LOCUS       NM_009259               3751 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus sialophorin (Spn), transcript variant 1, mRNA.
ACCESSION   NM_009259
VERSION     NM_009259.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3751)
  AUTHORS   Chen,X., Tober,J., Dominguez,M., Tang,A.T., Bockman,J., Yang,J.,
            Mani,S., Lee,C.N., Chen,M., Thillaikumaran,T., Mericko-Ishizuka,P.,
            Mainigi,M., Speck,N.A. and Kahn,M.L.
  TITLE     Lineage tracing studies suggest that the placenta is not a de novo
            source of hematopoietic stem cells
  JOURNAL   PLoS Biol 23 (1), e3003003 (2025)
   PUBMED   39874373
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3751)
  AUTHORS   Hao,Q., Kundu,S., Shetty,S. and Tang,H.
  TITLE     Runx3 Regulates CD8+ T Cell Local Expansion and CD43 Glycosylation
            in Mice by H1N1 Influenza A Virus Infection
  JOURNAL   Int J Mol Sci 25 (8), 4220 (2024)
   PUBMED   38673806
  REMARK    GeneRIF: Runx3 Regulates CD8[+] T Cell Local Expansion and CD43
            Glycosylation in Mice by H1N1 Influenza A Virus Infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3751)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3751)
  AUTHORS   Bai,J., Fan,F., Gao,C., Li,S., Li,W., Wei,T., Cheng,S., Yu,J.,
            Zheng,C., Zhao,J., Zou,L., Feng,L., Yi,J. and Qin,H.
  TITLE     CD169-CD43 interaction is involved in erythroblastic island
            formation and erythroid differentiation
  JOURNAL   Haematologica 108 (8), 2205-2217 (2023)
   PUBMED   36861412
  REMARK    GeneRIF: CD169-CD43 interaction is involved in erythroblastic
            island formation and erythroid differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3751)
  AUTHORS   Chuang,C.K., Chen,S.F., Su,Y.H., Chen,W.H., Lin,W.M., Wang,I.C. and
            Shyue,S.K.
  TITLE     The Role of SCL Isoforms in Embryonic Hematopoiesis
  JOURNAL   Int J Mol Sci 24 (7), 6427 (2023)
   PUBMED   37047400
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3751)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 3751)
  AUTHORS   Misawa,Y. and Shibuya,M.
  TITLE     Amplification and rearrangement of melF/mouse CD43 (leukosialin)
            gene encoding a highly glycosylated membrane protein gp120 in
            Friend erythroleukemia cells
  JOURNAL   Oncogene 7 (5), 919-926 (1992)
   PUBMED   1533277
REFERENCE   8  (bases 1 to 3751)
  AUTHORS   Dorfman,K.S., Litaker,W., Baecher,C.M. and Frelinger,J.G.
  TITLE     The nucleotide sequence of Ly 48 (mouse leukosialin, sialophorin):
            the mouse homolog of CD43
  JOURNAL   Nucleic Acids Res 18 (16), 4932 (1990)
   PUBMED   2144340
REFERENCE   9  (bases 1 to 3751)
  AUTHORS   Cyster,J., Somoza,C., Killeen,N. and Williams,A.F.
  TITLE     Protein sequence and gene structure for mouse leukosialin (CD43), a
            T lymphocyte mucin without introns in the coding sequence
  JOURNAL   Eur J Immunol 20 (4), 875-881 (1990)
   PUBMED   2347365
REFERENCE   10 (bases 1 to 3751)
  AUTHORS   Baecher,C.M., Dorfman,K.S., Mattei,M.G. and Frelinger,J.G.
  TITLE     cDNA cloning and localization of the mouse leukosialin gene (Ly48)
            to chromosome 7
  JOURNAL   Immunogenetics 31 (5-6), 307-314 (1990)
   PUBMED   1973410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122537.4, AK134098.1, AK077764.1 and AW540100.2.
