LOCUS       NM_133903               2237 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus spondin 2, extracellular matrix protein (Spon2), mRNA.
ACCESSION   NM_133903
VERSION     NM_133903.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2237)
  AUTHORS   Rana,I., Kataria,S., Tan,T.L., Hajam,E.Y., Kashyap,D.K., Saha,D.,
            Ajnabi,J., Paul,S., Jayappa,S., Ananthan,A.S.H.P., Kumar,P.,
            Zaarour,R.F., Haarshaadri,J., Kansagara,G., Rizvi,A., Zirmire,R.K.,
            Badarinath,K., Khedkar,S.U., Chandra,Y., Samuel,R., George,R.,
            Danda,D., Jacob,P.M., Dey,R., Dhandapany,P.S., He,Y.W., Varga,J.,
            Varghese,S. and Jamora,C.
  TITLE     Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse
            Model of Systemic Sclerosis
  JOURNAL   J Invest Dermatol 143 (5), 699-710 (2023)
   PUBMED   36528128
  REMARK    GeneRIF: Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in
            a Mouse Model of Systemic Sclerosis.
REFERENCE   2  (bases 1 to 2237)
  AUTHORS   Badarinath,K., Dam,B., Kataria,S., Zirmire,R.K., Dey,R.,
            Kansagara,G., Ajnabi,J., Hegde,A., Singh,R., Masudi,T., Sambath,J.,
            Sachithanandan,S.P., Kumar,P., Gulyani,A., He,Y.W., Krishna,S. and
            Jamora,C.
  TITLE     Snail maintains the stem/progenitor state of skin epithelial cells
            and carcinomas through the autocrine effect of matricellular
            protein Mindin
  JOURNAL   Cell Rep 40 (12), 111390 (2022)
   PUBMED   36130502
REFERENCE   3  (bases 1 to 2237)
  AUTHORS   Cheng,X.S., Huo,Y.N., Fan,Y.Y., Xiao,C.X., Ouyang,X.M., Liang,L.Y.,
            Lin,Y., Wu,J.F., Ren,J.L. and Guleng,B.
  TITLE     Mindin serves as a tumour suppressor gene during colon cancer
            progression through MAPK/ERK signalling pathway in mice
  JOURNAL   J Cell Mol Med 24 (15), 8391-8404 (2020)
   PUBMED   32614521
  REMARK    GeneRIF: Mindin serves as a tumour suppressor gene during colon
            cancer progression through MAPK/ERK signalling pathway in mice.
REFERENCE   4  (bases 1 to 2237)
  AUTHORS   Yang,K., Li,W., Bai,T., Xiao,Y., Yu,W., Luo,P. and Cheng,F.
  TITLE     Mindin deficiency alleviates renal fibrosis through inhibiting
            NF-kappaB and TGF-beta/Smad pathways
  JOURNAL   J Cell Mol Med 24 (10), 5740-5750 (2020)
   PUBMED   32253812
  REMARK    GeneRIF: Mindin deficiency alleviates renal fibrosis through
            inhibiting NF-kappaB and TGF-beta/Smad pathways.
REFERENCE   5  (bases 1 to 2237)
  AUTHORS   Ardura,J.A., Gutierrez-Rojas,I., Alvarez-Carrion,L.,
            Rodriguez-Ramos,M.R., Pozuelo,J.M. and Alonso,V.
  TITLE     The secreted matrix protein mindin increases prostate tumor
            progression and tumor-bone crosstalk via ERK 1/2 regulation
  JOURNAL   Carcinogenesis 40 (7), 828-839 (2019)
   PUBMED   31168562
  REMARK    GeneRIF: Study identified the extracelular matrix protein mindin in
            the secretome of prostate adenocarcinoma cells and show that mindin
            overexpression in human and mouse TRAMP-C1-induced prostate tumors
            correlates with upregulated levels of bone-related genes in the
            tumorigenic prostate tissues. Mindin silencing decreased
            osteomimicry in adenocarcinoma cells and in the prostate tumor mice
            model.
REFERENCE   6  (bases 1 to 2237)
  AUTHORS   Li,Z., Garantziotis,S., Jia,W., Potts,E.N., Lalani,S., Liu,Z.,
            He,Y.W., Foster,W.M. and Hollingsworth,J.W.
