LOCUS       NM_199019               2225 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus signal peptide peptidase 2C (Sppl2c), transcript
            variant 1, mRNA.
ACCESSION   NM_199019 XM_137871
VERSION     NM_199019.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2225)
  AUTHORS   Contreras,W., Wiesehofer,C., Schreier,D., Leinung,N., Peche,P.,
            Wennemuth,G., Gentzel,M., Schroder,B. and Mentrup,T.
  TITLE     C11orf94/Frey is a key regulator for male fertility by controlling
            Izumo1 complex assembly
  JOURNAL   Sci Adv 8 (32), eabo6049 (2022)
   PUBMED   35960805
REFERENCE   2  (bases 1 to 2225)
  AUTHORS   Park,S., Shimada,K., Fujihara,Y., Xu,Z., Shimada,K., Larasati,T.,
            Pratiwi,P., Matzuk,R.M., Devlin,D.J., Yu,Z., Garcia,T.X.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched
            genes are dispensable for male fecundity
  JOURNAL   Biol Reprod 103 (2), 195-204 (2020)
   PUBMED   32561905
REFERENCE   3  (bases 1 to 2225)
  AUTHORS   Papadopoulou,A.A., Muller,S.A., Mentrup,T., Shmueli,M.D.,
            Niemeyer,J., Haug-Kroper,M., von Blume,J., Mayerhofer,A.,
            Feederle,R., Schroder,B., Lichtenthaler,S.F. and Fluhrer,R.
  TITLE     Signal peptide peptidase-like 2c impairs vesicular transport and
            cleaves SNARE proteins
  JOURNAL   EMBO Rep 20 (3) (2019)
   PUBMED   30733281
  REMARK    GeneRIF: These data suggest involvement of SPPL2c in acrosome
            formation during spermatogenesis.
            Erratum:[EMBO Rep. 2019 May;20(5):e48133. doi:
            10.15252/embr.201948133.. PMID: 31061204]
REFERENCE   4  (bases 1 to 2225)
  AUTHORS   Niemeyer,J., Mentrup,T., Heidasch,R., Muller,S.A., Biswas,U.,
            Meyer,R., Papadopoulou,A.A., Dederer,V., Haug-Kroper,M.,
            Adamski,V., Lullmann-Rauch,R., Bergmann,M., Mayerhofer,A.,
            Saftig,P., Wennemuth,G., Jessberger,R., Fluhrer,R.,
            Lichtenthaler,S.F., Lemberg,M.K. and Schroder,B.
  TITLE     The intramembrane protease SPPL2c promotes male germ cell
            development by cleaving phospholamban
  JOURNAL   EMBO Rep 20 (3) (2019)
   PUBMED   30733280
  REMARK    GeneRIF: the sarco/endoplasmic reticulum Ca(2+)-ATPase
            (SERCA2)-regulating protein phospholamban (PLN) is identified as a
            physiological SPPL2c substrate.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077122.1, BC090973.1 and AV279514.2.
            
            On Mar 8, 2007 this sequence version replaced NM_199019.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK077122.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-943               AK077122.1         2-944
            944-944             BC090973.1         919-919
            945-1613            AK077122.1         946-1614
            1614-1892           AK077122.1         1616-1894
            1893-2225           AV279514.2         335-667
FEATURES             Location/Qualifiers
     source          1..2225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.79 cM"
     gene            1..2225
                     /gene="Sppl2c"
                     /gene_synonym="4933407P14Rik; IMP5"
                     /note="signal peptide peptidase 2C"
                     /db_xref="GeneID:237958"
                     /db_xref="MGI:MGI:3045264"
     exon            1..2225
                     /gene="Sppl2c"
                     /gene_synonym="4933407P14Rik; IMP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..2122
                     /gene="Sppl2c"
                     /gene_synonym="4933407P14Rik; IMP5"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; signal peptide peptidase-like 2C; ortholog of
                     human intramembrane protease 5 IMP5; IMP-5; protein
                     SPPL2c; protein SPP-like 2C"
                     /codon_start=1
                     /product="signal peptide peptidase-like 2C isoform a
                     precursor"
                     /protein_id="NP_950184.2"
                     /db_xref="CCDS:CCDS36352.1"
