LOCUS       NM_182927               4094 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus sprouty-related EVH1 domain containing 3 (Spred3),
            mRNA.
ACCESSION   NM_182927
VERSION     NM_182927.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4094)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4094)
  AUTHORS   Zhao,G., Bailey,C.G., Feng,Y., Rasko,J. and Lovicu,F.J.
  TITLE     Negative regulation of lens fiber cell differentiation by RTK
            antagonists Spry and Spred
  JOURNAL   Exp Eye Res 170, 148-159 (2018)
   PUBMED   29501879
REFERENCE   3  (bases 1 to 4094)
  AUTHORS   Heng,X., Guo,Q., Leung,A.W. and Li,J.Y.
  TITLE     Analogous mechanism regulating formation of neocortical basal
            radial glia and cerebellar Bergmann glia
  JOURNAL   Elife 6, e23253 (2017)
   PUBMED   28489004
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4094)
  AUTHORS   Zhao,G., Wojciechowski,M.C., Jee,S., Boros,J., McAvoy,J.W. and
            Lovicu,F.J.
  TITLE     Negative regulation of TGFbeta-induced lens epithelial to
            mesenchymal transition (EMT) by RTK antagonists
  JOURNAL   Exp Eye Res 132, 9-16 (2015)
   PUBMED   25576668
REFERENCE   5  (bases 1 to 4094)
  AUTHORS   Sylvestersen,K.B., Herrera,P.L., Serup,P. and Rescan,C.
  TITLE     Fgf9 signalling stimulates Spred and Sprouty expression in
            embryonic mouse pancreas mesenchyme
  JOURNAL   Gene Expr Patterns 11 (1-2), 105-111 (2011)
   PUBMED   20934536
REFERENCE   6  (bases 1 to 4094)
  AUTHORS   Kato,R., Nonami,A., Taketomi,T., Wakioka,T., Kuroiwa,A., Matsuda,Y.
            and Yoshimura,A.
  TITLE     Molecular cloning of mammalian Spred-3 which suppresses tyrosine
            kinase-mediated Erk activation
  JOURNAL   Biochem Biophys Res Commun 302 (4), 767-772 (2003)
   PUBMED   12646235
  REMARK    GeneRIF: The finding of Spred-3 revealed the presence of a novel
            family of regulators for the Ras/MAP kinase pathway, each member of
            which may have different specificities for extracellular signals.
            [Spred-3]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062119.1, CF538218.1 and EL606697.1.
            
            On May 15, 2008 this sequence version replaced NM_182927.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062119.1, CA324469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               BC062119.1         1-661
            662-981             CF538218.1         301-620
            982-2125            BC062119.1         982-2125
            2126-2126           EL606697.1         574-574             c
            2127-4094           BC062119.1         2126-4093
FEATURES             Location/Qualifiers
     source          1..4094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.94 cM"
     gene            1..4094
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /note="sprouty-related EVH1 domain containing 3"
                     /db_xref="GeneID:101809"
                     /db_xref="MGI:MGI:2142186"
     exon            1..128
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /inference="alignment:Splign:2.1.0"
     exon            129..309
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1359
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /note="Sprouty-related EVH1 domain-containing protein"
                     /codon_start=1