  TITLE     The extracellular matrix protein mindin regulates trafficking of
            murine eosinophils into the airspace
  JOURNAL   J Leukoc Biol 85 (1), 124-131 (2009)
   PUBMED   18818374
  REMARK    GeneRIF: mindin participates in integrin-dependent trafficking of
            eosinophils and can contribute to the severity of allergic airways
            disease.
REFERENCE   7  (bases 1 to 2237)
  AUTHORS   Jia,W., Li,H. and He,Y.W.
  TITLE     Pattern recognition molecule mindin promotes intranasal clearance
            of influenza viruses
  JOURNAL   J Immunol 180 (9), 6255-6261 (2008)
   PUBMED   18424748
  REMARK    GeneRIF: mindin plays an essential role in the host innate immune
            response to influenza virus infection and suggest that mindin may
            be used as an immune-enhancing agent in influenza infection.
REFERENCE   8  (bases 1 to 2237)
  AUTHORS   Li,H., Oliver,T., Jia,W. and He,Y.W.
  TITLE     Efficient dendritic cell priming of T lymphocytes depends on the
            extracellular matrix protein mindin
  JOURNAL   EMBO J 25 (17), 4097-4107 (2006)
   PUBMED   16917498
  REMARK    GeneRIF: Mindin-integrin interactions play a key role in regulating
            Rho GTPase expression in DCs and DC priming of T lymphocytes.
REFERENCE   9  (bases 1 to 2237)
  AUTHORS   Jia,W., Li,H. and He,Y.W.
  TITLE     The extracellular matrix protein mindin serves as an integrin
            ligand and is critical for inflammatory cell recruitment
  JOURNAL   Blood 106 (12), 3854-3859 (2005)
   PUBMED   16105980
REFERENCE   10 (bases 1 to 2237)
  AUTHORS   He,Y.W., Li,H., Zhang,J., Hsu,C.L., Lin,E., Zhang,N., Guo,J.,
            Forbush,K.A. and Bevan,M.J.
  TITLE     The extracellular matrix protein mindin is a pattern-recognition
            molecule for microbial pathogens
  JOURNAL   Nat Immunol 5 (1), 88-97 (2004)
   PUBMED   14691481
  REMARK    GeneRIF: Mindin is a pattern-recognition molecule for microbial
            pathogens.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB848417.1, AK028987.1 and AC115070.9.
            
            On Jul 31, 2009 this sequence version replaced NM_133903.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028987.1, BC017616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BB848417.1         2-58
            58-1018             AK028987.1         3-963
            1019-1019           AC115070.9         86523-86523         c
            1020-2235           AK028987.1         965-2180
            2236-2237           AC115070.9         84409-84410         c
FEATURES             Location/Qualifiers
     source          1..2237
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.5 cM"
     gene            1..2237
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /note="spondin 2, extracellular matrix protein"
                     /db_xref="GeneID:100689"
                     /db_xref="MGI:MGI:1923724"
     exon            1..291
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /inference="alignment:Splign:2.1.0"
     exon            292..511
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1287
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /note="spondin-2"
                     /codon_start=1
                     /product="spondin-2 precursor"
                     /protein_id="NP_598664.3"
                     /db_xref="CCDS:CCDS19200.1"
                     /db_xref="GeneID:100689"
                     /db_xref="MGI:MGI:1923724"
                     /translation="MENVSLALGRALWVFLLAMIGSTTSQPLGGESVCTARPLARYSI
                     TFIGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEA
                     WALMKEIEAAGEKLQSVHAVFSAPAIPSGTGQTSTELEVHPRHSLVSFVVRIVPSPDW
