LOCUS       NM_029773               2761 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus speckle-type BTB/POZ protein-like (Spopl), transcript
            variant 1, mRNA.
ACCESSION   NM_029773 XM_196253
VERSION     NM_029773.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2761)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2761)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2761)
  AUTHORS   Cai,H. and Liu,A.
  TITLE     Spop regulates Gli3 activity and Shh signaling in dorsoventral
            patterning of the mouse spinal cord
  JOURNAL   Dev Biol 432 (1), 72-85 (2017)
   PUBMED   28412462
REFERENCE   4  (bases 1 to 2761)
  AUTHORS   Cai,H. and Liu,A.
  TITLE     Spop promotes skeletal development and homeostasis by positively
            regulating Ihh signaling
  JOURNAL   Proc Natl Acad Sci U S A 113 (51), 14751-14756 (2016)
   PUBMED   27930311
REFERENCE   5  (bases 1 to 2761)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2761)
  AUTHORS   Choo,K.B., Chuang,T.J., Lin,W.Y., Chang,C.M., Tsai,Y.H. and
            Huang,C.J.
  TITLE     Evolutionary expansion of SPOP and associated TD/POZ gene family:
            impact of evolutionary route on gene expression pattern
  JOURNAL   Gene 460 (1-2), 39-47 (2010)
   PUBMED   20399258
REFERENCE   7  (bases 1 to 2761)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   8  (bases 1 to 2761)
  AUTHORS   Zhang,Q., Zhang,L., Wang,B., Ou,C.Y., Chien,C.T. and Jiang,J.
  TITLE     A hedgehog-induced BTB protein modulates hedgehog signaling by
            degrading Ci/Gli transcription factor
  JOURNAL   Dev Cell 10 (6), 719-729 (2006)
   PUBMED   16740475
REFERENCE   9  (bases 1 to 2761)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 2761)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ128267.1, BC111867.1, AK014913.1 and CK329864.1.
            
            On Oct 2, 2009 this sequence version replaced NM_029773.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14995048.1603506.1,
                                           SRR1660813.135267.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               CJ128267.1         1-126
            127-800             BC111867.1         1-674
            801-1545            BC111867.1         772-1516
            1546-2401           AK014913.1         604-1459
            2402-2761           CK329864.1         1-360               c
FEATURES             Location/Qualifiers
     source          1..2761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 15.48 cM"
     gene            1..2761
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /note="speckle-type BTB/POZ protein-like"
                     /db_xref="GeneID:76857"
                     /db_xref="MGI:MGI:1924107"
     exon            1..262
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            263..398
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            399..520
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            521..672
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            673..800
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            801..978
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1034
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1157
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1300
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1354
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..2761
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2640..2645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
                     /note="hexamer: AATATA"
     polyA_site      2666
