LOCUS       NM_011896               2493 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus sprouty RTK signaling antagonist 1 (Spry1), transcript
            variant 1, mRNA.
ACCESSION   NM_011896 XM_913606
VERSION     NM_011896.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2493)
  AUTHORS   Cui,Y.Z., Xu,F., Zhou,Y., Wang,Z.Y., Yang,X.Y., Fu,N.C., Chen,X.B.,
            Zheng,Y.X., Chen,X.Y., Ye,L.R., Li,Y.Y. and Man,X.Y.
  TITLE     SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte
            Stem Cell Migration to the Epidermis through p53/Stem Cell
            Factor/C-KIT Signaling
  JOURNAL   J Invest Dermatol 144 (10), 2255-2266 (2024)
   PUBMED   38462125
  REMARK    GeneRIF: SPRY1 Deficiency in Keratinocytes Induces Follicular
            Melanocyte Stem Cell Migration to the Epidermis through p53/Stem
            Cell Factor/C-KIT Signaling.
REFERENCE   2  (bases 1 to 2493)
  AUTHORS   Altes,G., Olomi,A., Perramon-Guell,A., Hernandez,S., Casanovas,A.,
            Perez,A., Diaz-Tocados,J.M., Valdivielso,J.M., Megino,C.,
            Navaridas,R., Matias-Guiu,X., Klein,O.D., Egea,J., Dolcet,X.,
            Yeramian,A. and Encinas,M.
  TITLE     Multiple endocrine defects in adult-onset Sprouty1/2/4 triple
            knockout mice
  JOURNAL   Sci Rep 14 (1), 19479 (2024)
   PUBMED   39174793
  REMARK    GeneRIF: Multiple endocrine defects in adult-onset Sprouty1/2/4
            triple knockout mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2493)
  AUTHORS   Ju,H., Yu,M., Du,X., Xue,S., Ye,N., Sun,L., Wu,X., Xu,H. and
            Shen,Q.
  TITLE     Gestational diabetes mellitus induces congenital anomalies of the
            kidney and urinary tract in mice by altering RET/MAPK/ERK pathway
  JOURNAL   Biochem Biophys Res Commun 714, 149959 (2024)
   PUBMED   38657443
REFERENCE   4  (bases 1 to 2493)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2493)
  AUTHORS   Wazin,F. and Lovicu,F.J.
  TITLE     Conditional Ablation of Spred1 and Spred2 in the Eye Lens
            Negatively Impacts Its Development and Growth
  JOURNAL   Cells 13 (4), 290 (2024)
   PUBMED   38391903
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2493)
  AUTHORS   Gross,I., Bassit,B., Benezra,M. and Licht,J.D.
  TITLE     Mammalian sprouty proteins inhibit cell growth and differentiation
            by preventing ras activation
  JOURNAL   J Biol Chem 276 (49), 46460-46468 (2001)
   PUBMED   11585837
REFERENCE   7  (bases 1 to 2493)
  AUTHORS   Impagnatiello,M.A., Weitzer,S., Gannon,G., Compagni,A., Cotten,M.
            and Christofori,G.
  TITLE     Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein
            inhibitors of growth factor signaling in endothelial cells
  JOURNAL   J Cell Biol 152 (5), 1087-1098 (2001)
   PUBMED   11238463
REFERENCE   8  (bases 1 to 2493)
  AUTHORS   Lim,J., Wong,E.S., Ong,S.H., Yusoff,P., Low,B.C. and Guy,G.R.
  TITLE     Sprouty proteins are targeted to membrane ruffles upon growth
            factor receptor tyrosine kinase activation. Identification of a
            novel translocation domain
  JOURNAL   J Biol Chem 275 (42), 32837-32845 (2000)
   PUBMED   10887178
REFERENCE   9  (bases 1 to 2493)
  AUTHORS   Goldman,D.C., Martin,G.R. and Tam,P.P.
