LOCUS       NM_029269                879 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus secreted phosphoprotein 2 (Spp2), mRNA.
ACCESSION   NM_029269
VERSION     NM_029269.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 879)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   2  (bases 1 to 879)
  AUTHORS   Christians,A., Weiss,A.C., Martens,H., Klopf,M.G., Hennies,I.,
            Haffner,D., Kispert,A. and Weber,R.G.
  TITLE     Inflammation-like changes in the urothelium of Lifr-deficient mice
            and LIFR-haploinsufficient humans with urinary tract anomalies
  JOURNAL   Hum Mol Genet 29 (7), 1192-1204 (2020)
   PUBMED   32179912
REFERENCE   3  (bases 1 to 879)
  AUTHORS   Braitsch,C.M., Azizoglu,D.B., Htike,Y., Barlow,H.R., Schnell,U.,
            Chaney,C.P., Carroll,T.J., Stanger,B.Z. and Cleaver,O.
  TITLE     LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit
            pancreatic progenitor differentiation
  JOURNAL   PLoS Biol 17 (7), e3000382 (2019)
   PUBMED   31323030
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 879)
  AUTHORS   Heliot,C., Desgrange,A., Buisson,I., Prunskaite-Hyyrylainen,R.,
            Shan,J., Vainio,S., Umbhauer,M. and Cereghini,S.
  TITLE     HNF1B controls proximal-intermediate nephron segment identity in
            vertebrates by regulating Notch signalling components and Irx1/2
  JOURNAL   Development 140 (4), 873-885 (2013)
   PUBMED   23362348
REFERENCE   5  (bases 1 to 879)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 879)
  AUTHORS   Brochmann,E.J., Simon,R.J., Jawien,J., Behnam,K., Sintuu,C.,
            Wang,J.C. and Murray,S.S.
  TITLE     Carboxy terminus of secreted phosphoprotein-24 kDa (spp24) is
            essential for full inhibition of BMP-2 activity
  JOURNAL   J Orthop Res 28 (9), 1200-1207 (2010)
   PUBMED   20162696
  REMARK    GeneRIF: proteolytic processing of spp24 affects the interaction of
            this protein with BMP-2 and this affects the function of the
            protein
REFERENCE   7  (bases 1 to 879)
  AUTHORS   Bennett,C.S., Khorram Khorshid,H.R., Kitchen,J.A., Arteta,D. and
            Dalgleish,R.
  TITLE     Characterization of the human secreted phosphoprotein 24 gene
            (SPP2) and comparison of the protein sequence in nine species
  JOURNAL   Matrix Biol 22 (8), 641-651 (2004)
   PUBMED   15062857
REFERENCE   8  (bases 1 to 879)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY787973.1 and AK002814.1.
            
            On Sep 1, 2015 this sequence version replaced NM_029269.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002814.1, AJ315513.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY787973.1         1-9
            10-879              AK002814.1         2-871
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.63 cM"
     gene            1..879
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /note="secreted phosphoprotein 2"
                     /db_xref="GeneID:75396"
                     /db_xref="MGI:MGI:1922646"
     exon            1..207
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..752
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /note="secreted phosphoprotein 2, 24kDa; secreted
                     phosphoprotein 24"
                     /codon_start=1
                     /product="secreted phosphoprotein 24 precursor"
                     /protein_id="NP_083545.1"
                     /db_xref="CCDS:CCDS15145.1"
                     /db_xref="GeneID:75396"
                     /db_xref="MGI:MGI:1922646"
                     /translation="MEQAMLKTLALLVLGMHYWCATGFPVYDYDPSSLQEALSASVAK
                     VNSQSLSPYLFRATRSSLKRVNVLDEDTLVMNLEFSVQETTCLRDSGDPSTCAFQRGY
                     SVPTAACRSTVQMSKGQVKDVWAHCRWASSSESNSSEEMMFGDMARSHRRRNDYLLGF
                     LSDESRSEQFRDRSLEIMRRGQPPAHRRFLNLHRRARVNSGFE"
     exon            208..332
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /inference="alignment:Splign:2.1.0"
     exon            333..452
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /inference="alignment:Splign:2.1.0"
     exon            453..560
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /inference="alignment:Splign:2.1.0"
     exon            561..615
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /inference="alignment:Splign:2.1.0"
     exon            616..666
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /inference="alignment:Splign:2.1.0"
     exon            667..762
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /inference="alignment:Splign:2.1.0"
     exon            763..879
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      850..855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /note="hexamer: AATAAA"
     polyA_site      873
                     /gene="Spp2"
                     /gene_synonym="0610038O04Rik; pp-24; spp24"
                     /note="major polyA site"
ORIGIN      
        1 tgaggttcca gattgctcca gccagccagg gcagctaggt cacaggtgac aagaataaga
       61 cagccaccct ctgaaagagc tgtcatccag aagcctggag agaggccgtc tccctgactc
      121 tgggtcgcca tcctctcagt atggagcagg caatgctgaa gacgctggct ttgttggtgc
      181 tgggcatgca ctactggtgt gccacaggtt tcccggtgta cgactacgac ccttcctctc
      241 tgcaggaagc tctcagtgcc tcagtggcaa aggtgaactc gcagtccctg agtccttacc
      301 tgtttcgggc gacccggagc tccttgaaga gagtcaacgt cctggatgaa gacacattgg
      361 tcatgaactt agagttcagt gttcaggaaa ccacatgcct gagagattct ggtgatccct
      421 ccacctgtgc cttccaaagg ggctactctg tgccaacagc tgcttgcagg agcactgtgc
      481 agatgtccaa gggacaggta aaggatgtgt gggctcactg ccgctgggcg tcctcatctg
      541 agtccaacag cagtgaggag atgatgtttg gggacatggc aagatcccac agacgaagaa
      601 atgattatct acttggtttt ctttctgatg aatccagaag tgaacaattc cgtgaccggt
      661 cacttgaaat catgaggagg ggacagcctc ccgcccatag aaggttcctg aacctccatc
      721 gcagagcaag agtaaattct ggctttgagt gacatcctgg agatttcatg aaagaaagag
      781 aagcagaagc tgaaatgaag aaaggcatgg agaatggtgt ctttttcctt tttataatct
      841 ccactctgca ataaagatct ttcccttcct ttactgctc
//