            
            On Jan 18, 2014 this sequence version replaced NM_009259.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134098.1, AK077764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC122537.4         112887-112892       c
            7-1985              AK134098.1         2-1980
            1986-1986           AK077764.1         1977-1977
            1987-3634           AK134098.1         1982-3629
            3635-3736           AK077764.1         3628-3729
            3737-3751           AW540100.2         1-15                c
FEATURES             Location/Qualifiers
     source          1..3751
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.35 cM"
     gene            1..3751
                     /gene="Spn"
                     /gene_synonym="A630014B01Rik; Cd43; Galgp; Ly-48; Ly48"
                     /note="sialophorin"
                     /db_xref="GeneID:20737"
                     /db_xref="MGI:MGI:98384"
     exon            1..77
                     /gene="Spn"
                     /gene_synonym="A630014B01Rik; Cd43; Galgp; Ly-48; Ly48"
                     /inference="alignment:Splign:2.1.0"
     exon            78..3751
                     /gene="Spn"
                     /gene_synonym="A630014B01Rik; Cd43; Galgp; Ly-48; Ly48"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1299
                     /gene="Spn"
                     /gene_synonym="A630014B01Rik; Cd43; Galgp; Ly-48; Ly48"
                     /note="lymphocyte antigen 48; leukocyte sialoglycoprotein;
                     B-cell differentiation antigen LP-3; 3E8 antigen;
                     leukosialin"
                     /codon_start=1
                     /product="leukosialin precursor"
                     /protein_id="NP_033285.1"
                     /db_xref="CCDS:CCDS21858.1"
                     /db_xref="GeneID:20737"
                     /db_xref="MGI:MGI:98384"
                     /translation="MALHLLLLFGACWVQVASPDSLQRTTMLPSTPHITAPSTSEAQN
                     ASPSVSVGSGTVDSKETISPWGQTTIPVSLTPLETTELSSLETSAGASMSTPVPEPTA
                     SQEVSSKTSALLPEPSNVASDPPVTAANPVTDGPAANPVTDGTAASTSISKGTSAPPT
                     TVTTSSNETSGPSVATTVSSKTSGPPVTTATGSLGPSSEMHGLPATTATSSVESSSVA
                     RGTSVSSRKTSTTSTQDPITTRSPSQESSGMLLVPMLIALVVVLALVALLLLWRQRQK
                     RRTGALTLSGGGKRNGVVDAWAGPARVPDEEATTTSGAGGNKGSEVLETEGSGQRPTL
                     TTFFSRRKSRQGSLVLEELKPGSGPNLKGEEEPLVGSEDEAVETPTSDGPQAKDEAAP
                     QSL"
     regulatory      3602..3607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spn"
                     /gene_synonym="A630014B01Rik; Cd43; Galgp; Ly-48; Ly48"
                     /note="hexamer: ATTAAA"
     polyA_site      3636
                     /gene="Spn"
                     /gene_synonym="A630014B01Rik; Cd43; Galgp; Ly-48; Ly48"
                     /note="major polyA site"
     regulatory      3718..3723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spn"
                     /gene_synonym="A630014B01Rik; Cd43; Galgp; Ly-48; Ly48"
                     /note="hexamer: AATAAA"
     polyA_site      3739
                     /gene="Spn"
                     /gene_synonym="A630014B01Rik; Cd43; Galgp; Ly-48; Ly48"
ORIGIN      
        1 gtctgcccca gtcctgacca agcctcagga agaactggag gtacttgccc tggccctgtg
       61 ccttaaccat taatctggtc ccaactcctg ctcctgcctg tccctctgga gatggccttg
      121 caccttctcc tcctctttgg ggcatgctgg gtccaggtgg cgagcccaga cagtctgcag
      181 aggacgacga tgctaccatc taccccacat atcacagctc caagtacctc tgaagcccag
      241 aatgccagcc catcagtttc tgtggggtca gggacagtgg actcgaagga gaccatcagc
      301 ccctgggggc agaccacaat cccagtttct ttgaccccct tggaaactac tgaattgtct
      361 tctttggaga cttctgctgg tgccagcatg agcacccctg tacctgagcc tactgcctct
      421 caggaagttt ccagcaagac atcagcactg cttccagaac catcaaatgt agccagtgac
      481 cctcctgtca ctgcagccaa tcctgtgaca gacggacctg cagccaatcc tgtgacagac
      541 ggaactgcag catctacatc tatctctaaa ggaaccagtg caccccccac cactgtgaca
