LOCUS       NM_001164787            3518 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus small proline-rich protein 2A2 (Sprr2a2), mRNA.
ACCESSION   NM_001164787
VERSION     NM_001164787.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Zhang,C., Hu,Z., Lone,A.G., Artami,M., Edwards,M., Zouboulis,C.C.,
            Stein,M. and Harris-Tryon,T.A.
  TITLE     Small proline-rich proteins (SPRRs) are epidermally produced
            antimicrobial proteins that defend the cutaneous barrier by direct
            bacterial membrane disruption
  JOURNAL   Elife 11, e76729 (2022)
   PUBMED   35234613
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Hu,Z., Zhang,C., Sifuentes-Dominguez,L., Zarek,C.M.,
            Propheter,D.C., Kuang,Z., Wang,Y., Pendse,M., Ruhn,K.A.,
            Hassell,B., Behrendt,C.L., Zhang,B., Raj,P., Harris-Tryon,T.A.,
            Reese,T.A. and Hooper,L.V.
  TITLE     Small proline-rich protein 2A is a gut bactericidal protein
            deployed during helminth infection
  JOURNAL   Science 374 (6568), eabe6723 (2021)
   PUBMED   34735226
  REMARK    GeneRIF: Small proline-rich protein 2A is a gut bactericidal
            protein deployed during helminth infection.
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Patel,S., Kartasova,T. and Segre,J.A.
  TITLE     Mouse Sprr locus: a tandem array of coordinately regulated genes
  JOURNAL   Mamm Genome 14 (2), 140-148 (2003)
   PUBMED   12584609
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129296.2.
            
            On Jun 30, 2022 this sequence version replaced NM_001164787.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF617639.1, CK030885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC129296.2         21735-21834
            101-3518            AC129296.2         24946-28363
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..3518
                     /gene="Sprr2a2"
                     /gene_synonym="Sprr2a; Sprr2a1; Sprr2a3"
                     /note="small proline-rich protein 2A2"
                     /db_xref="GeneID:100303744"
                     /db_xref="MGI:MGI:3845026"
     exon            1..100
                     /gene="Sprr2a2"
                     /gene_synonym="Sprr2a; Sprr2a1; Sprr2a3"
                     /inference="alignment:Splign:2.1.0"
     exon            101..3518
                     /gene="Sprr2a2"
                     /gene_synonym="Sprr2a; Sprr2a1; Sprr2a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..371
                     /gene="Sprr2a2"
                     /gene_synonym="Sprr2a; Sprr2a1; Sprr2a3"
                     /note="Small proline-rich protein 2A3; small proline-rich
                     protein 2A"
                     /codon_start=1
                     /product="small proline-rich protein 2A1"
                     /protein_id="NP_001158259.1"
                     /db_xref="CCDS:CCDS50975.1"
                     /db_xref="GeneID:100303744"
                     /db_xref="MGI:MGI:3845026"
                     /translation="MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEP
                     CLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK"
ORIGIN      
        1 actccccatg gggtgaggca ggcaatccta taaaaaagag tctcagtgct tgactgcagt
       61 attcctggta ctcaagcatt ggtctgctcc ggagaacctg attctgagac tcaagtacga
      121 tgtcttacta ccagcagcag tgcaatcagc cgtgccggcc tcctcctgtg tgcccacccc
      181 cgaagtgccc tgagccttgt cctccccaag tgtggcctgg gccttgtcgt cctgtcatgt
      241 gctttgagcc ttgtcttcct tcagtgtggc ctgggccgtg tcgtcctgta gtgtgctatg
      301 agcaatgccc acctcagcca tggcagtcaa catgccctcc tgtgcaattt ccaccatgcc
      361 agcagaagtg accacccaac aggtgaaggc ctcccagtca tcaggaccag gggaagtgaa
      421 agaaatctgt ctcaccagct caccgactcc atagcaacac ttccatcctc ctttgaaagc
