LOCUS       NM_009264                807 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus small proline-rich protein 1A (Sprr1a), mRNA.
ACCESSION   NM_009264
VERSION     NM_009264.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 807)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 807)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (bases 1 to 807)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 807)
  AUTHORS   Kawaguchi,S., Moukette,B., Sepulveda,M.N., Hayasaka,T., Aonuma,T.,
            Haskell,A.K., Mah,J., Liangpunsakul,S., Tang,Y., Conway,S.J. and
            Kim,I.M.
  TITLE     SPRR1A is a key downstream effector of MiR-150 during both
            maladaptive cardiac remodeling in mice and human cardiac fibroblast
            activation
  JOURNAL   Cell Death Dis 14 (7), 446 (2023)
   PUBMED   37468478
  REMARK    GeneRIF: SPRR1A is a key downstream effector of MiR-150 during both
            maladaptive cardiac remodeling in mice and human cardiac fibroblast
            activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 807)
  AUTHORS   Zhang,C., Hu,Z., Lone,A.G., Artami,M., Edwards,M., Zouboulis,C.C.,
            Stein,M. and Harris-Tryon,T.A.
  TITLE     Small proline-rich proteins (SPRRs) are epidermally produced
            antimicrobial proteins that defend the cutaneous barrier by direct
            bacterial membrane disruption
  JOURNAL   Elife 11, e76729 (2022)
   PUBMED   35234613
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 807)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
REFERENCE   7  (bases 1 to 807)
  AUTHORS   Marshall,D., Hardman,M.J. and Byrne,C.
  TITLE     SPRR1 gene induction and barrier formation occur as coordinated
            moving fronts in terminally differentiating epithelia
  JOURNAL   J Invest Dermatol 114 (5), 967-975 (2000)
   PUBMED   10771479
REFERENCE   8  (bases 1 to 807)
  AUTHORS   Song,H.J., Poy,G., Darwiche,N., Lichti,U., Kuroki,T., Steinert,P.M.
            and Kartasova,T.
  TITLE     Mouse Sprr2 genes: a clustered family of genes showing differential
            expression in epithelial tissues
  JOURNAL   Genomics 55 (1), 28-42 (1999)
   PUBMED   9888996
REFERENCE   9  (bases 1 to 807)
  AUTHORS   Reddy,S.P., Konkin,T. and Wu,R.
  TITLE     Structure and organization of the genes encoding mouse small
            proline-rich proteins, mSPRR1A and 1B
  JOURNAL   Gene 224 (1-2), 59-66 (1998)
   PUBMED   9931436
REFERENCE   10 (bases 1 to 807)
  AUTHORS   Kartasova,T., Darwiche,N., Kohno,Y., Koizumi,H., Osada,S., Huh,N.,
            Lichti,U., Steinert,P.M. and Kuroki,T.
  TITLE     Sequence and expression patterns of mouse SPR1: Correlation of
            expression with epithelial function
  JOURNAL   J Invest Dermatol 106 (2), 294-304 (1996)
   PUBMED   8601731
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC027534.1.
            
            On Mar 22, 2005 this sequence version replaced NM_009264.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027534.1, CB589468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..807
                     /gene="Sprr1a"
                     /gene_synonym="mSPRR1A; SPR1a"
                     /note="small proline-rich protein 1A"
                     /db_xref="GeneID:20753"
                     /db_xref="MGI:MGI:106660"
     exon            1..32
                     /gene="Sprr1a"
                     /gene_synonym="mSPRR1A; SPR1a"
                     /inference="alignment:Splign:2.1.0"
     exon            33..790
                     /gene="Sprr1a"
                     /gene_synonym="mSPRR1A; SPR1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..486
                     /gene="Sprr1a"
                     /gene_synonym="mSPRR1A; SPR1a"
                     /note="SPR1 A"
                     /codon_start=1
                     /product="cornifin-A"
                     /protein_id="NP_033290.1"
                     /db_xref="CCDS:CCDS17559.1"
                     /db_xref="GeneID:20753"
                     /db_xref="MGI:MGI:106660"
                     /translation="MSSHQQKQPCTVPPQLHQQQVKQPCQPPPQEPCAPKTKDPCHPV
                     PEPCNPKGPEPCHPKAPEPCHPKAPEPCNPKVPEPCQPKVPEPCQPKVPEPCNPKVPE
                     PCQPKAPEPCHPKAPEPCHPVVPEPCPSTVTPSPYQQKTKQK"
     regulatory      770..775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sprr1a"
                     /gene_synonym="mSPRR1A; SPR1a"
                     /note="hexamer: ATTAAA"
     polyA_site      790
                     /gene="Sprr1a"
                     /gene_synonym="mSPRR1A; SPR1a"
                     /note="major polyA site"
ORIGIN      
        1 caacagagaa cctgctcttc tctgagtatt aggaccaagt gctatctaac catgagttcc
       61 caccagcaga agcagccctg cactgtacct cctcagctgc accagcagca ggtgaagcag
      121 ccttgccagc caccacccca ggaaccttgt gcccccaaaa ccaaggatcc ctgccaccct
      181 gttcctgagc cctgcaaccc caaggggcca gagccctgcc accccaaggc acccgagccc
      241 tgccacccca aggcacctga gccctgcaac cccaaggtgc cagagccctg ccagcctaag
      301 gtgccagagc cctgccagcc taaggtgcca gagccctgca accccaaggt gccagagccc
      361 tgccaaccta aggcaccaga gccttgccac cccaaggcgc ctgagccctg ccaccctgtt
      421 gttcccgagc cctgcccctc aactgtcact ccatcaccat accagcagaa gacaaagcag
      481 aagtaatatt gtccagagcc atgcctgaag acctgatcac cagatgctga ggctgctgtc
      541 tatcctgctt atgagtccca ttgccttgtg ctaccaatgc tgtgaccttc aatcttaatc
      601 cctctctcct tgcaccacct aaaaagttga ctctcatcct catcttcaag ggctcctgag
      661 cctcttaaca ttgcccaaag tcatattgaa tggctacact tttcatggct caggattcat
      721 ctgaaggggg tgaggagtga gacaagtgta tggtcaatat tttcccccca ttaaatgcca
      781 tttaactcca aaaaaaaaaa aaaaaaa
//
