LOCUS       NM_011467               1226 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus sepiapterin reductase (Spr), mRNA.
ACCESSION   NM_011467
VERSION     NM_011467.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Kim,H.K., Jeon,J., Song,I.S., Heo,H.J., Jeong,S.H., Long,L.T.,
            Thu,V.T., Ko,T.H., Kim,M., Kim,N., Lee,S.R., Yang,J.S., Kang,M.S.,
            Ahn,J.M., Cho,J.Y., Ko,K.S., Rhee,B.D., Nilius,B., Ha,N.C.,
            Shimizu,I., Minamino,T., Cho,K.I., Park,Y.S., Kim,S. and Han,J.
  TITLE     Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac
            contractility via stimulation of PGC1alpha signaling
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1865 (11), 165524 (2019)
   PUBMED   31381993
  REMARK    Erratum:[Biochim Biophys Acta Mol Basis Dis. 2020 May
            1;1866(5):165619. doi: 10.1016/j.bbadis.2019.165619.. PMID:
            31787471]
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   Kim,J., Kim,Y., Nakajima,R., Shin,A., Jeong,M., Park,A.H.,
            Jeong,Y., Jo,S., Yang,S., Park,H., Cho,S.H., Cho,K.H., Shim,I.,
            Chung,J.H., Paik,S.B., Augustine,G.J. and Kim,D.
  TITLE     Inhibitory Basal Ganglia Inputs Induce Excitatory Motor Signals in
            the Thalamus
  JOURNAL   Neuron 95 (5), 1181-1196 (2017)
   PUBMED   28858620
REFERENCE   4  (bases 1 to 1226)
  AUTHORS   Sumi-Ichinose,C., Suganuma,Y., Kano,T., Ihira,N., Nomura,H.,
            Ikemoto,K., Hata,T., Katoh,S., Ichinose,H. and Kondo,K.
  TITLE     Sepiapterin reductase gene-disrupted mice suffer from hypertension
            with fluctuation and bradycardia
  JOURNAL   Physiol Rep 5 (6) (2017)
   PUBMED   28320892
  REMARK    GeneRIF: Our results suggest that the hypertension with fluctuation
            and bradycardia of Spr(-/-) mice would be caused by an imbalance of
            sympathetic and parasympathetic input and impaired nitric oxide
            production in endothelial cells.
REFERENCE   5  (bases 1 to 1226)
  AUTHORS   Homma,D., Katoh,S., Tokuoka,H. and Ichinose,H.
  TITLE     The role of tetrahydrobiopterin and catecholamines in the
            developmental regulation of tyrosine hydroxylase level in the brain
  JOURNAL   J Neurochem 126 (1), 70-81 (2013)
   PUBMED   23647001
REFERENCE   6  (bases 1 to 1226)
  AUTHORS   Auerbach,G., Herrmann,A., Gutlich,M., Fischer,M., Jacob,U.,
            Bacher,A. and Huber,R.
  TITLE     The 1.25 A crystal structure of sepiapterin reductase reveals its
            binding mode to pterins and brain neurotransmitters
  JOURNAL   EMBO J 16 (24), 7219-7230 (1997)
   PUBMED   9405351
REFERENCE   7  (bases 1 to 1226)
  AUTHORS   Kim,J., Park,Y.S., Chung,J.H. and Stubbs,L.
  TITLE     The gene encoding sepiapterin reductase is located in central mouse
            chromosome 6
  JOURNAL   Mamm Genome 8 (12), 942 (1997)
   PUBMED   9383299
REFERENCE   8  (bases 1 to 1226)
  AUTHORS   Ota,A., Ichinose,H. and Nagatsu,T.
  TITLE     Mouse sepiapterin reductase: an enzyme involved in the final step
            of tetrahydrobiopterin biosynthesis. Primary structure deduced from
            the cDNA sequence
  JOURNAL   Biochim Biophys Acta 1260 (3), 320-322 (1995)
   PUBMED   7873607
REFERENCE   9  (bases 1 to 1226)
  AUTHORS   Maier,J., Schott,K., Werner,T., Bacher,A. and Ziegler,I.
  TITLE     Detection of a novel sepiapterin reductase mRNA: assay of mRNA in
            various cells and tissues of various species
  JOURNAL   Exp Cell Res 204 (2), 217-222 (1993)
   PUBMED   8440319
REFERENCE   10 (bases 1 to 1226)
  AUTHORS   Maier,J., Schott,K., Werner,T., Bacher,A. and Ziegler,I.
