LOCUS       NM_011463                402 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus serine peptidase inhibitor, Kazal type 4 (Spink4),
            mRNA.
ACCESSION   NM_011463
VERSION     NM_011463.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 402)
  AUTHORS   Wang,Y., Han,J., Yang,G., Zheng,S., Zhou,G., Liu,X., Cao,X., Li,G.,
            Zhang,B., Xie,Z., Li,L., Zhang,M., Li,X., Chen,M. and Zhang,S.
  TITLE     Therapeutic potential of the secreted Kazal-type serine protease
            inhibitor SPINK4 in colitis
  JOURNAL   Nat Commun 15 (1), 5874 (2024)
   PUBMED   38997284
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 402)
  AUTHORS   Hu,B.L., Yin,Y.X., Li,K.Z., Li,S.Q. and Li,Z.
  TITLE     SPINK4 promotes colorectal cancer cell proliferation and inhibits
            ferroptosis
  JOURNAL   BMC Gastroenterol 23 (1), 104 (2023)
   PUBMED   37013514
  REMARK    GeneRIF: SPINK4 promotes colorectal cancer cell proliferation and
            inhibits ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 402)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 402)
  AUTHORS   Gregorieff,A., Stange,D.E., Kujala,P., Begthel,H., van den Born,M.,
            Korving,J., Peters,P.J. and Clevers,H.
  TITLE     The ets-domain transcription factor Spdef promotes maturation of
            goblet and paneth cells in the intestinal epithelium
  JOURNAL   Gastroenterology 137 (4), 1333-45 (2009)
   PUBMED   19549527
REFERENCE   5  (bases 1 to 402)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 402)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   7  (bases 1 to 402)
  AUTHORS   Krause,R., Hemberger,M., Messerschmid,M., Mayer,W., Kothary,R.,
            Dixkens,C. and Fundele,R.
  TITLE     Molecular cloning and characterization of murine Mpgc60, a gene
            predominantly expressed in the intestinal tract
  JOURNAL   Differentiation 63 (5), 285-294 (1998)
   PUBMED   9810707
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC117050.1 and CF381698.1.
            
            On Sep 20, 2006 this sequence version replaced NM_011463.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            47 bp suspected to be vector contamination from the 5' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y11505.1, CK377505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               BC117050.1         3-364
            363-402             CF381698.1         369-408
FEATURES             Location/Qualifiers
     source          1..402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 20.64 cM"
     gene            1..402
                     /gene="Spink4"
                     /gene_synonym="MPGC60"
                     /note="serine peptidase inhibitor, Kazal type 4"
                     /db_xref="GeneID:20731"
                     /db_xref="MGI:MGI:1341848"
     exon            1..100
                     /gene="Spink4"
                     /gene_synonym="MPGC60"
                     /inference="alignment:Splign:2.1.0"
     exon            101..141
                     /gene="Spink4"
                     /gene_synonym="MPGC60"
                     /inference="alignment:Splign:2.1.0"
     exon            142..254
                     /gene="Spink4"
                     /gene_synonym="MPGC60"
                     /inference="alignment:Splign:2.1.0"
     exon            255..393
                     /gene="Spink4"
                     /gene_synonym="MPGC60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      371..376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spink4"
                     /gene_synonym="MPGC60"
                     /note="hexamer: AATAAA"
     polyA_site      389
                     /gene="Spink4"
                     /gene_synonym="MPGC60"
                     /note="major polyA site"
ORIGIN      
        1 ggcccacact tgactgcagt cacatagctc acaagcagca tggctatgca tctgtggctg
       61 gtcaccctga ccttggttcc cctccttggc atggacaggg aactgatggt gtcagctggg
      121 agccttgttt tccccagaat gcccttctgt gagcacatgg ctgagcttcc aaactgtccc
      181 cagacaccca acctgatctg tggcacggat gggctcacat atgaaaatga atgccacctt
      241 tgcctgaccc ggatgaaaac catgaaggac attcaaatca tgaaggatgg ccaatgctga
      301 gctcagaggt gcactcaagc catgaaactt catgctggag aacagtgatg ccccagaggc
      361 tatgacatga aataaaagat gcagcccaag ctaaaaaaaa aa
//
