LOCUS       NM_175195               2887 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus signal peptide peptidase like 2B (Sppl2b), transcript
            variant 1, mRNA.
ACCESSION   NM_175195
VERSION     NM_175195.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2887)
  AUTHORS   Maccioni,R., Travisan,C., Badman,J., Zerial,S., Wagener,A.,
            Andrade-Talavera,Y., Picciau,F., Grassi,C., Chen,G., Lemoine,L.,
            Fisahn,A., Jiang,R., Fluhrer,R., Mentrup,T., Schroder,B.,
            Nilsson,P. and Tambaro,S.
  TITLE     Signal peptide peptidase-like 2b modulates the amyloidogenic
            pathway and exhibits an Abeta-dependent expression in Alzheimer's
            disease
  JOURNAL   Prog Neurobiol 235, 102585 (2024)
   PUBMED   38367747
  REMARK    GeneRIF: Signal peptide peptidase-like 2b modulates the
            amyloidogenic pathway and exhibits an Abeta-dependent expression in
            Alzheimer's disease.
REFERENCE   2  (bases 1 to 2887)
  AUTHORS   Ballin,M., Griep,W., Patel,M., Karl,M., Mentrup,T.,
            Rivera-Monroy,J., Foo,B., Schwappach,B. and Schroder,B.
  TITLE     The intramembrane proteases SPPL2a and SPPL2b regulate the
            homeostasis of selected SNARE proteins
  JOURNAL   FEBS J 290 (9), 2320-2337 (2023)
   PUBMED   36047592
  REMARK    GeneRIF: The intramembrane proteases SPPL2a and SPPL2b regulate the
            homeostasis of selected SNARE proteins.
REFERENCE   3  (bases 1 to 2887)
  AUTHORS   Mentrup,T., Theodorou,K., Cabrera-Cabrera,F., Helbig,A.O., Happ,K.,
            Gijbels,M., Gradtke,A.C., Rabe,B., Fukumori,A., Steiner,H.,
            Tholey,A., Fluhrer,R., Donners,M. and Schroder,B.
  TITLE     Atherogenic LOX-1 signaling is controlled by SPPL2-mediated
            intramembrane proteolysis
  JOURNAL   J Exp Med 216 (4), 807-830 (2019)
   PUBMED   30819724
  REMARK    GeneRIF: SPPL2a/b negatively regulates LOX-1 signaling and
            atherosclerosis.
REFERENCE   4  (bases 1 to 2887)
  AUTHORS   Schneppenheim,J., Huttl,S., Mentrup,T., Lullmann-Rauch,R.,
            Rothaug,M., Engelke,M., Dittmann,K., Dressel,R., Araki,M.,
            Araki,K., Wienands,J., Fluhrer,R., Saftig,P. and Schroder,B.
  TITLE     The intramembrane proteases signal Peptide peptidase-like 2a and 2b
            have distinct functions in vivo
  JOURNAL   Mol Cell Biol 34 (8), 1398-1411 (2014)
   PUBMED   24492962
  REMARK    GeneRIF: in vivo SPPL2a, but not SPPL2b, exhibit a physiologically
            relevant contribution to CD74 proteolysis in B and dendritic cells
REFERENCE   5  (bases 1 to 2887)
  AUTHORS   Behnke,J., Schneppenheim,J., Koch-Nolte,F., Haag,F., Saftig,P. and
            Schroder,B.
  TITLE     Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to
            lysosomes/late endosomes by a tyrosine motif in its C-terminal tail
  JOURNAL   FEBS Lett 585 (19), 2951-2957 (2011)
   PUBMED   21896273
REFERENCE   6  (bases 1 to 2887)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2887)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   8  (bases 1 to 2887)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 2887)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB848740.1, AK148109.1 and BC052094.1.
