LOCUS       NM_011898               4687 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus sprouty RTK signaling antagonist 4 (Spry4), mRNA.
ACCESSION   NM_011898 XM_988191
VERSION     NM_011898.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4687)
  AUTHORS   Altes,G., Olomi,A., Perramon-Guell,A., Hernandez,S., Casanovas,A.,
            Perez,A., Diaz-Tocados,J.M., Valdivielso,J.M., Megino,C.,
            Navaridas,R., Matias-Guiu,X., Klein,O.D., Egea,J., Dolcet,X.,
            Yeramian,A. and Encinas,M.
  TITLE     Multiple endocrine defects in adult-onset Sprouty1/2/4 triple
            knockout mice
  JOURNAL   Sci Rep 14 (1), 19479 (2024)
   PUBMED   39174793
  REMARK    GeneRIF: Multiple endocrine defects in adult-onset Sprouty1/2/4
            triple knockout mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4687)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4687)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4687)
  AUTHORS   Li,S., Zhao,S., Liang,N., Zhang,S., Zhang,L., Zhou,L., Liu,A.,
            Cao,X., Tian,J., Yu,Y., Fan,Z., Xiao,K., Wang,M., Zhao,H., Bai,R.
            and Sun,J.
  TITLE     SPRY4 inhibits and sensitizes the primary KIT mutants in
            gastrointestinal stromal tumors (GISTs) to imatinib
  JOURNAL   Gastric Cancer 26 (5), 677-690 (2023)
   PUBMED   37222910
  REMARK    GeneRIF: SPRY4 inhibits and sensitizes the primary KIT mutants in
            gastrointestinal stromal tumors (GISTs) to imatinib.
REFERENCE   5  (bases 1 to 4687)
  AUTHORS   Chen,R., Cao,C., Liu,H., Jiang,W., Pan,R., He,H., Ding,K. and
            Meng,Q.
  TITLE     Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung
            injury in mice
  JOURNAL   Redox Biol 58, 102513 (2022)
   PUBMED   36334381
  REMARK    GeneRIF: Macrophage Sprouty4 deficiency diminishes sepsis-induced
            acute lung injury in mice.
            Erratum:[Redox Biol. 2023 Jun;62:102667. doi:
            10.1016/j.redox.2023.102667.. PMID: 36948902]
REFERENCE   6  (bases 1 to 4687)
  AUTHORS   Zhang,S., Lin,Y., Itaranta,P., Yagi,A. and Vainio,S.
  TITLE     Expression of Sprouty genes 1, 2 and 4 during mouse organogenesis
  JOURNAL   Mech Dev 109 (2), 367-370 (2001)
   PUBMED   11731251
REFERENCE   7  (bases 1 to 4687)
  AUTHORS   Impagnatiello,M.A., Weitzer,S., Gannon,G., Compagni,A., Cotten,M.
            and Christofori,G.
  TITLE     Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein
            inhibitors of growth factor signaling in endothelial cells
  JOURNAL   J Cell Biol 152 (5), 1087-1098 (2001)
   PUBMED   11238463
REFERENCE   8  (bases 1 to 4687)
  AUTHORS   Goldman,D.C., Martin,G.R. and Tam,P.P.
  TITLE     Fate and function of the ventral ectodermal ridge during mouse tail
            development
  JOURNAL   Development 127 (10), 2113-2123 (2000)
   PUBMED   10769235
REFERENCE   9  (bases 1 to 4687)
  AUTHORS   Minowada,G., Jarvis,L.A., Chi,C.L., Neubuser,A., Sun,X.,
            Hacohen,N., Krasnow,M.A. and Martin,G.R.
  TITLE     Vertebrate Sprouty genes are induced by FGF signaling and can cause
            chondrodysplasia when overexpressed
  JOURNAL   Development 126 (20), 4465-4475 (1999)
   PUBMED   10498682
REFERENCE   10 (bases 1 to 4687)
  AUTHORS   de Maximy,A.A., Nakatake,Y., Moncada,S., Itoh,N., Thiery,J.P. and
            Bellusci,S.
