttg ttctcatttg gagtggatgg tgttcagtgg tatagatccc agcgtgtcac
     3121 cccgatccca gctgtactcc catgcatgct ggtgaatttc caggctctcc tgtgtccccc
     3181 atactccacc accccaggac tcgccacacc tccctgacat cccgtcacca gcaccgtaaa
     3241 gccttgtggc atgtatagtt ctgaaacccc cgttctgttc tgttttatga tgactcataa
     3301 cagtcagcaa cctaataaag gaaagtttgt taaaatatga aa
//
