LOCUS       NM_011469                755 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus small proline-rich protein 2B (Sprr2b), mRNA.
ACCESSION   NM_011469
VERSION     NM_011469.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 755)
  AUTHORS   Butera,A., Agostini,M., Cassandri,M., De Nicola,F., Fanciulli,M.,
            D'Ambrosio,L., Falasca,L., Nardacci,R., Wang,L., Piacentini,M.,
            Knight,R.A., Jia,W., Sun,Q., Shi,Y., Wang,Y., Candi,E. and
            Melino,G.
  TITLE     ZFP750 affects the cutaneous barrier through regulating lipid
            metabolism
  JOURNAL   Sci Adv 9 (17), eadg5423 (2023)
   PUBMED   37115925
REFERENCE   2  (bases 1 to 755)
  AUTHORS   Burke,R.M., Lighthouse,J.K., Quijada,P., Dirkx,R.A. Jr.,
            Rosenberg,A., Moravec,C.S., Alexis,J.D. and Small,E.M.
  TITLE     Small proline-rich protein 2B drives stress-dependent p53
            degradation and fibroblast proliferation in heart failure
  JOURNAL   Proc Natl Acad Sci U S A 115 (15), E3436-E3445 (2018)
   PUBMED   29581288
  REMARK    GeneRIF: Knockdown of the Sprr2b gene or inhibition of SPRR2B
            phosphorylation attenuates USP7/MDM2 binding and p53 degradation,
            leading to fibroblasts cell cycle arrest.
REFERENCE   3  (bases 1 to 755)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 755)
  AUTHORS   Zimmermann,N., Doepker,M.P., Witte,D.P., Stringer,K.F.,
            Fulkerson,P.C., Pope,S.M., Brandt,E.B., Mishra,A., King,N.E.,
            Nikolaidis,N.M., Wills-Karp,M., Finkelman,F.D. and Rothenberg,M.E.
  TITLE     Expression and regulation of small proline-rich protein 2 in
            allergic inflammation
  JOURNAL   Am J Respir Cell Mol Biol 32 (5), 428-435 (2005)
   PUBMED   15731505
  REMARK    GeneRIF: Data show that SPRR2a and b are allergen- and
            IL-13-induced in experimental allergic responses that may be
            involved in disease pathophysiology.
REFERENCE   5  (bases 1 to 755)
  AUTHORS   Martin,N., Patel,S. and Segre,J.A.
  TITLE     Long-range comparison of human and mouse Sprr loci to identify
            conserved noncoding sequences involved in coordinate regulation
  JOURNAL   Genome Res 14 (12), 2430-2438 (2004)
   PUBMED   15574822
REFERENCE   6  (bases 1 to 755)
  AUTHORS   Hong,S.H., Nah,H.Y., Lee,J.Y., Lee,Y.J., Lee,J.W., Gye,M.C.,
            Kim,C.H., Kang,B.M. and Kim,M.K.
  TITLE     Estrogen regulates the expression of the small proline-rich 2 gene
            family in the mouse uterus
  JOURNAL   Mol Cells 17 (3), 477-484 (2004)
   PUBMED   15232223
REFERENCE   7  (bases 1 to 755)
  AUTHORS   Patel,S., Kartasova,T. and Segre,J.A.
  TITLE     Mouse Sprr locus: a tandem array of coordinately regulated genes
  JOURNAL   Mamm Genome 14 (2), 140-148 (2003)
   PUBMED   12584609
REFERENCE   8  (bases 1 to 755)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   9  (bases 1 to 755)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129296.2.
            
            On Jun 30, 2022 this sequence version replaced NM_011469.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158987.1, BC132518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC129296.2         87765-87807
            44-755              AC129296.2         88490-89201
FEATURES             Location/Qualifiers
     source          1..755
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..755
                     /gene="Sprr2b"
                     /note="small proline-rich protein 2B"
                     /db_xref="GeneID:20756"
                     /db_xref="MGI:MGI:1330352"
     exon            1..43
                     /gene="Sprr2b"
                     /inference="alignment:Splign:2.1.0"
     exon            44..755
                     /gene="Sprr2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..359
                     /gene="Sprr2b"
                     /codon_start=1
                     /product="small proline-rich protein 2B"
                     /protein_id="NP_035599.2"
                     /db_xref="CCDS:CCDS38509.1"
                     /db_xref="GeneID:20756"
                     /db_xref="MGI:MGI:1330352"
                     /translation="MSYHQQQCKQPCQPPPVCPPPKCPEPCPPPKCPEPCPPPVCCEP
                     CPPPKCPEPCPPPVCCEPCPPPVCCEPCPPQPWQPKCPPVQFPPCQQKCPPKNK"
     regulatory      735..740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sprr2b"
                     /note="hexamer: AATACA"
     polyA_site      755
                     /gene="Sprr2b"
                     /note="major polyA site"
ORIGIN      
        1 agtattcctg gtactcaagc attggtctgc tccggagaac ctgattctga gactccagaa
       61 caatgtctta ccaccagcag cagtgcaagc agccgtgcca gcctcctcct gtgtgcccac
      121 ccccgaagtg ccctgagcct tgtcctcctc caaagtgccc tgagccttgt cctcccccag
      181 tatgctgtga gccttgtcct cctccaaagt gccctgagcc ttgtcctccc ccagtatgct
      241 gtgagccttg tcctccccca gtgtgctgtg agccatgccc ccctcagcca tggcagccaa
      301 aatgccctcc tgtgcaattt ccaccatgcc agcagaagtg tccacccaag aataaatgag
      361 ggtttcccag tcatcaggac tgggaagtaa gagaaatctg tctcactggc tcaccaactc
      421 catagcaaca cttccatcct cctttgaacg cctgtcctgg atgcagaaga atcttctcca
      481 cccttcatcc tccatgtgct tatgatggct cctcacagag aaggcatttc tctcaggctg
      541 atctcctgct gctttcctgg ggatgctgag aatgatcttt tctcttgttt cagtacacca
      601 gtggaagcac aacaggtatc tactgtgtgc tttcagagga gccttctcag cctgcctgtt
      661 acctgatcag ggcaatggtc actgctgttt catttcctga aaaaaaaaag aacccctttg
      721 gtgatggtct aataaataca ttctttcttg caaaa
//
