LOCUS       NM_001359107            3083 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus speckle-type BTB/POZ protein (Spop), transcript
            variant 2, mRNA.
ACCESSION   NM_001359107
VERSION     NM_001359107.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3083)
  AUTHORS   Qin,T., So,K.K.H., Hui,C.C. and Sham,M.H.
  TITLE     Ptch1 is essential for cochlear marginal cell differentiation and
            stria vascularis formation
  JOURNAL   Cell Rep 43 (4), 114083 (2024)
   PUBMED   38602877
REFERENCE   2  (bases 1 to 3083)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3083)
  AUTHORS   Yang,W., Zhuang,Y., Wu,H., Su,S., Li,Y., Wang,C., Tian,Z., Peng,L.,
            Zhang,X., Liu,J., Pei,X., Yuan,W., Hu,X., Meng,B., Li,D., Zhang,Y.,
            Shan,H., Pan,Z. and Lu,Y.
  TITLE     Substrate-dependent interaction of SPOP and RACK1 aggravates
            cardiac fibrosis following myocardial infarction
  JOURNAL   Cell Chem Biol 30 (10), 1248-1260 (2023)
   PUBMED   37442135
  REMARK    GeneRIF: Substrate-dependent interaction of SPOP and RACK1
            aggravates cardiac fibrosis following myocardial infarction.
REFERENCE   4  (bases 1 to 3083)
  AUTHORS   Wang,Z., Song,Y., Ye,M., Dai,X., Zhu,X. and Wei,W.
  TITLE     The diverse roles of SPOP in prostate cancer and kidney cancer
  JOURNAL   Nat Rev Urol 17 (6), 339-350 (2020)
   PUBMED   32355326
  REMARK    Review article
REFERENCE   5  (bases 1 to 3083)
  AUTHORS   Clark,A. and Burleson,M.
  TITLE     SPOP and cancer: a systematic review
  JOURNAL   Am J Cancer Res 10 (3), 704-726 (2020)
   PUBMED   32266086
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3083)
  AUTHORS   Song,Y., Xu,Y., Pan,C., Yan,L., Wang,Z.W. and Zhu,X.
  TITLE     The emerging role of SPOP protein in tumorigenesis and cancer
            therapy
  JOURNAL   Mol Cancer 19 (1), 2 (2020)
   PUBMED   31901237
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3083)
  AUTHORS   Cuneo,M.J. and Mittag,T.
  TITLE     The ubiquitin ligase adaptor SPOP in cancer
  JOURNAL   FEBS J 286 (20), 3946-3958 (2019)
   PUBMED   31495053
  REMARK    Review article
REFERENCE   8  (bases 1 to 3083)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
REFERENCE   9  (bases 1 to 3083)
  AUTHORS   Takahashi,I., Kameoka,Y. and Hashimoto,K.
  TITLE     MacroH2A1.2 binds the nuclear protein Spop
  JOURNAL   Biochim Biophys Acta 1591 (1-3), 63-68 (2002)
   PUBMED   12183056
  REMARK    GeneRIF: MacroH2A1.2 binds the nuclear protein Spop.
REFERENCE   10 (bases 1 to 3083)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY172312.1, AK132383.1 and BF662657.1.
            
            Transcript Variant: This variant (2) uses alternate splice sites in
            the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849376 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY172312.1         2-26
            26-1952             AK132383.1         2-1928
            1953-3075           AK132383.1         1931-3053
            3076-3083           BF662657.1         1-8                 c
FEATURES             Location/Qualifiers
     source          1..3083
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..3083
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /note="speckle-type BTB/POZ protein"
                     /db_xref="GeneID:20747"
                     /db_xref="MGI:MGI:1343085"
     exon            1..322
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..466
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1513
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /note="HIB homolog 1; PDX-1 C-terminal-interacting factor
                     1"
                     /codon_start=1
                     /product="speckle-type POZ protein"
                     /protein_id="NP_001346036.1"
                     /db_xref="CCDS:CCDS36286.1"
                     /db_xref="GeneID:20747"
                     /db_xref="MGI:MGI:1343085"
                     /translation="MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFC
                     REEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKF
                     KFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCE
                     VSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAIL
                     AARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAA
                     ADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLE
                     TSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS"
     exon            467..588
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            589..740
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..868