            
            On Oct 27, 2006 this sequence version replaced NM_175195.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046804.1, AK148109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BB848740.1         3-36
            35-2629             AK148109.1         2-2596
            2630-2887           BC052094.1         2304-2561
FEATURES             Location/Qualifiers
     source          1..2887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2887
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /note="signal peptide peptidase like 2B"
                     /db_xref="GeneID:73218"
                     /db_xref="MGI:MGI:1920468"
     exon            1..114
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1803
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /EC_number="3.4.23.-"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein SPP-like 2B; protein SPPL2b"
                     /codon_start=1
                     /product="signal peptide peptidase-like 2B isoform 1
                     precursor"
                     /protein_id="NP_780404.2"
                     /db_xref="CCDS:CCDS35988.1"
                     /db_xref="GeneID:73218"
                     /db_xref="MGI:MGI:1920468"
                     /translation="MAAARLAAALLLLAAQVACEFGVLRVVSQTSRTRSRDYCILYNP
                     QWAHLPHDLSKVSLLKLRDLSTTQLCSYLDVPAEDFTNQIALVARGNCTFYEKVRLAQ
                     GSGAHGLLIVSKEKLVPPGGNKTQYEEISIPVALLSHRDLQDIFRRFGREVMVALYAP
                     SEPVMDYNMVIIFVMAVGTVAIGGYWAGSHDVKKYMKHKRDDGPEKQEDEAVDVTPVM
                     ICVFVVMCCFMLVLLYYFYDRLVYVIIGIFCLASSTGLYSCLAPFVRKLPFCTCRVPD
                     NNLPYFHKRPQARMLLLALFCVTVSVVWGIFRNEDQWAWVLQDTLGIAFCLYMLKTIR
                     LPTFKACTLLLLVLFIYDIFFVFITPFLTKSGNSIMVEVATGPSNSSTHEKLPMVLKV
                     PRLNTSPLSLCDRPFSLLGFGDILVPGLLVAYCHRFDIQVQSSRIYFVACTIAYGLGL
                     LVTFVALVLMQRGQPALLYLVPCTLLTSCTVALWRRELGAFWTGSGFAKDAPQTPWAA
                     TQGPVPPKAVGSSLSEQPPSEELAKSPLSTEEAGAADPAKDPDNPVASPLSPSNGDEA
                     QPIPVVKPETSA"
     exon            115..234
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            235..417
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..507
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            508..647
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..787
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..884
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1001
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1083
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1158
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1221
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1321
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1399
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1560
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..2869
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2846..2851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2869
                     /gene="Sppl2b"
                     /gene_synonym="3110056O03Rik; PSL1"
                     /note="major polyA site"
ORIGIN      
        1 cgttgcggcg tcccgaaggc gttgccagga aaccttccgc ctagagctgc ggggggaccg
       61 gcggacatgg ccgcggcgcg gctggccgca gctttgctgc tactcgcggc ccaggtggcc
      121 tgtgagttcg gcgtgcttcg agtggtgtcc caaaccagta ggactcggag cagggactac