                     /db_xref="GeneID:237958"
                     /db_xref="MGI:MGI:3045264"
                     /translation="MACLGSLHPLGSLLLLFLLLLLSPEARGEYGLVRVVSKNWSKDY
                     CVLYSSDYVNLPRDLHHAPLLSLHDGTKTPWCPDEDSFHQAQDSSPRQRPLHQTTTMV
                     TRGNCSFYAKGWLAQDQGAQGLLIVSRARNQQCSDTISKPQDPSKPWPALTIPVAVLR
                     YTDMLDIVSHTYGDTDVRVAMFAPLEPVTDYNMAIIFILAVGTVAAGGYWAGLMEANK
                     LQRRQAQRGGGLGGHNQQQTVAAERSQRAWEDDDFEDAPMDFTPAMTGAVVTMSCSIM
                     ILLYFFYDCFVYVMIGIFSLGASTGLYSCLAPILCHLPLWRYQWVLPGQRVSVTWPLL
                     LLAGLCAMVTVLWVIHRNEDHWAWLLQDTLGVAYCLFVLRRVRLPTFKNCTLFLLALL
                     AFDVFFVFITPLFTKTGESIMVEVASGPADSSSHERLPMVLKVPRLSFSALTLCNQPF
                     SILGFGDIVVPGFLVAYCHRFDMQVQSRQVYYMACTVAYAVGLLVTFVAMILMQMGQP
                     ALLYLVSSTLLTSLAVATCRQEFTLFWTGQGRAKIPAEPVAQPCIASAVGSKMKLEDA
                     KDSRTTNRFEQAVDGESGDLESSTGDDMAEMVTLSEDEATSPEGHSESSEGWSDTNLD
                     PNELPSGSPMALEAMLIPLIQPIPHPSELGHIRTQSRVHDSSLPWMGLHKRKGLKVKK
                     SMSAQAPL"
     polyA_site      2225
                     /gene="Sppl2c"
                     /gene_synonym="4933407P14Rik; IMP5"
                     /note="major polyA site"
ORIGIN      
        1 agagctgtgg gcagctgctt ccttgggagg aagcaggcgt ctgaggagga tggcatgcct
       61 gggttccctc caccccttgg gctcactcct cctcctcttc ctcctcctcc tcctcagccc
      121 cgaggcccgg ggagaatacg gcctggtccg agtcgtgtca aagaactgga gcaaggacta
      181 ctgtgtcctg tacagctctg actacgtcaa cctcccccgg gacctgcacc atgccccact
      241 tctgtccctg catgatggca ccaagacacc ctggtgtcca gatgaagact ctttccacca
      301 ggcccaggac agttccccta gacagcgacc cctgcaccag actactacca tggtcacgcg
      361 tggcaactgt agcttctatg ccaagggctg gctggctcaa gatcaaggcg cccaggggtt
      421 gctcattgtg agccgggcca ggaatcaaca gtgttcagac accatctcaa agccccagga
      481 ccccagcaag ccctggcctg ccctcaccat cccagtggcc gtgctccgct acactgacat
      541 gttggacatt gtcagccaca cttacggtga caccgatgtc cgagtagcca tgtttgcacc
      601 cctcgagcct gttactgact ataacatggc gattatcttc atcttggcag tgggtactgt
      661 tgctgcaggt ggctactggg ctggtttgat ggaggcaaac aagctgcaga ggcgccaggc
      721 ccaaagagga ggggggcttg gtggtcacaa tcaacaacaa acagtggcag ctgagaggtc
      781 ccaaagggcc tgggaagatg acgactttga agatgcacct atggatttca caccagccat
      841 gacgggcgct gtggtcacca tgtcctgctc catcatgatc ctgctgtatt ttttctatga
      901 ctgctttgtc tacgtcatga ttgggatctt tagcctgggt gccagtaccg gcctctacag
      961 ctgcctggca cccatactgt gccacctgcc cctatggcga taccagtggg tcttgcctgg
     1021 acaacgggtt tctgtaacat ggccattact actgctggca ggcctgtgtg ccatggtgac
     1081 tgtcctctgg gtcatccacc gaaatgagga ccattgggca tggctcctgc aggacacttt
     1141 gggtgtcgcc tactgccttt ttgtcctgag gcgggtacgg ctgcccacgt tcaagaactg
     1201 cactttgttc ctgctggccc tactagcctt cgatgtcttc tttgtcttta tcactcccct
     1261 gttcaccaag actggtgaga gcattatggt agaagtggca tcaggtccag cagattcttc
     1321 aagccacgag aggttaccaa tggtgctcaa ggtgccccgg ctaagctttt ccgccttgac
     1381 gttgtgcaac cagcccttct ccatccttgg ctttggggac attgttgtcc ctggcttcct
     1441 agtggcctac tgtcaccgct tcgacatgca agtccaatct cgccaggtct actatatggc
     1501 ctgtacagtg gcctatgccg tgggcctgct ggtcaccttt gtcgccatga tcctcatgca
     1561 gatgggccag cctgccctgc tctacttagt gtccagcact ctgctcacca gccttgctgt
     1621 ggccacctgc cgccaagagt tcaccctttt ctggactggc cagggcagag ccaagattcc
     1681 tgctgagcct gtggcacagc cctgcattgc ctctgctgtg ggctccaaga tgaagctgga
     1741 ggatgcgaag gattcccgta caaccaacag gtttgagcag gccgttgatg gagagtcagg
     1801 ggacttagag agcagcactg gggacgatat ggcagagatg gtcaccctat ctgaggatga
     1861 agccacgagt ccagagggcc acagcgagag ttctgagggc tggagtgaca ccaacctgga
     1921 ccccaatgag ctaccctctg gctcccccat ggccctagag gccatgttga tcccactgat
     1981 ccaaccaatc ccacacccct ccgagctggg ccacatccgc actcaatctc gggtccatga
     2041 tagcagcctg ccctggatgg ggttgcacaa gagaaagggc ttgaaggtga agaagagtat
     2101 gtcagcccag gctcccctat gaacagagtt ccctaggacc tgcacctctc aaagggcttc
     2161 cagaacactg cacggggatg ctagacagga taagagatcg ggcattagag aaactcccta
     2221 tcttc
//