      601 acaagctcta acgagaccag tggaccctct gtggctacaa cagtaagctc caagaccagt
      661 ggtccccctg tcaccacagc tactgggtct ctggggccct cgagtgagat gcatggactc
      721 cctgctacca cagcaaccag ttctgtggag agttccagtg tggcccgtgg cacctcagtt
      781 tccagcagaa aaacatccac gacgtctacc caagatccca taaccaccag gtcaccaagc
      841 caagaatcaa gtggcatgtt actggtgccc atgcttattg ccttggtggt ggttttggcc
      901 ctcgtggcgc tactgctgtt gtggcgccag aggcaaaagc ggaggactgg ggccctgacc
      961 ctgagcggag gaggaaaacg aaatggggtg gtggatgcct gggctgggcc agcccgggtt
     1021 cctgatgaag aggccacaac cacatcaggg gcagggggca acaagggctc tgaggtactg
     1081 gagacagaag gctccgggca gagacccacg ctcactacgt tcttcagcag acggaagtct
     1141 cgccagggct ctttagtact agaagagctg aagcctgggt cgggtcccaa cctgaagggg
     1201 gaggaagagc cgcttgtggg cagtgaggat gaagctgtgg aaaccccaac ttctgacggt
     1261 ccacaagcca aagatgaggc cgcacctcaa tctctatgag caacaggtat tcatccaatc
     1321 tgctccttag ccccggatcc tgctgttagc tgccgcacac tctgcatttg tgaatatttg
     1381 tggaccaaat ccgtccatcc atccatccat acattcattt ccttcccccc accccccgca
     1441 accccccagc cccgctgtct cccacctccc cttcctctgt gctttctttg gaaccaattg
     1501 ctgaatcacc atgaggatga tcttagtgga cccacatttt ccccgaggat cccccttgga
     1561 attctgggat cccaacaggc cagaaaactc cctaggatga agctgtgaag cccatgcact
     1621 cacatccttc tcagcagggg ccccttcagg aatgcctctc aactaccatt tgctttgggg
     1681 ccagcttaga gcctggatgg caacatccag cttgctcttg ggtgaactgt gacctgtgac
     1741 ttttcccaga gcactctgat ttggggctgg ctggaagctg ctggtgggag cctgccagag
     1801 atccatcact tctccttggg ttagggatgc ggagagttcc tggctggtgg tgtaggtgta
     1861 ggtggtatag tcccgcacct actgtgtcca ctcagaagta tggtttgtgt gcaagatagg
     1921 acaatttagg tgatggctgc aaacagtact ggtgaatata gaccatggga gaaagcaggg
     1981 caggtgctgg tgagttccaa aaggagggac ccaggagctg taccctgtct gctgaagacc
     2041 taagtgtgtc tgcagccccc agaagaatgc aaatgtgatg gggactaaat gtgccatcaa
     2101 gtgtgcgttc ttcagctaag ctgccatatc cttccctcag aggctccctc acaccagctc
     2161 tcaccacgcc cacaccgtgc acacaccagt aggcacacat gcaagatcgg gagaggagtc
     2221 agccaagtgc ggtgactggg tggcacaaac ccctggtgtt gatgcttttc tctacaggct
     2281 cagttgtctg tttcctcttc caccccaagg ctgaagtctt tcccttgtcg cagggtaata
     2341 agagagagtt aaatgaaaga caggcccaag gggtgggaca tggttgccag agagtcccta
     2401 agggtctgag gtacagagag gggacaggtc acaattgtgc tgcctctgac cccgccagcc
     2461 caggcacgtg gtccaaaggt ggttgctgga ggagatgtgc aagaggaagc tgttgagtca
     2521 gagggcgctg cccttgagaa cagactgacc tacagaaaga gatgtgtgcg tgcgattgtg
     2581 tgtgacctgg atgggaaagg ggaaggtggg agggagggga tgaggaatgg aaagggacat
     2641 ggaccagttg ctaccacatc aagctgccat cgttccctcc tcgagtctgt ggggaagagg
     2701 gaaggactga gctgggcaca cctgggccac actgaaccca tttctactgc tcactaggcg
     2761 ctgtgtgggc cagctacaac agagatggct cgagtgagtt gccagtggcc cttaagggac
     2821 acagcaactg ttgtggttgt ttttgccaaa ctgtgtgtcc tgatttcagg ctcagaagaa
     2881 aatatcgcta agttgagagg tcaatggctt gtttcactgc cacttctaag gtgtttcagg
     2941 ctgtcaggtg catggaggaa gacaaggaaa tggggtagag atggtggcta gcacccaaca
     3001 ggacctcagc ccagacaggg tcagatgttc tgggtgctaa gtggaatgac agacaaaagt
     3061 gtccacaaga ggaacaaaac taggaagtgg ttggtattct acctctgaag gaagacaagg
     3121 aagctgaacg cttgtcccgg atcttggcca catctctctt cccagtgact ccggtgcctg
     3181 gcaggcagca agcactcagt gcatgtcccc atgaatgaat gtatgtatgt atgtatggat
     3241 ggatggatgg atggatgaat gaatgaggca ttggcagata gcaggggaag gcacttaaca
     3301 caaagactag taatgcaaag tatgtaagtg gagcagagat catggtggac acagacaggt
     3361 ggacaggtgt ccttcagctc gggagagaga aagcccagtg agtaacagat acggaaaagg
     3421 caaaaataga agaaggagga ggaggaggag aaaaagcagg caaacagaaa acagggagat
     3481 gtaaaacagt ttcaactcca tcagttatga aaccatagct tgtgtttgtg acatcctggc
     3541 ctcgtcttca gaaatgtgta atgacctcag aaatgcctgt ggctgacgtg gggtcgggaa
     3601 aattaaatga tctgtaaata catctgtaag aagctacatc ctgcgtgttt agtgtggtcc
     3661 tcctaaacgt ggggaattta agtgtgattt ttcaccttag ttttctgtgt tttacacaat
     3721 aaatgtctct aatttcacag ttatgaaaaa c
//