                     FVGIDSLDLCEGGRWKEQVVLDLYPHDAGTDSGFTFSSPNFATIPQDTVTEITASSPS
                     HPANSFYYPRLKSLPPIAKVTFVRLQQSPRAFAPPSLDLASRGNEIVDSLSVPETPLD
                     CEVSLWSSWGLCGGPCGKLGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNCV"
     exon            512..735
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /inference="alignment:Splign:2.1.0"
     exon            736..927
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1102
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..2237
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /note="hexamer: AATAAA"
     polyA_site      1826
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
                     /note="major polyA site"
     polyA_site      1857
                     /gene="Spon2"
                     /gene_synonym="2310045I24Rik; M-spondin; Mindin; Mspondin"
ORIGIN      
        1 agcagttagc ccgagggggc ggagagtgag ctcaacttgg agcaggtcac agcagtcaga
       61 actagtgaga aggttgagca gagaacccct gcagcaggaa aacctcttgc ttccttgtct
      121 caagcccctt ctggcacttt ctgggaccag gcactgaggc agaagacagg aagagctggg
      181 gcctatctgc tggccagagg cactaacctt gggcacacat aggatctggg agctctggga
      241 ccaatcctcc agctgacaag cccagcagcc tgcctctgac gcttttgcca ggtgatggaa
      301 aacgtgagtc ttgccctggg cagagctctt tgggtcttcc tcctggccat gataggctcc
      361 accacgagcc agccgctggg gggagaatcg gtttgtacag cccggcctct ggctagatac
      421 agcatcactt tcattggcaa gtggagccag acagcatttc ccaagcagta ccccctgttc
      481 cggccccctg cacagtggtc ctctctgctg ggggcagctc acagctctga ctacagcatg
      541 tggcggaaga atgagtatgt cagcaatggg ctgagggact ttgctgagcg tggtgaggcc
      601 tgggcactga tgaaggagat cgaagctgca ggagagaaac ttcagagtgt gcacgcagtg
      661 ttctcagctc ctgccatccc tagcggtacc gggcagactt ccacagagtt agaggtgcac
      721 cctaggcact cgctggtgtc cttcgtggta cgcattgtcc ccagccctga ctggtttgtg
      781 ggcatcgaca gtctggacct gtgtgaggga ggccgctgga aggagcaggt ggtcctggat
      841 ctttatccac acgatgcagg gaccgacagt ggtttcacct tctcctcccc taactttgca
      901 actatcccac aagacacagt gactgagata acagcctcat cgcccagcca cccagcaaat
      961 tcattctact acccacgcct caagtcctta cctcccatcg ccaaagtgac cttcgtgcgg
     1021 ctacagcaga gtcccagggc ctttgcccca ccttccctgg acctggccag ccgaggcaac
     1081 gaaatcgttg acagcctttc agttccagag acaccgctgg actgtgaggt ttccctgtgg
     1141 tcatcctggg gactgtgtgg aggaccatgt ggaaagttgg gagccaagag cagaactcgc
     1201 tatgtccgtg ttcagcctgc taacaatggg actccctgtc ccgagcttga agaagaggcc
     1261 gagtgtgccc cagataactg cgtctaaacc cagactccag tagcaagcag ctcttaggat
     1321 ccctcaaggc tgggactcag atctgggcca caaggtgttt ccacaggagt cccatgcagg
     1381 cagggatgga gagcgtgggc agttttgcac cgtttcccac caatcctggg ctgacagagg
     1441 tcttcaccca gaggaccgca gtggcaggta agccacagac tgcctctccc actgtgtgac
     1501 tcctgaggct cgtgggtttg atctacataa attcccttgt aatttattac tgtggtggga
     1561 gggaggctgc ctttgataca gagagcaggc atgccaggaa cagctgagag gatgctctaa
     1621 gcctgtgaac cccacaacta cactgctgtc agatacctca gacctgctgc caccacatgt
     1681 gccagggagt caaccttcac accactcctg tgcccacatg ggggtgacca caggaggaac
     1741 aaacgaagag gggcagtttt tcgaaacttg gcccttgtgt gtcgttgatc cccttgcatt
     1801 cgaataaagg tcgtgttcct gaaaaatgtc agagggtgac ctcccaccat ccctggacac
     1861 cctggagcgg aggcgcttat ttgtatgtac aagtaggggt cacacattca caggaatctg
     1921 cagtgatgtc atggcacatc acttgctctt gtgtcaggac tgcccagtcc tcctcccatc
     1981 ccagtagatt ccgaagtcac tctggcatct tatcccaggc taggcaacac tctggggata
     2041 tcctcctagc cctgctccat cagcttgaat gtgaagaact tctcctcctt gcttcaaggg
     2101 gaccctggag ggctactctt ctgactgctg agacctttac cccgatgggt ccagagtcag
     2161 atgccaggcc cacttcccac cactagatac cttactgtta ttgaaaattc ttgaccataa
     2221 accaagttca cagggtc
//
