LOCUS       NM_011468               3547 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus small proline-rich protein 2A1 (Sprr2a1), mRNA.
ACCESSION   NM_011468 XM_905249
VERSION     NM_011468.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3547)
  AUTHORS   Zhang,C., Hu,Z., Lone,A.G., Artami,M., Edwards,M., Zouboulis,C.C.,
            Stein,M. and Harris-Tryon,T.A.
  TITLE     Small proline-rich proteins (SPRRs) are epidermally produced
            antimicrobial proteins that defend the cutaneous barrier by direct
            bacterial membrane disruption
  JOURNAL   Elife 11, e76729 (2022)
   PUBMED   35234613
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3547)
  AUTHORS   Hu,Z., Zhang,C., Sifuentes-Dominguez,L., Zarek,C.M.,
            Propheter,D.C., Kuang,Z., Wang,Y., Pendse,M., Ruhn,K.A.,
            Hassell,B., Behrendt,C.L., Zhang,B., Raj,P., Harris-Tryon,T.A.,
            Reese,T.A. and Hooper,L.V.
  TITLE     Small proline-rich protein 2A is a gut bactericidal protein
            deployed during helminth infection
  JOURNAL   Science 374 (6568), eabe6723 (2021)
   PUBMED   34735226
REFERENCE   3  (bases 1 to 3547)
  AUTHORS   Miura,H., Kusakabe,Y., Hashido,K., Hino,A., Ooki,M. and Harada,S.
  TITLE     The glossopharyngeal nerve controls epithelial expression of Sprr2a
            and Krt13 around taste buds in the circumvallate papilla
  JOURNAL   Neurosci Lett 580, 147-152 (2014)
   PUBMED   25123441
  REMARK    GeneRIF: Sprr2a is selectively expressed in the upper layer of the
            epithelium surrounding taste buds in the circumvallate papilla
REFERENCE   4  (bases 1 to 3547)
  AUTHORS   Lee,H.A., Kim,H.R., Lee,Y.J., Lee,S.J., Kim,W.J., Han,S.S.,
            Yang,S.R., Woo,H.M., Na,S., Song,H. and Hong,S.H.
  TITLE     Immunolocalisation and oestrogen regulation of small proline-rich
            protein 2a protein in the mouse uterus
  JOURNAL   Reprod Fertil Dev 26 (5), 682-689 (2014)
   PUBMED   23735658
  REMARK    GeneRIF: Immunohistochemical staining revealed that Sprr2a protein
            is detected only in the adult uterus, and not in the ovary, oviduct
            or testis.
REFERENCE   5  (bases 1 to 3547)
  AUTHORS   Lin,C., Hindes,A., Burns,C.J., Koppel,A.C., Kiss,A., Yin,Y., Ma,L.,
            Blumenberg,M., Khnykin,D., Jahnsen,F.L., Crosby,S.D., Ramanan,N.
            and Efimova,T.
  TITLE     Serum response factor controls transcriptional network regulating
            epidermal function and hair follicle morphogenesis
  JOURNAL   J Invest Dermatol 133 (3), 608-617 (2013)
   PUBMED   23151848
REFERENCE   6  (bases 1 to 3547)
  AUTHORS   Patel,S., Kartasova,T. and Segre,J.A.
  TITLE     Mouse Sprr locus: a tandem array of coordinately regulated genes
  JOURNAL   Mamm Genome 14 (2), 140-148 (2003)
   PUBMED   12584609
REFERENCE   7  (bases 1 to 3547)
  AUTHORS   Lueders,K.K., Elliott,R.W., Marenholz,I., Mischke,D., DuPree,M. and
            Hamer,D.
  TITLE     Genomic organization and mapping of the human and mouse neuronal
            beta2-nicotinic acetylcholine receptor genes
  JOURNAL   Mamm Genome 10 (9), 900-905 (1999)
   PUBMED   10441742
REFERENCE   8  (bases 1 to 3547)
  AUTHORS   Segre,J.A., Bauer,C. and Fuchs,E.
  TITLE     Klf4 is a transcription factor required for establishing the
            barrier function of the skin
  JOURNAL   Nat Genet 22 (4), 356-360 (1999)
   PUBMED   10431239
REFERENCE   9  (bases 1 to 3547)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   10 (bases 1 to 3547)
  AUTHORS   Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
            and Backendorf,C.