  TITLE     Cloning and expression pattern of a mouse homologue of drosophila
            sprouty in the mouse embryo
  JOURNAL   Mech Dev 81 (1-2), 213-216 (1999)
   PUBMED   10330503
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151580.2, AK048122.1, BC050944.1 and AK034201.1.
            
            On Jul 18, 2018 this sequence version replaced NM_011898.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057005.1, AK048122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC151580.2         214231-214232       c
            3-79                AK048122.1         2-78
            80-4669             BC050944.1         1-4590
            4670-4687           AK034201.1         3176-3193
FEATURES             Location/Qualifiers
     source          1..4687
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 20.5 cM"
     gene            1..4687
                     /gene="Spry4"
                     /gene_synonym="A030006O18Rik; sprouty4"
                     /note="sprouty RTK signaling antagonist 4"
                     /db_xref="GeneID:24066"
                     /db_xref="MGI:MGI:1345144"
     exon            1..178
                     /gene="Spry4"
                     /gene_synonym="A030006O18Rik; sprouty4"
                     /inference="alignment:Splign:2.1.0"
     exon            179..4687
                     /gene="Spry4"
                     /gene_synonym="A030006O18Rik; sprouty4"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1128
                     /gene="Spry4"
                     /gene_synonym="A030006O18Rik; sprouty4"
                     /codon_start=1
                     /product="protein sprouty homolog 4"
                     /protein_id="NP_036028.2"
                     /db_xref="CCDS:CCDS29202.1"
                     /db_xref="GeneID:24066"
                     /db_xref="MGI:MGI:1345144"
                     /translation="MEPPVPQSSVPVNPSSVMVQPLLDSRAPHSRLQHPLTILPIDQM
                     KTSHVENDYIDNPSLAPATGPKRPRGGPPELAPTPARCDQDITHHWISFSGRPSSVSS
                     SSSTSSDQRLLDHMAPPPVAEQASPRAVRLQPKVVHCKPLDLKGPTAPPELDKHFLLC
                     EACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEG
                     SCADHPCSCSGSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRC
                     KHTNSVICKAASGDTKTSRSDKPF"
     regulatory      4650..4655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spry4"
                     /gene_synonym="A030006O18Rik; sprouty4"
                     /note="hexamer: AATATA"
     polyA_site      4669
                     /gene="Spry4"
                     /gene_synonym="A030006O18Rik; sprouty4"
                     /note="major polyA site"
ORIGIN      
        1 gcaacatcgc cgctgaggca gcgaacagag ctgacagcgc ggagctggcg ctgcagggct
       61 cagggagctt tgccggctcc tccgactgac gtctgcgact tcaacggcga ctgacccact
