LOCUS       NM_011474                752 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus small proline-rich protein 2H (Sprr2h), mRNA.
ACCESSION   NM_011474
VERSION     NM_011474.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 752)
  AUTHORS   Zhang,M., Wang,X., Guo,F., Jia,Q., Liu,N., Chen,Y., Yan,Y.,
            Huang,M., Tang,H., Deng,Y., Huang,S., Zhou,Z., Zhang,L. and
            Zhang,L.
  TITLE     Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by
            Regulating Intercellular Junctions and Keratinization of Epidermal
            Cells during Mouse Skin Development
  JOURNAL   Theranostics 9 (17), 5065-5084 (2019)
   PUBMED   31410202
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 752)
  AUTHORS   Miyai,M., Hamada,M., Moriguchi,T., Hiruma,J., Kamitani-Kawamoto,A.,
            Watanabe,H., Hara-Chikuma,M., Takahashi,K., Takahashi,S. and
            Kataoka,K.
  TITLE     Transcription Factor MafB Coordinates Epidermal Keratinocyte
            Differentiation
  JOURNAL   J Invest Dermatol 136 (9), 1848-1857 (2016)
   PUBMED   27208706
  REMARK    Review article
REFERENCE   3  (bases 1 to 752)
  AUTHORS   Kumar,V., Bouameur,J.E., Bar,J., Rice,R.H., Hornig-Do,H.T.,
            Roop,D.R., Schwarz,N., Brodesser,S., Thiering,S., Leube,R.E.,
            Wiesner,R.J., Vijayaraj,P., Brazel,C.B., Heller,S., Binder,H.,
            Loffler-Wirth,H., Seibel,P. and Magin,T.M.
  TITLE     A keratin scaffold regulates epidermal barrier formation,
            mitochondrial lipid composition, and activity
  JOURNAL   J Cell Biol 211 (5), 1057-1075 (2015)
   PUBMED   26644517
  REMARK    Erratum:[J Cell Biol. 2016 Mar 28;212(7):877. doi:
            10.1083/jcb.20140414703042016c.. PMID: 27002167]
REFERENCE   4  (bases 1 to 752)
  AUTHORS   Huebner,A.J., Dai,D., Morasso,M., Schmidt,E.E., Schafer,M.,
            Werner,S. and Roop,D.R.
  TITLE     Amniotic fluid activates the nrf2/keap1 pathway to repair an
            epidermal barrier defect in utero
  JOURNAL   Dev Cell 23 (6), 1238-1246 (2012)
   PUBMED   23237955
REFERENCE   5  (bases 1 to 752)
  AUTHORS   Martin,N., Patel,S. and Segre,J.A.
  TITLE     Long-range comparison of human and mouse Sprr loci to identify
            conserved noncoding sequences involved in coordinate regulation
  JOURNAL   Genome Res 14 (12), 2430-2438 (2004)
   PUBMED   15574822
REFERENCE   6  (bases 1 to 752)
  AUTHORS   Hong,S.H., Nah,H.Y., Lee,J.Y., Lee,Y.J., Lee,J.W., Gye,M.C.,
            Kim,C.H., Kang,B.M. and Kim,M.K.
  TITLE     Estrogen regulates the expression of the small proline-rich 2 gene
            family in the mouse uterus
  JOURNAL   Mol Cells 17 (3), 477-484 (2004)
   PUBMED   15232223
REFERENCE   7  (bases 1 to 752)
  AUTHORS   Patel,S., Kartasova,T. and Segre,J.A.
  TITLE     Mouse Sprr locus: a tandem array of coordinately regulated genes
  JOURNAL   Mamm Genome 14 (2), 140-148 (2003)
   PUBMED   12584609
REFERENCE   8  (bases 1 to 752)
  AUTHORS   Koch,P.J., de Viragh,P.A., Scharer,E., Bundman,D., Longley,M.A.,
            Bickenbach,J., Kawachi,Y., Suga,Y., Zhou,Z., Huber,M., Hohl,D.,
            Kartasova,T., Jarnik,M., Steven,A.C. and Roop,D.R.
  TITLE     Lessons from loricrin-deficient mice: compensatory mechanisms
            maintaining skin barrier function in the absence of a major
            cornified envelope protein
  JOURNAL   J Cell Biol 151 (2), 389-400 (2000)
   PUBMED   11038185
REFERENCE   9  (bases 1 to 752)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   10 (bases 1 to 752)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127036.3.
            
            On Jan 29, 2019 this sequence version replaced NM_011474.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158992.1, AJ005566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC127036.3         49052-49091
            41-752              AC127036.3         49980-50691
FEATURES             Location/Qualifiers
     source          1..752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..752
                     /gene="Sprr2h"
                     /note="small proline-rich protein 2H"
                     /db_xref="GeneID:20762"
                     /db_xref="MGI:MGI:1330343"
     exon            1..40
                     /gene="Sprr2h"
                     /inference="alignment:Splign:2.1.0"
     exon            41..752
                     /gene="Sprr2h"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..386
                     /gene="Sprr2h"
                     /codon_start=1
                     /product="small proline-rich protein 2H"
                     /protein_id="NP_035604.1"
                     /db_xref="CCDS:CCDS17553.1"
                     /db_xref="GeneID:20762"
                     /db_xref="MGI:MGI:1330343"
                     /translation="MSYQQQQCKQPCQPPPVCPPPQCPEPCPPPKCPEPCPPPKCTEP
                     CPPPKCPEPCPPPKCPEPCPPPKCPEPCPPPKCTEPCPPPSYQQKCPSVQPSPPCQQK
                     CPPKNK"
ORIGIN      
        1 aagacacttg gtactcaagc tctggactaa ggagaacctg aacctaagac ttcagcataa
       61 tgtcttacca acagcagcag tgcaagcagc cttgccagcc tcctcctgtg tgcccacccc
      121 ctcagtgccc agagccttgt cctcccccaa agtgcccaga gccttgtcct cccccaaagt
      181 gcactgagcc ttgtcctccc ccaaagtgcc cagagccttg tcctccccca aagtgcccag
      241 agccttgtcc tcccccaaag tgcccagagc cttgtcctcc cccaaagtgc actgagccat
      301 gtccccctcc ctcataccag cagaaatgcc cttctgtgca accttctcca ccatgtcaac
      361 agaagtgtcc acccaagaac aaatgaggtc ctcagcagtc atcatgacaa ggggaagaga
      421 agagtatcca tctcatgtac ttccatagca acacctccat cttccctcca aagccattca
      481 tggatgccaa gaaacccctg tacttcagcc ttccacctcc atgtgcctgt gataactcct
      541 gaaaggaaag tcatttccct gtttttgctg tcaagcagat actgagaata gtccttcctc
      601 agcgcttcac tgtcccagat gctcagaagg aagagttgca gcagtctacc ctgttcccac
      661 ccaggacatt tttcaaatct ttctgacatt ttgccatagt agtggtcatt gtttcttatt
      721 tcctgaataa aaagaacaat cttgttgatt gt
//