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1046
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1102
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1225
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1368
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..3078
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2665..2670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /note="hexamer: TATAAA"
     polyA_site      2686
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /note="major polyA site"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
                     /note="hexamer: AATAAA"
     polyA_site      3075
                     /gene="Spop"
                     /gene_synonym="Pcif1; TEF2"
ORIGIN      
        1 gggtacgcgc tcgctgcgtc gacgtgctga cgacaggacg cccaggccgg tgtgtgtcgg
       61 tgtgtatgtg tgtgtgtgtg tgtgtgtatg tgtgtgtgtg tgtgtgtgtg tggtgtgtgt
      121 gtgtgtggtg tgtgtgtgtg tgtggtgtgt gtgtgtgtat gtgtgtatgt gtgtgtgtgt
      181 atgtgtgtgt atgtgtttgt atgtgtgtgc gcgctccaag agtgtatttg tgtatcggcg
      241 gtcccgcagg tcccggatgt tgcgggcagt atgaggcgag cgcaggggga cagggaccag
      301 cagctgtcgc cgccgttctc agggtgaaga aaaaccagaa acctttgccc cctgactttg
      361 gagactcagt ttaaccttca aactggcgat gtcaagggtt ccaagtcctc cacctccggc
      421 agaaatgtcg agtggtcccg ttgccgagag ctggtgctat acacagatca aggtagtgaa
      481 gttctcctac atgtggacca tcaataactt tagtttttgc cgggaggaaa tgggtgaagt
      541 cataaaaagt tcaacttttt catcaggagc caatgataaa ctgaaatggt gtttgcgagt
      601 aaacccgaaa gggctagatg aagaaagcaa agattacctg tcgctttacc tgttgttggt
      661 cagctgtcca aagagtgaag ttcgggcaaa gttcaagttc tccatcctga atgccaaggg
      721 agaagaaacc aaagctatgg agagtcagcg agcttatagg ttcgtgcaag gcaaagactg
      781 gggattcaaa aaattcatcc gcagagattt tctcttggac gaggccaatg ggcttctccc
      841 tgatgacaag ctcaccctct tctgtgaggt gagtgtagta caagactctg tcaatatttc
      901 tgggcagaat actatgaaca tggtaaaggt tcctgaatgc cggttggcag atgagttagg
      961 agggctgtgg gagaactctc gattcaccga ctgctgcttg tgtgtggctg gtcaagaatt
     1021 ccaggctcac aaggctatct tagcagctcg gtctccagtc ttcagtgcca tgtttgaaca
     1081 tgaaatggag gagagcaaaa agaatcgggt tgagattaac gacgtggagc ctgaggtgtt
     1141 taaggagatg atgtgcttca tctacacggg gaaggcgccg aacctcgaca agatggctga
     1201 cgacttgctg gcagctgccg ataagtacgc cctggagcgt ctgaaggtca tgtgtgagga
     1261 cgccctctgc agtaacctct ctgtggagaa cgctgcagag attctcatcc tggctgacct
     1321 ccacagcgca gatcagctga agacgcaggc agttgatttc atcaactatc atgcttcgga
     1381 tgtcttggag acctctgggt ggaagtcaat ggtggtgtca catccccact tagtggcaga
     1441 agcataccgt tctctggctt cagcacagtg ccctttcctg gggcccccac gcaaacgcct
     1501 gaagcaatcc taagatgctg ccagttggga gactccattt attttccaga agcagcagcc
     1561 accgttgctg ccactgacta ccaggtagac agcgcaatct gtggagcttt tactctgtgt
     1621 cagggaaaag actgcacgat gacccagact ttaaaacagc actaaataac ttagggggac
     1681 tgggggaggg aagggcccag gactcgggcc actcaacctg atgaaaccct gttgctctgt
     1741 caccgtgtgc cctttggcct gaccaagttt gacactggga ttcagtttag gcactggccc
     1801 caagcacatc ccagcagtgg tacttcggag aaatgggtgt ctgactgagc agaacaaatc
     1861 gtcagtgcct ggagcaaaac ggaaaaaaag cagaaacaag cggacattta gtcttcagag
     1921 gtggaaaagg aaagaagaaa gatttttttt ttccaaaaat cagtttgtgg attccagtag
     1981 tatttatgtt gaaagaagca aattttagtc cttccaactg tggatatttg tgaaaactcc
     2041 tcactaccat ccaagtatca gaagagctct ctcgttagca cttactgttt gcaagaacaa
     2101 gcccatcctt ttatcctctt atgacaagtg atgcgtgatg gcgggggaag tcatctgatc
     2161 tggaaaatga gtgtttggcg gtagtggctt ctgcaaaaat tcttattggt gttaaaaact
     2221 ggaaaaaaat aattcatcca gaattcatac tgtcttgata aaaactatgg ttctgttttt
     2281 tagatattgt ggaaaatgga tttttggggg ggcatttttc tctgatttta ttttttcttc
     2341 ccttcccctt ccctttttct aagagagaga gaaagagggg gagggagagg gagaggggag
     2401 agagaaagag agagaaagaa agagagagag aaagagagag agagagaaaa gaggagagga
     2461 gaaacaaatc cagaaaatac ataaaacaaa aggaagagta aaggagattt tattattatt
     2521 gctatgtgaa aaaaaatccc agcccagatg gcctggctgt ttgcacctga ctagttgcct
     2581 gcataggagc cggtcctgtc ccttctgatt agcccctctt ccaaagggga gacttccaaa
     2641 tgttaacttt tttctttttg aaaatataaa taattactat tttgtactgt gtggtatctc
     2701 tggtcttttg tttcattcac ttggcttgtc tcttgggtct gagatgcttg cctgtgagat
     2761 cttgaagccc tggtttgatc tccatcgtgc agggattatg ttcagaatgt ctaagaagcg
     2821 gtaggattta tttactctcc atagtctcac gcagctgcca gcctgttgtc ctccttgagg
     2881 agctgccagc catgtcctgg cgagtatctg ggaccaggtc ctactttgcc aaggcaagca
     2941 attgtagtgg gcttcttctg caccctgtgt gtgttaatac ccaatcccaa atctcctttc
     3001 tcctaacaaa atcaaaatat atatatattt aggggacatg aatatggaga ttaaataaag
     3061 ggaaattgtt gtgtcttcaa aaa
//