  TITLE     Molecular characterization and evolution of the SPRR family of
            keratinocyte differentiation markers encoding small proline-rich
            proteins
  JOURNAL   Genomics 16 (3), 630-637 (1993)
   PUBMED   8325635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY062071.1, AK168529.1 and AC148095.6.
            
            On Jan 27, 2006 this sequence version replaced NM_011468.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA466367.1, AK147183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BY062071.1         26-111
            87-974              AK168529.1         2-889
            975-3547            AC148095.6         7531-10103          c
FEATURES             Location/Qualifiers
     source          1..3547
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..3547
                     /gene="Sprr2a1"
                     /gene_synonym="Sprr2a; Sprr2a3"
                     /note="small proline-rich protein 2A1"
                     /db_xref="GeneID:20755"
                     /db_xref="MGI:MGI:1330350"
     exon            1..128
                     /gene="Sprr2a1"
                     /gene_synonym="Sprr2a; Sprr2a3"
                     /inference="alignment:Splign:2.1.0"
     exon            129..3547
                     /gene="Sprr2a1"
                     /gene_synonym="Sprr2a; Sprr2a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..399
                     /gene="Sprr2a1"
                     /gene_synonym="Sprr2a; Sprr2a3"
                     /note="small proline-rich protein 2A"
                     /codon_start=1
                     /product="small proline-rich protein 2A1"
                     /protein_id="NP_035598.2"
                     /db_xref="CCDS:CCDS17548.1"
                     /db_xref="GeneID:20755"
                     /db_xref="MGI:MGI:1330350"
                     /translation="MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEP
                     CLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK"
     regulatory      787..792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sprr2a1"
                     /gene_synonym="Sprr2a; Sprr2a3"
                     /note="hexamer: AATAAA"
     polyA_site      811
                     /gene="Sprr2a1"
                     /gene_synonym="Sprr2a; Sprr2a3"
                     /note="major polyA site"
ORIGIN      
        1 cctgtaccag cccattacag ggaaatccac tccccatggg gtgaggcagg caatcctata
       61 aaaaagagtc tcagtgcttg actgcagtat tcctggtact caagcattgg tctgctccgg
      121 agaacctgat tctgagactc aagtacgatg tcttactacc agcagcagtg caatcagccg
      181 tgccggcctc ctcctgtgtg cccacccccg aagtgccctg agccttgtcc tccccaagtg
      241 tggcctgggc cttgtcgtcc tgtcatgtgc tttgagcctt gtcttccttc agtgtggcct
      301 gggccgtgtc gtcctgtagt gtgctatgag caatgcccac ctcagccatg gcagtcaaca
      361 tgccctcctg tgcaatttcc accatgccag cagaagtgac cacccaacag gtgaaggcct
      421 cccagtcatc aggaccaggg gaagtgaaag aaatctgtct caccagctca ccgactccat
      481 agcaacactt ccatcctcct ttgaaagcct gtctggatgc agaagaatct tctccaccct
      541 tcatcctcca tgtgcttatg atggctcctc acagagaagg cattgctctc aggctgatct
      601 cctgctgctt tcctggggat gctgagaatg atcctttctc ttgtttttgt acaccagggg
      661 aagcacaaca ggtatctact ctgtgctttc agaggagcct tctcagcctg cctgttacct
      721 gatcagggca atggtcactg ctgtttcatt tcctgaaata aaaaaggacc cctttggtga
      781 tggtctaata aatacttttt ttcttgcaaa actgcctaat attgtattac tattttggct
