LOCUS       NM_001081236            2670 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus SREBF pathway regulator in golgi 1 (Spring1), mRNA.
ACCESSION   NM_001081236 XM_485677
VERSION     NM_001081236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2670)
  AUTHORS   Hendrix,S., Kingma,J., Ottenhoff,R., Valiloo,M., Svecla,M.,
            Zijlstra,L.F., Sachdev,V., Kovac,K., Levels,J.H.M., Jongejan,A., de
            Boer,J.F., Kuipers,F., Rimbert,A., Norata,G.D., Loregger,A. and
            Zelcer,N.
  TITLE     Hepatic SREBP signaling requires SPRING to govern systemic lipid
            metabolism in mice and humans
  JOURNAL   Nat Commun 14 (1), 5181 (2023)
   PUBMED   37626055
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2670)
  AUTHORS   Loregger,A., Raaben,M., Nieuwenhuis,J., Tan,J.M.E., Jae,L.T., van
            den Hengel,L.G., Hendrix,S., van den Berg,M., Scheij,S., Song,J.Y.,
            Huijbers,I.J., Kroese,L.J., Ottenhoff,R., van Weeghel,M., van de
            Sluis,B., Brummelkamp,T. and Zelcer,N.
  TITLE     Haploid genetic screens identify SPRING/C12ORF49 as a determinant
            of SREBP signaling and cholesterol metabolism
  JOURNAL   Nat Commun 11 (1), 1128 (2020)
   PUBMED   32111832
  REMARK    GeneRIF: Sterol-regulatory element binding proteins (SREBP)
            regulating gene (SPRING/C12ORF49) is a glycosylated Golgi membrane
            protein and its ablation reduces SREBP signaling. Spring deletion
            is embryonic lethal yet silencing of hepatic Spring expression
            attenuates the SREBP response. Attenuated SREBP signaling in
            SPRING(KO) cells results from reduced SREBP cleavage-activating
            protein (SCAP) and its mislocalization to the Golgi.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2670)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC125061.3.
            
            On Feb 6, 2007 this sequence version replaced XM_485677.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090380.1, SRR1660811.210980.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC125061.3         52893-53124
            233-389             AC125061.3         63336-63492
            390-541             AC125061.3         66642-66793
            542-655             AC125061.3         67041-67154
            656-2670            AC125061.3         68766-70780
FEATURES             Location/Qualifiers
     source          1..2670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 58.32 cM"
     gene            1..2670
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /note="SREBF pathway regulator in golgi 1"
                     /db_xref="GeneID:76792"
                     /db_xref="MGI:MGI:1924042"
     exon            1..232
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..739
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /note="UPF0454 protein C12orf49 homolog"
                     /codon_start=1
                     /product="SREBP regulating gene protein"
                     /protein_id="NP_001074705.1"
                     /db_xref="CCDS:CCDS39237.1"
                     /db_xref="GeneID:76792"
                     /db_xref="MGI:MGI:1924042"
                     /translation="MLNLAALLWRRLLRKRWVLALVFGLSLVYFLSSTFKQEERAVRD
                     RNLLQVQDREQPIPWKVQFNLGNSSRPSNQCRNSVQGKHLLTDELGYVCERKDLLANG
                     CCDVSVPSTKQYCCDGCLANGCCEAYEYCVSCCLQPSKQLLLERFLNRAAVAFQNLFM
                     AVEDHFELCLAKCRTSSQSVQHENTYRDPIAKYCYGESPPELFPA"
     exon            233..389
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /inference="alignment:Splign:2.1.0"
     exon            390..541
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /inference="alignment:Splign:2.1.0"
     exon            542..655