  TITLE     Fate and function of the ventral ectodermal ridge during mouse tail
            development
  JOURNAL   Development 127 (10), 2113-2123 (2000)
   PUBMED   10769235
REFERENCE   10 (bases 1 to 2493)
  AUTHORS   Minowada,G., Jarvis,L.A., Chi,C.L., Neubuser,A., Sun,X.,
            Hacohen,N., Krasnow,M.A. and Martin,G.R.
  TITLE     Vertebrate Sprouty genes are induced by FGF signaling and can cause
            chondrodysplasia when overexpressed
  JOURNAL   Development 126 (20), 4465-4475 (1999)
   PUBMED   10498682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110508.8, AK140405.1, BC051977.1 and AV377285.1.
            
            On Mar 12, 2015 this sequence version replaced NM_011896.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, and 4, encode the same protein.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140405.1, AF176903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC110508.8         78777-78787
            12-387              AK140405.1         1-376
            388-388             BC051977.1         669-669
            389-1896            AK140405.1         378-1885
            1897-1899           BC051977.1         2178-2180
            1900-2480           AK140405.1         1888-2468
            2481-2492           AV377285.1         247-258
            2493-2493           AC110508.8         83429-83429
FEATURES             Location/Qualifiers
     source          1..2493
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 18.46 cM"
     gene            1..2493
                     /gene="Spry1"
                     /gene_synonym="sprouty1; spry-1"
                     /note="sprouty RTK signaling antagonist 1"
                     /db_xref="GeneID:24063"
                     /db_xref="MGI:MGI:1345139"
     exon            1..159
                     /gene="Spry1"
                     /gene_synonym="sprouty1; spry-1"
                     /inference="alignment:Splign:2.1.0"
     exon            160..448
                     /gene="Spry1"
                     /gene_synonym="sprouty1; spry-1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..2493
                     /gene="Spry1"
                     /gene_synonym="sprouty1; spry-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..1445
                     /gene="Spry1"
                     /gene_synonym="sprouty1; spry-1"
                     /note="inhibitor of receptor tyrosine kinases; sprouty
                     homolog 1"
                     /codon_start=1
                     /product="protein sprouty homolog 1"
                     /protein_id="NP_036026.1"
                     /db_xref="CCDS:CCDS17322.1"
                     /db_xref="GeneID:24063"
                     /db_xref="MGI:MGI:1345139"
                     /translation="MDSPSQHGSHTSLVVIQPPAVEGRQRLDYDRDTQPATILSLDQI
                     KAIRGSNEYTEGPSVARRPAPRTAPRPEKQERTHEIIPANVNSSYEHRPASHPGNARG
                     SVLSRSTSTGSAASSGSSSSVSSEQGLLGRSPPTRPIPGHRSDRVIRTQPKQLLVEDL
                     KASLKEDPTQHKFICEQCGKCKCGECTAPRALPSCLACDRQCLCSAESMVEYGTCMCL
                     VKGIFYHCSNDDDGGSYSDNPCSCSQSHCCSRYLCMGALSLCLPCLLCYPPAKGCLKL
                     CRGCYDWTHRPGCRCRNSNTVYCKLESCPSRAQGKLS"
     regulatory      2469..2474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spry1"
                     /gene_synonym="sprouty1; spry-1"
                     /note="hexamer: AATATA"
     polyA_site      2483