      841 tttttctatc ctgtggtaga gagtttaaat tttaattcaa tgtttcctaa atgtagtcaa
      901 atcaaagacc aatacaaact tttcctttcc attgattagt tgatttattt atatttcaaa
      961 tattttcccc ctgcctggtt tccccttgaa aaccccctac tccaccaccc cctcctccca
     1021 attcaatcta atttcaaagt tatgtcttga ccatacaaag atttcattgt tttgaagacc
     1081 aaatttctta acttcttaaa atattatcat tttaaatata aggtaaaaca ctatcatcag
     1141 tcagccacct atttatctac aatcaattac taactttcat ctttagtata catttgaatt
     1201 gtcacctatg gtatagttac tgtcagaccc catacatgct atagagttca gtaattgtcc
     1261 atgcactagg agaagcagct ctccatcatt atcagcaata cccctgtgac actttctcat
     1321 aactactcag caaatgctat tttaaaacta catttttctt ccccaatgcc ttctttcttt
     1381 attaatttaa tacatttctt ttgtgatact aaagaaaggg ggctttgtgg ttcttatgaa
     1441 atctcttgat atgatagcaa tccttaaaaa caggtttgat tgaagaaatg gggagaaaag
     1501 catttttgag aggtcaaatt gccttttcca taggtatcct tgctattctg acatctcaca
     1561 aaatcctgta cattacgacc ttcctcattc ttagcttctg gaagccagtc tttacagaat
     1621 aacatggtta atggcagctg aagacatagt ggagttaaga agttactggg gattcccaaa
     1681 gaaacaactt gatcaaagtt ctgaaggcaa ggaatccctg actttacatt acagaggaat
     1741 ctccaagtga gcttcaggca ctgatgagat tcaggcagaa atttaggcaa aacctcttct
     1801 tttaaaaaga cttgaacagg tgtccccttg ggaaggataa gccacagaga gacatgaaac
     1861 acacaaggca gaagcaatgg aagatggcca tcttgggtca cactgcccga gaaagcatat
     1921 aaagcctgtt ctcacatgct tttcctgtta tcattaaaca tatacgacaa tcactagcag
     1981 atttctgcag atctacaaag atgtagtgat gctatataga caattagatg acttcttaat
     2041 tcttaatgat gattctataa gaattcttaa gattatatca gtattcatta agctctttta
     2101 tagtgggact gctattaggt cctttctgat ataaaatctt caatgaaaat tctacctgtc
     2161 tcccatgtgt caccaattaa ttgcatctta gagagtaagc agacatctac tactcagatt
     2221 ccaagaggct gtaaaaatat tataggtgct aggacaaaag ataaaatatc gagtgggata
     2281 tctataaaaa attcactaat aacttagtta tgatttttaa ctctccatga accttttgag
     2341 ctgtgacagg tgataaatgt ttagccggat aattatttct aatggatatg aatgtaaaca
     2401 ttaaatgttg taaacttctt attcaattta taatttaaat ttatgtgtaa atttgtgatg
     2461 aaccttttac tatatgatca tgtattctga aagatgtata agtgctgacg acaaagaaaa
     2521 gagacagaac tgagctgaag agaacttttt gacataactg aactcaggaa gggtgatatt
     2581 gcagacatca agggaatggg tactattcaa aaaggaatgc cccataagtg taaccacggc
     2641 aaaacagaag agtctacatt gtcactcggt gggccgtggg catcattgta aacaagcaag
     2701 ttaataaggg caagattcta gccaagagga tcaatgtgcg gattgagcac atcaagctct
     2761 caaatagcag aaacagcttc ttgaagtggg tgaaggagaa cgaccagaag aaagagaagc
     2821 caaagagaag ggcacctggg tacagttgat gtgccagcct gcaccaccta tagaagcaca
     2881 ctttgtgagg accaacagaa aagagcctga gctgttggag cccattccat atgaattcat
     2941 ggcctaataa acaaaaacga aaaaaggacc cagactccaa agtgttttcc ttaaaaaaaa
     3001 ataataatgc ttgtcagaca ttaatacttt ttcctttgga aaatattggt tcatgtttgt
     3061 agctactttt ttgtttgggt tgtttgattt gtttattatt tgttcagtat ttatttattt
     3121 atttagggtt tttttttttg agacagaatt tgtgtatttt ctttctagta ctagctgttc
     3181 ttgaacttgt tctgtagatg aggctggact taaacttagg gatccacctg tctctgctca
     3241 agtgatggca ttaaaggttt gtgctatatc tatcgttgca gaaacttgat gtgccagggt
     3301 ggaaggagac acaagtggcc tctattctct cagaggaaag ggctaaaggg gacagattat
     3361 cagcggtgaa ctgccaggag gggaggcagt aatatggata caaagtgaat aaatatatta
     3421 attaatagaa aaattacaga tgaactgctc tcagaaaaac aaacaaactg aaacaataac
     3481 aaaaaacaaa aaagcaaagc tacccataca cataattaaa aataaatttt aaaacatctt
     3541 taaaaac
//