      481 ctgtctggat gcagaagaat cttctccacc cttcatcctc catgtgctta tgatggctcc
      541 tcacagagaa ggcattgctc tcaggctgat ctcctgctgc tttcctgggg atgctgagaa
      601 tgatcctttc tcttgttttt gtacaccagg ggaagcacaa caggtatcta ctctgtgctt
      661 tcagaggagc cttctcagcc tgcctgttac ctgatcaggg caatggtcac tgctgtttca
      721 tttcctgaaa taaaaaagga cccctttggt gatggtctaa taaatacttt ttttcttgca
      781 aaactgccta atattgtatt actattttgg cttttttcta tcctgtggta gagagtttaa
      841 attttaattc aatgtttcct aaatgtagtc aaatcaaaga ccaatacaaa cttttccttt
      901 ccattgatta gttgatttat ttatatttca aatattttcc ccctgcctgg tttccccttg
      961 aaaaccccct actccaccac cccctcctcc caattcaatc taatttcaaa gttatgtctt
     1021 gaccatacaa agatttcatt gttttgaaga ccaaatttct taacttctta aaatattatc
     1081 attttaaata taaggtaaaa cactatcatc agtcagccac ctatttatct acaatcaatt
     1141 actaactttc atctttagta tacatttgaa ttgtcaccta tggtatagtt actgtcagac
     1201 cccatacatg ctatagagtt cagtaattgt ccatgcacta ggagaagcag ctctccatca
     1261 ttatcagcaa tacccctgtg acactttctc ataactactc agcaaatgct attttaaaac
     1321 tacatttttc ttccccaatg ccttctttct ttattaattt aatacatttc ttttgtgata
     1381 ctaaagaaag ggggctttgt ggttcttatg aaatctcttg atatgatagc aatccttaaa
     1441 aacaggtttg attgaagaaa tgggtagaaa agcatttttg agaggtcaaa ttgccttttc
     1501 cataggtatc cttgctattc tgacatctca caaaatcctg tacattacga ccttcctcat
     1561 tcttagcttc tggaagccag tctttacaga ataacatggt taatggcagc tgaagacata
     1621 gtggagttaa gaagttactg gggattccca aagaaacaac ttgatcaaag ttctgaaggc
     1681 aaggaatccc tgactttaca ttacagagga atctccaagt gagcttcagg cactgatgag
     1741 attcaggcag aaatttaggc aaaacctctt cttttaaaaa gacttgaaca ggtgtcccct
     1801 tgggaaggat aagccacaga gagacatgaa acacacaagg cagaagcaat ggaagatggc
     1861 catcttgggt cacactgccc gagaaagcat ataaagcctg ttctcacatg cttttcctgt
     1921 taccattaaa catatacgac aatcactagc agatttctgc agatctacaa agatgtagtg
     1981 atgctatata gacaattaga tgacttctta attcttaatg atgattctat aagaattctt
     2041 aagattatat cagtattcat taagctcttt tatagtggga ctgctattag gtcctttctg
     2101 atataaaatc ttcaatgaaa attctacctg tctcccatgt gtcaccaatt aattgcatct
     2161 tagagagtaa gcagacatct actactcaga ttccaagagg ctgtaaaaat attataggtg
     2221 ctaggacaaa agataaaata tcgagtggga tatctataaa aaattcacta ataacttagt
     2281 tatgattttt aactctccat gaaccttttg agctgtgaca ggtgataaat gtttagccgg
     2341 ataattattt ctaatggata tgaatgtaaa cattaaatgt tgtaaacttc ttattcaatt
     2401 tataatttaa atttatgtgt aaatttgtga tgaacctttt actatatgat catgtattct
     2461 gaaagatgta taagtgctga cgacaaagaa aagagacaga actgagctga agagaacttt
     2521 ttgacataac tgaactcagg aagggtgata ttgcagacat caagggaatg ggtactattc
     2581 aaaaaggaat gccccataag tgtaaccacg gcaaaacaga agagtctaca ttgtcactcg
     2641 gtgggccgtg ggcatcattg taaacaagca agttaataag ggcaagattc tagccaagag
     2701 gatcaatgtg cggattgagc acatcaagct ctcaaatagc agaaacagct tcttgaagtg
     2761 ggtgaaggag aacgaccaga agaaagagaa gccaaagaga agggcacctg ggtacagttg
     2821 atgtgccagc ctgcaccacc tatagaagca cactttgtga ggaccaacag aaaagagcct
     2881 gagctgttgg agcccattcc atatgaattc atggcctaat aaacaaaaac gaaaaaagga
     2941 cccagactcc aaagtgtttt ccttaaaaaa aaataataat gcttgtcaga cattaatact
     3001 ttttcctttg gaaaatattg gttcatgttt gtagctactt ttttgtttgg gttgtttgat
     3061 ttgtttatta tttgttcagt atttatttat ttatttaggg tttttttttt tgagacagaa
     3121 tttgtgtatt ttctttctag tactagctgt tcttgaactt gttctgtaga tgaggctgga
     3181 cttaaactta gggatccacc tgtctctgct caagtgatgg cattaaaggt ttgtgctata
     3241 tctatcgttg cagaaacttg atgtgccagg gtggaaggag acacaagtgg cctctattct
     3301 ctcagaggaa agggctaaag gggacagatt atcagcggtg aactgccagg aggggaggca
     3361 gtaatatgga tacaaagtga ataaatatat taattaatag aaaaattaca gatgaactgc
     3421 tctcagaaaa acaaacaaac tgaaacaata acaaaaaaca aaaaagcaaa gctacccata
     3481 cacataatta aaaataaatt ttaaaacatc tttaaaaa
//