                     /product="sprouty-related, EVH1 domain-containing protein
                     3"
                     /protein_id="NP_891557.3"
                     /db_xref="CCDS:CCDS21065.1"
                     /db_xref="GeneID:101809"
                     /db_xref="MGI:MGI:2142186"
                     /translation="MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGAR
                     QGHYVIHGERLRDQKTTLECTLRPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEF
                     QKSLLAALAALSRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPT
                     APIATVESAAAFPLATPPQRRRSSAQSYPPLLPFTGIPEPSESLAGAGSQGWGSRGYE
                     DYRRSGPPPPPLALSTCVVRFAKTGALRGAALGPPVSLPAPLTEAAPPAPPARPPPGP
                     GPTPAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAE
                     SLLYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAA
                     RCGCAGCGGRHEEAAR"
     exon            310..478
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /inference="alignment:Splign:2.1.0"
     exon            479..555
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /inference="alignment:Splign:2.1.0"
     exon            556..690
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..4056
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4037..4042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /note="hexamer: AAGAAA"
     polyA_site      4056
                     /gene="Spred3"
                     /gene_synonym="D130060H24Rik; Spred-3"
                     /note="major polyA site"
ORIGIN      
        1 gctccttgta tcttttcggt ctccggttgc tggttttctc tgcctccatc tccttctcgg
       61 cctctctttc tggccatttc tggttctctc tctgctccct gcccatctcc tggttgctgg
      121 gtgactcagt acatggtgcg ggtccgagcc gtggtgatgg cccgagatga ctccagtggg
      181 ggctggctgc ctgtgggggg cgggggcctc agccaggtga gcgtatgtcg ggtccgaggg
      241 gccaggcccg aggggggggc ccgccagggg cactacgtca tccacgggga gcggcttcgg
      301 gaccagaaaa ccaccttgga gtgtaccctg aggccaggtt tggtttacaa caaagtgaat
      361 cccatcttcc accattggag cttgggggac tgcaagtttg ggctgacgtt tcagagtcct
      421 gcagaagcgg atgagttcca gaagagcctg ctggctgcgc tggctgccct gagtcgaggt
      481 tcgctgactc cttcctcttc ctcttcctcc tcctcccctt cccaggacac tgcagagact
      541 ccctgccctc tgacgtccca cgtggacagc gactcctcct ccagtcacag ccgccaggag
      601 actcctccca cagctcccat tgccacagtg gagtcagcag ctgccttccc actggccacg
      661 cccccacaaa ggcgccgctc ctctgctcag agctaccctc cgcttctacc gttcactggg
      721 attcctgaac cttcagagtc tttagctggg gcagggagcc agggctgggg cagccgcggc
      781 tatgaggact accggcgatc tggaccaccg cctccacctc ttgccctgtc tacctgcgtt
      841 gtgcgctttg ccaagactgg tgcattgcgg ggtgcagccc tgggtcctcc agtgtcactc
      901 cctgcccctc tcacagaggc tgcaccccca gcaccccctg ctcgtccacc cccaggtcca
      961 ggccccaccc ctgctccagc caaagcctcc ccagaggctg aggaggctgc acgctgtgtg
     1021 cactgccgag cactcttccg ccgccgggca gatgggcgtg gtggtcgctg cgcagaggcc
     1081 cctgacccag gtcgcctgct agtgcgccgg ctcagctgct tgtggtgtgc cgagagcttg
     1141 ctgtaccact gcctgtcaga cgccgagggt gacttctcgg acccgtgtgc ttgtgagcca
     1201 ggccacccac gccctgctgc gcgctgggct gctctggctg ctctgtctct ggcagtgccc
     1261 tgtctctgtt gttatgcgcc cctgcgcgcc tgtcactggg ttgcagcacg ttgtggctgt
     1321 gcgggctgtg ggggtcgcca cgaggaggct gcacggtgag gattgttgag ctggtttgga
     1381 aatcggtctg aagacccaaa aattgaaggt ccaggaccct gaacagcata tgaacctaaa
