LOCUS       NM_011897               2103 bp    mRNA    linear   ROD 10-SEP-2023
DEFINITION  Mus musculus sprouty RTK signaling antagonist 2 (Spry2), mRNA.
ACCESSION   NM_011897
VERSION     NM_011897.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Luzzio A, Edie S, Palmer K, Caddle LB, Urban R, Goodwin LO, Welsh
            IC, Reinholdt LG, Bergstrom DE, Cox TC, Donahue LR and Murray SA.
  TITLE     The spontaneous mouse mutant low set ears (Lse) is caused by tandem
            duplication of Fgf3 and Fgf4
  JOURNAL   Mamm Genome 34 (3), 453-463 (2023)
   PUBMED   37341808
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Dai H, Xu W, Wang L, Li X, Sheng X, Zhu L, Li Y, Dong X, Zhou W,
            Han C, Mao Y and Yao L.
  TITLE     Loss of SPRY2 contributes to cancer-associated fibroblasts
            activation and promotes breast cancer development
  JOURNAL   Breast Cancer Res 25 (1), 90 (2023)
   PUBMED   37507768
  REMARK    GeneRIF: Loss of SPRY2 contributes to cancer-associated fibroblasts
            activation and promotes breast cancer development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Schumacher MA, Liu CY, Katada K, Thai MH, Hsieh JJ, Hansten BJ,
            Waddell A, Rosen MJ and Frey MR.
  TITLE     Deep Crypt Secretory Cell Differentiation in the Colonic Epithelium
            Is Regulated by Sprouty2 and Interleukin 13
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (4), 971-984 (2023)
   PUBMED   36414210
  REMARK    GeneRIF: Deep Crypt Secretory Cell Differentiation in the Colonic
            Epithelium Is Regulated by Sprouty2 and Interleukin 13.
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Wei W, Tang X, Jiang N, Ni C, He H, Sun S, Yu M, Yu C, Qiu M, Yan
            D, Zhou Z, Song Y, Liu H, Zhao B and Lin X.
  TITLE     Chromatin remodeler Znhit1 controls bone morphogenetic protein
            signaling in embryonic lung tissue branching
  JOURNAL   J Biol Chem 298 (10), 102490 (2022)
   PUBMED   36115458
REFERENCE   5  (bases 1 to 2103)
  AUTHORS   Altes G, Vaquero M, Cuesta S, Anerillas C, Macia A, Espinet C,
            Ribera J, Bellusci S, Klein OD, Yeramian A, Dolcet X, Egea J and
            Encinas M.
  TITLE     A dominant negative mutation uncovers cooperative control of caudal
            Wolffian duct development by Sprouty genes
  JOURNAL   Cell Mol Life Sci 79 (10), 514 (2022)
   PUBMED   36098804
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2103)
  AUTHORS   Chambers D, Medhurst AD, Walsh FS, Price J and Mason I.
  TITLE     Differential display of genes expressed at the midbrain - hindbrain
            junction identifies sprouty2: an FGF8-inducible member of a family
            of intracellular FGF antagonists
  JOURNAL   Mol Cell Neurosci 15 (1), 22-35 (2000)
   PUBMED   10662503
REFERENCE   7  (bases 1 to 2103)
  AUTHORS   Minowada G, Jarvis LA, Chi CL, Neubuser A, Sun X, Hacohen N,
            Krasnow MA and Martin GR.
  TITLE     Vertebrate Sprouty genes are induced by FGF signaling and can cause
            chondrodysplasia when overexpressed
  JOURNAL   Development 126 (20), 4465-4475 (1999)
   PUBMED   10498682
REFERENCE   8  (bases 1 to 2103)
  AUTHORS   Tefft JD, Lee M, Smith S, Leinwand M, Zhao J, Bringas P Jr, Crowe
            DL and Warburton D.
  TITLE     Conserved function of mSpry-2, a murine homolog of Drosophila
            sprouty, which negatively modulates respiratory organogenesis
  JOURNAL   Curr Biol 9 (4), 219-222 (1999)
   PUBMED   10074434
REFERENCE   9  (bases 1 to 2103)
  AUTHORS   Holmberg M, Leonardsson G and Ny T.
  TITLE     The species-specific differences in the cAMP regulation of the
            tissue-type plasminogen activator gene between rat, mouse and human
            is caused by a one-nucleotide substitution in the cAMP-responsive
            element of the promoters
  JOURNAL   Eur J Biochem 231 (2), 466-474 (1995)
   PUBMED   7543410
REFERENCE   10 (bases 1 to 2103)
  AUTHORS   Atlung T, Nielsen A, Rasmussen LJ, Nellemann LJ and Holm F.
  TITLE     A versatile method for integration of genes and gene fusions into
            the lambda attachment site of Escherichia coli
  JOURNAL   Gene 107 (1), 11-17 (1991)
   PUBMED   1660428
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF176905.1, AK086832.1 and BE654412.1.
            
            [WARNING] On Sep 29, 2023 this sequence was replaced by
            NM_011897.4.