      121 cgggttcggg gatttacaca gacgtggagc gatgcttgtg actctgcagc tcctcaaaga
      181 cccctagaag cctgtccctt ggtgcagttc aggacctcca gcctcatgga gcccccggtt
      241 ccacagagca gcgtccctgt gaatcccagc tcagtcatgg tgcagcccct ccttgacagc
      301 agagcgcccc acagccggct ccagcaccca ctcaccatct tacccattga ccagatgaag
      361 accagccacg tggagaatga ctacatagac aaccctagcc tggcccctgc cacgggtccc
      421 aagcggcccc ggggcgggcc accagagctg gctcctacac ctgcccgctg tgaccaggat
      481 attactcacc actggatctc cttcagcggt cggcccagct ctgtaagcag cagtagcagc
      541 acttcctccg accagaggct cctagatcac atggctccac cgcccgtggc tgagcaggcc
      601 tcacccaggg ctgtgcgcct ccagcccaag gtggttcact gtaagccgct ggacctcaaa
      661 ggcccgacag ctccgccaga gctagacaag cacttcttgc tgtgtgaggc ctgtggaaag
      721 tgtaagtgca aagagtgtgc gtcccctcgg acgttacctt cctgctgggt ctgcaaccag
      781 gagtgcctgt gctcggctca gacgctggtc aactatggca catgcatgtg tctggtgcaa
      841 ggtatcttct atcactgtac taatgaggat gatgagggct cttgcgccga ccacccctgc
      901 tcctgttccg gctccaactg ctgcgcccgc tggtccttca tgggcgccct ctctgtggtg
      961 ctgccctgtc tgctgtgcta cctgccggcc acaggctgcg tcaagctggc ccagcgaggc
     1021 tacgaccgcc tgagacgccc cggttgccgc tgcaagcaca cgaacagcgt catctgcaag
     1081 gcagccagtg gggacaccaa gaccagcagg tctgacaagc ctttctgaca ctttggatga
     1141 aaaaaacatg gtccctcctg ccagtctcct gagactgacc ttgctcatct gtcctctcct
     1201 aaaaccctag attgggaaga aaccggcaga gaacactact gcctagcctt gagtccccaa
     1261 aaggatgaag atgtactttg gggattttca cagtcttgaa actttgttaa acagcagtga
     1321 cagtgttagg gtatggtggt agggggccca gttttcctat ttcagaagac ggaagacaga
     1381 tgcggacaca gggtctgcaa gttcagccac tcaatggcct tcccagcccc tctgcttcct
     1441 ctcattttgc cattctctct ggctcctgct ggagccttct acctgggagg aacagctaat
     1501 gggaggcaag atacctcgag gaagaccctc cgagccttga cttctatctt tgccgcctcc
     1561 gtccatgcct gttggccttg gcctcttggg aaggtgcacc gtagccattc ctgctgtatg
     1621 cacttgatgt ccgagaacaa aatcgccggt aagctgctgc ctcccgtgag tagcaggatg
     1681 gagaaggaac cacctggcag tgtgttcctc ctagctttca atcactaact tgggggttgt
     1741 ccgctcatca cgccatcctc cagttcacag actggcctgc ctgctatgcg tcctgagcac
     1801 tctttctact cggattcttt gtagaaactc gctgggttaa gaaggccagg atgacacaag
     1861 caagaccaaa tatcattttg ccaatgagtc tgaggctgtg gtctctggat ccagccatga
     1921 tgtttttata tgtttaatta aactagatgc tattggtgtt taaacaataa taatacaaca
     1981 accttgcttc cttttgggcc acccccagga agggctgatt tcaaaatctg ggggtaagca
     2041 acctcaagga gcgtttcccc tgcacatcga gaatggcaaa gaagaggccg tacctcccat
     2101 tggcaggatg acagttgagc cgaactgggg ttgggttttc ttgtgattct gctgcttgct
     2161 gtctctagcc ttttgtgtat agtgatgcgt ctgtctttat gtaaatagag atgacagagt
     2221 ctattttagt gttaagaagc cctggtgggg aagtcggaag atgccagaga aggtggggaa
     2281 cgatcctcca ggggctgctg ggtttgagcc ccactttttg tgtgcacaca cacagacacc
     2341 cctcccaaca gcccccaaag acgtagcaac tctttctctc acggtgctaa aggactcaga
