LOCUS       NM_199455                898 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus sperm microtubule inner protein 8 (Spmip8), transcript
            variant 1, mRNA.
ACCESSION   NM_199455 XM_134307
VERSION     NM_199455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Bera,T.K., Hahn,Y., Lee,B. and Pastan,I.H.
  TITLE     TEPP, a new gene specifically expressed in testis, prostate, and
            placenta and well conserved in chordates
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1209-1215 (2003)
   PUBMED   14652002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102518.11, BC087870.1 and BY706785.1.
            
            On Feb 6, 2013 this sequence version replaced NM_199455.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001511.1, BC087870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC102518.11        12165-12168         c
            5-882               BC087870.1         1-878
            883-898             BY706785.1         643-658
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..898
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /note="sperm microtubule inner protein 8"
                     /db_xref="GeneID:73407"
                     /db_xref="MGI:MGI:1920657"
     exon            1..93
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /inference="alignment:Splign:2.1.0"
     exon            94..318
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..746
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis, prostate and placenta-expressed protein; testis,
                     prostate and placenta expressed"
                     /codon_start=1
                     /product="sperm microtubule inner protein 8 isoform 1"
                     /protein_id="NP_955534.1"
                     /db_xref="CCDS:CCDS22557.1"
                     /db_xref="GeneID:73407"
                     /db_xref="MGI:MGI:1920657"
                     /translation="MAQIIDLVPWDECSAHLYASPAVLLPLERVRHPLAGVKHQLYHP
                     ALPSLRRMDMDTVKGCLSDEHCQSSTYFSKDDFNKAHFTLLGVPNKPLQCLDFTATGQ
                     KLCHKYRGGKMIPIAPGINRVDWPCFTRAIEDWSKFVSRSEEFKLPCANKRVEGFSGY
                     AVRYLKPEVTQNWRYCLNQNPSLDRYGQKPLPFDSLNAFRRFGSHYSRINYLTPWH"
     exon            319..380
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /inference="alignment:Splign:2.1.0"
     exon            381..555
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /inference="alignment:Splign:2.1.0"
     exon            556..617
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /inference="alignment:Splign:2.1.0"
     exon            618..682
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /inference="alignment:Splign:2.1.0"
     exon            683..715
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /inference="alignment:Splign:2.1.0"
     exon            716..885
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      865..870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /note="hexamer: AATAAA"
     polyA_site      885
                     /gene="Spmip8"
                     /gene_synonym="1700055M20Rik; Tepp"
                     /note="major polyA site"
ORIGIN      
        1 gcacgcccac atcctttctt ttgcccactg agcagcagga ggatagacgg ttcttacctg
       61 cctgtgcact tgggcctgtg ccctgcagat gagcgatggc ccaaatcata gacctggtgc
      121 cctgggacga atgctccgcc cacttgtatg cttccccagc ggtcctcctc cccctggagc
      181 gagtgcgcca cccactggcc ggtgtgaagc accagctcta ccacccggcc ttgccttccc
      241 ttcggcgcat ggatatggac actgtcaagg gttgcctctc cgatgaacac tgccagtctt
      301 ccacctactt ctccaaagat gatttcaaca aggcccactt cacactccta ggggtcccca
      361 acaaacccct gcaatgcctg gatttcacag caaccggcca gaagctctgt cacaagtatc
      421 gtggcggcaa gatgattccc atcgcgccag gcatcaaccg ggtcgactgg ccctgcttca
      481 cgcgtgccat cgaagattgg tctaaattcg tgtccaggtc cgaagagttc aagctgcctt
      541 gtgccaacaa aagggtggag ggtttcagtg gctacgcggt gcggtacttg aagccggagg
      601 tgacccagaa ctggcggtac tgcctcaacc agaaccccag cctggaccgc tacggacaga
      661 agcccctgcc tttcgactcg ctgaacgcgt tcaggcgctt tggctcccac tacagtcgca
      721 tcaactatct gactccctgg cattaatccg tggggggaaa aggctgattc ttctatggct
      781 ggaccgtgcc acctcagggc ccctagccgg acagagggca tatggtggca ccacccatct
      841 tctccccagg agttcagttc aagaaataaa cctaatgctt cctcaaaaaa aaaaaaaa
//
