LOCUS       NM_001204427            1086 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus small proline-rich protein 3 (Sprr3), transcript
            variant 2, mRNA.
ACCESSION   NM_001204427
VERSION     NM_001204427.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Saraswati,S., Lietman,C.D., Li,B., Mathew,S., Zent,R. and
            Young,P.P.
  TITLE     Small proline-rich repeat 3 is a novel coordinator of PDGFRbeta and
            integrin beta1 crosstalk to augment proliferation and matrix
            synthesis by cardiac fibroblasts
  JOURNAL   FASEB J 34 (6), 7885-7904 (2020)
   PUBMED   32297675
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Lietman,C.D., Segedy,A.K., Li,B., Fazio,S., Atkinson,J.B.,
            Linton,M.F. and Young,P.P.
  TITLE     Loss of SPRR3 in ApoE-/- mice leads to atheroma vulnerability
            through Akt dependent and independent effects in VSMCs
  JOURNAL   PLoS One 12 (9), e0184620 (2017)
   PUBMED   28886156
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Segedy,A.K., Pyle,A.L., Li,B., Zhang,Y., Babaev,V.R., Jat,P.,
            Fazio,S., Atkinson,J.B., Linton,M.F. and Young,P.P.
  TITLE     Identification of small proline-rich repeat protein 3 as a novel
            atheroprotective factor that promotes adaptive Akt signaling in
            vascular smooth muscle cells
  JOURNAL   Arterioscler Thromb Vasc Biol 34 (12), 2527-2536 (2014)
   PUBMED   25278290
  REMARK    GeneRIF: SPRR3 protects an atheroma lesion from vascular smooth
            muscle cell (VSMC) loss by promoting survival signaling in plaque
            VSMCs, thereby significantly decreasing atherosclerosis
            progression.
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Patel,S., Kartasova,T. and Segre,J.A.
  TITLE     Mouse Sprr locus: a tandem array of coordinately regulated genes
  JOURNAL   Mamm Genome 14 (2), 140-148 (2003)
   PUBMED   12584609
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Steinert,P.M., Candi,E., Tarcsa,E., Marekov,L.N., Sette,M.,
            Paci,M., Ciani,B., Guerrieri,P. and Melino,G.
  TITLE     Transglutaminase crosslinking and structural studies of the human
            small proline rich 3 protein
  JOURNAL   Cell Death Differ 6 (9), 916-930 (1999)
   PUBMED   10510474
REFERENCE   8  (bases 1 to 1086)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   9  (bases 1 to 1086)
  AUTHORS   Steinert,P.M., Kartasova,T. and Marekov,L.N.
  TITLE     Biochemical evidence that small proline-rich proteins and
            trichohyalin function in epithelia by modulation of the
            biomechanical properties of their cornified cell envelopes
  JOURNAL   J Biol Chem 273 (19), 11758-11769 (1998)
   PUBMED   9565599
REFERENCE   10 (bases 1 to 1086)
  AUTHORS   Steinert,P.M., Candi,E., Kartasova,T. and Marekov,L.
  TITLE     Small proline-rich proteins are cross-bridging proteins in the
            cornified cell envelopes of stratified squamous epithelia
  JOURNAL   J Struct Biol 122 (1-2), 76-85 (1998)
   PUBMED   9724607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127036.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB590101.1, SRR17253014.1304255.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC127036.3         122054-122087       c
            35-1086             AC127036.3         119869-120920       c
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..1086
                     /gene="Sprr3"
                     /gene_synonym="SPR3"
                     /note="small proline-rich protein 3"
                     /db_xref="GeneID:20766"
                     /db_xref="MGI:MGI:1330237"
     exon            1..34
                     /gene="Sprr3"
                     /gene_synonym="SPR3"
                     /inference="alignment:Splign:2.1.0"
     exon            35..1086
                     /gene="Sprr3"
                     /gene_synonym="SPR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..769
                     /gene="Sprr3"
                     /gene_synonym="SPR3"
                     /note="cornifin beta"
                     /codon_start=1
                     /product="small proline-rich protein 3"
                     /protein_id="NP_001191356.1"
                     /db_xref="CCDS:CCDS17558.1"
                     /db_xref="GeneID:20766"
                     /db_xref="MGI:MGI:1330237"
                     /translation="MSSYQQKQPFVPPPQPEQHQVKQPCQPPPQGKFVPIATSEPCHT
                     DVPQPGNTKIPEPCSTKVPEPGNTVVLEPDYTTMPGPCSTNITEPDYTTIPGPCSTNI
                     TEPDYTTIPGPCSTNIPGPDRTVVPGSCSTNITEPDYTTIPGPSSTKIPDPGCAMVPG
                     PSPSSTSEPSSEPCSINVREPGYMNASEPTHAKVPDQGYTKIPDQGSSKVPEPCQSRV
                     PEVCPPTVTPVSAKQKTKQK"
     regulatory      1066..1071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sprr3"
                     /gene_synonym="SPR3"
                     /note="hexamer: AATAAT"
     polyA_site      1085
                     /gene="Sprr3"
                     /gene_synonym="SPR3"
                     /note="major polyA site"
ORIGIN      
        1 aaatccaaga acccagtgat cttcagcatc taaggtcaac atcctttgaa gcatgagttc
       61 ttaccagcaa aagcagccct ttgtcccacc tcctcagcct gaacagcatc aagtgaagca
      121 accttgtcag cctccaccac aaggaaaatt tgttcccata gccacctctg agccatgcca
      181 cacagatgtt ccacaaccag gaaacaccaa gattccagaa ccatgcagca ccaaagtgcc
      241 tgagccaggg aacactgttg ttcttgagcc agattatact acgatgcctg ggccatgttc
      301 tacaaacatc actgagccag attataccac aattcctggg ccatgctcta ccaacatcac
      361 agagccagat tatactacaa ttcctgggcc atgctctacc aacatccctg ggccagatcg
      421 taccgtggtt cctggatcat gctctaccaa catcacagag ccagattata ccacaattcc
      481 tgggccatcc tctaccaaaa tccctgaccc aggctgtgcc atggttcctg ggcccagtcc
      541 ttccagtact tctgagccaa gctcagaacc atgctctatc aatgttcgtg aacctggcta
      601 catgaatgcc tcagagccca cccatgccaa ggttcctgat cagggctaca ccaagatacc
      661 tgaccaggga tcctctaagg taccagagcc atgccagtcc agggttcctg aggtgtgccc
      721 cccaactgtc acccctgtat cagctaagca gaagaccaag cagaagtaat acagtccaca
      781 gccagccaga cccttgagga gctgaccacc tgctgctgaa gtctttcctg taagctctgt
      841 gtccccattg tctagagacc atgtaacaat atgttgctac agtctctatt tgtaacctaa
      901 aattgcatgc tgttatgtct tctccatacc ctctaaggtg tctccagagc ctctgagtta
      961 agcagaactt cttagtgcct tgaatgctct ctgggtactc taagttcatc tgaagcagaa
     1021 atctatggga ttttctatgg gaaaaaaatg attgtttccc cattaaataa ttacttttaa
     1081 ctccac
//