                     /gene="Spry1"
                     /gene_synonym="sprouty1; spry-1"
     polyA_site      2492
                     /gene="Spry1"
                     /gene_synonym="sprouty1; spry-1"
                     /note="major polyA site"
ORIGIN      
        1 cgcgagtgct cagcacgcag gggtttgcgg cggccccgca gccagagctc tgcgggctaa
       61 ggagcggctg cgagcggcgt gcatgtgccg ggagggccgg ccccaggctc tgcactaggt
      121 aagagccttc ccctcccgcc gaggacctgg caagatcagc cggcgtggcg actgcgggga
      181 cgcggacctg cggggacccg agagcccggg acgacgccgg gccgcgcgcc tgacgaccgg
      241 gacgggacgg tgctgtggag cgggcgccgc gcgcacccgg cggatgtccc cgagccgccc
      301 tcggccgccg ccaaccgcgg agaagcgccc ctgcccgggg gccgccgagg ccgcagcgcg
      361 ggccatgcgc gcccggccgc cccgccgcgc ttgatgcggc gcgcgctccg cccgctcggc
      421 gcccccggcc ggcgccgcgg aggccgagga tttcagatgc atggcagatt tccgctgact
      481 gctggaactg gagatcactc cacatggatt ccccaagtca gcatggcagc cacacttcgc
      541 tagtggtgat tcagccaccg gctgtggaag gccggcagag gttagactat gacagggaca
      601 ctcagcctgc tacgattctg tccctagacc agatcaaagc catcagaggc agcaatgaat
      661 acacagaggg accttcggta gcgagaagac ctgctcctcg cactgcacca agacccgaaa
      721 agcaggaaag gactcatgaa atcataccag ccaatgtgaa tagcagctac gagcaccgac
      781 ctgccagcca cccgggcaac gccaggggct cggtgctgag caggtccacc agcaccggaa
      841 gcgcggccag ctcagggagc agcagcagtg tgtcttctga gcagggccta ttaggacggt
      901 ctccgcccac caggcccatc ccaggtcata ggtcagatcg ggtcatccgg acccagccca
      961 agcagctgct ggtggaagac ttgaaggcct ccttgaaaga ggaccccacc cagcacaagt
     1021 tcatctgcga acagtgtggc aagtgcaaat gtggagagtg tacggccccc cgggccctgc
     1081 cctcctgtct ggcctgtgat cggcagtgcc tctgctccgc ggagagcatg gtggaatacg
     1141 ggacctgcat gtgcctggtc aagggcattt tctaccactg ctccaatgat gatgatggag
     1201 gttcttactc ggataaccca tgctcctgtt cacagtccca ctgctgctcc agatacctgt
     1261 gcatgggagc cctgtctttg tgcctaccct gcttgctctg ctaccctccc gccaagggct
     1321 gcctgaagct gtgcaggggc tgttacgact ggacccaccg ccctggctgc aggtgtagaa
     1381 actccaacac tgtctattgt aagctggaga gctgcccctc aagggctcag ggcaaactgt
     1441 catgacttct ggaggtgggt tggacctccg cggaatgtct agcttccaaa ctttggctgt
     1501 tggtattaga ggcagatttt cttctcgagt ctctcctgcc ttggatgggc ctcaatagga
     1561 gtggactgtg aaactgcacc cagcttgttc tcattccacc tcgagggttc tgggagcagc
     1621 gagggcctgt gtgctgcatc cgctctccag ctgcttccgt gaagatatac gcatgcccgg
     1681 atttggccga gagttgtttg gggtctggta ctgtgggatc gtggacttag tttggtttat
     1741 aaaaaagtaa ccatgtaagt gcttaaataa gctatatatt aatctgcctc tgatgagatc
     1801 tatcttagtg tccttctcct agccggatgg gaggagctac tccttagaac acggttttcc
     1861 cagccttctc cttacagccc tctgaacccc ccccccccac aatgcattgc gcagatgcca
     1921 gtgggtcgtc cccgcacacc cctttggcat agctctgtgc ggtgttggtc ttcacatcag
     1981 atatgatgtt ggcaaccctt ttcctcctcc agcgcccagt atctgtgaag gacttccctt
     2041 cacgcccccc acttcactga ggacacttgg taactgtagt tgaaattcct gtctgatttg
     2101 cccctggtat ctcagagcta cagctcccta aggtgccttt ggctcttggc cttttgactc
     2161 ttaacagctg agtatttcca acccttcctg tgttttcatt gccttaacca caaattgtgg
     2221 tgcttttttg tatattttat gtataaatca caaagttgaa tcctggctat ttttaagaca
     2281 aaagtctgtt aaactttttt ttattgtaaa gaatatttat tatgcgaatc tctattattt
     2341 tatgatattt attgcaaaag actgttgaaa tgtactcatg tctgaatata acatatcact
     2401 acttcaagaa aagcaaggtg actcgaagaa agtatataaa aaacatctat gttaactaca
     2461 atgcagaaaa tatattaatt aatgaaaccg gct
//