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /inference="alignment:Splign:2.1.0"
     exon            656..2670
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /note="hexamer: AATACA"
     polyA_site      1074
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
                     /note="major polyA site"
     polyA_site      2668
                     /gene="Spring1"
                     /gene_synonym="2410131K14Rik; Spring"
ORIGIN      
        1 ggggcggggc gtgcggcgga tcacgtggcc ggcgcgttgg ctgcgggaag gtaaagcagt
       61 gctggaagcg gattgcaggg gtcatgccgt ggggtcgtct ctgcgcctgc gccctaccgg
      121 gatgctgaac ctggcggcgc tgctgtggcg ccggctcctg cgcaagcgct gggtgctcgc
      181 cctggttttc ggcctctcgc tagtttactt cctcagcagc accttcaagc aggaagagag
      241 ggctgtgaga gaccggaacc tcctccaggt tcaagaccgg gaacagccca tcccgtggaa
      301 ggtgcagttt aacctaggca acagcagccg acccagcaac cagtgccgga actctgtcca
      361 aggaaaacac ctcctcactg atgagctggg ctatgtctgc gagaggaagg acctgctggc
      421 gaatggctgt tgcgacgtca gcgtccccag cacaaagcag tactgctgtg atgggtgcct
      481 ggccaatggc tgctgtgaag cctacgagta ctgcgtctcc tgctgcctgc agcccagcaa
      541 gcaacttctc ctggagcgct tcctcaaccg ggcagctgtg gccttccaga acctcttcat
      601 ggcagttgaa gaccacttcg aactgtgctt ggctaaatgc aggacctcct cccagagtgt
      661 gcaacacgag aacacgtacc gtgaccccat agccaagtac tgctatggag agagcccgcc
      721 tgaactcttc ccggcgtgag gcctgacgga gatacacacc cagaaccagg ctggtccact
      781 ggagtaaaga aggagaaagc cacacaaggg tccttgtggc tttgggtgtc tccagctccc
      841 tcaccgacag ctggagctga tgggcggagc tgttctgtag agcaggctgg atgaggtcct
      901 ggcaccttgc aggcccctgg gactgctggt cagaggccag gcacttgctt ctgttttgct
      961 cctaccttgt agttatttat tgacttttca gagtggtgga aggtacggtc attttttaat
     1021 ttttttggtg caggacacct ctgcctgtcc agatgaatac attggaggag gtgaccgttg
     1081 ctctcatttc ctgagcgtcg catggatgtg cgtgcatgct ccttcaccgg atgaaagtta
     1141 gtctctggga gtgcgggtgt acagactcag ttgtggttct gttttaacat ctgaccagca
     1201 ggcccttgta tccatacccc aacattcagg ggtatctgaa gcctcaggga ggtgctggtc
     1261 cccactgagc cttcatagag ctgcctcagt gtgctcatat actgaaatgg tagacaggaa
     1321 gcctgaatcc caggctgact ctcccagtgg agtttgctgt gtctccttga aacccctcat
     1381 cctcagggca ggggagccct tcccttgtct gtcacagagg ctagggggac tgcgactgtg
     1441 tgcatgcaca gtggccattc attcttggct gctctccacg cccggtggca tttataaaga
     1501 aaagccccag ctcttagtcc aatctgtcgc aagtttcaca tccaccatca gtgggagacg
     1561 aatgtggtag ccacagtcta gggagcgtcc caaaggcagg tccatgtcca gtgctcacag
     1621 gacagttgtt accagcgact gaaacggagg tttgaagcct aaggtcaaga cacctcctcc
     1681 cgtactctcc tgtcctgttt acaggccagc ctttagcaca cacttcctcc caagaccttt
     1741 gacccaccct tccagtggac cacggtgttt tgtggttttg gttcaggttg acctgggatg
     1801 gacgggccgc gagtctcaag atttcctatc ggggccacat ggaacacagc tctttgtacc
     1861 gtcaggatgg aatttccctc tgctccctcc tgcttcctct tgctgttcac atcggatttg
     1921 tattctctca gctctacaga aggacaaact gactgtcagt tgctcccttg ttctgtcttg
     1981 ccatgctggg atcgaaccca ggactttgtg tgggattggc aaacttgctg ttcctgagcc
     2041 acggccctgg ccagggagtt gatttttagt gttagatgcc agtgattctc ttctgtttgc
     2101 tctggacttc acggtgtgtt gactcaaact tgatagaaga actgggtgat cctgcacgtt
     2161 ctggcacatc ctggaatgtt ctggcacgtt ctgacatgtg ctatatgcgt ttgacaccag
     2221 ccttaaactc ctgactctcc tgccctggga ggagtccacc cttggttgcc agtggcattg
     2281 gtcatattta gagtgttgac ccaagtttta gtatgagcag tcacatctgt tgccagctct
     2341 ccccggcttg gcaccagaaa cgcatgctgt gtgcgtttgt gagtttatag tctgtgccgt
     2401 catgatcaag aatccagtct gctcgtgctt cactcaattg atgaggacat tgcaagagac
     2461 aggccctcca gagccacagc caagacagaa tgaacagacc cacacaggaa cttgtcttga
     2521 atcccacccc catgtcctct agtgcagaat cacctccata ccgtctcccc ctaagagcag
     2581 atggccttcc attatcccag acaggagagg gcagagtggt cgtctatatc cactccaagt
     2641 ctgtaacacg aatgtcactt tcaaattggc
//