            
            On Jan 9, 2008 this sequence version replaced NM_011897.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF176905.1, CN686969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1435              AF176905.1         4-1438
            1436-1766           AK086832.1         20-350
            1767-2103           BE654412.1         10-346              c
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 56.16 cM"
     gene            1..2103
                     /gene="Spry2"
                     /gene_synonym="sprouty2"
                     /note="sprouty RTK signaling antagonist 2"
                     /db_xref="GeneID:24064"
                     /db_xref="MGI:MGI:1345138"
     exon            1..232
                     /gene="Spry2"
                     /gene_synonym="sprouty2"
                     /inference="alignment:Splign:2.1.0"
     exon            233..2087
                     /gene="Spry2"
                     /gene_synonym="sprouty2"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1231
                     /gene="Spry2"
                     /gene_synonym="sprouty2"
                     /note="spry-2; sprouty homolog 2"
                     /codon_start=1
                     /product="protein sprouty homolog 2"
                     /protein_id="NP_036027.1"
                     /db_xref="CCDS:CCDS27321.1"
                     /db_xref="GeneID:24064"
                     /db_xref="MGI:MGI:1345138"
                     /translation="MEARAQSGNGSQPLLQTAHDSGRQRGEPDPRDALTQQVHVLSLD
                     QIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQPSQVHSS
                     RAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGPSFSHGPAAADGIIRVQPKSELKP
                     GDVKPLSKDDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTC
                     VCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCL
                     KLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT"
ORIGIN      
        1 ccgcgtgcgc ttctggaagg gaggtcatct atcccggaat ccgggagggt tccaacggtg
       61 gaggactggg ttccaaaatt tccccgtggt tttaatccac cgattgcttg gaagttggac
      121 tgaagcagag tttggaaaga aggaaaaagt ttgcatcagg actggattta tttgcacatc
      181 gctggaagaa gaggattcaa gggagagggg ttggtgcaaa gccgcgatca cggagttcag
      241 atgtgttcta agcctgctgg ggtgaacaca ctgccaagac ctgatggagg ccagagctca
      301 gagtggcaac gggtcgcagc ctttgctgca gacagcccat gacagtggca ggcagcgcgg
      361 ggagccggat ccaagagatg cccttaccca gcaggtacac gtcttgtctc tggatcagat
      421 cagagccatc cgaaacacca atgagtacac agagggccct actgtggtcc caagacctgg
      481 gctcaagcct gctcctcgcc cctccactca gcacaaacat gaaagactcc acggtctgcc
      541 ggagcaccgc cagcctccca ggctccagcc ctcgcaggtc cattcttcac gggcccctct
      601 gtccaggtcc atcagcactg tcagctcagg gtctcggagc agtacaagga caagtaccag
      661 cagcagctcc tcggaacaga gactgttagg accgtccttc tcccacgggc ctgctgctgc
      721 tgatggaata atccgagtgc agcctaaatc ggagctcaag cctggtgacg ttaagccact
      781 gagcaaggat gatttgggtc tgcatgccta caggtgtgag gactgcggca agtgcaagtg
      841 taaggagtgc acctacccga ggcccctgcc gtcggactgg atctgtgaca agcagtgcct
      901 ctgctcagcc cagaacgtca ttgactatgg gacttgtgtg tgctgtgtga aaggtctctt
      961 ctatcactgc tccaatgacg atgaggacaa ttgtgctgac aacccgtgct cttgcagcca
     1021 gtcccattgt tgtacgcgat ggtcagcgat gggagtcatg tctctctttt tgccttgttt
     1081 atggtgttac cttccagcca agggttgcct taaattgtgc caggggtgtt atgaccgagt
     1141 gaacaggccg ggttgtcgtt gtaaaaactc aaatacagtt tgctgcaaag ttcccactgt
     1201 cccccctagg aactttgaaa agccgacata gcattattaa tcaggaatat tgcagtaata
     1261 gggattgttg ctccgccccc tcccatcccc cccccctttt aacacatatg caaccaacta
     1321 aacagttgta atcttggcac tgttcgtaga gggttagggg atttgtggtt tgcagtgaga
     1381 ggcttttctt tctcttttcc tttttttttt tttttttttt tttttttttt ttttttttgg
     1441 tccatgtgcc attttaactg atacgcttgc tacaattcag ctaatggaac ccgaaggaag
     1501 aacaacagaa gttggagacc cacattgcat aagctaaagc agccaacact cctaggcgaa
     1561 gaagttgttc ttgtttgtga atagcccatg caaaatgtgt aaattagcaa atggctcccg
     1621 gacccctcct tgttttctcc agagataatg tgctatattt ttgtatatac gataatattt
     1681 gcaactgtga aaaaaaaaca agttgtgcta tgcttcatgg cacagtcaca aaatattata
     1741 ctaatatgtt gtacattcgg aagaatgtga atcaatcagt atgtttttag attgtatttt
     1801 gccttacagg aaacctttat tgtaagtctc tgatttccct ttggacttga tgtatattgt
     1861 acagttacag taaaattcaa cctttatttt ctaatttttt caacatattg tttagtgtaa
     1921 agaatattta tttgaagttt tattatttta taaaaaaaaa gaatatttat tttaagaggc
     1981 atcataaatt ttgccccttt tatgaggatg tgatggttgc tgccaaggag aggttacaga
     2041 tgctatgttc aatataaaat agaaaatata ttaacgtttg aaattaaaaa aaaaaaaaaa
     2101 aaa
//