      181 tgcatcctct acaacccaca gtgggcccac ttgccacatg acctcagcaa agtgtctctc
      241 ctgaagcttc gagacttgag caccacccag ctctgttcct accttgacgt ccctgcagaa
      301 gacttcacca accaaatcgc actggtggcc cggggcaact gtaccttcta tgagaaagtg
      361 cggctggccc agggcagtgg ggctcacggg ctgctgatag tcagcaagga gaagctggtc
      421 cctccaggag gcaacaagac acagtatgag gagataagca tccctgtggc cctgctgagc
      481 cacagagacc ttcaagacat cttcaggcgc tttggccgtg aggtaatggt ggcactgtat
      541 gctccgagcg agccagtgat ggactacaac atggtcatca tctttgtcat ggccgtgggc
      601 accgtcgcca tcggtggcta ctgggctggc agccatgatg tgaagaagta catgaagcat
      661 aagcgagacg atggtcctga gaaacaggag gatgaggcgg tggacgtgac gccagtcatg
      721 atctgcgtgt ttgttgtaat gtgctgcttc atgcttgtgc ttctctacta cttctatgac
      781 cgcctggtct acgtgatcat tggaatcttc tgcctggcct cctccaccgg tctctacagc
      841 tgtctggcac cctttgtgcg gaagctgccc ttctgcacgt gcagggtccc cgacaacaac
      901 ctgccgtact tccacaagcg cccacaggcc cgcatgctgc tgctggcact cttctgtgtc
      961 actgtctccg tggtgtgggg tatcttccga aatgaggacc agtgggcatg ggtcctgcaa
     1021 gacaccctgg gcattgcctt ctgcctgtac atgctgaaga ccatccgcct gcctaccttc
     1081 aaggcctgca cgctgctgct gctggtgctc ttcatctacg acatcttctt tgtcttcatc
     1141 acccccttcc tgaccaagag tggcaacagc atcatggtgg aggtggccac cgggccctcg
     1201 aactcatcca cccatgagaa gctgcccatg gtgctgaagg tgcccaggct gaacacctcg
     1261 ccactctccc tgtgtgaccg gcccttctcc ctcctgggct ttggagacat cttggtgcca
     1321 gggctgctgg tggcctactg tcacaggttt gatatccagg tgcagtcctc cagaatttac
     1381 tttgtggcct gtaccattgc ctatggcctg ggcctcctgg tgaccttcgt ggctcttgtc
     1441 ctcatgcagc gtggccagcc tgcactactc tacctggtcc cttgcacact gctgaccagc
     1501 tgcaccgtgg ctctgtggcg ccgggagctg ggtgccttct ggacgggcag cggttttgcg
     1561 aaggatgcac ctcagacccc gtgggccgca acccagggac ctgtgcctcc gaaggctgtg
     1621 ggttcctccc tctccgagca gcctccaagt gaagagctag ccaagagccc cctgtccact
     1681 gaggaggccg gagccgcaga ccctgccaag gatcctgaca accctgtggc cagtcccctc
     1741 agcccctcaa atggggatga ggctcagcct atccctgtgg tgaagccaga gacttcggcc
     1801 taggaagaag aggggtgaga gctgggccct cgccgccttc cacgccacac agatgctgac
     1861 cacctgggac ctgcagggga cagggacagc tgccacccac cagggtgaca gacctgctct
     1921 gtgtcccccc taacatggtg ctcaggcctc tgaggcctca agtagattct cccagctgca
     1981 ccccgcgccc agctctgctt tgcaccaggc cgtgagcttc atctgctgcc cactccatgc
     2041 aaggccgctg cccacagtgc tcggccgatg ctcaccctgc agatgctcct acggccgcgc
     2101 ctccctccac agggctgggc tctggggcca gagcaacccc aacaagcagg ttcctatgtt
     2161 gggagcagcc tcgaggggcc tgtctgtggg cactctgccc gcggggccca aaccccttca
     2221 ggagagtcca tgccaagatg gagttgagag cgtgggccac tgctctaagc cagtaaatgg
     2281 ctccagctcc aggtcctgcg ctgtgcagcc tggtgggagc tggccacgtg tggatgggtc
     2341 catgtcccca gcaagtccat cagctcagac atgcaagtct tccaggacac tgccctctgc
     2401 cccagcagtg gcttctggac tggcatctgt cctctacctc accaaccagg ctctggactc
     2461 catgacagat ctgcctgcag ggagcccagc acacatgctg catgtcaccg aggcagaggc
     2521 cacagtcccc acactctggg atagaactcg ggagccacgg ccacccacac ttgcatggga
     2581 aagggtgtct gctgcaggat gacaagcagg gacagctggg tggtcctcct agagctctgg
     2641 ggatgggggc aggggacatc ccctaggcac cctgtctaac cagaatggat agttagagga
     2701 gcgctggggc ctagccacct gcttctgcca ttggatttga caagccattt tatattgggt
     2761 gtccaagcag tcctttcacc tcttgggtag tcggaggtgc tccgcgaggt cccgctcgag
     2821 ggccctggct ttaggttgtc aggggattaa acagcttttc atactcacaa aaaaaaaaaa
     2881 aaaaaaa
//