  TITLE     Northern blot analysis of sepiapterin reductase mRNA in mammalian
            cell lines and tissues
  JOURNAL   Adv Exp Med Biol 338, 195-198 (1993)
   PUBMED   8304109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY113096.1, CK620382.1, W65601.1 and BY590544.1.
            
            On Nov 15, 2007 this sequence version replaced NM_011467.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054423.1, BI148125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY113096.1         2-33
            33-541              CK620382.1         1-509
            542-972             W65601.1           1-431
            973-1226            BY590544.1         216-469
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.15 cM"
     gene            1..1226
                     /gene="Spr"
                     /gene_synonym="Gm10328"
                     /note="sepiapterin reductase"
                     /db_xref="GeneID:20751"
                     /db_xref="MGI:MGI:103078"
     exon            1..326
                     /gene="Spr"
                     /gene_synonym="Gm10328"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..808
                     /gene="Spr"
                     /gene_synonym="Gm10328"
                     /EC_number="1.1.1.153"
                     /codon_start=1
                     /product="sepiapterin reductase"
                     /protein_id="NP_035597.2"
                     /db_xref="CCDS:CCDS51826.1"
                     /db_xref="GeneID:20751"
                     /db_xref="MGI:MGI:103078"
                     /translation="MEAGGLGCAVCVLTGASRGFGRALAPQLARLLSPGSVMLVSARS
                     ESMLRQLKEELGAQQPDLKVVLAAADLGTEAGVQRLLSAVRELPRPEGLQRLLLINNA
                     ATLGDVSKGFLNVNDLAEVNNYWALNLTSMLCLTSGTLNAFQDSPGLSKTVVNISSLC
                     ALQPYKGWGLYCAGKAARDMLYQVLAAEEPSVRVLSYAPGPLDNDMQQLARETSKDPE
                     LRSKLQKLKSDGALVDCGTSAQKLLGLLQKDTFQSGAHVDFYDC"
     exon            327..617
                     /gene="Spr"
                     /gene_synonym="Gm10328"
                     /inference="alignment:Splign:2.1.0"
     exon            618..1226
                     /gene="Spr"
                     /gene_synonym="Gm10328"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtctga gttccaggca tggaggcagg cgggctgggc tgcgctgtgt gcgtgttgac
       61 cggggcctcc cggggctttg gtcgcgccct ggccccgcag ctggcccggt tgctgtctcc
      121 cggttccgtg atgctcgtaa gcgcacgcag tgagtcgatg ctgcggcaac tgaaggagga
      181 gctgggcgct cagcagcctg acctgaaagt ggtgctggca gccgccgatc tgggcaccga
      241 ggctggcgtg cagcggttgc tgagcgcagt acgcgagctc ccgaggcccg aggggctgca
      301 gcgcctgctg ctcatcaaca acgcagccac tcttggggat gtttccaaag gcttcctcaa
      361 cgtgaatgac ctagctgagg tgaacaacta ctgggctctg aacctgacct ccatgctctg
      421 tttgacttcc ggcaccttga atgccttcca ggatagccct ggcctgagca agactgtggt
      481 taacatctca tctctgtgtg ccctgcagcc ctacaaaggc tggggtctgt actgtgcggg
      541 gaaggctgcc cgagacatgc tctaccaggt cctggctgct gaggaaccga gtgtgcgggt
      601 gctgagctat gctccaggtc ccctggacaa tgacatgcag cagttggctc gggaaacctc
      661 caaggaccca gagttaagga gcaaactgca gaagttgaag tcggatgggg cgctggtgga
      721 ctgtgggact tcagcccaga aactgctggg cttgctgcaa aaggacacct tccagtctgg
      781 agcccatgtg gacttctatg actgttaagc tcatgtcctg tcacagtggc ccccttctcc
      841 cccccccccc aagccctgcc taacacacat ataagccctt caacccagcc agcagcgagc
      901 ggtgggcact gccagtcctc ggaaggcttc tgcagaggct tgggagcgag ctgatgtgca
      961 ctggagttct ctgtcccctg gaagagtgct ttagaggtgg gaagagcagg agaagcagaa
     1021 acactggacg gatgaggttg aggctcttgt ttgtggtcag tctgtggggt gaggagggtg
     1081 ggctctgatg cacagagagg acggagggca tcacgtctgg atggatgctc cttgaacttc
     1141 atttgtttgt tgtactgcct gcatcctgtg gtgttcactg gtcttccctt gactctggtc
     1201 caaatacata gttatgaggc agatgc
//