     2401 acgcgcagcc cgtccagtgg gtaggtactt gttgcatgca aaaagctatc gtgtctctgg
     2461 tccttgcccc cagctgttgt gtgggtgggt tttttttgtt ttttttgttt ttttttttgt
     2521 tgttgttttt ggttttggtt ttttctttgt gtggtatttt gtccccatcc ctgcctctga
     2581 ttcaagaaat agcctgggtc agaagaggta ccccaggtaa aattgagaga gcattaggca
     2641 aaaatcatgt ggagcatttc tggttctttt gtgtgagcag cccctaggga ggaggcaagg
     2701 agtcaggtag ctgtaagtgg agtgtaccta ttgctctttt ctcaaggatt cacccccacc
     2761 cccaccttgg aagctactag tagtaatagt aacaccttat gatttagaat aagttaattg
     2821 taaccatagg tatttattga ttggaggaag ggagggtttt attttcagct ttatttatgc
     2881 aacatttact ggcttgtaaa aggcaagtat aaaatcctgc atcttcatcg tctataacta
     2941 atccatacat atacctgccc ttgccacatt gcagtgttct tgcacagaac ggaaggaaag
     3001 atagaagaca aacccctgcg atcagcaaac cacttacact aattgaatgt attagaagct
     3061 ttctgaaggg gctggagatg ttttcctcga atgaggggtg tggagggacc ccccccccaa
     3121 aaaaaaaccc tgatagcgca cacgtgcact ctttctaaga agcctgggag cttcacccag
     3181 ggtccctccc tcaatttgta tccacaggac agctgaccca gtggcaggtt gcactttggt
     3241 gatcttggtc tgcatacgtc tgtggacagt tgagctatat aagccgtgta tgcgcacatg
     3301 cacacgtgac acttacatac acagaccctc taccacacag accctgtttc ctggcaaccc
     3361 ttcccaaacc ctgactttgt gtacatagct gtaaacacgg atttgggggg ttttggtttg
     3421 cttccccacc tcaccaaccc cttgttctgg tttggaaatg atgtctacag aattcttcct
     3481 ccccacagaa gttgaccttg ggactcactt gctcagtggt aagggaaggg gagaaggaag
     3541 gaaggaagca tcctttttcc tctgctctgt tgttttttct ctgacttctt ggcaaacaca
     3601 cataggggat gcaaacacag aaaaggggta gtttgtttat agggccccct ccccttccca
     3661 ggttagtcaa caggcattgg gaacacaggc tctcacaaac agaacatttc tgtagctgtt
     3721 tctgacttct tggctagcat ttgcagcttt tgcttggctt gagttaacat cacttccaaa
     3781 gtgccagctg gttcccactt ctagacctgg ggtggctgtc agttgtgcct ggagccaagg
     3841 atggcttccg ggatctttct taaggtgcct gggctacttg gtaccattgt agggaaaggc
     3901 tggttctcct gtaagcactc tgggggctga gtttaggcta gcaacatctt ccaaggtacc
     3961 atcaatgctc ctcaagccaa ctggaagaga gcaacgagcg gcctttctca gcgatgggag
     4021 gcatccttac gactgatagg ttctttgagc tagtgtagtt ctgcatcaat ggggcccagc
     4081 tggatcacag cctcaaggga acaacacata ccaagttggt caggggcaga accaggcagg
     4141 tacccatcat tctagagcag cttggtctcc agtgctgctc caagaaatag tggaggcgtg
     4201 tgggcagcac acatttgcac tgtacaattg aacatccggg gcttccccgg cttcccaatt
     4261 tatgcatttg gtgagtagct ccgtgccctt ccccgctctg taatggtgga tgtcgatcct
     4321 gtgtttccat tttgattgtg ggtgactgtg ctgtttctta gcttgctttt ctcttgtgtc
     4381 ctgtggttga tttcctgtta gcagcactag agctgtgccc agcaccccac tccaccacat
     4441 tcctgtgtct ctgtagctcc ccctccccgc ccctgttcat cccaccacaa aagttaccac
     4501 agaaggtttc ctttgtaaaa aatatttatt ttgaagctct attttaatag tatttatttt
     4561 agaaagtcta ctattgtaag agttcttctg tttgtgaaga aaaaaaaaca agttaaaaac
     4621 tgaatgtact gatctagaag atatctataa atatatattg ttaaatatac acatggctgc
     4681 cattctc
//
