LOCUS       NM_001309382             852 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus small proline-rich protein 2A3 (Sprr2a3), mRNA.
ACCESSION   NM_001309382 XR_375836
VERSION     NM_001309382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Zhang,C., Hu,Z., Lone,A.G., Artami,M., Edwards,M., Zouboulis,C.C.,
            Stein,M. and Harris-Tryon,T.A.
  TITLE     Small proline-rich proteins (SPRRs) are epidermally produced
            antimicrobial proteins that defend the cutaneous barrier by direct
            bacterial membrane disruption
  JOURNAL   Elife 11, e76729 (2022)
   PUBMED   35234613
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Hu,Z., Zhang,C., Sifuentes-Dominguez,L., Zarek,C.M.,
            Propheter,D.C., Kuang,Z., Wang,Y., Pendse,M., Ruhn,K.A.,
            Hassell,B., Behrendt,C.L., Zhang,B., Raj,P., Harris-Tryon,T.A.,
            Reese,T.A. and Hooper,L.V.
  TITLE     Small proline-rich protein 2A is a gut bactericidal protein
            deployed during helminth infection
  JOURNAL   Science 374 (6568), eabe6723 (2021)
   PUBMED   34735226
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129296.2, BY094335.1, EH096608.1, EH099857.1 and EH102273.1.
            
            On May 28, 2015 this sequence version replaced XR_375836.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA497620.1, BC056231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC129296.2         56364-56480
            118-346             BY094335.1         2-230
            347-680             EH096608.1         18-351              c
            681-688             EH099857.1         5-12
            689-842             EH099857.1         14-167
            843-852             EH102273.1         185-194
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..852
                     /gene="Sprr2a3"
                     /gene_synonym="Sprr2a; Sprr2a1"
                     /note="small proline-rich protein 2A3"
                     /db_xref="GeneID:100042514"
                     /db_xref="MGI:MGI:3845028"
     exon            1..156
                     /gene="Sprr2a3"
                     /gene_synonym="Sprr2a; Sprr2a1"
                     /inference="alignment:Splign:2.1.0"
     exon            157..852
                     /gene="Sprr2a3"
                     /gene_synonym="Sprr2a; Sprr2a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..427
                     /gene="Sprr2a3"
                     /gene_synonym="Sprr2a; Sprr2a1"
                     /note="Small proline-rich protein 2A1; small proline-rich
                     protein 2A"
                     /codon_start=1
                     /product="small proline-rich protein 2A3"
                     /protein_id="NP_001296311.1"
                     /db_xref="CCDS:CCDS84652.1"
                     /db_xref="GeneID:100042514"
                     /db_xref="MGI:MGI:3845028"
                     /translation="MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEP
                     CLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK"
ORIGIN      
        1 ctctgtgatc tgctggccag acacaacacc tgtaccagcc cattacaggg aaatccactc
       61 cccatggggt gaggcaggca atcctataaa aaagtgtctc agtgcttgac tgcagtattc
      121 ctggtactca agcattggtc tgctccggag aacctgattc tgagactcaa gtacgatgtc
      181 ttactaccag cagcagtgca atcagccgtg ccggcctcct cctgtgtgcc cacccccaaa
      241 gtgccctgag ccttgtcctc cccaagtgtg gcctgggcct tgtcgtcctg tcatgtgctt
      301 tgagccttgt cttccttcag tgtggcctgg gccttgtcgt cctgtagtgt gctatgagca
      361 atgccctcct cagccatggc agtcaacatg ccctcctgtg caatttccac catgccagca
      421 gaagtgacca cccaacaagt gaaggcctcc cagtcatcag gaccagggga agtgaaagaa
      481 atctgtctca tcacctcacc gactccatag caacacttcc atcctccttt gaaagcctgt
      541 ctggatgcag aagaatcttc tccacccttc atcctccatg tgcttatgat ggctcctcac
      601 agaaaaggca ttgctctcag gctgatctcc tgctgctttc ctggctatac tgagaatgat
      661 cctttctctt gtttttgtac accaggggaa gcacaacagg tatctactct gtgctttcag
      721 aggagccttc tcagcctgcc tgttacctga tcagggcaat ggtcactgct gtttcatttc
      781 ctgaaataaa aaaggacccc tttggtgatg gtctaataaa tacttttttt cttgcaaaac
      841 tgcctaatat tg
//