                     /gene="Spopl"
                     /gene_synonym="4921517N04Rik; E430033K04Rik"
ORIGIN      
        1 ttggcgcacg cgccctgatg actggcgggg cggaaactgg acgcccgagc ctcaacacct
       61 agagcgggct cgggctaggc gcactctttg gcggcgggtg tgtttaatct tggggaagaa
      121 gtttagcagc cggtgaggac aaggagggag gccgggagga ggatgcggct tggccggggg
      181 gtgcccgctg caggagctcg ccgccgcctc agcctcggtc cccggggccg ccgagggccc
      241 gcccgccgcc ccgcgtgtcc ggctaaatta ttcaagtttg tgggatacta tatgaatctt
      301 aagactgtaa taaggtggca atgtctcggg aacctactcc acctctgcct ggagatatgt
      361 ctactagtcc tgttgcagaa agctggtgtt acacacaggt taaagtagtg aaattttcct
      421 acatgtggac tattaataac ttcagttttt gtagagaaga aatgggtgaa gtgttaaaga
      481 gttcaacgtt ttcttcaggc ccaaatgata aaatgaaatg gtgcctgagg gtaaacccaa
      541 agggattaga tgacgaaagt aaagactatt tgtccttata tttgctccta gtcagctgcc
      601 caaaaagtga ggttcgagct aaattcaaat tctctcttct caatgataaa agggaagaaa
      661 caaaagcaat ggaaagccaa agagcatatc gatttgtaca ggggaaggac tggggattta
      721 aaaaattcat tagaagggat tttttgcttg atgaagctaa tggtctcctt ccagatgaca
      781 agcttacgtt attctgtgag gtgagtgtgg tccaagattc agtaaatgta tcaggacaca
      841 ctagtacaaa cactttgaag gtgccagaat gtcgactagc agaagattta ggtaatctct
      901 gggaaaacac aagatttaca gattgctgct tttttgtgag aggaaaagaa ttcaaagctc
      961 ataagtctgt gcttgcagct cgatccccag tttttaatgc aatgtttgaa catgaaatgg
     1021 aagaatgcac aaagaatcga gtggaaataa atgatttaga ccctgaggta tttaaagaaa
     1081 tgatgagatt tgtttacaca ggaaaagcac caaatcttga taaaatggct gacaacttgt
     1141 tggcagctgc agacaaatat gcactggaac ggctgaaggt catgtgtgaa gaagctttgt
     1201 gtagtaacct ctcagtagaa aatgttgctg atacccttgt ccttgcagat ttgcacagtg
     1261 cagaacagtt gaaagcccag gcaatagact ttattaatag gtgcagtgtt cttcgacaac
     1321 ttgggtgtaa ggatgggaaa aactggaaca acaaccaagc aactgacata atggaaacat
     1381 cggggtggaa gtccatgatt cagtctcatc cccatttagt ggcagaagcg ttccgagcac
     1441 tagcatcttc acagtgtcca cagtttggta ttccacgcaa aaggttaaag cagtcttgag
     1501 tcttgtgtgg acagtaggaa atgcatttgc ctttcctccc caggtcccga aggattccaa
     1561 tacaaaccat aagtaacagc cgcttctgtc tctcgtccac ggacagaagc tggaaaggca
     1621 ttgcttgctt tcacatggat aattcatggt ttatacttca gctttaaatc tgactgattg
     1681 attcacttca aggccttaaa ttgtcttcag tgacttctct tgttcataga atagtttaat
     1741 tttttttatt gtgccttgtc agtttgccaa ggctctgcag gattgcacta gctccacaat
     1801 gcagtaatat tgataactga taatactgag tttcaaagga tcttccatta ttttagaaac
     1861 aaaagtattt tataggtttt gttctgtatg atctccaagt ataaaactag gttctattgg
     1921 attttgagat tgccacaggc atgtccaatc tcagttgtgt agacactaaa gagcccgttg
     1981 ccatccaggt aagtgatggc catacactgc tctggtttaa gttatttttc atttcaagga
     2041 gcagataagc aatgagttga cctaaaatct tagtaatatt tgtttagtaa tatgtgtttg
     2101 tctgtatatt aactgctcaa gaactggttt tatgcacatt tgtaaagatt gaaaaataat
     2161 atgaagttaa gatttcaata aaaagaaagc atggtttttg ttaatgtttt aaatttataa
     2221 tgacttacat ttgaaagaaa aattcaatag atgttaaagt caggatgacc aagtacatgt
     2281 aatgaatgag tgggccgatt aagcaagata tatgtgcact tttaatgtgg aaattttcta
     2341 tgataaatgg tacatatata ttttcctttt tcgtggatta ataagattta aattatgttt
     2401 taacatttaa aagaagtttt tatgacacat ggagccaatt tggatattca tgataataga
     2461 taaaattaca cttgatttta gattcattga cttggatttc aaatatttat cattgagttt
     2521 attatagttt tattacattt ggggaaggca cctaacaaat tagtcctata tagtcctatt
     2581 ctctacataa agacggagca tgttagtgga aaaacgggtg tatatgcttg tattttgcga
     2641 atatagcttt attccctgta ttaaaatttg tgtaatttgt ttattataaa attcaggaaa
     2701 aaaagtaagc attttttggg gtttatgcaa ctttattgaa aaataaatca attactagga
     2761 g
//
