LOCUS       NM_011475                616 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus small proline-rich protein 2I (Sprr2i), mRNA.
ACCESSION   NM_011475
VERSION     NM_011475.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 616)
  AUTHORS   Krishnaswami,S.R., Kumar,S., Ordoukhanian,P. and Yu,B.D.
  TITLE     Fate and plasticity of the epidermis in response to congenital
            activation of BRAF
  JOURNAL   J Invest Dermatol 135 (2), 481-489 (2015)
   PUBMED   25202828
REFERENCE   2  (bases 1 to 616)
  AUTHORS   Gunschmann,C., Stachelscheid,H., Akyuz,M.D., Schmitz,A.,
            Missero,C., Bruning,J.C. and Niessen,C.M.
  TITLE     Insulin/IGF-1 controls epidermal morphogenesis via regulation of
            FoxO-mediated p63 inhibition
  JOURNAL   Dev Cell 26 (2), 176-187 (2013)
   PUBMED   23906066
REFERENCE   3  (bases 1 to 616)
  AUTHORS   Martin,N., Patel,S. and Segre,J.A.
  TITLE     Long-range comparison of human and mouse Sprr loci to identify
            conserved noncoding sequences involved in coordinate regulation
  JOURNAL   Genome Res 14 (12), 2430-2438 (2004)
   PUBMED   15574822
REFERENCE   4  (bases 1 to 616)
  AUTHORS   Hong,S.H., Nah,H.Y., Lee,J.Y., Lee,Y.J., Lee,J.W., Gye,M.C.,
            Kim,C.H., Kang,B.M. and Kim,M.K.
  TITLE     Estrogen regulates the expression of the small proline-rich 2 gene
            family in the mouse uterus
  JOURNAL   Mol Cells 17 (3), 477-484 (2004)
   PUBMED   15232223
REFERENCE   5  (bases 1 to 616)
  AUTHORS   Patel,S., Kartasova,T. and Segre,J.A.
  TITLE     Mouse Sprr locus: a tandem array of coordinately regulated genes
  JOURNAL   Mamm Genome 14 (2), 140-148 (2003)
   PUBMED   12584609
REFERENCE   6  (bases 1 to 616)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   7  (bases 1 to 616)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127036.3.
            
            On Jun 30, 2022 this sequence version replaced NM_011475.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158993.1, BC120622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC127036.3         71358-71399
            43-616              AC127036.3         72064-72637
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..616
                     /gene="Sprr2i"
                     /note="small proline-rich protein 2I"
                     /db_xref="GeneID:20763"
                     /db_xref="MGI:MGI:1330309"
     exon            1..42
                     /gene="Sprr2i"
                     /inference="alignment:Splign:2.1.0"
     exon            43..616
                     /gene="Sprr2i"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..292
                     /gene="Sprr2i"
                     /codon_start=1
                     /product="small proline-rich protein 2I"
                     /protein_id="NP_035605.1"
                     /db_xref="CCDS:CCDS38511.1"
                     /db_xref="GeneID:20763"
                     /db_xref="MGI:MGI:1330309"
                     /translation="MSYQQQQCKQPCQPPPVCPPKKCPEPCPPPQCPEPCPPPKCPEP
                     CPESCPPPSYQQKCPPVQPPPPCQQKCPPKSK"
     regulatory      593..598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sprr2i"
                     /note="hexamer: AATAAA"
     polyA_site      616
                     /gene="Sprr2i"
                     /note="major polyA site"
ORIGIN      
        1 agactcctgg tattcaagtt ctagactact tcggagaagt agatcctgag aattcagcac
       61 tatgtcttac caacagcagc agtgcaagca gccttgccag cctccacctg tgtgcccacc
      121 caagaagtgc cctgagcctt gtcctcctcc acagtgtcct gaaccttgtc ctcctccaaa
      181 gtgccctgag ccttgtcctg agtcatgtcc ccctccctca taccagcaga aatgccctcc
      241 tgtgcaacct cctccaccat gccagcagaa gtgcccaccc aaaagcaagt gaatgcctca
      301 gcattcatcg agaccaagag aagaagagga actccatctc acatgcctcc atagcaacaa
      361 ctgatgtctt cccttcagag tctgtcacag atgcagaaga atttgctcca catagcacct
      421 ccttctacat gccagtgatt atctctgata gggaaggcat taacctgaga tgataatcct
      481 gctgctgtaa agggcctgca gagaatgatc cttcttgcat ggttcagtag accatttttc
      541 aaatctctct gtcactttgg caagctagat ctcactgttt tttcatttcc tgaataaagt
      601 accgtcttgt tgaagg
//