     1441 acccaaactt aggtatatct ggaacttgaa tggatttgag agatcccaga tctggtacct
     1501 ggaccccaaa ctgaggactg agataccgag gccctgcttc atcagggtgt ctgcccaccc
     1561 gaagtcctga attctggatt ctccatacct tttccccact gagaagactt agaatatttt
     1621 caaacattgc atctcaaggg gcccaggagc tcacatcttg gaccctgact ctgtctaaat
     1681 gcccaaccca gacttcaggt catacttgac attgtaaaca ctcatcttac ggcccccaaa
     1741 ctagtcaaga gttactcaaa cttgacacta ttatcaaatg acttagacct tgagaccaga
     1801 ggacccagaa tcaccagaaa atggtccctg aattttcacc tgagacctgg tatcttcaca
     1861 tttagatgct cttatagccc caggatggtt tggaatcacc agatactggc ctgaactcta
     1921 cccgctcctg agagtccaca gacattgcca tcagttcatg tgcaagtgac ccgcaaattc
     1981 cctagcaccc cagatttaaa atgtattaac tccttagata tcctcacata tgaggtattt
     2041 tcagaccaaa attacttggg aggctctttt cagagctcag caaggtccag atatcagata
     2101 ccaagatgct gggggggggg ggggggagcc aggctccaaa cacctactcc ttaagccagc
     2161 catgagaatt tgagtcttgt ggatgggctc tgagatgcct ggtatcctta aatgtctgcc
     2221 tgaaggccac ctgcactttg ggcccaacac actggtttgt agagattagc taaccttccg
     2281 gtttccctta ggcctgaatt ttaaaatatt ctggaaacat cggcttcctt ctgcctacac
     2341 tccccttcca ccacgttggg tggaagcctg gaacttagaa gatgcggtgg tcatggtaac
     2401 ccaggtcctt cattccttga ctctcagccc gagagcaaat ccaaagggct ttatgagccc
     2461 tggatctaag acccaagatg ccattggacc ctgggtgcag gagtcaagcc ctcacaattt
     2521 tgggattggt tttggcctga caccttgatc ccttcagacc agagacattc agcaacaaga
     2581 tgccacagtc tttcagcacc gttaggctcc aggtgttctt gaattcaaag tacttgtaga
     2641 ctaatgaagc ccccatttcc tcactacctg atttccccgt ctcccatgtc ctgccatcca
     2701 gaggcccata aaactgaaat gccctagcaa tgcccagact cccaccccca ccccctttat
     2761 cctagggcag ggtacttaag ccagtgtaaa ttcagattcc tggaatccgg gatcacctag
     2821 cagtttcccc tttcccctct ctagggcctg gctttgctat ggaagattgt gtgctgtcag
     2881 ctcagcagag gcaggcagct acagggatca agcagagacc gcagaaggcc taccctttgc
     2941 acacctgtaa ttccggggcc agcaattgat ccccagaaga cccaccccca ccccaacctt
     3001 gcagatttcc cacactataa cccctagtac attcaggtcc ctcccctgtg aacctcttcc
     3061 atctcagttg ggggttgctc tgaaaagctc agtattgttt tgtagtactt ccccatggag
     3121 aagagaggag ccacagcctc ttttccctaa gtagagacac taggatcagg tgtcctggat
     3181 aggagaacta agatttcaga gccaaagtct tgatggttca tgggcttagg acctacatct
     3241 ggccctaagt acctgggaat gtacacttga atcatttttc attacccaga cttgggtggc
     3301 cttgtggggg ttcaagggat gaatatttgt gtcacttcct ttaaattatt aactatttat
     3361 tgtatccgga acctgtgatt cagctccccc aagcagatcc tgggatgggt gagagaaaat
     3421 ggggaaagag ggtgtccctc ccatccccct tctgcccagc tctcatcaat tgtcagaccc
     3481 accagagctg agggcagagg gactgggggc tggggcagcc tgcgtcccca tcctctcttt
     3541 gtgcctcggt ctccccccct tccatggtaa gcgggggaag ctccattctt aacctacctc
     3601 gttttgggaa ggggtgggga gggggaccag agtgctgtat ggtgctgtga gatcttcgga
     3661 ttaagcagtg gggacttggg gaaggttccc tagtccccca tctccagtac cccctctccc
     3721 aggtcccctt gccctgttcc ttgtcgatac ccacctctga tccatgatta cctttcattg
     3781 cccccatatc tggggtgcat ggaggactga accctgggag ccaggaagac ctcagatcct
     3841 agagctcccg agcccaattt tccagctgct tgccccccag accttggggg aggtccgcca
     3901 acatttctct tcctgatctt gattccaagc cagtctgtaa ccttgttagt gtcagggcag
     3961 gctgatgtgg agggaggatg ggggccaaag acccagcctt gtcattgggg gagggagggg
     4021 acttgagatc tgctccaaga aatgtctgtg actgtgaaaa aaaaaaaaaa aaaaaaaaaa
     4081 aaaaaaaaaa aaaa
//
