LOCUS       NM_011470                688 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus small proline-rich protein 2D (Sprr2d), mRNA.
ACCESSION   NM_011470
VERSION     NM_011470.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 688)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   2  (bases 1 to 688)
  AUTHORS   Yang,J., Wang,L., Huang,Y., Liu,K., Lu,C., Si,N., Wang,R., Liu,Y.
            and Zhang,X.
  TITLE     Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like
            mouse model leads to a markedly increased IL-36a and Sprr2
            expression
  JOURNAL   Front Med 14 (3), 305-317 (2020)
   PUBMED   31884525
  REMARK    GeneRIF: Keratin 5-Cre-driven deletion of Ncstn in an acne
            inversa-like mouse model leads to a markedly increased IL-36a and
            Sprr2 expression.
REFERENCE   3  (bases 1 to 688)
  AUTHORS   Zhang,M., Wang,X., Guo,F., Jia,Q., Liu,N., Chen,Y., Yan,Y.,
            Huang,M., Tang,H., Deng,Y., Huang,S., Zhou,Z., Zhang,L. and
            Zhang,L.
  TITLE     Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by
            Regulating Intercellular Junctions and Keratinization of Epidermal
            Cells during Mouse Skin Development
  JOURNAL   Theranostics 9 (17), 5065-5084 (2019)
   PUBMED   31410202
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 688)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   5  (bases 1 to 688)
  AUTHORS   Kumar,V., Bouameur,J.E., Bar,J., Rice,R.H., Hornig-Do,H.T.,
            Roop,D.R., Schwarz,N., Brodesser,S., Thiering,S., Leube,R.E.,
            Wiesner,R.J., Vijayaraj,P., Brazel,C.B., Heller,S., Binder,H.,
            Loffler-Wirth,H., Seibel,P. and Magin,T.M.
  TITLE     A keratin scaffold regulates epidermal barrier formation,
            mitochondrial lipid composition, and activity
  JOURNAL   J Cell Biol 211 (5), 1057-1075 (2015)
   PUBMED   26644517
  REMARK    Erratum:[J Cell Biol. 2016 Mar 28;212(7):877. doi:
            10.1083/jcb.20140414703042016c. PMID: 27002167]
REFERENCE   6  (bases 1 to 688)
  AUTHORS   Hong,S.H., Nah,H.Y., Lee,J.Y., Lee,Y.J., Lee,J.W., Gye,M.C.,
            Kim,C.H., Kang,B.M. and Kim,M.K.
  TITLE     Estrogen regulates the expression of the small proline-rich 2 gene
            family in the mouse uterus
  JOURNAL   Mol Cells 17 (3), 477-484 (2004)
   PUBMED   15232223
REFERENCE   7  (bases 1 to 688)
  AUTHORS   Patel,S., Kartasova,T. and Segre,J.A.
  TITLE     Mouse Sprr locus: a tandem array of coordinately regulated genes
  JOURNAL   Mamm Genome 14 (2), 140-148 (2003)
   PUBMED   12584609
REFERENCE   8  (bases 1 to 688)
  AUTHORS   Koch,P.J., de Viragh,P.A., Scharer,E., Bundman,D., Longley,M.A.,
            Bickenbach,J., Kawachi,Y., Suga,Y., Zhou,Z., Huber,M., Hohl,D.,
            Kartasova,T., Jarnik,M., Steven,A.C. and Roop,D.R.
  TITLE     Lessons from loricrin-deficient mice: compensatory mechanisms
            maintaining skin barrier function in the absence of a major
            cornified envelope protein
  JOURNAL   J Cell Biol 151 (2), 389-400 (2000)
   PUBMED   11038185
REFERENCE   9  (bases 1 to 688)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   10 (bases 1 to 688)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129296.2.
            
            On Jun 30, 2022 this sequence version replaced NM_011470.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158988.1, AK008778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC129296.2         110200-110241
            43-688              AC129296.2         111295-111940
FEATURES             Location/Qualifiers
     source          1..688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..688
                     /gene="Sprr2d"
                     /note="small proline-rich protein 2D"
                     /db_xref="GeneID:20758"
                     /db_xref="MGI:MGI:1330347"
     exon            1..42
                     /gene="Sprr2d"
                     /inference="alignment:Splign:2.1.0"
     exon            43..688
                     /gene="Sprr2d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      665..670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sprr2d"
                     /note="hexamer: AATAAA"
     polyA_site      688
                     /gene="Sprr2d"
                     /note="major polyA site"
ORIGIN      
        1 agactcctgg tactcaaggc cgagactact ttggagaacc cgatcctgag aatccagcac
       61 tatgtcttac cagcagcagc agtgcaagca gccttgccag cctccacctg tgtgcccacc
      121 caagaagtgc cctgagcctt gtcctcctct aaagtgtcct gagccttgtc ctccaccaaa
      181 gtgccctgag ccttgtcctc ctccaaaatg cccagagcct tgtcctgagc catgtccccc
      241 tccctcatgc cagcagaaat gccctcctgc gcaacctcct ccaccctgcc agcagaagtg
      301 cccacctaag agcaagtgag gtcttcagca gtcatcagga caaagggaaa agaagagaat
      361 ctatctcatg tacttccaaa gcaacaccca tcttccttcc aaatcctggc atgattgcag
      421 aggaatctcc ttcacctttc accctccatg ttcctgtgat gtcccctaac agggaagatg
      481 tttccccgaa gttgtcctgc ttttggtgtc aaggggctgc agagaatgat ctgtcctcag
      541 ttattcagta tcccaggtgc tcagtgggaa ctatagctgc tatctatcct gtgccctcag
      601 gagatgttgc caaaaactct caatcacctt tggttttgtg ttgtcagcat ggtttcattt
      661 cctgaataaa gtacaatcta cataatga
//
